Donald Dougherty

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Impulsivity, attention, memory, and decision-making among adolescent marijuana users
    Donald M Dougherty
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, NRLC MC 7793, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychopharmacology (Berl) 226:307-19. 2013
  2. pmc Comparing the detection of transdermal and breath alcohol concentrations during periods of alcohol consumption ranging from moderate drinking to binge drinking
    Donald M Dougherty
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Exp Clin Psychopharmacol 20:373-81. 2012
  3. pmc A test of alcohol dose effects on multiple behavioral measures of impulsivity
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Drug Alcohol Depend 96:111-20. 2008
  4. pmc Comparison of 50- and 100-g L -tryptophan depletion and loading formulations for altering 5-HT synthesis: pharmacokinetics, side effects, and mood states
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, School of Medicine, The University of Texas Health Science Center at San Antonio, Mail Code 7793, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychopharmacology (Berl) 198:431-45. 2008
  5. pmc Impulsivity and clinical symptoms among adolescents with non-suicidal self-injury with or without attempted suicide
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Psychiatry Res 169:22-7. 2009
  6. ncbi request reprint The effects of alcohol on laboratory-measured impulsivity after L: -Tryptophan depletion or loading
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 193:137-50. 2007
  7. pmc Behavioral measures of impulsivity and the law
    Charles W Mathias
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, Mail Code 7792, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Behav Sci Law 26:691-707. 2008
  8. pmc Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporter
    Michael A Dawes
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Stud Alcohol Drugs 70:899-907. 2009
  9. ncbi request reprint Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorder
    Alan C Swann
    Department of Psychiatry, University of Texas Medical School at Houston, 1300 Moursund, Rm 270, Houston, TX 77030, USA
    Am J Psychiatry 162:1680-7. 2005
  10. ncbi request reprint Serotonin 2a receptor T102C polymorphism and impaired impulse control
    James M Bjork
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Am J Med Genet 114:336-9. 2002

Detail Information

Publications31

  1. pmc Impulsivity, attention, memory, and decision-making among adolescent marijuana users
    Donald M Dougherty
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, NRLC MC 7793, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychopharmacology (Berl) 226:307-19. 2013
    ..This study used a logistic regression model that combines performance on a range of tasks to identify which measures were most altered among adolescent marijuana users...
  2. pmc Comparing the detection of transdermal and breath alcohol concentrations during periods of alcohol consumption ranging from moderate drinking to binge drinking
    Donald M Dougherty
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Exp Clin Psychopharmacol 20:373-81. 2012
    ....
  3. pmc A test of alcohol dose effects on multiple behavioral measures of impulsivity
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Drug Alcohol Depend 96:111-20. 2008
    ..Acute alcohol administration affects impulsive behavior, although these effects vary as a function of alcohol dose, assessment instrument, and time of measurement following administration...
  4. pmc Comparison of 50- and 100-g L -tryptophan depletion and loading formulations for altering 5-HT synthesis: pharmacokinetics, side effects, and mood states
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, School of Medicine, The University of Texas Health Science Center at San Antonio, Mail Code 7793, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychopharmacology (Berl) 198:431-45. 2008
    ..While most researchers have used a 100-g formulation, there has been ongoing interest in using smaller-sized formulations...
  5. pmc Impulsivity and clinical symptoms among adolescents with non-suicidal self-injury with or without attempted suicide
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Psychiatry Res 169:22-7. 2009
    ..Risk assessments for adolescents with NSSI+SA should include consideration not only of the severity of clinical symptoms but of the current level impulsivity as well...
  6. ncbi request reprint The effects of alcohol on laboratory-measured impulsivity after L: -Tryptophan depletion or loading
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 193:137-50. 2007
    ....
  7. pmc Behavioral measures of impulsivity and the law
    Charles W Mathias
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, Mail Code 7792, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Behav Sci Law 26:691-707. 2008
    ..Legal implications for defining behavioral deficits using behavioral measures of impulsivity and their current limitations are discussed...
  8. pmc Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporter
    Michael A Dawes
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Stud Alcohol Drugs 70:899-907. 2009
    ..Specifically, we wanted to examine the relationships between the following: platelet 5-HTT and 5-HTT genotype; platelet 5-HTT parameters and age at onset, as well as duration of drinking; and 5-HTT genotype and impulse control...
  9. ncbi request reprint Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorder
    Alan C Swann
    Department of Psychiatry, University of Texas Medical School at Houston, 1300 Moursund, Rm 270, Houston, TX 77030, USA
    Am J Psychiatry 162:1680-7. 2005
    ..The purpose of this study was to investigate the relationship between impulsivity and severity of past suicidal behavior, a potential predictor of eventual suicide, in patients with bipolar disorder...
  10. ncbi request reprint Serotonin 2a receptor T102C polymorphism and impaired impulse control
    James M Bjork
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Am J Med Genet 114:336-9. 2002
    ..These preliminary data suggest that the T102C 5-HT2a receptor polymorphism may be a marker for impaired behavior control-perhaps in the context of psychiatric disorder history...
  11. ncbi request reprint Age at first drink relates to behavioral measures of impulsivity: the immediate and delayed memory tasks
    Donald M Dougherty
    University of Texas Health Science Center at Houston, Neurobehavioral Research Laboratory and Clinic, Houston, Texas 77030, USA
    Alcohol Clin Exp Res 28:408-14. 2004
    ..This study examined the relationship between laboratory-measured impulsivity and age at first drink...
  12. ncbi request reprint Behavioral impulsivity paradigms: a comparison in hospitalized adolescents with disruptive behavior disorders
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 77030 3406, USA
    J Child Psychol Psychiatry 44:1145-57. 2003
    ..As a result, comparisons between measures are difficult, with little consensus regarding which method may be most sensitive to individual impulsivity differences of different populations...
  13. ncbi request reprint Impulsivity and phase of illness in bipolar disorder
    Alan C Swann
    Department of Psychiatry, University of Texas Mental Sciences Institute, University of Texas Health Science Center, Houston, TX, USA
    J Affect Disord 73:105-11. 2003
    ..Impulsivity is prominent in bipolar disorder, but there is little quantitative information relating it to phase of illness...
  14. pmc Characterizing aggressive behavior with the Impulsive/Premeditated Aggression Scale among adolescents with conduct disorder
    Charles W Mathias
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychiatry Res 151:231-42. 2007
    ..As in the adult and child literature, characterization of aggressive behavior into two subtypes appears to be relevant to understanding individual differences among adolescents with Conduct Disorder...
  15. ncbi request reprint Commission error rates on a continuous performance test are related to deficits measured by the Benton Visual Retention Test
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 77030, USA
    Assessment 10:3-12. 2003
    ..These results may be explained by a shared association between processes of impulsivity and other deficits of executive control that may interfere with successful performance of the Benton...
  16. pmc Candidate endophenotypes for genetic studies of suicidal behavior
    J John Mann
    Department of Psychiatry, NewYork State Psychiatric Institute ColumbiaUniversity, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 65:556-63. 2009
    ..Other candidate endophenotypes requiring further investigation include serotonergic neurotransmission, second messenger systems, and borderline personality disorder traits...
  17. ncbi request reprint Two models of impulsivity: relationship to personality traits and psychopathology
    Alan C Swann
    Department of Psychiatry, University of Texas Medical School, Houston, Texas, USA
    Biol Psychiatry 51:988-94. 2002
    ....
  18. ncbi request reprint Suicidal behaviors and drug abuse: impulsivity and its assessment
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 1300 Moursund Street, Houston, TX 77030, USA
    Drug Alcohol Depend 76:S93-S105. 2004
    ..To better account for influence of impulsivity in these psychiatric disturbances, no single source of measurement should be used without the consideration of other types of instruments...
  19. ncbi request reprint Immediate and delayed memory tasks: a computerized behavioral measure of memory, attention, and impulsivity
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund Street, Houston, TX 77030, USA
    Behav Res Methods Instrum Comput 34:391-8. 2002
    ..Preliminary studies have demonstrated that these laboratory tasks are sensitive to group differences, produce stable baselines of performance, and are sensitive to drug-induced performance decrements...
  20. ncbi request reprint Impulsive and premeditated subtypes of aggression in conduct disorder: differences in time estimation
    Donald M Dougherty
    Department of Psychiatry and Behavioral Medicine, Neurobehavioral Research Laboratory and Clinic, Wake Forest University School of Medicine Winston Salem, North Carolina 27157, USA
    Aggress Behav 33:574-82. 2007
    ..This study confirms the importance of considering the role and type of physical aggression when studying heterogeneous diagnostic groups like CD and supports the relevance of time estimation to certain subgroups of adolescents with CD...
  21. ncbi request reprint Laboratory behavioral measures of impulsivity
    Donald M Dougherty
    Department of Psychiatry and Behavioral Medicine, School of Medicine, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Behav Res Methods 37:82-90. 2005
    ..The four paradigms in this software package are available at no cost and can be obtained by contacting the corresponding author...
  22. ncbi request reprint Familial transmission of Continuous Performance Test behavior: attentional and impulsive response characteristics
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 77030, USA
    J Gen Psychol 130:5-21. 2003
    ..e., BIS) was correlated with commission errors for parents, but not for adolescents. The findings of this study support the use of an objective behavioral measure of impulsivity to assess familial relationships of impulsivity...
  23. ncbi request reprint Reliability estimates for the immediate and delayed memory tasks
    Charles W Mathias
    Neurobehavioral Research Laboratory and Clinic, University of Texas Health Science Center at Houston, 77030, USA
    Percept Mot Skills 95:559-69. 2002
    ..Analyses indicated that the primary variable of interest, i.e., commission of errors, showed acceptable reliability within and across testing periods...
  24. ncbi request reprint The biphasic effects of alcohol: comparisons of subjective and objective measures of stimulation, sedation, and physical activity
    Merideth A Addicott
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Alcohol Clin Exp Res 31:1883-90. 2007
    ..However, little is known about the effects of alcohol on physical activity or the relationship between physical activity and subjective self-report measures of stimulation and sedation following alcohol consumption in humans...
  25. ncbi request reprint Acute yohimbine increases laboratory-measured impulsivity in normal subjects
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, Texas 77030, USA
    Biol Psychiatry 57:1209-11. 2005
    ....
  26. ncbi request reprint Impulsivity and BOLD fMRI activation in MDMA users and healthy control subjects
    Ignacio H Valdes
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund, Houston, TX 77030, USA
    Psychiatry Res 147:239-42. 2006
    ..A significant correlation between BIS scores and DLPFC activation was found, supporting a role for the DLPFC in BIS-measured impulsivity...
  27. ncbi request reprint Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: diffusion tensor imaging
    Frederick Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Neuropsychopharmacology 30:610-7. 2005
    ....
  28. ncbi request reprint Increased impulsivity in cocaine dependent subjects independent of antisocial personality disorder and aggression
    F Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center Houston, 1300 Moursund, Houston, TX 77030, USA
    Drug Alcohol Depend 68:105-11. 2002
    ..This study supports the hypothesis that the increased impulsivity as measured by the BIS-11 in cocaine dependent individuals is not exclusively due to concomitant increases in aggression or ASPD...
  29. ncbi request reprint P300 event-related potential amplitude and impulsivity in cocaine-dependent subjects
    F Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center Houston, Moursund, Houston, Texas, USA
    Neuropsychobiology 50:167-73. 2004
    ..This study supports the hypothesis that the basic neurophysiology responsible for the P300 amplitude in cocaine-dependent individuals is associated with impulsivity independent of a history of childhood conduct disorder symptoms...
  30. ncbi request reprint Laboratory-measured aggressive behavior of women: acute tryptophan depletion and augmentation
    Dawn M Marsh
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund Street, Houston, TX 77030, USA
    Neuropsychopharmacology 26:660-71. 2002
    ..These findings indicate that both T+ and T- can influence aggressive behavior and that certain subgroups of women may be more susceptible to serotonin manipulation...
  31. ncbi request reprint Functional MRI study of working memory in MDMA users
    F Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center Houston, 1300 Moursund, Houston, TX 77030, USA
    Psychopharmacology (Berl) 177:185-94. 2004
    ..Similarly, behavioral studies in human MDMA users regularly find abnormalities in memory, mood, and impulse control. However, studies of brain function using brain imaging in MDMA users have been less consistent...

Research Grants33

  1. Impulsivity and Information Processing in Adolescent Cannabis Abuse
    Donald Dougherty; Fiscal Year: 2007
    ....
  2. Impulsivity and Biological Markers for Suicidality and Drug Use in Adolescents
    Donald M Dougherty; Fiscal Year: 2010
    ....
  3. Behavioral Models of Impulsivity: ETOH and 5-HT Effects
    Donald Dougherty; Fiscal Year: 2009
    ....
  4. Impulsivity and Biological Markers for Suicidality and Drug Use in Adolescents
    Donald Dougherty; Fiscal Year: 2009
    ....
  5. Binge Drinking: Individual Differences in the Capacity to Alter Drinking Patterns
    Donald M Dougherty; Fiscal Year: 2010
    ....
  6. Behavioral Models of Impulsivity: ETOH and 5-HT Effects
    Donald Dougherty; Fiscal Year: 2009
    ....
  7. Behavioral Models of Impulsivity: ETOH and 5-HT Effects
    Donald Dougherty; Fiscal Year: 2005
    ....
  8. Impulsivity Models: Behavioral Mechanisms
    Donald Dougherty; Fiscal Year: 2006
    ..This research will advance our understanding of the construct of impulsivity and will provide a firmer context within which future research can better study the role impulsivity plays in the development of severe conduct problems. ..
  9. The Relationship of Impulsivity to Symptoms of Suicide
    Donald Dougherty; Fiscal Year: 2004
    ....
  10. AGGRESSION AND WOMEN--ALCOHOL AND SEROTONIN RELATIONSHIP
    Donald Dougherty; Fiscal Year: 2003
    ..These proposed studies will answer several questions regarding how alcohol, serotonin, premenstrual symptomatology, and the menstrual cycle are related to the susceptibility for aggressive behavior. ..
  11. Consequences of Adolescent Substance Use on the Development of Impulse Control
    Donald M Dougherty; Fiscal Year: 2010
    ..The advancement of better prevention programs and substance use treatments are dependent on a gaining a better understanding of these complex relationships. ..