SUSAN DORSEY

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint HIV peripheral neuropathy: pathophysiology and clinical implications
    Susan G Dorsey
    School of Nursing, University of Maryland, Baltimore, 21201, USA
    AACN Clin Issues 17:30-6. 2006
  2. pmc Multimodal assessment of painful peripheral neuropathy induced by chronic oxaliplatin-based chemotherapy in mice
    Cynthia L Renn
    School of Nursing, Center for Pain Studies, University of Maryland, Baltimore, MD, USA
    Mol Pain 7:29. 2011
  3. pmc In vivo evidence that truncated trkB.T1 participates in nociception
    Cynthia L Renn
    School of Nursing, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 5:61. 2009
  4. pmc Genetic deletion of trkB.T1 increases neuromuscular function
    Susan G Dorsey
    University of Maryland Baltimore School of Nursing, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 302:C141-53. 2012
  5. ncbi request reprint In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model
    Susan G Dorsey
    Neural Development Group, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Neuron 51:21-8. 2006
  6. pmc Genome-wide screen identifies drug-induced regulation of the gene giant axonal neuropathy (Gan) in a mouse model of antiretroviral-induced painful peripheral neuropathy
    Susan G Dorsey
    University of Maryland School of Nursing, Baltimore, MD 21201, USA
    Biol Res Nurs 11:7-16. 2009
  7. ncbi request reprint Full-length tropomyosin-related kinase B expression in the brainstem in response to persistent inflammatory pain
    Cynthia L Renn
    Department of Organizational Systems and Adult Health, School of Nursing, University of Maryland, Baltimore, Maryland 21201 1579, USA
    Neuroreport 17:1175-9. 2006
  8. ncbi request reprint The physiology and processing of pain: a review
    Cynthia L Renn
    Department of Organizational Systems and Adult Health, School of Nursing, University of Maryland, Baltimore, Maryland 21201 1579, USA
    AACN Clin Issues 16:277-90; quiz 413-5. 2005
  9. ncbi request reprint Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16
    Susan G Dorsey
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 22:2571-8. 2002
  10. pmc A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin
    Pedro F Esteban
    Neural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD 21702, USA
    J Cell Biol 173:291-9. 2006

Research Grants

  1. BDNF Signal Strength Modulates NRTI-Induced Allodynia in the Mouse
    SUSAN DORSEY; Fiscal Year: 2007
  2. UMB Center for Pain Studies
    Susan G Dorsey; Fiscal Year: 2010
  3. BDNF Signal Strength Modulates NRTI-Induced Allodynia in the Mouse
    Susan G Dorsey; Fiscal Year: 2010
  4. TrkB.T1 as a Genetic Disease Modifier of Muscular Dystrophy
    CHRISTOPHER WILLIAM WARD; Fiscal Year: 2010
  5. BDNF Signal Strength Modulates NRTI-Induced Allodynia in the Mouse
    Susan G Dorsey; Fiscal Year: 2010
  6. ADMINISTRATIVE CORE
    SUSAN DORSEY; Fiscal Year: 2009
  7. UMB Center for Pain Studies
    SUSAN DORSEY; Fiscal Year: 2009
  8. Epigenetic Modifications of BDNF and trkB Genes Underlie Pain Plasticity
    John David Sweatt; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. ncbi request reprint HIV peripheral neuropathy: pathophysiology and clinical implications
    Susan G Dorsey
    School of Nursing, University of Maryland, Baltimore, 21201, USA
    AACN Clin Issues 17:30-6. 2006
    ..This article provides the latest information regarding the pathophysiology and clinical implications of HIV peripheral neuropathy...
  2. pmc Multimodal assessment of painful peripheral neuropathy induced by chronic oxaliplatin-based chemotherapy in mice
    Cynthia L Renn
    School of Nursing, Center for Pain Studies, University of Maryland, Baltimore, MD, USA
    Mol Pain 7:29. 2011
    ..To further characterize the model, we examined nocifensive behavior and central nervous system excitability by in vivo electrophysiological recording of spinal dorsal horn (SDH) wide dynamic range neurons in oxaliplatin-treated mice..
  3. pmc In vivo evidence that truncated trkB.T1 participates in nociception
    Cynthia L Renn
    School of Nursing, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 5:61. 2009
    ..T1 up-regulation following antiretroviral treatment and tissue inflammation participates in the development and maintenance of nocifensive behavior and may represent a novel therapeutic target for pain treatment...
  4. pmc Genetic deletion of trkB.T1 increases neuromuscular function
    Susan G Dorsey
    University of Maryland Baltimore School of Nursing, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 302:C141-53. 2012
    ..On the basis of these findings, we conclude that the trkB signaling pathway might represent a novel target for intervention across diseases characterized by deficits in neuromuscular function...
  5. ncbi request reprint In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model
    Susan G Dorsey
    Neural Development Group, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Neuron 51:21-8. 2006
    ..These data provide a direct link between neuronal cell death and abnormalities in Trk neurotrophin receptor levels...
  6. pmc Genome-wide screen identifies drug-induced regulation of the gene giant axonal neuropathy (Gan) in a mouse model of antiretroviral-induced painful peripheral neuropathy
    Susan G Dorsey
    University of Maryland School of Nursing, Baltimore, MD 21201, USA
    Biol Res Nurs 11:7-16. 2009
    ....
  7. ncbi request reprint Full-length tropomyosin-related kinase B expression in the brainstem in response to persistent inflammatory pain
    Cynthia L Renn
    Department of Organizational Systems and Adult Health, School of Nursing, University of Maryland, Baltimore, Maryland 21201 1579, USA
    Neuroreport 17:1175-9. 2006
    ..These results demonstrate a temporal increase in the number of cells expressing trkB in response to persistent inflammation, suggesting a role for trkB signaling in activity-dependent plasticity in the pain modulatory circuitry...
  8. ncbi request reprint The physiology and processing of pain: a review
    Cynthia L Renn
    Department of Organizational Systems and Adult Health, School of Nursing, University of Maryland, Baltimore, Maryland 21201 1579, USA
    AACN Clin Issues 16:277-90; quiz 413-5. 2005
    ..There is also a network of pathways that carry modulatory signals from the brain and brainstem that alter the incoming flow of pain information. This article provides a review to the physiology and processing of pain...
  9. ncbi request reprint Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16
    Susan G Dorsey
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 22:2571-8. 2002
    ..Thus, the failure of Ts16 neurons to respond to BDNF is caused by dysregulation of trkB isoform expression. Such a neurotrophin signaling defect could contribute to developmental and degenerative disorders of the nervous system...
  10. pmc A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin
    Pedro F Esteban
    Neural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD 21702, USA
    J Cell Biol 173:291-9. 2006
    ..Thus, our data identify a new signaling pathway elicited by the kinase-deficient TrkCT1 receptor. Moreover, we establish NT3 as an upstream regulator of Arf6...

Research Grants14

  1. BDNF Signal Strength Modulates NRTI-Induced Allodynia in the Mouse
    SUSAN DORSEY; Fiscal Year: 2007
    ..This study may help us understand this type of pain better so that we can find better ways to reduce pain. ..
  2. UMB Center for Pain Studies
    Susan G Dorsey; Fiscal Year: 2010
    ..abstract_text> ..
  3. BDNF Signal Strength Modulates NRTI-Induced Allodynia in the Mouse
    Susan G Dorsey; Fiscal Year: 2010
    ..This study may help us understand this type of pain better so that we can find better ways to reduce pain. ..
  4. TrkB.T1 as a Genetic Disease Modifier of Muscular Dystrophy
    CHRISTOPHER WILLIAM WARD; Fiscal Year: 2010
    ..This study will try to figure out why these two molecules may be possible therapeutic targets. Our goal is to prevent, improve, or restore muscle function in patients with muscular dystrophy. ..
  5. BDNF Signal Strength Modulates NRTI-Induced Allodynia in the Mouse
    Susan G Dorsey; Fiscal Year: 2010
    ..This study may help us understand this type of pain better so that we can find better ways to reduce pain. ..
  6. ADMINISTRATIVE CORE
    SUSAN DORSEY; Fiscal Year: 2009
    ..This Center funding will enable us to formalize, enhance, and enact plans to sustain our Center on campus. ..
  7. UMB Center for Pain Studies
    SUSAN DORSEY; Fiscal Year: 2009
    ..This Center will help to fund research aimed at eliminating cancer treatment pain. CENTER AS A WHOLE, INCLUDING ADMINISTRATIVE CORE AND EVALUATION PLAN ..
  8. Epigenetic Modifications of BDNF and trkB Genes Underlie Pain Plasticity
    John David Sweatt; Fiscal Year: 2010
    ..The results from the proposed studies may help us to understand treatment-related pain in more detail, and may provide new molecular targets for analgesic therapy. ..