Terrence M Donohue

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Early growth response-1 contributes to steatosis development after acute ethanol administration
    Terrence M Donohue
    Liver Study Unit, Nebraska Western Iowa Health Care System, College of Medicine, University of Nebraska Medical Center, Omaha, USA
    Alcohol Clin Exp Res 36:759-67. 2012
  2. ncbi request reprint Contrasting effects of acute and chronic ethanol administration on rat liver tyrosine aminotransferase
    T M Donohue
    Dept of Veterans Affairs Medical Center and the Department of Internal Medicine, The University of Nebraska College of Medicine, Omaha 68105, USA
    Alcohol 15:141-6. 1998
  3. pmc Autophagy and ethanol-induced liver injury
    Terrence M Donohue
    Liver Study Unit, The Omaha Veterans Affairs Medical Center, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68105, United States
    World J Gastroenterol 15:1178-85. 2009
  4. ncbi request reprint Alcohol-induced steatosis in liver cells
    Terrence M Donohue
    Liver Study Unit, Research Service 151, VA Medical Center, 4101 Woolworth Ave, Omaha, NE 68105, USA
    World J Gastroenterol 13:4974-8. 2007
  5. ncbi request reprint Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats
    Terrence M Donohue
    Liver Study Unit, VA Nebraska, Western Iowa Health Care Network, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 31:1944-52. 2007
  6. ncbi request reprint Role of the proteasome in ethanol-induced liver pathology
    Terrence M Donohue
    Liver Study Unit, Omaha VA Medical Center, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Alcohol Clin Exp Res 31:1446-59. 2007
  7. ncbi request reprint L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury
    Terrence M Donohue
    Liver Study Unit, U S Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 31:1053-60. 2007
  8. ncbi request reprint Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity
    Terrence M Donohue
    Liver Study Unit, VA Medical Center, Omaha, NE 68105, USA
    Int J Biochem Cell Biol 38:92-101. 2006
  9. ncbi request reprint Decreased proteasome activity is associated with increased severity of liver pathology and oxidative stress in experimental alcoholic liver disease
    Terrence M Donohue
    Liver Study Unit, The Omaha Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 28:1257-63. 2004
  10. ncbi request reprint The ubiquitin-proteasome system and its role in ethanol-induced disorders
    Terrence M Donohue
    Liver Study Unit, Department of Veterans Affairs Medical Center and the Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
    Addict Biol 7:15-28. 2002

Collaborators

Detail Information

Publications36

  1. pmc Early growth response-1 contributes to steatosis development after acute ethanol administration
    Terrence M Donohue
    Liver Study Unit, Nebraska Western Iowa Health Care System, College of Medicine, University of Nebraska Medical Center, Omaha, USA
    Alcohol Clin Exp Res 36:759-67. 2012
    ..Here, we determined the extent to which Egr-1 is involved in fatty liver development in mice subjected to acute EtOH administration...
  2. ncbi request reprint Contrasting effects of acute and chronic ethanol administration on rat liver tyrosine aminotransferase
    T M Donohue
    Dept of Veterans Affairs Medical Center and the Department of Internal Medicine, The University of Nebraska College of Medicine, Omaha 68105, USA
    Alcohol 15:141-6. 1998
    ..The data suggest that ethanol itself does not directly induce TAT. Rather, enzyme synthesis is regulated by one or more endogenous secondary effector(s) whose production is influenced differently by acute or chronic ethanol feeding...
  3. pmc Autophagy and ethanol-induced liver injury
    Terrence M Donohue
    Liver Study Unit, The Omaha Veterans Affairs Medical Center, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68105, United States
    World J Gastroenterol 15:1178-85. 2009
    ..The implications of autophagic suppression are discussed in relation to the pathogenesis of alcohol-induced liver injury...
  4. ncbi request reprint Alcohol-induced steatosis in liver cells
    Terrence M Donohue
    Liver Study Unit, Research Service 151, VA Medical Center, 4101 Woolworth Ave, Omaha, NE 68105, USA
    World J Gastroenterol 13:4974-8. 2007
    ..Because steatosis is now regarded as a significant risk factor for advanced liver pathology, an understanding of the molecular mechanisms in its etiology is essential for development of effective therapies...
  5. ncbi request reprint Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats
    Terrence M Donohue
    Liver Study Unit, VA Nebraska, Western Iowa Health Care Network, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 31:1944-52. 2007
    ..Here, we determined whether differential liver injury occurred in male and female rats after feeding these animals liquid diets containing either ethanol or isocaloric dextrose with fish oil as the sole source of lipid...
  6. ncbi request reprint Role of the proteasome in ethanol-induced liver pathology
    Terrence M Donohue
    Liver Study Unit, Omaha VA Medical Center, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Alcohol Clin Exp Res 31:1446-59. 2007
    ....
  7. ncbi request reprint L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury
    Terrence M Donohue
    Liver Study Unit, U S Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 31:1053-60. 2007
    ..Here we investigated whether treatment with BSO enhanced ethanol-induced liver injury in mice...
  8. ncbi request reprint Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity
    Terrence M Donohue
    Liver Study Unit, VA Medical Center, Omaha, NE 68105, USA
    Int J Biochem Cell Biol 38:92-101. 2006
    ..Furthermore, the metabolism of ethanol by these cells via ADH and CYP2E1 is sufficient to bring about an inhibition of proteasome activity that may lead to apoptotic cell death...
  9. ncbi request reprint Decreased proteasome activity is associated with increased severity of liver pathology and oxidative stress in experimental alcoholic liver disease
    Terrence M Donohue
    Liver Study Unit, The Omaha Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 28:1257-63. 2004
    ..This study examined the relationship of proteasome activity and content with ethanol-induced oxidative stress and the degree of liver injury...
  10. ncbi request reprint The ubiquitin-proteasome system and its role in ethanol-induced disorders
    Terrence M Donohue
    Liver Study Unit, Department of Veterans Affairs Medical Center and the Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
    Addict Biol 7:15-28. 2002
    ....
  11. ncbi request reprint Inhibition of bone repair in a rat model for chronic and excessive alcohol consumption
    Dennis A Chakkalakal
    Orthopaedic Research Laboratory, VA Medical Center, Omaha, NE 68105, USA
    Alcohol 36:201-14. 2005
    ..We conclude that ethanol (as 36% of calories) in the rat diet, especially during the postinjury period, was solely responsible for the observed inhibition of bone repair...
  12. doi request reprint Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient mice
    Tiana V Curry-McCoy
    Liver Study Unit, Omaha Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Alcohol Clin Exp Res 34:251-61. 2010
    ..Because the absence of SOD would confer less resistance to oxidative stress, we determined whether damage to hepatic proteolytic systems was greater in SOD(-/-) than in SOD(+/+) mice after chronic ethanol feeding...
  13. pmc Proteasome activation by hepatitis C core protein is reversed by ethanol-induced oxidative stress
    Natalia A Osna
    Liver Study Unit, Omaha Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Gastroenterology 134:2144-52. 2008
    ..The aim was to investigate whether core protein, by its ability to generate oxidants, alters proteasome activity and whether these alterations are further affected by ethanol exposure...
  14. pmc Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells
    Natalia A Osna
    Liver Study Unit, Omaha Veterans Affairs VA Medical Center, Omaha, NE 68105, USA
    Hepatology 49:1308-15. 2009
    ..However, in primary hepatocytes, even in the absence of IFNgamma, we observed a similar decline in proteasome activity and antigen presentation after ethanol exposure...
  15. ncbi request reprint Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells
    Natalia A Osna
    Liver Study Unit, The Omaha Veterans Affairs VA Medical Center, Omaha, NE 68105, USA
    Hepatology 45:53-61. 2007
    ..Treatment of cells with interferon gamma, which enhances proteasome activity, did not reverse the effects of ethanol. Ethanol exerted similar effects on WIFB cells, indicating that its effects are not unique to one cell type...
  16. pmc Impaired methylation as a novel mechanism for proteasome suppression in liver cells
    Natalia A Osna
    Liver Study Unit, The Omaha Veterans Affairs VA Medical Center, Omaha, NE 68105, USA
    Biochem Biophys Res Commun 391:1291-6. 2010
    ..We conclude that impaired methylation of proteasome subunits suppressed proteasome activity in liver cells indicating an additional, yet novel mechanism of proteasome activity regulation by ethanol...
  17. pmc Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells
    Paul G Thomes
    Liver Study Unit, Department of Veterans Affairs, VA Nebraska Western Iowa Health Care System NWIHCS, Omaha, NE, USA
    Autophagy 9:63-73. 2013
    ....
  18. pmc Ethanol and hepatitis C virus suppress peptide-MHC class I presentation in hepatocytes by altering proteasome function
    Natalia A Osna
    Research Service, Veterans Affairs Nebraska Western Iowa Health Care System, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 36:2028-35. 2012
    ..Here, we examined the effects of EtOH consumption by HCV core transgenic mice on proteasome activity in hepatocytic lysates and in partially purified 26S proteasome and the impact of these changes on antigen presentation...
  19. pmc Cellular steatosis in ethanol oxidizing-HepG2 cells is partially controlled by the transcription factor, early growth response-1
    Paul G Thomes
    VA Nebraska Western Iowa Health Care System, Omaha, NE 68105, USA
    Int J Biochem Cell Biol 45:454-63. 2013
    ..Double knockdown of both Egr-1 and SREBP-1c abolished ethanol-elicited steatosis. Collectively, our findings provide important new insights into the temporal regulation by ethanol oxidation of Egr-1 and cellular steatosis...
  20. doi request reprint Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment
    Paul G Thomes
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, United States
    Biochem Biophys Res Commun 417:262-7. 2012
    ..Conclusion: Our findings demonstrate that ethanol metabolism generates oxidants, the levels of which differentially influence the activities of the proteasome and autophagy...
  21. ncbi request reprint Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells
    Natalia A Osna
    Liver Study Unit, Research Service, The Omaha Veterans Affairs VA Medical Center, University of Nebraska Medical Center, Omaha, NE 68105, USA
    Hepatology 42:1109-17. 2005
    ..In conclusion, under conditions of ethanol-elicited oxidative stress, PN prevents STAT1 phosphorylation by stabilization of SOCS1, and possibly by nitration of tyrosine residues in STAT1 protein...
  22. ncbi request reprint Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo
    Natalia A Osna
    Liver Study Unit, The Omaha Veterans Affairs VA Medical Center, Omaha, NE 68105, USA
    Hepatology 40:574-82. 2004
    ..In conclusion, PN dose-dependently modulated proteasome activity, regulating protein degradation by the proteasome in liver cells...
  23. ncbi request reprint Interferon gamma enhances proteasome activity in recombinant Hep G2 cells that express cytochrome P4502E1: modulation by ethanol
    Natalia A Osna
    Liver Study Unit, Research Service 151, The Veterans Affairs Medical Center, University of Nebraska Medical Center, 4101 Woolworth Ave, Omaha, NE 68105 8090, USA
    Biochem Pharmacol 66:697-710. 2003
    ..Ethanol metabolism by VL-17A cells suppresses IFNgamma-mediated induction of proteasome activity, in part, by preventing STAT1 phosphorylation...
  24. ncbi request reprint Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease
    James Haorah
    Liver Study Unit, The Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    Cell Immunol 229:139-48. 2004
    ..The latter was restored by anti-oxidant. The data support the notion that HIV-1 infection and EtOH may work in concert to affect immune function including antigen presentation and thereby affect disease progression...
  25. ncbi request reprint Ethanol consumption decreases the synthesis of the mannose 6-phosphate/insulin-like growth factor II receptor but does not decrease its messenger RNA
    James Haorah
    Liver Study Unit, Research Service 151, The Veterans Affairs VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    Biochem Pharmacol 65:637-48. 2003
    ..Thus, the ethanol-elicited decline in receptor protein synthesis may be due to defective M6P/IGF-IIR mRNA translation...
  26. ncbi request reprint Implication of altered proteasome function in alcoholic liver injury
    Natalia A Osna
    Liver Study Unit, Research Service 151, VA Medical Center, 4101 Woolworth Ave, Omaha, NE 68105, USA
    World J Gastroenterol 13:4931-7. 2007
    ..Finally, ethanol-elicited blockade of interferon type 1 and 2 signaling and decreased proteasome function impairs generation of peptides for MHC class I-restricted antigen presentation...
  27. ncbi request reprint Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats
    Carol A Casey
    Liver Study Unit, Department of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha NE 68198, USA
    J Appl Physiol (1985) 96:76-80. 2004
    ..These results demonstrate that a correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content...
  28. pmc Autophagy in alcohol-induced liver diseases
    Angela Dolganiuc
    Department of Internal Medicine, University of Florida, Gainesville, USA
    Alcohol Clin Exp Res 36:1301-8. 2012
    ..Our review summarizes the current knowledge about the role and implications of autophagy in alcohol-induced liver disease...
  29. ncbi request reprint Chronic ethanol administration decreases the ligand binding properties and the cellular content of the mannose 6-phosphate/insulin-like growth factor II receptor in rat hepatocytes
    James Haorah
    Liver Study Unit, Research Service 151, The Veterans Affairs VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    Biochem Pharmacol 63:1229-39. 2002
    ..This reduction may account, in part, for the impaired processing and delivery of acid hydrolases to lysosomes previously observed in ethanol-fed rats...
  30. pmc Modulation of lysozyme function and degradation after nitration with peroxynitrite
    Tiana V Curry-McCoy
    Liver Study Unit, Omaha Veterans Affairs Medical Center, USA
    Biochim Biophys Acta 1790:778-86. 2009
    ..Here, we investigated PN-induced alterations in lysozyme structure and function, and whether they altered the protein's susceptibility to proteasome-catalyzed degradation...
  31. ncbi request reprint Chronic ethanol consumption results in deficient bone repair in rats
    Dennis A Chakkalakal
    Omaha Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    Alcohol Alcohol 37:13-20. 2002
    ..On the other hand, the restoration of normal bone healing in group D cannot be attributed solely to the cessation of ethanol feeding after bone injury because of the increased food consumption during this period...
  32. doi request reprint CYP2E1-Catalyzed Alcohol Metabolism: Role of Oxidant Generation in Interferon Signaling, Antigen Presentation and Autophagy
    Natalia A Osna
    Department of Veterans Affairs, VA Nebraska Western Iowa Health Care System, Omaha VA Medical Center, Omaha, NE, USA
    Subcell Biochem 67:177-97. 2013
    ..Here, we describe our own and other published work relevant to the importance of CYP2E1-catalyzed ethanol oxidation and how this catalysis affects the aforementioned cellular processes to produce liver injury...
  33. pmc Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain
    Travis J Rump
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 49:1494-504. 2010
    ..These findings suggest the potential clinical utility of ALC as a neuroprotective agent that prevents alcohol-induced brain damage and development of neurological disorders...
  34. ncbi request reprint Intracellular proteolytic systems in alcohol-induced tissue injury
    Terrence M Donohue
    Omaha VA Medical Center, Nebraska, USA
    Alcohol Res Health 27:317-24. 2003
    ..In contrast to the lysosomal and ubiquitin-proteasome systems, calpains in brain cells are activated by alcohol, to potentially detrimental effect...
  35. ncbi request reprint Use of cultured cells in assessing ethanol toxicity and ethanol-related metabolism
    T M Donohue
    Liver Study Unit, Omaha Veterans Affairs Medical Center, University of Nebraska Medical Center 68105, USA
    Alcohol Clin Exp Res 25:87S-93S. 2001
    ..Barve...
  36. doi request reprint A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury
    George L Tipoe
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Alcohol Clin Exp Res 32:669-82. 2008
    ....