Gabriela Dontu

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1253-70. 2003
  2. ncbi request reprint Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Mammary Gland Biol Neoplasia 10:75-86. 2005
  3. pmc Mammary stem cells, self-renewal pathways, and carcinogenesis
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Breast Cancer Res 7:86-95. 2005
  4. ncbi request reprint Cancer stem cells: an old idea--a paradigm shift
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0942, USA
    Cancer Res 66:1883-90; discussion 1895-6. 2006
  5. pmc ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    Christophe Ginestier
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 1:555-67. 2007
  6. ncbi request reprint Stem cells in normal breast development and breast cancer
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Prolif 36:59-72. 2003
  7. ncbi request reprint Breast cancer, stem/progenitor cells and the estrogen receptor
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Endocrinol Metab 15:193-7. 2004
  8. pmc Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
    Gabriela Dontu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Breast Cancer Res 6:R605-15. 2004
  9. ncbi request reprint Stem cells in mammary development and carcinogenesis: implications for prevention and treatment
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Stem Cell Rev 1:207-13. 2005
  10. pmc CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    Christophe Ginestier
    University of Michigan Comprehensive Cancer Center, Department of Internal Medicine Oncology, Ann Arbor, Michigan 48109 0015, USA
    J Clin Invest 120:485-97. 2010

Detail Information

Publications19

  1. pmc In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1253-70. 2003
    ..The isolation and characterization of these stem cells should help elucidate the molecular pathways that govern normal mammary development and carcinogenesis...
  2. ncbi request reprint Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Mammary Gland Biol Neoplasia 10:75-86. 2005
    ....
  3. pmc Mammary stem cells, self-renewal pathways, and carcinogenesis
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Breast Cancer Res 7:86-95. 2005
    ..If 'tumor stem cells' are inherently resistant to current therapies, targeting stem cell self-renewal pathways might provide a novel approach for breast cancer treatment...
  4. ncbi request reprint Cancer stem cells: an old idea--a paradigm shift
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0942, USA
    Cancer Res 66:1883-90; discussion 1895-6. 2006
    ..The development of more effective cancer therapies may thus require targeting this important cell population...
  5. pmc ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    Christophe Ginestier
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 1:555-67. 2007
    ..These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts...
  6. ncbi request reprint Stem cells in normal breast development and breast cancer
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Prolif 36:59-72. 2003
    ..This phenotypic diversity is driven by a small subset of mammary tumour stem cells. We will discuss the important implications of this mammary tumour stem-cell model...
  7. ncbi request reprint Breast cancer, stem/progenitor cells and the estrogen receptor
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Endocrinol Metab 15:193-7. 2004
    ..Furthermore, the concept of breast cancer as a disease of mammary stem and progenitor cells has profound implications for the development of new strategies for breast cancer prevention and therapy...
  8. pmc Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
    Gabriela Dontu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Breast Cancer Res 6:R605-15. 2004
    ..The vertebrate Notch1 and Notch4 homologs are involved in normal development of the mammary gland, and mutated forms of these genes are associated with development of mouse mammary tumors...
  9. ncbi request reprint Stem cells in mammary development and carcinogenesis: implications for prevention and treatment
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Stem Cell Rev 1:207-13. 2005
    ..Furthermore, the concept of cancer as a disease of stem and progenitor cells has profound implications for the development of new strategies for cancer prevention and therapy...
  10. pmc CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    Christophe Ginestier
    University of Michigan Comprehensive Cancer Center, Department of Internal Medicine Oncology, Ann Arbor, Michigan 48109 0015, USA
    J Clin Invest 120:485-97. 2010
    ..Our data therefore suggest that CXCR1 blockade may provide a novel means of targeting and eliminating breast CSCs...
  11. ncbi request reprint Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0946, USA
    Cancer Res 66:6063-71. 2006
    ..These studies support a cancer stem cell model in which the hedgehog pathway and Bmi-1 play important roles in regulating self-renewal of normal and tumorigenic human mammary stem cells...
  12. pmc Targeting breast stem cells with the cancer preventive compounds curcumin and piperine
    Madhuri Kakarala
    Division of Hematology Oncology, Department of Internal Medicine and Comprehensive Cancer Center, University of Michigan, 2150 Cancer Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Breast Cancer Res Treat 122:777-85. 2010
    ..Mammosphere formation assays may be a quantifiable biomarker to assess cancer preventive agent efficacy and Wnt signaling assessment can be a mechanistic biomarker for use in human clinical trials...
  13. pmc BRCA1 regulates human mammary stem/progenitor cell fate
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:1680-5. 2008
    ..Because BRCA1 also plays a role in DNA repair, our work suggests that loss of BRCA1 may result in the accumulation of genetically unstable breast stem cells, providing prime targets for further carcinogenic events...
  14. pmc Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
    Suling Liu
    Comprehensive Cancer Center and School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 71:614-24. 2011
    ..Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population...
  15. pmc Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors
    Anne F Schott
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 19:1512-24. 2013
    ..The Notch pathway is important for stem cell renewal and is a potential target for BCSC-directed therapy...
  16. pmc Monitoring serial changes in circulating human breast cancer cells in murine xenograft models
    Jean Pierre Eliane
    Breast Oncology Program, Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0942, USA
    Cancer Res 68:5529-32. 2008
    ..These results establish a new method for studying CTC in mouse models of epithelial cancer, providing the foundation for studies of molecular regulation of CTC in cancer and CTC as biomarker for therapeutic efficacy...
  17. ncbi request reprint [The cancer stem cell: the breast cancer driver]
    Christophe Ginestier
    University of Michigan Medical Center, Comprehensive Cancer Center, Int Med Hematology Oncology, 1500 E Medical Center Drive, Ann Arbor, MI, USA
    Med Sci (Paris) 23:1133-9. 2007
    ..This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future...
  18. ncbi request reprint Breast cancer stem cells-research opportunities utilizing mathematical modeling
    Rina Ashkenazi
    Department of Mathematics, University of Michigan, 530 Church St, Ann Arbor, MI 48109, USA
    Stem Cell Rev 3:176-82. 2007
    ....
  19. pmc Cancer stem cells in breast: current opinion and future challenges
    Emmanuelle Charafe-Jauffret
    Département d Oncologie Moléculaire, Centre de Recherche en Cancerologie de Marseille, Marseille, France
    Pathobiology 75:75-84. 2008
    ..Following this approach, new molecules are currently in development. Focusing on the cross-talk between stem cells and their microenvironment is also a promising way to explore how to better target cancer stem cells and be curative...