Research Topics
| Terrence M DonohueSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Early growth response-1 contributes to steatosis development after acute ethanol administrationTerrence M Donohue
Liver Study Unit, Nebraska Western Iowa Health Care System, College of Medicine, University of Nebraska Medical Center, Omaha, USA
Alcohol Clin Exp Res 36:759-67. 2012..Here, we determined the extent to which Egr-1 is involved in fatty liver development in mice subjected to acute EtOH administration...
Contrasting effects of acute and chronic ethanol administration on rat liver tyrosine aminotransferaseT M Donohue
Dept of Veterans Affairs Medical Center and the Department of Internal Medicine, The University of Nebraska College of Medicine, Omaha 68105, USA
Alcohol 15:141-6. 1998..The data suggest that ethanol itself does not directly induce TAT. Rather, enzyme synthesis is regulated by one or more endogenous secondary effector(s) whose production is influenced differently by acute or chronic ethanol feeding...- Autophagy and ethanol-induced liver injuryTerrence M Donohue
Liver Study Unit, The Omaha Veterans Affairs Medical Center, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68105, United States
World J Gastroenterol 15:1178-85. 2009..The implications of autophagic suppression are discussed in relation to the pathogenesis of alcohol-induced liver injury... - Alcohol-induced steatosis in liver cellsTerrence M Donohue
Liver Study Unit, Research Service 151, VA Medical Center, 4101 Woolworth Ave, Omaha, NE 68105, USA
World J Gastroenterol 13:4974-8. 2007..Because steatosis is now regarded as a significant risk factor for advanced liver pathology, an understanding of the molecular mechanisms in its etiology is essential for development of effective therapies... - Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female ratsTerrence M Donohue
Liver Study Unit, VA Nebraska, Western Iowa Health Care Network, Omaha, Nebraska 68105, USA
Alcohol Clin Exp Res 31:1944-52. 2007..Here, we determined whether differential liver injury occurred in male and female rats after feeding these animals liquid diets containing either ethanol or isocaloric dextrose with fish oil as the sole source of lipid... - Role of the proteasome in ethanol-induced liver pathologyTerrence M Donohue
Liver Study Unit, Omaha VA Medical Center, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Alcohol Clin Exp Res 31:1446-59. 2007.... - L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injuryTerrence M Donohue
Liver Study Unit, U S Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
Alcohol Clin Exp Res 31:1053-60. 2007..Here we investigated whether treatment with BSO enhanced ethanol-induced liver injury in mice... - Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicityTerrence M Donohue
Liver Study Unit, VA Medical Center, Omaha, NE 68105, USA
Int J Biochem Cell Biol 38:92-101. 2006..Furthermore, the metabolism of ethanol by these cells via ADH and CYP2E1 is sufficient to bring about an inhibition of proteasome activity that may lead to apoptotic cell death... - Decreased proteasome activity is associated with increased severity of liver pathology and oxidative stress in experimental alcoholic liver diseaseTerrence M Donohue
Liver Study Unit, The Omaha Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
Alcohol Clin Exp Res 28:1257-63. 2004..This study examined the relationship of proteasome activity and content with ethanol-induced oxidative stress and the degree of liver injury... - The ubiquitin-proteasome system and its role in ethanol-induced disordersTerrence M Donohue
Liver Study Unit, Department of Veterans Affairs Medical Center and the Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
Addict Biol 7:15-28. 2002.... - Inhibition of bone repair in a rat model for chronic and excessive alcohol consumptionDennis A Chakkalakal
Orthopaedic Research Laboratory, VA Medical Center, Omaha, NE 68105, USA
Alcohol 36:201-14. 2005..We conclude that ethanol (as 36% of calories) in the rat diet, especially during the postinjury period, was solely responsible for the observed inhibition of bone repair... 
Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient miceTiana V Curry-McCoy
Liver Study Unit, Omaha Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
Alcohol Clin Exp Res 34:251-61. 2010..These and other atypical responses to ethanol, including the absence of ethanol-induced steatosis and enhanced glutathione levels, appear to be linked to enhanced oxidative stress due to lack of antioxidant enzyme capacity...- Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cellsNatalia A Osna
Liver Study Unit, The Omaha Veterans Affairs VA Medical Center, Omaha, NE 68105, USA
Hepatology 45:53-61. 2007..This defect may potentially result in decreased MHC class I-restricted antigen presentation on virally infected liver cells... - Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cellsNatalia A Osna
Liver Study Unit, Omaha Veterans Affairs VA Medical Center, Omaha, NE 68105, USA
Hepatology 49:1308-15. 2009..Ethanol-elicited reduction in proteasome activity contributes to the suppression of SIINFEKL-H2Kb presentation on the surface of liver cells... - Proteasome activation by hepatitis C core protein is reversed by ethanol-induced oxidative stressNatalia A Osna
Liver Study Unit, Omaha Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
Gastroenterology 134:2144-52. 2008..The aim was to investigate whether core protein, by its ability to generate oxidants, alters proteasome activity and whether these alterations are further affected by ethanol exposure... - Impaired methylation as a novel mechanism for proteasome suppression in liver cellsNatalia A Osna
Liver Study Unit, The Omaha Veterans Affairs VA Medical Center, Omaha, NE 68105, USA
Biochem Biophys Res Commun 391:1291-6. 2010..We conclude that impaired methylation of proteasome subunits suppressed proteasome activity in liver cells indicating an additional, yet novel mechanism of proteasome activity regulation by ethanol... - Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatmentPaul G Thomes
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, United States
Biochem Biophys Res Commun 417:262-7. 2012..Conclusion: Our findings demonstrate that ethanol metabolism generates oxidants, the levels of which differentially influence the activities of the proteasome and autophagy... - Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cellsNatalia A Osna
Liver Study Unit, Research Service, The Omaha Veterans Affairs VA Medical Center, University of Nebraska Medical Center, Omaha, NE 68105, USA
Hepatology 42:1109-17. 2005..In conclusion, under conditions of ethanol-elicited oxidative stress, PN prevents STAT1 phosphorylation by stabilization of SOCS1, and possibly by nitration of tyrosine residues in STAT1 protein... - Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivoNatalia A Osna
Liver Study Unit, The Omaha Veterans Affairs VA Medical Center, Omaha, NE 68105, USA
Hepatology 40:574-82. 2004..In conclusion, PN dose-dependently modulated proteasome activity, regulating protein degradation by the proteasome in liver cells... - Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during diseaseJames Haorah
Liver Study Unit, The Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5215, USA
Cell Immunol 229:139-48. 2004..The latter was restored by anti-oxidant. The data support the notion that HIV-1 infection and EtOH may work in concert to affect immune function including antigen presentation and thereby affect disease progression... - Interferon gamma enhances proteasome activity in recombinant Hep G2 cells that express cytochrome P4502E1: modulation by ethanolNatalia A Osna
Liver Study Unit, Research Service 151, The Veterans Affairs Medical Center, University of Nebraska Medical Center, 4101 Woolworth Ave, Omaha, NE 68105 8090, USA
Biochem Pharmacol 66:697-710. 2003..Ethanol metabolism by VL-17A cells suppresses IFNgamma-mediated induction of proteasome activity, in part, by preventing STAT1 phosphorylation... - Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in ratsCarol A Casey
Liver Study Unit, Department of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha NE 68198, USA
J Appl Physiol 96:76-80. 2004..These results demonstrate that a correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content... - Implication of altered proteasome function in alcoholic liver injuryNatalia A Osna
Liver Study Unit, Research Service 151, VA Medical Center, 4101 Woolworth Ave, Omaha, NE 68105, USA
World J Gastroenterol 13:4931-7. 2007..Finally, ethanol-elicited blockade of interferon type 1 and 2 signaling and decreased proteasome function impairs generation of peptides for MHC class I-restricted antigen presentation... - Ethanol consumption decreases the synthesis of the mannose 6-phosphate/insulin-like growth factor II receptor but does not decrease its messenger RNAJames Haorah
Liver Study Unit, Research Service 151, The Veterans Affairs VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
Biochem Pharmacol 65:637-48. 2003..Thus, the ethanol-elicited decline in receptor protein synthesis may be due to defective M6P/IGF-IIR mRNA translation... - Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cellsPaul G Thomes
Liver Study Unit, Department of Veterans Affairs, VA Nebraska Western Iowa Health Care System NWIHCS, Omaha, NE, USA
Autophagy 9:63-73. 2013.... - Autophagy in alcohol-induced liver diseasesAngela Dolganiuc
Department of Internal Medicine, University of Florida, Gainesville, USA
Alcohol Clin Exp Res 36:1301-8. 2012..Our review summarizes the current knowledge about the role and implications of autophagy in alcohol-induced liver disease... - Chronic ethanol administration decreases the ligand binding properties and the cellular content of the mannose 6-phosphate/insulin-like growth factor II receptor in rat hepatocytesJames Haorah
Liver Study Unit, Research Service 151, The Veterans Affairs VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
Biochem Pharmacol 63:1229-39. 2002..This reduction may account, in part, for the impaired processing and delivery of acid hydrolases to lysosomes previously observed in ethanol-fed rats... - Modulation of lysozyme function and degradation after nitration with peroxynitriteTiana V Curry-McCoy
Liver Study Unit, Omaha Veterans Affairs Medical Center, USA
Biochim Biophys Acta 1790:778-86. 2009..Here, we investigated PN-induced alterations in lysozyme structure and function, and whether they altered the protein's susceptibility to proteasome-catalyzed degradation... - Ethanol and hepatitis C virus suppress peptide-MHC class I presentation in hepatocytes by altering proteasome functionNatalia A Osna
Research Service, Veterans Affairs Nebraska Western Iowa Health Care System, Omaha, Nebraska 68105, USA
Alcohol Clin Exp Res 36:2028-35. 2012..Here, we examined the effects of EtOH consumption by HCV core transgenic mice on proteasome activity in hepatocytic lysates and in partially purified 26S proteasome and the impact of these changes on antigen presentation... - Cellular steatosis in ethanol oxidizing-HepG2 cells is partially controlled by the transcription factor, early growth response-1Paul G Thomes
VA Nebraska Western Iowa Health Care System, Omaha, NE 68105, USA
Int J Biochem Cell Biol 45:454-63. 2013..Double knockdown of both Egr-1 and SREBP-1c abolished ethanol-elicited steatosis. Collectively, our findings provide important new insights into the temporal regulation by ethanol oxidation of Egr-1 and cellular steatosis... - Chronic ethanol consumption results in deficient bone repair in ratsDennis A Chakkalakal
Omaha Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
Alcohol Alcohol 37:13-20. 2002..On the other hand, the restoration of normal bone healing in group D cannot be attributed solely to the cessation of ethanol feeding after bone injury because of the increased food consumption during this period... - CYP2E1-Catalyzed Alcohol Metabolism: Role of Oxidant Generation in Interferon Signaling, Antigen Presentation and AutophagyNatalia A Osna
Department of Veterans Affairs, VA Nebraska Western Iowa Health Care System, Omaha VA Medical Center, Omaha, NE, USA
Subcell Biochem 67:177-97. 2013..Here, we describe our own and other published work relevant to the importance of CYP2E1-catalyzed ethanol oxidation and how this catalysis affects the aforementioned cellular processes to produce liver injury... - Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brainTravis J Rump
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
Free Radic Biol Med 49:1494-504. 2010..These findings suggest the potential clinical utility of ALC as a neuroprotective agent that prevents alcohol-induced brain damage and development of neurological disorders... - Intracellular proteolytic systems in alcohol-induced tissue injuryTerrence M Donohue
Omaha VA Medical Center, Nebraska, USA
Alcohol Res Health 27:317-24. 2003..In contrast to the lysosomal and ubiquitin-proteasome systems, calpains in brain cells are activated by alcohol, to potentially detrimental effect... - Use of cultured cells in assessing ethanol toxicity and ethanol-related metabolismT M Donohue
Liver Study Unit, Omaha Veterans Affairs Medical Center, University of Nebraska Medical Center 68105, USA
Alcohol Clin Exp Res 25:87S-93S. 2001..Barve... - A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injuryGeorge L Tipoe
Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
Alcohol Clin Exp Res 32:669-82. 2008....