Research Topics
| Steven M DonnSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Can mechanical ventilation strategies reduce chronic lung disease?Steven M Donn
The Division of Neonatal Perinatal Medicine, Department of Pediatrics, C S Mott Children s Hospital, University of Michigan Health System, Ann Arbor, MI, USA
Semin Neonatol 8:441-8. 2003..These include continuous positive airway pressure, permissive hypercapnia, patient-triggered ventilation, volume-targeted ventilation, proportional assist ventilation, high-frequency ventilation and real-time monitoring...
Pulmonary dysfunction and therapeutic hypothermia in asphyxiated newborns: whole body versus selective head coolingSubrata Sarkar
Department of Pediatrics, Toledo Children s Hospital, Toledo, Ohio, USA
Am J Perinatol 26:265-70. 2009..9%, P = 0.72, OR 1.5, 95% CI 0.3 to 6.1). Pulmonary dysfunction is common but not severe in asphyxiated infants during therapeutic hypothermia. Pulmonary mechanics and gas exchange do not differ with the method of achieving hypothermia...- Aerosolized lucinactant: a potential alternative to intratracheal surfactant replacement therapySteven M Donn
Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Michigan Health System, F5790 C S Mott Children s Hospital, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 0254, USA
Expert Opin Pharmacother 9:475-8. 2008..However, administration of the various available suspensions has required endotracheal intubation and its inherent risks. Delivery of aerosolized SRT would be a laudable goal... - The relationship between clinically identifiable intrapartum sentinel events and short-term outcome after therapeutic hypothermiaSubrata Sarkar
Division of Neonatal Perinatal Medicine, University of Michigan Health System, C S Mott Children s Hospital, Ann Arbor, MI, USA
J Pediatr 159:726-30. 2011..To determine the impact of intrapartum sentinel events on short-term outcome post-hypothermia... - Invasive and noninvasive neonatal mechanical ventilationSteven M Donn
Division of Neonatal Perinatal Medicine, Holden Neonatal Intensive Care Unit, University of Michigan Health System, Ann Arbor, USA
Respir Care 48:426-39; discussion 439-41. 2003.... - Distribution and severity of hypoxic-ischaemic lesions on brain MRI following therapeutic cooling: selective head versus whole body coolingSubrata Sarkar
University of Michigan, Pediatrics and Communicable Disease, University of Michigan Health System, C S Mott Children s Hospital, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0254, USA
Arch Dis Child Fetal Neonatal Ed 97:F335-9. 2012..In this study, the authors hypothesised that the hypoxic-ischaemic lesions on brain MRI following cooling would differ between modalities of cooling... - Esophageal and rectal temperatures as estimates of core temperature during therapeutic whole-body hypothermiaSubrata Sarkar
Division of Neonatal Perinatal Medicine, University of Michigan Health System, C S Mott Children s Hospital, Ann Arbor, MI 48109 0254, USA
J Pediatr 162:208-10. 2013..46 to 1.03°C (median, 0.8°C; IQR, 0.6-0.8°C). During rewarming, this temperature difference disappeared... - Newer techniques of mechanical ventilation: an overviewSteven M Donn
Division of Neonatal-Perinatal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
Semin Neonatol 7:401-7. 2002..The trend towards increasing sophistication and greater versatility is likely to continue, and clinicians involved in the care of sick newborn infants must keep abreast of these developments... - Mechanisms of ventilator-induced lung injury in premature infantsMohammad Ali Attar
Department of Pediatrics, Division of Neonatal Perinatal Medicine, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0254, USA
Semin Neonatol 7:353-60. 2002..Therapies targeting specific processes in lung injury, and which complement the protective ventilator management strategies to avoid atelectotrauma and lung overdistension are an area of active research... - Real-time pulmonary graphic monitoringMichael A Becker
Department of Critical Care Services, Pediatric Respiratory Therapy, C S Mott Children s Hospital, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0254, USA
Clin Perinatol 34:1-17, v. 2007..Graphics also provide objective information about the efficacy of pharmacologic agents and changes in patient status over time... - In support of pressure supportSubrata Sarkar
Department of Pediatrics, Division of Neonatal Perinatal Medicine, F5790 C S Mott Children s Hospital, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0254, USA
Clin Perinatol 34:117-28, vii. 2007..This article reviews the principles and clinical applications of PSV for newborns who have respiratory failure... - Surfactant replacement therapy in the neonate: beyond respiratory distress syndromeSteven M Donn
Division of Neonatal Perinatal Medicine, Department of Pediatrics, F5790, Mott Children s Hospital, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor MI 48109 0254, USA
Respir Care 54:1203-8. 2009..This paper discusses the use of surfactant-replacement therapy beyond respiratory distress syndrome and examines the evidence to date... - Clinical course of symptomatic spontaneous pneumothorax in term and late preterm newborns: report from a large cohortJoann Smith
Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Michigan Health System, C S Mott Children s Hospital, Ann Arbor, 48109 0254, USA
Am J Perinatol 28:163-8. 2011.... - Gentamicin pharmacokinetics in term newborn infants receiving high-frequency oscillatory ventilation or conventional mechanical ventilation: a case-controlled studyVarsha Bhatt-Mehta
Department of Clinical Sciences, College of Pharmacy, University of Michigan, 200 E. Hospital Drive, Ann Arbor, MI 48109-0225, USA
J Perinatol 23:559-62. 2003..05). CONCLUSION: Infants receiving HFOV had reduced gentamicin clearance. Full-term infants receiving HFOV should be initiated at gentamicin dosing intervals of 18 hours rather than the traditional 12 hours recommended for this age group... - Mechanical ventilation of the neonate: should we target volume or pressure?Steven M Donn
Division of Neonatal Perinatal Medicine, Department of Pediatrics, F5790, Mott Children s Hospital, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor MI 48109 0254, USA
Respir Care 54:1236-43. 2009..The advent of microprocessor-based devices gives the clinician an option to choose either target variable to treat neonatal patients. This paper reviews the principles of each and the accumulated evidence... - Lucinactant: a novel synthetic surfactant for the treatment of respiratory distress syndromeSteven M Donn
Department of Pediatrics, Division of Neonatal Perinatal Medicine, F5790 C S Mott Children s Hospital, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0254, USA
Expert Opin Investig Drugs 14:329-34. 2005..Its non-animal origin may make it an attractive alternative to present animal-derived surfactants by eliminating the risks of infection and immunogenicity related to the latter... - Immediate changes in lung compliance following natural surfactant administration in premature infants with respiratory distress syndrome: a controlled trialMohammad A Attar
Department of Pediatrics and Communicable Diseases, University of Michigan, MI, USA
J Perinatol 24:626-30. 2004..CONCLUSIONS: We found no significant difference in acute changes in lung compliance. However, treatment with Infasurf seems to be more long lasting than Survanta... - A crossover analysis of mandatory minute ventilation compared to synchronized intermittent mandatory ventilation in neonatesScott O Guthrie
Department of Pediatrics, Division of Neonatology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Perinatol 25:643-6. 2005..While this mode generates similar PIP and PEEP, the decrease in mechanical breaths and the mean airway pressure generated with MMV may reduce the risk of some of the long-term complications associated with mechanical ventilation... - Severe intraventricular hemorrhage in preterm infants: comparison of risk factors and short-term neonatal morbidities between grade 3 and grade 4 intraventricular hemorrhageSubrata Sarkar
Department of Pediatrics, Division of Neonatal Perinatal Medicine, Critical Care Support Services, University of Michigan Health System, CS Mott Children s Hospital, Ann Arbor, Michigan 48109 0254, USA
Am J Perinatol 26:419-24. 2009..This information may be useful for prognostication and may improve the quality of parental counseling... - Exposure to the pharmaceutical excipients benzyl alcohol and propylene glycol among critically ill neonatesNadine Shehab
Department of Clinical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
Pediatr Crit Care Med 10:256-9. 2009..To document neonatal exposures to the potentially harmful pharmaceutical excipients benzyl alcohol (BA) and propylene glycol (PG) present in parenteral medications routinely administered in the intensive care unit... - Intractable respiratory failure in a term newbornLisa Allred
Division of Neonatal Perinatal Medicine, Department of Pediatrics, CS Mott Children s Hospital, University of Michigan Health System, Ann Arbor, MI 48109 0254, USA
Am J Perinatol 25:101-3. 2008..Postmortem examination revealed bilateral pulmonary artery thrombi, which underscores the importance of careful exploration of possible pathogenetic mechanisms... - Relationship of neonatal endotracheal tube size and airway resistanceMelisa J Oca
Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Unviersity of Michigan Health System, Ann Arbor, Michigan, USA
Respir Care 47:994-7. 2002..5 mm tube may be detrimental to extremely low birthweight infants kept on mechanical support merely "to grow." The higher resistance may increase the work of breathing and thus increase caloric expenditure and impede growth... - Weaning newborns from mechanical ventilationSunil K Sinha
The James Cook University Hospital, Middlesbrough, UK
Semin Neonatol 7:421-8. 2002..The purpose of this paper is to review the physiological, mechanical, and clinical principles of weaning, and to highlight areas still in need of investigation... - Immediate respiratory management of the preterm infantSunil K Sinha
Paediatrics and Neonatal Medicine, University of Durham, Durham, UK
Semin Fetal Neonatal Med 13:24-9. 2008..However, considerable controversy exists about how best to use these therapies. This paper will review the pathophysiology of RDS and the evidence supporting each of these treatments... - Surfactant for respiratory distress syndrome: are there important clinical differences among preparations?Sunil Sinha
University of Durham, James Cook University Hospital, Middlesbrough, UK
Curr Opin Pediatr 19:150-4. 2007.... - Volume-targeted ventilation of newbornsJaideep Singh
James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK
Clin Perinatol 34:93-105, vii. 2007..This article reviews salient features of volume-targeted ventilation and a review of the evidence base... - Matching ventilatory support strategies to respiratory pathophysiologyAnne Greenough
Division of Asthma, Allergy and Lung Biology, King s College London, Children Nationwide Regional Neonatal Intensive Care Centre, 4th Floor, Golden Jubilee Wing, King s College Hospital, London SE5 9PJ, UK
Clin Perinatol 34:35-53, v-vi. 2007..Research is required to identify the optimum respiratory strategy for infants who have other respiratory disorders, particularly bronchopulmonary dysplasia... - Mechanical ventilation of very low birth weight infants: is volume or pressure a better target variable?Jaideep Singh
Paediatrics and Neonatal Medicine, University of Durham and James Cook University Hospital, Marton Road, Middlesbrough, United Kingdom
J Pediatr 149:308-13. 2006..To compare the efficacy and safety of volume-controlled (VC) ventilation to time-cycled pressure-limited (TCPL) ventilation in very low birth weight infants with respiratory distress syndrome (RDS)... - Fetal-to-neonatal maladaptationSunil K Sinha
The James Cook University Hospital, University of Durham, Marton Road, Middlesborough TS4 3BW, UK
Semin Fetal Neonatal Med 11:166-73. 2006..An understanding of the normal and abnormal perinatal physiology is important to appreciate the practical differences in the approach to caring for such babies, and also for avoiding actions that might be detrimental in the longer term... - Usefulness of the minute ventilation test in predicting successful extubation in newborn infants: a randomized controlled trialLorna M Gillespie
Department of Neonatal Medicine, The James Cook University Hospital, Middlesbrough, UK
J Perinatol 23:205-7. 2003..In this study, it significantly shortened the time for extubation and was not associated with a higher rate of reintubation... - A multicenter, randomized, controlled trial comparing Surfaxin (Lucinactant) lavage with standard care for treatment of meconium aspiration syndromeThomas E Wiswell
Discovery Laboratories, Inc, Doylestown, Pennsylvania, USA
Pediatrics 109:1081-7. 2002..The objective of this study was to compare treatment with bronchoalveolar lavage using dilute Surfaxin with standard therapy in a population of newborn infants with MAS...