Research Topics
| Grant DorseySummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugsRic N Price
International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
Malar J 6:119. 2007..This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed...
Difficulties in the prevention, diagnosis, and treatment of imported malariaG Dorsey
Box 0811, Department of Medicine, University of California, San Francisco, CA 94143, USA
Arch Intern Med 160:2505-10. 2000..Imported malaria is quite common in the United States. Increasing antimalarial drug resistance and changes in travel patterns may have important implications for the prevention, clinical presentation, and management of this disease...- Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in UgandaGrant Dorsey
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
Am J Trop Med Hyg 71:758-63. 2004..The dhps Glu-540 mutation played a principal role and the dhfr Arg-59 mutation a secondary role in mediating resistance to SP alone and in combination... - The impact of age, temperature, and parasite density on treatment outcomes from antimalarial clinical trials in Kampala, UgandaGrant Dorsey
Department of Medicine, San Francisco General Hospital, University of California San Francisco, Parnassus Avenue Box 0811, San Francisco, CA 94143, USA
Am J Trop Med Hyg 71:531-6. 2004..Caution should be taken when comparing results from drug efficacy studies with different subject selection criteria... - Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malariaGrant Dorsey
Department of Medicine, San Francisco General Hospital, University of California, San Francisco 94143, USA
J Infect Dis 188:1231-8. 2003..Our results suggest that the use of combination antimalarial therapy in Africa may slow the spread of drug-resistant malaria and prolong the therapeutic life span of available treatment regimens... - Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, UgandaG Dorsey
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143 0811, USA
J Infect Dis 183:1417-20. 2001.... - Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trialGrant Dorsey
Department of Medicine, San Francisco General Hospital, University of California, 94110, USA
Lancet 360:2031-8. 2002..We aimed to compare the short-term and long-term effectiveness of three antimalarial regimens in children from Kampala, Uganda... 
Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistanceBryan Greenhouse
Department of Medicine, University of California, San Francisco, California, USA
J Infect Dis 199:758-65. 2009..Improved control efforts are reducing the burden of malaria in Africa but may result in decreased antimalarial immunity...- Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trialGrant Dorsey
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
JAMA 297:2210-9. 2007..Combination therapy is now widely advocated as first-line treatment for uncomplicated malaria in Africa. However, it is not clear which treatment regimens are optimal or how to best assess comparative efficacies in highly endemic areas... - Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistanceDamon Francis
Department of Medicine, San Francisco General Hospital, University of California, San Francisco 94110, USA
J Infect Dis 193:978-86. 2006..Our findings strongly suggest that geographic differences in response to antimalarial therapy in Uganda are primarily mediated by acquired immunity associated with malaria transmission intensity, rather than by parasite factors... - Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan childrenTamara D Clark
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e11759. 2010..Combination therapies are now recommended to treat uncomplicated malaria. We used a longitudinal design to assess the incidence of malaria and compare the efficacies of 3 combination regimens in Kampala, Uganda... - Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurpAdithya Cattamanchi
Department of Medicine, San Francisco General Hospital University of California, San Francisco, San Francisco, California 94143, USA
Am J Trop Med Hyg 68:133-9. 2003..Comparing the 3 studied genes, msp-2 results were most accurate, and analysis of this single gene effectively distinguished recrudescence from reinfection in our study population... - Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in UgandaAlissa Myrick
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Trop Med Hyg 74:758-61. 2006..These results highlight the complexity of malaria in Africa and have implications for efficacy trials, because missing late reappearances of strains could lead to misclassification of outcomes... - Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina FasoChristian Dokomajilar
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
Am J Trop Med Hyg 75:162-5. 2006..The dhfr 164L and dhps 540E mutations were not seen in any isolates. These results clarify the key roles of a small number of mutations in P. falciparum resistance to SP and AQ in west Africa... - Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trialSarah G Staedke
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
Lancet 364:1950-7. 2004..Combinations of amodiaquine and sulfadoxine-pyrimethamine or artesunate were significantly more efficacious, and each regimen could be an appropriate alternative for treatment of uncomplicated malaria in Africa... - Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trialsBryan Greenhouse
Department of Medicine, University of California, San Francisco, Box 0811, San Francisco, CA 94143, USA
Antimicrob Agents Chemother 51:3096-103. 2007..Genotyping-adjusted estimates of treatment failure from high-transmission sites may represent substantial overestimates of the true risk of treatment failure... 
Factors determining the heterogeneity of malaria incidence in children in Kampala, UgandaTamara D Clark
Department of Medicine, University of California, San Francisco, CA 94143, USA
J Infect Dis 198:393-400. 2008..Malaria risk may be heterogeneous in urban areas of Africa. Identifying those at highest risk for malaria may lead to more targeted approaches to malaria control...- Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemicChristian Dokomajilar
Department of Medicine, University of California-San Francisco, San Francisco General Hospital, Box 0811, San Francisco, CA 94143, USA
Antimicrob Agents Chemother 50:1893-5. 2006..All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response... - Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, UgandaJulia Mwesigwa
Department of Medicine, 1001 Potrero Avenue, Building 30, Room 3402, University of California, San Francisco, San Francisco, CA 94143 0811, USA
Antimicrob Agents Chemother 54:52-9. 2010..For the artemisinin derivatives, differences between children and adults were variable and drug specific. The PK results generated for children must be considered to optimize the dosing strategies for these widely utilized ACT regimens... - Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of UgandaPatrick M Newman
School of Medicine, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94131, USA
Malar J 8:254. 2009..TS decreases the risk of malaria in HIV-infected adults and children but has not been evaluated among pregnant women... - Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, UgandaHeidi Hopkins
University of California, San Francisco, San Francisco, California 94143, USA
Am J Trop Med Hyg 76:1092-7. 2007..RDTs may provide an effective strategy for improving rational delivery of antimalarial therapy; in Kampala, either test could dramatically decrease inappropriate presumptive treatments... - Protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children in rural Uganda: a randomised clinical trialTaylor G Sandison
Department of Medicine, University of Washington, UW FHCRC Clinical Research, Box 358080, Seattle, WA 98195 8080, USA
BMJ 342:d1617. 2011..To evaluate the protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children (uninfected children born to HIV infected mothers) in Africa... - Virologic suppression in nevirapine-exposed HIV-infected infants initiating antiretroviral therapy in rural UgandaJenna Kay
Department of Medicine, San Francisco General Hospital, University of California San Francisco, CA 94110, USA
J Trop Pediatr 58:194-9. 2012.... - Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell traitLauren Gong
University of California, Berkeley University of California, San Francisco Joint Medical Program, 94110, USA
Blood 119:3808-14. 2012..24; 95% CI, 0.10-0.54; P = .001; at 9 years of age: relative density = 0.59; 95% CI, 0.30-1.19; P = .14), suggesting an innate mechanism of protection against this end point... - Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared with artemether-lumefantrine for uncomplicated malariaDarren Creek
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Trop Med Hyg 83:873-5. 2010..27, P = 0.02). Our findings indicate that AL may be better tolerated than DP among young breastfeeding children treated for uncomplicated malaria... - Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in UgandaVinay Gupta
Department of Medicine, University of California, San Francisco, CA 94143, USA
Malar J 9:19. 2010..The use of capillary instead of agarose gel electrophoresis for genotyping offers technical advantages, but it is unclear whether capillary electrophoresis will result in improved classification of anti-malarial treatment outcomes... - Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, UgandaSarah G Staedke
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
Trop Med Int Health 9:624-9. 2004..The use of molecular markers of SP resistance to predict treatment failure rates should take age into account... - Rapid diagnostic tests for malaria at sites of varying transmission intensity in UgandaHeidi Hopkins
University of California, San Francisco, San Francisco, California, USA
J Infect Dis 197:510-8. 2008..In Africa, fever is often treated presumptively as malaria, resulting in misdiagnosis and the overuse of antimalarial drugs. Rapid diagnostic tests (RDTs) for malaria may allow improved fever management... - Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic reviewJimee Hwang
Department of Internal Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Trop Med Int Health 11:789-99. 2006..To compare the efficacies against uncomplicated falciparum malaria of chloroquine (CQ), amodiaquine (AQ), sulfadoxine-pyrimethamine (SP) and combinations of these inexpensive drugs... - Effect of nutritional status on response to treatment with artemisinin-based combination therapy in young Ugandan children with malariaWendy J Verret
Epidemiology Division, School of Public Health, University of California, 101 Haviland Hall, Berkeley, CA 94720 7358, USA
Antimicrob Agents Chemother 55:2629-35. 2011..However, children with mild to moderate chronic malnutrition not taking TS are at higher risk for recurrent parasitemia and may be considered a target for chemoprevention... - Prevention and treatment strategies used for the community management of childhood fever in Kampala, UgandaSarah K Kemble
Department of Medicine, San Francisco General Hospital, University of California, 94110, USA
Am J Trop Med Hyg 74:999-1007. 2006..The only independent predictor of treatment with an adequate anti-malarial was accessing a clinic or hospital as the first source of care. In this urban area, use of appropriate malaria control measures occurs uncommonly... - Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapyEdwin D Charlebois
School of Medicine, University of California, San Francisco, CA 94105, USA
J Acquir Immune Defic Syndr 55:330-5. 2010..Increasing numbers of HIV-infected children not yet eligible for antiretroviral therapy (ART) are entering health care in Africa. We sought to characterize the risk of short-term disease progression in this population... - CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malariaMark P Eggena
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Trop Med Hyg 74:41-3. 2006..The results provide insight into the role of cellular immunity in response to antimalarial therapy and underscore the need to investigate the mechanisms behind immune activation... - Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteersLiusheng Huang
Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, CA Department of Medicine, University of California, San Francisco, CA
J Acquir Immune Defic Syndr 61:310-6. 2012..A study in healthy volunteers was completed to address the concern that EFV impacts AL pharmacokinetics (PKs)... - Breastfeeding and the risk of malaria in children born to HIV-infected and uninfected mothers in rural UgandaNeil Vora
Department of Medicine, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 55:253-61. 2010..However, data on whether breastfeeding reduces the risk of malaria in HIV-exposed and HIV-infected children is limited... - The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005William J Collins
Department of Medicine, University of California, San Francisco, Box 0811, CA 94143, USA
Malar J 5:122. 2006..However, genotyping-adjusted drug efficacy estimates may vary between trials due to the use of different genotyping methods and to the different settings in which these methods are applied... - Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan childrenEmmanuel Arinaitwe
Makerere University University of California San Francisco Research Collaboration, University of California, San Francisco 94143, USA
Clin Infect Dis 49:1629-37. 2009..However, which therapies are optimal is a matter of debate. We aimed to compare the short- and longer-term efficacy of 2 leading therapies in a cohort of young Ugandan children... - Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan childrenTrevor P Jensen
Department of Medicine, University of California, San Francisco, USA
Malar J 8:213. 2009..Yet measurement of incidence is challenging. The slide positivity rate (SPR) has been used as a surrogate measure of malaria incidence, but limited data exist on the relationship between SPR and the incidence of malaria... - Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemicBryan Greenhouse
Department of Medicine, University of California, San Francisco, CA, USA
J Infect Dis 204:19-26. 2011..falciparum and protection against disease... - Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacyMadeline Slater
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
Am J Trop Med Hyg 73:256-62. 2005..The method used to classify treatment outcomes can have a major impact on estimates of drug efficacy, especially in areas of high transmission intensity... - Health facility-based malaria surveillance: the effects of age, area of residence and diagnostics on test positivity ratesDamon Francis
Department of Medicine, University of California, San Francisco General Hospital, 1001 Potrero Ave, Bldg, 30, RM, 408, San Francisco, CA 94110, USA
Malar J 11:229. 2012..This study examines the effects of age, area of residence and diagnostic test on TPR at two health facilities in regions of Uganda with differing malaria endemicity... - Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell countsTheodore D Ruel
Division of Infectious Disease, Department of Pediatrics, UCSF Benioff Children s Hospital, University of California, San Francisco, CA 94143 0136, USA
Clin Infect Dis 54:1001-9. 2012.... - Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infectionsBryan Greenhouse
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
Am J Trop Med Hyg 75:836-42. 2006..31 versus P = 0.03). Four microsatellite markers performed well on polyclonal samples and may provide a valuable addition to genotyping for clinical drug efficacy studies in high transmission areas... - PCR-based pooling of dried blood spots for detection of malaria parasites: optimization and application to a cohort of Ugandan childrenMichelle S Hsiang
Department of Global Health Sciences, Division of Pediatric Infectious Diseases, University of California, San Francisco, San Francisco, CA 94105, USA
J Clin Microbiol 48:3539-43. 2010.... - Surveillance for malaria elimination in Swaziland: a national cross-sectional study using pooled PCR and serologyMichelle S Hsiang
Global Health Group, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 7:e29550. 2012..Pooled-PCR has potential to efficiently improve sensitivity to detect infections; serology may clarify temporal and spatial trends in exposure... - Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitmentJennifer C Davis
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Malar J 5:18. 2006..To generate a sampling frame for a longitudinal study of malaria incidence and treatment in Kampala, Uganda, a census, mapping and survey project was conducted... - Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteersPolina German
Department of Clinical Pharmacy, Drug Research, University of California, School of Medicine, San Francisco, CA 94143 0622, USA
J Acquir Immune Defic Syndr 51:424-9. 2009.... - Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan childrenSarah G Staedke
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
Am J Trop Med Hyg 69:244-6. 2003..6-6.9, P < 0.001) between residence within a swamp and >100 meters from a swamp. In this urban setting, incidence of clinical episodes of malaria was strongly associated with proximity of residence to potential mosquito breeding sites... - Associations between Antibodies to a Panel of Plasmodium falciparum Specific Antigens and Response to Sub-Optimal Antimalarial Therapy in Kampala, UgandaChris E Keh
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 7:e52571. 2012..Assessment of response to partially effective antimalarial therapy, which requires the host to assist in clearing parasites, offers an opportunity to measure protection independent of exposure... - Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan childrenTheodore D Ruel
Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143 0136, USA
J Acquir Immune Defic Syndr 56:44-50. 2011..We sought to determine the prevalence of early virologic failure (EVF), to characterize the evolution of ARV-resistance mutations and to predict the impact on second-line therapy... - Host polymorphisms and the incidence of malaria in Ugandan childrenSunil Parikh
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Trop Med Hyg 71:750-3. 2004..69, P = 0.05). Host polymorphisms appear to impact upon the incidence of uncomplicated malaria in Ugandan children... - Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmissionLisa M Butler
University of California, San Francisco, 50 Beale St, Suite 120, San Francisco, California 94105, USA
J Infect Dis 200:430-8. 2009..However, few studies have directly examined children, particularly in locations where KS is not commonly endemic... - Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypesPeilin Li
University of California, San Francisco UCSF, Department of Medicine, San Francisco, CA 94121, USA
J Virol Methods 170:115-20. 2010..765, p<0.0001). This approach to Taqman probe design should be explored further for use in diagnosis and monitoring of HIV in resource-limited settings, especially where several subtypes co-circulate... - Evaluating tuberculosis case detection via real-time monitoring of tuberculosis diagnostic servicesJlucian Davis
Divisions of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, California
Am J Respir Crit Care Med 184:362-7. 2011..Real-time monitoring and evaluation of adherence to widely endorsed standards of tuberculosis care might facilitate improved case finding...