Cynthia D Downard

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. doi request reprint Treatment of necrotizing enterocolitis: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review
    Cynthia D Downard
    Kosair Children s Hospital, University of Louisville, Louisville, KY, USA
    J Pediatr Surg 47:2111-22. 2012
  2. doi request reprint Direct peritoneal resuscitation augments ileal blood flow in necrotizing enterocolitis via a novel mechanism
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 47:1128-34. 2012
  3. doi request reprint Maternal cigarette smoking and the development of necrotizing enterocolitis
    Cynthia D Downard
    MMSc, Division of Pediatric Surgery, Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 130:78-82. 2012
  4. doi request reprint Congenital diaphragmatic hernia: an ongoing clinical challenge
    Cynthia D Downard
    Division of Pediatric Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Curr Opin Pediatr 20:300-4. 2008
  5. doi request reprint Altered intestinal microcirculation is the critical event in the development of necrotizing enterocolitis
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 46:1023-8. 2011
  6. ncbi request reprint Intestinal microcirculatory flow alterations in necrotizing enterocolitis are improved by direct peritoneal resuscitation
    Alexandra C Maki
    Robley Rex Veterans Affairs Medical Center, and the Department of Surgery, and Division of Pediatric Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Am Surg 78:803-7. 2012
  7. doi request reprint Intraperitoneal 1.5% Delflex improves intestinal blood flow in necrotizing enterocolitis
    Sarah K Walker
    Hiram C Polk, Jr, MD, Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    J Surg Res 184:358-64. 2013
  8. doi request reprint Direct peritoneal resuscitation improves obesity-induced hepatic dysfunction after trauma
    Paul J Matheson
    Robley Rex Veteran s Affairs Medical Center, Louisville, KY, USA
    J Am Coll Surg 214:517-28; discussion 528-30. 2012
  9. doi request reprint Increased hepatic blood flow during enteral immune-enhancing diet gavage requires intact enterohepatic bile cycling
    Andrea K Nagengast
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    Nutrition 30:313-8. 2014
  10. ncbi request reprint Oral relaxin maintains intestinal blood flow in a rat model of NEC
    Paul J Matheson
    Robley Rex Veterans Affairs Medical Center at Louisville, KY Hiram C Polk, Jr, M D Department of Surgery, University of Louisville, Louisville, KY
    J Pediatr Surg 49:961-4; discussion 964-5. 2014

Detail Information

Publications15

  1. doi request reprint Treatment of necrotizing enterocolitis: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review
    Cynthia D Downard
    Kosair Children s Hospital, University of Louisville, Louisville, KY, USA
    J Pediatr Surg 47:2111-22. 2012
    ..The aim of this systematic review is to review and evaluate the currently available evidence for the surgical care of patients with NEC...
  2. doi request reprint Direct peritoneal resuscitation augments ileal blood flow in necrotizing enterocolitis via a novel mechanism
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 47:1128-34. 2012
    ..We hypothesized that direct peritoneal resuscitation (DPR) dilates the intestinal microvasculature and improves blood flow independent of these mechanisms...
  3. doi request reprint Maternal cigarette smoking and the development of necrotizing enterocolitis
    Cynthia D Downard
    MMSc, Division of Pediatric Surgery, Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 130:78-82. 2012
    ..We hypothesized that maternal risk factors were the primary determinant of future development of NEC...
  4. doi request reprint Congenital diaphragmatic hernia: an ongoing clinical challenge
    Cynthia D Downard
    Division of Pediatric Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Curr Opin Pediatr 20:300-4. 2008
    ..The following review should update any clinician treating infants with congenital diaphragmatic hernia regarding the latest developments affecting treatment and ultimate outcome in these patients...
  5. doi request reprint Altered intestinal microcirculation is the critical event in the development of necrotizing enterocolitis
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 46:1023-8. 2011
    ..We hypothesized that vasoconstriction of the neonatal intestinal microvasculature is the essential mechanistic event in NEC and that these microvascular changes correlate with alterations in mediators of inflammation...
  6. ncbi request reprint Intestinal microcirculatory flow alterations in necrotizing enterocolitis are improved by direct peritoneal resuscitation
    Alexandra C Maki
    Robley Rex Veterans Affairs Medical Center, and the Department of Surgery, and Division of Pediatric Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Am Surg 78:803-7. 2012
    ..All groups had an increase in blood flow with dialysate treatment. This may represent a novel initial therapy to improve intestinal ischemia in human necrotizing enterocolitis...
  7. doi request reprint Intraperitoneal 1.5% Delflex improves intestinal blood flow in necrotizing enterocolitis
    Sarah K Walker
    Hiram C Polk, Jr, MD, Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    J Surg Res 184:358-64. 2013
    ..We hypothesized that buffered 1.5% dextrose solution would increase ileal blood flow compared with baseline in NEC...
  8. doi request reprint Direct peritoneal resuscitation improves obesity-induced hepatic dysfunction after trauma
    Paul J Matheson
    Robley Rex Veteran s Affairs Medical Center, Louisville, KY, USA
    J Am Coll Surg 214:517-28; discussion 528-30. 2012
    ..We hypothesized that obesity-related liver dysfunction could be mitigated with the novel technique of adjunctive direct peritoneal resuscitation (DPR)...
  9. doi request reprint Increased hepatic blood flow during enteral immune-enhancing diet gavage requires intact enterohepatic bile cycling
    Andrea K Nagengast
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    Nutrition 30:313-8. 2014
    ..My colleagues and I hypothesized that liver blood flow would be similarly affected by IEDs containing n-3 PUFAs...
  10. ncbi request reprint Oral relaxin maintains intestinal blood flow in a rat model of NEC
    Paul J Matheson
    Robley Rex Veterans Affairs Medical Center at Louisville, KY Hiram C Polk, Jr, M D Department of Surgery, University of Louisville, Louisville, KY
    J Pediatr Surg 49:961-4; discussion 964-5. 2014
    ..Relaxin (RLXN), a hormone found in breast milk but absent from formula, is a potent vasodilator. We hypothesized that relaxin-supplemented feeds with an NEC protocol would decrease NEC severity and increase intestinal blood flow...
  11. ncbi request reprint Application of prostaglandin E2 improves ileal blood flow in NEC
    Sarah K Walker
    Hiram C Polk, Jr, M D Department of Surgery, University of Louisville, Louisville, KY
    J Pediatr Surg 49:945-9; discussion 949. 2014
    ..We sought to define the contribution of prostaglandin E2 (PG E2) and its receptor EP4 to intestinal blood flow regulation in premature neonates with NEC...
  12. doi request reprint Strategies for the prevention of central venous catheter infections: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review
    Eunice Y Huang
    Division of Pediatric Surgery, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    J Pediatr Surg 46:2000-11. 2011
    ..The aim of this study is to review the current evidence-based data regarding strategies for prevention of central venous catheter (CVC) infections at the time of catheter insertion and as a part of routine care...
  13. ncbi request reprint Current therapy of infants with congenital diaphragmatic hernia
    Cynthia D Downard
    Department of Surgery, Children s Hospital, Boston Harvard Medical School, Fegan 3, 300 Longwood Avenue, Boston, MA 02445, USA
    Semin Neonatol 8:215-21. 2003
    ..Through co-ordinated, multidisciplinary evaluation of CDH survivors, improved long-term outcome for these challenging patients can be attained...
  14. ncbi request reprint Impact of AMICAR on hemorrhagic complications of ECMO: a ten-year review
    Cynthia D Downard
    Department of Surgery and Respiratory Therapy, Children s Hospital, Boston Harvard Medical School, Boston, MA 02445, USA
    J Pediatr Surg 38:1212-6. 2003
    ..The purpose of this analysis is to determine if these benefits remain when AMICAR is used in a large population...
  15. ncbi request reprint Analysis of an improved survival rate for congenital diaphragmatic hernia
    Cynthia D Downard
    Department of Surgery, Children s Hospital, Boston Harvard Medical School, Boston, MA, USA
    J Pediatr Surg 38:729-32. 2003
    ..This study examines the survival rate of neonates with CDH treated by a multidisciplinary team in a single pediatric hospital. Actual survival rate is compared with predicted outcome based on severity of illness...