Cynthia D Downard

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi Treatment of necrotizing enterocolitis: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review
    Cynthia D Downard
    Kosair Children s Hospital, University of Louisville, Louisville, KY, USA
    J Pediatr Surg 47:2111-22. 2012
  2. ncbi Direct peritoneal resuscitation augments ileal blood flow in necrotizing enterocolitis via a novel mechanism
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 47:1128-34. 2012
  3. ncbi Maternal cigarette smoking and the development of necrotizing enterocolitis
    Cynthia D Downard
    MMSc, Division of Pediatric Surgery, Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 130:78-82. 2012
  4. ncbi Congenital diaphragmatic hernia: an ongoing clinical challenge
    Cynthia D Downard
    Division of Pediatric Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Curr Opin Pediatr 20:300-4. 2008
  5. ncbi Altered intestinal microcirculation is the critical event in the development of necrotizing enterocolitis
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 46:1023-8. 2011
  6. ncbi Intestinal microcirculatory flow alterations in necrotizing enterocolitis are improved by direct peritoneal resuscitation
    Alexandra C Maki
    Robley Rex Veterans Affairs Medical Center, and the Department of Surgery, and Division of Pediatric Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Am Surg 78:803-7. 2012
  7. ncbi Direct peritoneal resuscitation improves obesity-induced hepatic dysfunction after trauma
    Paul J Matheson
    Robley Rex Veteran s Affairs Medical Center, Louisville, KY, USA
    J Am Coll Surg 214:517-28; discussion 528-30. 2012
  8. ncbi Strategies for the prevention of central venous catheter infections: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review
    Eunice Y Huang
    Division of Pediatric Surgery, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    J Pediatr Surg 46:2000-11. 2011
  9. ncbi Current therapy of infants with congenital diaphragmatic hernia
    Cynthia D Downard
    Department of Surgery, Children's Hospital, Boston--Harvard Medical School, Fegan 3, 300 Longwood Avenue, Boston, MA 02445, USA
    Semin Neonatol 8:215-21. 2003
  10. ncbi Impact of AMICAR on hemorrhagic complications of ECMO: a ten-year review
    Cynthia D Downard
    Department of Surgery and Respiratory Therapy, Children's Hospital, Boston-Harvard Medical School, Boston, MA 02445, USA
    J Pediatr Surg 38:1212-6. 2003

Detail Information

Publications11

  1. ncbi Treatment of necrotizing enterocolitis: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review
    Cynthia D Downard
    Kosair Children s Hospital, University of Louisville, Louisville, KY, USA
    J Pediatr Surg 47:2111-22. 2012
    ..The aim of this systematic review is to review and evaluate the currently available evidence for the surgical care of patients with NEC...
  2. ncbi Direct peritoneal resuscitation augments ileal blood flow in necrotizing enterocolitis via a novel mechanism
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 47:1128-34. 2012
    ..We hypothesized that direct peritoneal resuscitation (DPR) dilates the intestinal microvasculature and improves blood flow independent of these mechanisms...
  3. ncbi Maternal cigarette smoking and the development of necrotizing enterocolitis
    Cynthia D Downard
    MMSc, Division of Pediatric Surgery, Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 130:78-82. 2012
    ..We hypothesized that maternal risk factors were the primary determinant of future development of NEC...
  4. ncbi Congenital diaphragmatic hernia: an ongoing clinical challenge
    Cynthia D Downard
    Division of Pediatric Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Curr Opin Pediatr 20:300-4. 2008
    ..The following review should update any clinician treating infants with congenital diaphragmatic hernia regarding the latest developments affecting treatment and ultimate outcome in these patients...
  5. ncbi Altered intestinal microcirculation is the critical event in the development of necrotizing enterocolitis
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 46:1023-8. 2011
    ..We hypothesized that vasoconstriction of the neonatal intestinal microvasculature is the essential mechanistic event in NEC and that these microvascular changes correlate with alterations in mediators of inflammation...
  6. ncbi Intestinal microcirculatory flow alterations in necrotizing enterocolitis are improved by direct peritoneal resuscitation
    Alexandra C Maki
    Robley Rex Veterans Affairs Medical Center, and the Department of Surgery, and Division of Pediatric Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Am Surg 78:803-7. 2012
    ..All groups had an increase in blood flow with dialysate treatment. This may represent a novel initial therapy to improve intestinal ischemia in human necrotizing enterocolitis...
  7. ncbi Direct peritoneal resuscitation improves obesity-induced hepatic dysfunction after trauma
    Paul J Matheson
    Robley Rex Veteran s Affairs Medical Center, Louisville, KY, USA
    J Am Coll Surg 214:517-28; discussion 528-30. 2012
    ..We hypothesized that obesity-related liver dysfunction could be mitigated with the novel technique of adjunctive direct peritoneal resuscitation (DPR)...
  8. ncbi Strategies for the prevention of central venous catheter infections: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review
    Eunice Y Huang
    Division of Pediatric Surgery, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    J Pediatr Surg 46:2000-11. 2011
    ..The aim of this study is to review the current evidence-based data regarding strategies for prevention of central venous catheter (CVC) infections at the time of catheter insertion and as a part of routine care...
  9. ncbi Current therapy of infants with congenital diaphragmatic hernia
    Cynthia D Downard
    Department of Surgery, Children's Hospital, Boston--Harvard Medical School, Fegan 3, 300 Longwood Avenue, Boston, MA 02445, USA
    Semin Neonatol 8:215-21. 2003
    ..Through co-ordinated, multidisciplinary evaluation of CDH survivors, improved long-term outcome for these challenging patients can be attained...
  10. ncbi Impact of AMICAR on hemorrhagic complications of ECMO: a ten-year review
    Cynthia D Downard
    Department of Surgery and Respiratory Therapy, Children's Hospital, Boston-Harvard Medical School, Boston, MA 02445, USA
    J Pediatr Surg 38:1212-6. 2003
    ..AMICAR remains a valuable tool for the prevention of hemorrhage in patients undergoing operation prior to or while on ECMO...
  11. ncbi Analysis of an improved survival rate for congenital diaphragmatic hernia
    Cynthia D Downard
    Department of Surgery, Children's Hospital, Boston-Harvard Medical School, Boston, MA, USA
    J Pediatr Surg 38:729-32. 2003
    ..Thus, it may be possible to identify other centers with higher than expected survival rates and to define common therapeutic strategies associated with decreased mortality...