Levi S Downs

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Endometrial carcinoma expresses an increased cathepsin B/D ratio
    William H Bradley
    The Mount Sinai School of Medicine, 1176 Fifth Avenue, Box 1170, New York, NY 10029, USA
    Gynecol Oncol 108:84-9. 2008
  2. ncbi request reprint Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers
    Melissa A Geller
    Department of Obstetrics, Gynecology and Women s Health, University of Minnesota, MMC 395 420 Delaware St SE, Minneapolis, MN, 55455, USA
    Cancer Immunol Immunother 59:1877-84. 2010
  3. ncbi request reprint Stage IV carcinoma of the Bartholin gland managed with primary chemoradiation
    Levi S Downs
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, The University of Minnesota, 420 Delaware Street SE, MMC 395, Minneapolis, Minnesota 55404, USA
    Gynecol Oncol 87:210-2. 2002
  4. doi request reprint Ifosfamide, paclitaxel, and carboplatin, a novel triplet regimen for advanced, recurrent, or persistent carcinoma of the cervix: a phase II trial
    Levi S Downs
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 120:265-9. 2011
  5. doi request reprint Overcoming the barriers to HPV vaccination in high-risk populations in the US
    Levi S Downs
    Division of Gynecologic, The University of Minnesota, Minneapolis, MN, USA
    Gynecol Oncol 117:486-90. 2010
  6. doi request reprint The disparity of cervical cancer in diverse populations
    Levi S Downs
    University of Minnesota, Dept of OB GYN and Women s Health, 420 Delaware Street, 8395 SE, MMC 395 Mayo, Minneapolis, MN 55455, USA
    Gynecol Oncol 109:S22-30. 2008
  7. ncbi request reprint A prospective randomized trial of thalidomide with topotecan compared with topotecan alone in women with recurrent epithelial ovarian carcinoma
    Levi S Downs
    Division of Gynecologic Oncology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer 112:331-9. 2008
  8. ncbi request reprint Cathepsins B and D activity and activity ratios in normal ovaries, benign ovarian neoplasms, and epithelial ovarian cancer
    Levi S Downs
    Department of Obstetrics, Gynecology and Women s Health, The University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Soc Gynecol Investig 12:539-44. 2005
  9. ncbi request reprint Thalidomide and angiostatin inhibit tumor growth in a murine xenograft model of human cervical cancer
    Levi S Downs
    The University of Minnesota Medical School, Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, 420 Delaware Street SE, MMC 395, Minneapolis, MN 55455, USA
    Gynecol Oncol 98:203-10. 2005
  10. ncbi request reprint A phase I study of ifosfamide, paclitaxel, and carboplatin in advanced and recurrent cervical cancer
    Levi S Downs
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Gynecol Oncol 95:347-51. 2004

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Endometrial carcinoma expresses an increased cathepsin B/D ratio
    William H Bradley
    The Mount Sinai School of Medicine, 1176 Fifth Avenue, Box 1170, New York, NY 10029, USA
    Gynecol Oncol 108:84-9. 2008
    ..As such they may function as biomarkers for the aggressiveness of a given tumor. We examined the enzymatic activity of these proteins as well as the cellular and extracellular distribution of cathepsins B and D...
  2. ncbi request reprint Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers
    Melissa A Geller
    Department of Obstetrics, Gynecology and Women s Health, University of Minnesota, MMC 395 420 Delaware St SE, Minneapolis, MN, 55455, USA
    Cancer Immunol Immunother 59:1877-84. 2010
    ..Secondary objectives included assessment of safety and immune system activation...
  3. ncbi request reprint Stage IV carcinoma of the Bartholin gland managed with primary chemoradiation
    Levi S Downs
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, The University of Minnesota, 420 Delaware Street SE, MMC 395, Minneapolis, Minnesota 55404, USA
    Gynecol Oncol 87:210-2. 2002
    ..Although the management of advanced vulvar cancer has shifted toward conservative management with primary chemoradiation, there is limited information on the similar approach to the management of advanced Bartholin's gland carcinoma...
  4. doi request reprint Ifosfamide, paclitaxel, and carboplatin, a novel triplet regimen for advanced, recurrent, or persistent carcinoma of the cervix: a phase II trial
    Levi S Downs
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 120:265-9. 2011
    ....
  5. doi request reprint Overcoming the barriers to HPV vaccination in high-risk populations in the US
    Levi S Downs
    Division of Gynecologic, The University of Minnesota, Minneapolis, MN, USA
    Gynecol Oncol 117:486-90. 2010
    ....
  6. doi request reprint The disparity of cervical cancer in diverse populations
    Levi S Downs
    University of Minnesota, Dept of OB GYN and Women s Health, 420 Delaware Street, 8395 SE, MMC 395 Mayo, Minneapolis, MN 55455, USA
    Gynecol Oncol 109:S22-30. 2008
    ..Strategies to reduce cervical cancer disparities need to be employed in order to reverse these trends...
  7. ncbi request reprint A prospective randomized trial of thalidomide with topotecan compared with topotecan alone in women with recurrent epithelial ovarian carcinoma
    Levi S Downs
    Division of Gynecologic Oncology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer 112:331-9. 2008
    ..Thalidomide is an antiangiogenic agent with immune modulating potential. The objective of this study was to determine response rates among women who were treated for recurrent ovarian cancer using topotecan with or without thalidomide...
  8. ncbi request reprint Cathepsins B and D activity and activity ratios in normal ovaries, benign ovarian neoplasms, and epithelial ovarian cancer
    Levi S Downs
    Department of Obstetrics, Gynecology and Women s Health, The University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Soc Gynecol Investig 12:539-44. 2005
    ..Our objective was to determine if activity ratios of these two isoforms might enhance their usefulness as biomarkers...
  9. ncbi request reprint Thalidomide and angiostatin inhibit tumor growth in a murine xenograft model of human cervical cancer
    Levi S Downs
    The University of Minnesota Medical School, Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, 420 Delaware Street SE, MMC 395, Minneapolis, MN 55455, USA
    Gynecol Oncol 98:203-10. 2005
    ..To determine the impact of thalidomide and angiostatin on tumor growth, angiogenesis, and apoptosis in a xenograft model of cervical cancer...
  10. ncbi request reprint A phase I study of ifosfamide, paclitaxel, and carboplatin in advanced and recurrent cervical cancer
    Levi S Downs
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Gynecol Oncol 95:347-51. 2004
    ..To determine toxicity and establish a maximum tolerated dose of outpatient therapy with ifosfamide, paclitaxel, and carboplatin in women with advanced and recurrent cervical cancer...
  11. doi request reprint A phase II trial of carboplatin and docetaxel followed by radiotherapy given in a "Sandwich" method for stage III, IV, and recurrent endometrial cancer
    Melissa A Geller
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, USA
    Gynecol Oncol 121:112-7. 2011
    ..To determine feasibility and efficacy of administering docetaxel and carboplatin chemotherapy followed by pelvic radiotherapy and then consolidation chemotherapy in patients with advanced or recurrent endometrial cancer...
  12. doi request reprint Hyperthermic intraperitoneal chemotherapy with carboplatin for optimally-cytoreduced, recurrent, platinum-sensitive ovarian carcinoma: a pilot study
    Peter A Argenta
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, USA
    Gynecol Oncol 129:81-5. 2013
    ..We aimed to evaluate the feasibility and tolerability of hyperthermic intraperitoneal carboplatin (HIPEC-carboplatin) following secondary cytoreduction for recurrent, platinum-sensitive ovarian cancer...
  13. ncbi request reprint Treatment and recurrence patterns in endometrial stromal sarcomas and the relation to c-kit expression
    Melissa A Geller
    Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Gynecol Oncol 95:632-6. 2004
    ..With the successful application of directed biological therapy in other sarcomas, a review of the behavior and biology of this disease is warranted...
  14. ncbi request reprint Widespread lymph node metastases in a young woman with FIGO stage IA1 squamous cervical cancer
    Peter A Argenta
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Gynecol Oncol 97:659-61. 2005
    ..This option is particularly appealing for younger or nulliparous patients, in whom fertility may be highly desired...
  15. ncbi request reprint Preoperative detection of peripherally circulating cancer cells and its prognostic significance in ovarian cancer
    Patricia L Judson
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women s Health, University of Minnesota, 420 Delaware Street Southeast, MMC 395, Minneapolis, MN 55455, USA
    Gynecol Oncol 91:389-94. 2003
    ....
  16. doi request reprint A phase II study of fulvestrant in the treatment of multiply-recurrent epithelial ovarian cancer
    Peter A Argenta
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women s Health, University of Minnesota, Minneapolis MN 55455, USA
    Gynecol Oncol 113:205-9. 2009
    ..Grade 1 toxicity included headache (1 patient) and bromidrosis (2 patients). Conclusions. Fulvestrant is well-tolerated and efficacious. Objective response rates are low, but disease stabilization was common...
  17. pmc A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer
    Melissa A Geller
    Obstetrics and Gynecology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cytotherapy 13:98-107. 2011
    ..We evaluated the tumor response and in vivo expansion of allogeneic NK cells in recurrent ovarian and breast cancer...
  18. doi request reprint Learning about ovarian cancer at the time of diagnosis: video versus usual care
    Melissa A Geller
    Obstetrics and Gynecology, University of Minnesota, Minneapolis, MN, USA
    Gynecol Oncol 119:370-5. 2010
    ..We evaluated the effects of an educational video on patients' distress, cancer knowledge, coping skills and attitudes regarding learning about cancer at the time of ovarian cancer diagnosis...
  19. ncbi request reprint Routine pelvic examination during front-line chemotherapy for ovarian cancer: should it play a role?
    Peter A Argenta
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women s Health, University of Minnesota, Minneapolis, USA
    J Reprod Med 53:3-7. 2008
    ..To determine if pelvic examination affected management in patients undergoing first-line chemotherapy for ovarian cancer and to determine a threshold of change in tumor size reliably detectable by pelvic examination...
  20. ncbi request reprint A prospective, randomized study analyzing sartorius transposition following inguinal-femoral lymphadenectomy
    Patricia L Judson
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women s Health, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 95:226-30. 2004
    ....
  21. pmc Multiple-type human papillomavirus (HPV) infections: a cross-sectional analysis of the prevalence of specific types in 309,000 women referred for HPV testing at the time of cervical cytology
    Elizabeth Louise Dickson
    Department of Obstetrics, Gynecology and Women s Health, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Int J Gynecol Cancer 23:1295-302. 2013
    ..To determine the frequency of multiple-type cervical human papillomavirus (HPV) infections, and whether any types are involved in multiple-type infections more or less frequently than might be expected if these infections occur randomly...
  22. ncbi request reprint A phase II evaluation of Temozolomide in patients with recurrent epithelial ovarian cancer
    Patricia L Judson
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women s Health, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 93:667-70. 2004
    ..To identify the nature and degree of toxicity of Temozolomide in this group of patients...
  23. doi request reprint Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention in a mouse model of cervical cancer
    Amy L Jonson
    University of Minnesota Medical School, Department of Obstetrics, Gynecology and Women s Health, 420 Delaware Street S E, MMC 395, Minneapolis, MN 55455 0374, USA
    Gynecol Oncol 111:356-64. 2008
    ..Our objective was to determine if siRNA targeting E6/E7 would inhibit the growth of established tumors in a mouse model of cervical cancer...
  24. ncbi request reprint Clinical features and outcomes of uterine and ovarian carcinosarcoma
    Amy L Jonson
    Department of Obstetrics, Gynecology and Women s Health, University of Minnesota Medical School, MN 55455 0374, USA
    Gynecol Oncol 100:561-4. 2006
    ..The objective of this study was to compare the clinical presentation and outcomes of women with ovarian and uterine carcinosarcoma (CS)...
  25. ncbi request reprint Bevacizumab plus cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer
    Justin C Chura
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 107:326-30. 2007
    ..To investigate the efficacy and safety of bevacizumab in heavily pretreated patients with recurrent ovarian cancer...
  26. pmc A prospective clinical trial of lenalidomide with topotecan in women with advanced epithelial ovarian carcinoma
    Jori S Carter
    Department of Obstetrics, Gynecology, and Women s Health, University of Minnesota, 420 Delaware Street SE, MMC 395, Minneapolis, MN 55455, USA
    Int J Clin Oncol 16:666-70. 2011
    ....
  27. doi request reprint Solitary fibrous tumors arising from the female pelvis
    Thanasak Sueblinvong
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology University of Minnesota, Minneapolis, Minnesota, USA
    Obstet Gynecol 118:470-4. 2011
    ..Solitary fibrous tumor arising from the female genital tract is extremely rare and the management of this condition is controversial...
  28. doi request reprint Vulvar and vaginal cancer
    Jori S Carter
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women s Health, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Obstet Gynecol Clin North Am 39:213-31. 2012
    ..Prognosis is poor; however, adequate treatment can be delivered with a combination of external beam radiotherapy and brachytherapy, and with surgical resection for a select group of patients...
  29. ncbi request reprint Hysteroscopy and cytology in endometrial cancer
    William H Bradley
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecology Oncology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Obstet Gynecol 104:1030-3. 2004
    ..To estimate the effect of preoperative diagnostic hysteroscopy on peritoneal cytology in patients with endometrial cancer...
  30. ncbi request reprint Positron emission tomography and leiomyomas: clinicopathologic analysis of 3 cases of PET scan-positive leiomyomas and literature review
    Justin C Chura
    University of Minnesota, Department of Obstetrics, Gynecology, and Women s Health, 420 Delaware Street SE MMC 395, Minneapolis, MN 55455, USA
    Gynecol Oncol 104:247-52. 2007
    ..Studies have suggested that PET scans can differentiate between leiomyomas and leiomyosarcomas. Our experience, however, shows that PET scan-positive smooth muscle tumors are not necessarily malignant...
  31. pmc Water-fat MRI for assessing changes in bone marrow composition due to radiation and chemotherapy in gynecologic cancer patients
    Patrick J Bolan
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA
    J Magn Reson Imaging 38:1578-84. 2013
    ..To assess the feasibility of using fat-fraction imaging for measuring marrow composition changes over large regions in patients undergoing cancer therapy...
  32. ncbi request reprint Adenocarcinoma of the urinary bladder presenting as locally advanced endometrial carcinoma. Case report and review of the literature
    Justin C Chura
    Department of Obstetrics, Gynecology, and Women s Health, University of Minnesota, Division of Gynecologic Oncology, 420 Delaware Street SE MMC 395, Minneapolis, MN 55455, USA
    Gynecol Oncol 103:336-41. 2006
    ..Carcinoma of the urinary bladder that occurs after urinary diversion is a rare entity. We report a case of an adenocarcinoma arising in a defunctionalized bladder that presented as locally advanced endometrial carcinoma...
  33. pmc Cervical cytology and multiple type HPV infection: a study of 8182 women ages 31-65
    Elizabeth L Dickson
    Department of Obstetrics, Gynecology and Women s Health, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA Electronic address
    Gynecol Oncol 133:405-8. 2014
    ..The aim of this study is to determine the rates of single and multiple type human papillomavirus (HPV) infection in women in the United States ages 31-65 with known cervical cytology results...
  34. pmc Quantitative multiparametric MRI of ovarian cancer
    Jori S Carter
    University of Minnesota, Division of Gynecologic Oncology, Minneapolis, Minnesota, USA
    J Magn Reson Imaging 38:1501-9. 2013
    ..To identify parameters associated with ovarian malignancy using multiparametric quantitative magnetic resonance imaging (MRI)...
  35. ncbi request reprint Localized delivery of chemotherapy to the cervix for radiosensitization
    Lucy S Hodge
    Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA
    Gynecol Oncol 127:121-5. 2012
    ..The aim of this study was to examine the utility of localized drug delivery as a means of improving drug targeting of radiosensitizing chemotherapeutics to the cervix while limiting systemic toxicities...
  36. ncbi request reprint Stage II squamous cell carcinoma of the vagina in a patient with Bloom syndrome: a case report
    Christine S Goudge
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women s Health, University of Minnesota, 420 Delaware Street SE, MMC 395, Minneapolis, MN 55455, USA
    J Reprod Med 52:557-9. 2007
    ..Bloom syndrome (BS) is a rare autosomal recessive disorder characterized by dwarfism and a predisposition to cancer. Squamous cell vaginal cancer is also quite rare and has not before been reported in association with BS...
  37. ncbi request reprint Type-specific prevalence and persistence of human papillomavirus in women in the United States who are referred for typing as a component of cervical cancer screening
    Elizabeth Ralston Howe
    Maternal and Child Health Program, Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
    Am J Obstet Gynecol 200:245.e1-7. 2009
    ..The purpose of this study was to report type-specific prevalence and persistence of human papillomavirus (HPV) in women who underwent cytologic screening...