Julia E Dooher
Affiliation: University of Washington
Dooher J, Lingappa J. Cell-free systems for capsid assembly of primate lentiviruses from three different lineages. J Med Primatol. 2004;33:272-80 pubmed
..Therefore, cell-free systems reproduce assembly of Gag from three main primate lentiviral lineages, and can be used to compare mechanistic features of capsid assembly of genetically divergent primate lentiviruses. ..
Tanaka M, Robinson B, Chutiraka K, Geary C, Reed J, Lingappa J. Mutations of Conserved Residues in the Major Homology Region Arrest Assembling HIV-1 Gag as a Membrane-Targeted Intermediate Containing Genomic RNA and Cellular Proteins. J Virol. 2016;90:1944-63 pubmed publisher
Lingappa J, Zigmond R. Limited recovery of pineal function after regeneration of preganglionic sympathetic axons: evidence for loss of ganglionic synaptic specificity. J Neurosci. 2013;33:4867-74 pubmed publisher
Lingappa J, Newman M, Klein K, Dooher J. Comparing capsid assembly of primate lentiviruses and hepatitis B virus using cell-free systems. Virology. 2005;333:114-23 pubmed
..These findings reveal significant diversity in how different capsid proteins assemble in the same cellular extract...
Lingappa J, Reed J, Tanaka M, Chutiraka K, Robinson B. How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle. Virus Res. 2014;193:89-107 pubmed publisher
..Overall, we show how data obtained using a variety of techniques has led to our current understanding of HIV assembly. ..
Lingappa J, Dooher J, Newman M, Kiser P, Klein K. Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly. J Biol Chem. 2006;281:3773-84 pubmed
..Thus, in cells, basic residues in NC appear to act by two mechanisms, recruiting both RNA and a cellular ATPase in order to facilitate efficient assembly of HIV-1 capsids...