Anthony G Doufas

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi request reprint Consequences of inadvertent perioperative hypothermia
    Anthony G Doufas
    Department of Anesthesiology Neuroscience and Anesthesia ICU, and Outcomes Research Institute, University of Louisville Hospital, 530 South Jackson Street, Louisville, KY 40202, USA
    Best Pract Res Clin Anaesthesiol 17:535-49. 2003
  2. pmc Block-dependent sedation during epidural anaesthesia is associated with delayed brainstem conduction
    A G Doufas
    Outcomes Research Institute and Department of Anesthesiology, University of Louisville, KY 40202, USA
    Br J Anaesth 93:228-34. 2004
  3. pmc Induction speed is not a determinant of propofol pharmacodynamics
    Anthony G Doufas
    Department of Anesthesiology and Perioperative Medicine, and Outcomes Research Institute, University of Louisville, Kentucky, USA
    Anesthesiology 101:1112-21. 2004
  4. ncbi request reprint Physiology and clinical relevance of induced hypothermia
    Anthony G Doufas
    Outcomes Research Institute, Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, USA
    Neurocrit Care 1:489-98. 2004
  5. ncbi request reprint A new system to target the effect-site during propofol sedation
    A G Doufas
    OUTCOMES RESEARCH Institute and Department of Anesthesiology and Pharmacology, University of Louisville, Louisville, KY 40202, USA
    Acta Anaesthesiol Scand 47:944-50. 2003
  6. ncbi request reprint Neither arm nor face warming reduces the shivering threshold in unanesthetized humans
    Anthony G Doufas
    Outcomes Research Institute, Department of Anesthesiology, University of Louisville, Louisville, KY, USA
    Stroke 34:1736-40. 2003
  7. ncbi request reprint Dexmedetomidine and meperidine additively reduce the shivering threshold in humans
    Anthony G Doufas
    Outcomes Research Institute and the Department of Anesthesiology, Louisville, KY, USA
    Stroke 34:1218-23. 2003
  8. ncbi request reprint Initial experience with a novel heat-exchanging catheter in neurosurgical patients
    Anthony G Doufas
    Outcomes Research Institute and Department of Anesthesiology, University of Louisville, KY 40202, USA
    Anesth Analg 95:1752-6, table of contents. 2002
  9. pmc The timing of acupuncture stimulation does not influence anesthetic requirement
    Grigory Chernyak
    Outcomes Research Institute, 501 East Broadway, Louisville, KY 40202, USA
    Anesth Analg 100:387-92. 2005
  10. pmc Dantrolene reduces the threshold and gain for shivering
    Chun Ming Lin
    Outcomes Research Institute, University of Louisville, Louisville, Kentucky 40202, USA
    Anesth Analg 98:1318-24, table of contents. 2004

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Consequences of inadvertent perioperative hypothermia
    Anthony G Doufas
    Department of Anesthesiology Neuroscience and Anesthesia ICU, and Outcomes Research Institute, University of Louisville Hospital, 530 South Jackson Street, Louisville, KY 40202, USA
    Best Pract Res Clin Anaesthesiol 17:535-49. 2003
    ..Finally, mild core hypothermia influences pulse oximetry monitoring and various electrophysiological indices of the nervous system, with questionable clinical significance, as yet...
  2. pmc Block-dependent sedation during epidural anaesthesia is associated with delayed brainstem conduction
    A G Doufas
    Outcomes Research Institute and Department of Anesthesiology, University of Louisville, KY 40202, USA
    Br J Anaesth 93:228-34. 2004
    ..We used brainstem auditory evoked potentials (BAEP) to evaluate reticular function in 11 volunteers...
  3. pmc Induction speed is not a determinant of propofol pharmacodynamics
    Anthony G Doufas
    Department of Anesthesiology and Perioperative Medicine, and Outcomes Research Institute, University of Louisville, Kentucky, USA
    Anesthesiology 101:1112-21. 2004
    ..The authors concurrently evaluated the automated responsiveness monitor (ARM) against other sedation measures and the propofol effect site concentration...
  4. ncbi request reprint Physiology and clinical relevance of induced hypothermia
    Anthony G Doufas
    Outcomes Research Institute, Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, USA
    Neurocrit Care 1:489-98. 2004
    ..However, pharmacological induction of thermoregulatory tolerance to cold without excessive sedation, respiratory depression, or other serious toxicity remains a major focus of current therapeutic hypothermia research...
  5. ncbi request reprint A new system to target the effect-site during propofol sedation
    A G Doufas
    OUTCOMES RESEARCH Institute and Department of Anesthesiology and Pharmacology, University of Louisville, Louisville, KY 40202, USA
    Acta Anaesthesiol Scand 47:944-50. 2003
    ..We evaluated a new, integrated, covariate-adjusted, target-controlled infusion system during sedation with propofol combined with 50% nitrous oxide (N2O) and with propofol only (Air)...
  6. ncbi request reprint Neither arm nor face warming reduces the shivering threshold in unanesthetized humans
    Anthony G Doufas
    Outcomes Research Institute, Department of Anesthesiology, University of Louisville, Louisville, KY, USA
    Stroke 34:1736-40. 2003
    ..We tested the hypothesis that focal arm (forearm and hand) warming or lower facial warming, combined with inhalation of heated and humidified gas, only minimally reduces the shivering threshold (triggering core temperature)...
  7. ncbi request reprint Dexmedetomidine and meperidine additively reduce the shivering threshold in humans
    Anthony G Doufas
    Outcomes Research Institute and the Department of Anesthesiology, Louisville, KY, USA
    Stroke 34:1218-23. 2003
    ..We tested the hypothesis that meperidine and dexmedetomidine synergistically reduce the shivering threshold without producing substantial sedation or respiratory depression...
  8. ncbi request reprint Initial experience with a novel heat-exchanging catheter in neurosurgical patients
    Anthony G Doufas
    Outcomes Research Institute and Department of Anesthesiology, University of Louisville, KY 40202, USA
    Anesth Analg 95:1752-6, table of contents. 2002
    ..No thrombus or other particulate material was identified on the extracted catheters. None of the patients suffered any complications that could be attributed to the SetPoint system or thermal management...
  9. pmc The timing of acupuncture stimulation does not influence anesthetic requirement
    Grigory Chernyak
    Outcomes Research Institute, 501 East Broadway, Louisville, KY 40202, USA
    Anesth Analg 100:387-92. 2005
    ..2% +/- 0.6%), Preinduction (5.0% +/- 0.8%), and At-induction (4.7% +/- 0.3%; P = 0.125) days. This type of acupuncture is thus unlikely to facilitate general anesthesia or decrease the requirement for anesthetic drugs...
  10. pmc Dantrolene reduces the threshold and gain for shivering
    Chun Ming Lin
    Outcomes Research Institute, University of Louisville, Louisville, Kentucky 40202, USA
    Anesth Analg 98:1318-24, table of contents. 2004
    ..It thus seems unlikely to prove more effective than conventional muscle relaxants for treatment of life-threatening hyperthermia...
  11. doi request reprint Bispectral index dynamics during propofol hypnosis is similar in red-haired and dark-haired subjects
    Anthony G Doufas
    Department of Anesthesia, University of Louisville, Louisville, KY, USA
    Anesth Analg 116:319-26. 2013
    ..We tested the hypothesis that the propofol concentration in the effect site associated with half maximal electroencephalogram response, Ce50, is at least 50% higher in subjects with red hair...
  12. pmc Anesthetic requirement is increased in redheads
    Edwin B Liem
    Outcomes Research Institute, University of Louisville, Louisville, Kentucky USA
    Anesthesiology 101:279-83. 2004
    ..Therefore, the authors tested the hypothesis that the requirement for the volatile anesthetic desflurane is greater in natural redheaded than in dark-haired women...
  13. pmc The new perilaryngeal airway (CobraPLA) is as efficient as the laryngeal mask airway (LMA) but provides better airway sealing pressures
    Ozan Akca
    Outcomes Research Institute, Louisville, Kentucky 40202, USA
    Anesth Analg 99:272-8. 2004
    ..Airway sealing pressure was significantly greater with CobraPLA (23 +/- 6 cm H2O) than LMA (18 +/- 5 cm H2O, P < 0.001). The CobraPLA has insertion characteristics similar to the LMA but better airway sealing capabilities...
  14. ncbi request reprint Hypercapnia improves tissue oxygenation
    Ozan Akca
    Outcomes Research Institute and Department of Anesthesiology, University of Louisville, KY 40202, USA
    Anesthesiology 97:801-6. 2002
    ..Since hypercapnia improves cardiac output and peripheral tissue perfusion, we tested the hypothesis that peripheral tissue oxygenation increases as a function of arterial carbon dioxide tension (PaCO(2)) in anesthetized humans...
  15. pmc Women have the same desflurane minimum alveolar concentration as men: a prospective study
    Anupama Wadhwa
    Department of Anesthesiology, University of Louisville, Kentucky, USA
    Anesthesiology 99:1062-5. 2003
    ..The authors therefore tested the hypothesis that the desflurane concentration required to prevent movement in response to skin incision (MAC) differs between men and women...
  16. ncbi request reprint Electro-acupuncture at the Zusanli, Yanglingquan, and Kunlun points does not reduce anesthetic requirement
    Nobutada Morioka
    Department of Anesthesiology, University of Louisville, 501 East Broadway, Louisville, KY 40202, USA
    Anesth Analg 95:98-102, table of contents. 2002
    ..6% +/- 0.6%, mean +/- SD) and control (4.6% +/- 0.8%) days (P = 0.8). These data provided an 80% power for detecting a difference of 0.35 volume-percent between the groups...
  17. ncbi request reprint Effect of intra-operative end-tidal carbon dioxide partial pressure on tissue oxygenation
    O Akca
    Outcomes Research Institute, 501 E Broadway, Suite 210, Louisville, KY 40202, USA
    Anaesthesia 58:536-42. 2003
    ..Increases in subcutaneous tissue oxygen partial pressure similar to those observed in patients assigned to hypercapnia are associated with substantial reductions in wound infection risk...
  18. pmc Tissue oxygenation response to mild hypercapnia during cardiopulmonary bypass with constant pump output
    O Akca
    Outcomes Research Institute, University of Louisville, KY 40202, USA
    Br J Anaesth 96:708-14. 2006
    ..However, relative contributions of increased cardiac output and peripheral vasodilation to this response remains unknown. We thus tested the hypothesis that increased cardiac output is the dominant mechanism...
  19. ncbi request reprint Insufficiency in a new temporal-artery thermometer for adult and pediatric patients
    Mohammad Irfan Suleman
    Outcomes Research Institute and Department of Anesthesiology, University of Louisville, 501 East Broadway, Louisville, KY 40202, USA
    Anesth Analg 95:67-71, table of contents. 2002
    ..6. Infrared and bladder temperatures in children differed by only 0.3 degrees C, but the SD of the difference was 0.5 degrees C. Thus, 31% of the values in the infants and children differed by more than 0.5 degrees C...
  20. doi request reprint Ventilator-associated pneumonia in critically ill stroke patients: frequency, risk factors, and outcomes
    Yusuke Kasuya
    Department of Anesthesiology and Perioperative Medicine, University of Louisville, KY 40202, USA
    J Crit Care 26:273-9. 2011
    ..Our main objective was to assess incidence, risk factors, and outcomes of ventilator-associated pneumonia (VAP) in stroke patients...
  21. ncbi request reprint Midazolam causes less sedation in volunteers with red hair
    Marlene V Chua
    Department of Anesthesiology and the Outcomes Research Institute, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Can J Anaesth 51:25-30. 2004
    ..We studied sedation, cognition, and mood during midazolam infusion in volunteers with red and non-red (blond or brown) hair, to test the hypothesis that patients with red hair may require more drugs to attain desired levels of sedation...
  22. ncbi request reprint Automated responsiveness test and bispectral index monitoring during propofol and propofol/N2O sedation
    A G Doufas
    The Outcomes Research Institute and Department of Anesthesiology and Pharmacology, University of Louisville, Louisville, KY 40202, USA
    Acta Anaesthesiol Scand 47:951-7. 2003
    ....
  23. doi request reprint Nocturnal intermittent hypoxia is independently associated with pain in subjects suffering from sleep-disordered breathing
    Anthony G Doufas
    Associate Professor, Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, California, and Outcomes Research Consortium, Cleveland, Ohio Assistant Professor, Department of Health Research and Policy, Director of Faculty Development, Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine Postdoctoral Research Fellow, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, and Stanford Center for Sleep Sciences and Medicine
    Anesthesiology 119:1149-62. 2013
    ....
  24. pmc Magnesium sulphate only slightly reduces the shivering threshold in humans
    A Wadhwa
    Outcomes Research Institute and Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, USA
    Br J Anaesth 94:756-62. 2005
    ..We tested the hypothesis that magnesium reduces the threshold (triggering core temperature) and gain of shivering without substantial sedation or muscle weakness...
  25. ncbi request reprint Influence of administration rate on propofol plasma-effect site equilibration
    Michel M R F Struys
    Department of Anesthesia, Ghent University Hospital, Gent, Belgium
    Anesthesiology 107:386-96. 2007
    ..The authors hypothesized a difference in plasma-effect site equilibration, depicted by a first-order constant k(e0), depending on the injection rate of propofol...
  26. doi request reprint Lower-body warming mimics the normal epidural-induced reduction in the shivering threshold
    Anthony G Doufas
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
    Anesth Analg 106:252-6, table of contents. 2008
    ..We tested the hypothesis that increasing leg skin temperature to 38 degrees C mimics the normal approximately 0.6 degrees C reduction in the shivering threshold during epidural anesthesia...
  27. ncbi request reprint The threshold and gain of thermoregulatory vasoconstriction differs during anesthesia in the dependent and upper arms in the lateral position
    Robert Greif
    Department of Anesthesiology and Intensive Care Medicine, Donauspital SMZO, Vienna, Austria
    Anesth Analg 94:1019-22, table of contents. 2002
    ..The thermoregulatory system may thus recognize that hydrostatic forces reduce the vasoconstriction threshold and may compensate by sufficiently augmenting gain...
  28. ncbi request reprint Transcutaneous electrical stimulation of an auricular acupuncture point decreases anesthetic requirement
    Robert Greif
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA
    Anesthesiology 96:306-12. 2002
    ..This is known as auricular electrically stimulated analgesia. The authors therefore tested the hypothesis that auricular electrically stimulated analgesia reduces anesthetic requirement...
  29. ncbi request reprint Postoperative coma in a patient with complete basilar syndrome after anterior cervical discectomy
    Yung Fong Tsai
    Department of Anesthesiology, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    Can J Anaesth 53:202-7. 2006
    ....
  30. ncbi request reprint Sitting position does not alter minimum alveolar concentration for desflurane
    Chun Ming Lin
    Department of Anesthesiology, Chang Gung Memorial Hospital, 5, Fu Hsing St, Tao Yuan, Taiwan
    Can J Anaesth 54:523-30. 2007
    ....