Anna Dongari-Bagtzoglou

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint CD40 ligation triggers COX-2 expression in endothelial cells: evidence that CD40-mediated IL-6 synthesis is COX-2-dependent
    A I Dongari-Bagtzoglou
    University of Connecticut, School of Dental Medicine, 263 Farmington Ave, Farmington, CT 06030 1710, USA
    Inflamm Res 52:18-25. 2003
  2. pmc Role of Bcr1-activated genes Hwp1 and Hyr1 in Candida albicans oral mucosal biofilms and neutrophil evasion
    Prabhat Dwivedi
    Department of Microbiology, University of Texas, Houston, Texas, United States of America
    PLoS ONE 6:e16218. 2011
  3. pmc Oral Candida infection and colonization in solid organ transplant recipients
    A Dongari-Bagtzoglou
    Department of Oral Health and Diagnostic Sciences, Division of Periodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030 1710, USA
    Oral Microbiol Immunol 24:249-54. 2009
  4. pmc Pathogenesis of mucosal biofilm infections: challenges and progress
    Anna Dongari-Bagtzoglou
    Department of Oral Health Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Expert Rev Anti Infect Ther 6:201-8. 2008
  5. pmc Development of a highly reproducible three-dimensional organotypic model of the oral mucosa
    Anna Dongari-Bagtzoglou
    Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut, 263 Farmington Ave, Farmington, Connecticut 06030 1710, USA
    Nat Protoc 1:2012-8. 2006
  6. ncbi request reprint Development of a novel three-dimensional in vitro model of oral Candida infection
    A Dongari-Bagtzoglou
    School of Dental Medicine, University of Connecticut, Farmington, CT 06030 1710, USA
    Microb Pathog 40:271-8. 2006
  7. ncbi request reprint Granulocyte-macrophage colony-stimulating factor responses of oral epithelial cells to Candida albicans
    A Dongari-Bagtzoglou
    University of Connecticut, School of Dental Medicine, Farmington, CT, USA
    Oral Microbiol Immunol 18:165-70. 2003
  8. ncbi request reprint Candida albicans triggers interleukin-8 secretion by oral epithelial cells
    A Dongari-Bagtzoglou
    Department of Periodontology, School of Dental Medicine, University of Connecticut, 263 Farmington Ave, Farmington, CT 06030 1710, USA
    Microb Pathog 34:169-77. 2003
  9. ncbi request reprint Candida albicans-infected oral epithelial cells augment the anti-fungal activity of human neutrophils in vitro
    A Dongari-Bagtzoglou
    University Connecticut School of Dental Medicine, Department of Periodontology, Farmington, CT 06030 1710, USA
    Med Mycol 43:545-9. 2005
  10. ncbi request reprint The host cytokine responses and protective immunity in oropharyngeal candidiasis
    A Dongari-Bagtzoglou
    School of Dental Medicine, Department of Oral Health and Diagnostic Sciences, University of Connecticut, 263 Farmington Ave, Farmington, CT 06030 1710, USA
    J Dent Res 84:966-77. 2005

Research Grants

  1. ORAL EPITHELIAL CELL CYTOKINES--CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2000
  2. Oral Epithelial Cells, Candida and PMN Activation
    ANNA I DONGARI BAGTZOGLOU; Fiscal Year: 2010
  3. Oral Epithelial Cells, Candida and PMN Activation
    Anna Dongari Bagtzoglou; Fiscal Year: 2009
  4. ORAL EPITHELIAL CELL CYTOKINES CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2006
  5. ORAL EPITHELIAL CELL CYTOKINES CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2005
  6. Oral infection and inflammation in transplant patients
    Anna Dongari Bagtzoglou; Fiscal Year: 2005
  7. ORAL EPITHELIAL CELL CYTOKINES CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2004
  8. ORAL EPITHELIAL CELL CYTOKINES CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2002
  9. ORAL EPITHELIAL CELL CYTOKINES CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2001
  10. Oral Epithelial Cells, Candida and PMN Activation
    Anna Dongari Bagtzoglou; Fiscal Year: 2009

Collaborators

Detail Information

Publications23

  1. ncbi request reprint CD40 ligation triggers COX-2 expression in endothelial cells: evidence that CD40-mediated IL-6 synthesis is COX-2-dependent
    A I Dongari-Bagtzoglou
    University of Connecticut, School of Dental Medicine, 263 Farmington Ave, Farmington, CT 06030 1710, USA
    Inflamm Res 52:18-25. 2003
    ....
  2. pmc Role of Bcr1-activated genes Hwp1 and Hyr1 in Candida albicans oral mucosal biofilms and neutrophil evasion
    Prabhat Dwivedi
    Department of Microbiology, University of Texas, Houston, Texas, United States of America
    PLoS ONE 6:e16218. 2011
    ..These discoveries show that Bcr1 is critical for mucosal biofilm infection via regulation of epithelial cell adhesin and neutrophil function...
  3. pmc Oral Candida infection and colonization in solid organ transplant recipients
    A Dongari-Bagtzoglou
    Department of Oral Health and Diagnostic Sciences, Division of Periodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030 1710, USA
    Oral Microbiol Immunol 24:249-54. 2009
    ..The objectives of this study were to determine the prevalence of oropharyngeal candidiasis, the oral carrier status, Candida titers and species in this population...
  4. pmc Pathogenesis of mucosal biofilm infections: challenges and progress
    Anna Dongari-Bagtzoglou
    Department of Oral Health Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Expert Rev Anti Infect Ther 6:201-8. 2008
    ....
  5. pmc Development of a highly reproducible three-dimensional organotypic model of the oral mucosa
    Anna Dongari-Bagtzoglou
    Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut, 263 Farmington Ave, Farmington, Connecticut 06030 1710, USA
    Nat Protoc 1:2012-8. 2006
    ....
  6. ncbi request reprint Development of a novel three-dimensional in vitro model of oral Candida infection
    A Dongari-Bagtzoglou
    School of Dental Medicine, University of Connecticut, Farmington, CT 06030 1710, USA
    Microb Pathog 40:271-8. 2006
    ..Therefore, this investigation has added another useful tool in the study of host pathogen interactions in oral candidiasis...
  7. ncbi request reprint Granulocyte-macrophage colony-stimulating factor responses of oral epithelial cells to Candida albicans
    A Dongari-Bagtzoglou
    University of Connecticut, School of Dental Medicine, Farmington, CT, USA
    Oral Microbiol Immunol 18:165-70. 2003
    ..albicans with an increase in GM-CSF secretion. GM-CSF responses were contact-dependent, strain-dependent, required yeast viability and were optimal when the yeast germinated into hyphae...
  8. ncbi request reprint Candida albicans triggers interleukin-8 secretion by oral epithelial cells
    A Dongari-Bagtzoglou
    Department of Periodontology, School of Dental Medicine, University of Connecticut, 263 Farmington Ave, Farmington, CT 06030 1710, USA
    Microb Pathog 34:169-77. 2003
    ..albicans with an increase in IL-8 secretion. IL-8 responses were contact-dependent, strain-specific, required yeast viability and germination into hyphae, and were in part autoregulated by IL-1alpha...
  9. ncbi request reprint Candida albicans-infected oral epithelial cells augment the anti-fungal activity of human neutrophils in vitro
    A Dongari-Bagtzoglou
    University Connecticut School of Dental Medicine, Department of Periodontology, Farmington, CT 06030 1710, USA
    Med Mycol 43:545-9. 2005
    ....
  10. ncbi request reprint The host cytokine responses and protective immunity in oropharyngeal candidiasis
    A Dongari-Bagtzoglou
    School of Dental Medicine, Department of Oral Health and Diagnostic Sciences, University of Connecticut, 263 Farmington Ave, Farmington, CT 06030 1710, USA
    J Dent Res 84:966-77. 2005
    ..Identification of such cytokines with the ability to enhance anti-fungal activities of immune effector cells may have therapeutic implications in the treatment of this oral infection in the severely immunocompromised host...
  11. ncbi request reprint Bioactive interleukin-1alpha is cytolytically released from Candida albicans-infected oral epithelial cells
    A Dongari-Bagtzoglou
    Department of Periodontology, University of Connecticut, School of Dental Medicine, Farmington, CT 06030 1710, USA
    Med Mycol 42:531-41. 2004
    ..albicans. This process can act as an early innate immune surveillance system and may contribute to the clinicopathologic signs of infection in the oral mucosa...
  12. pmc Candida albicans biofilms do not trigger reactive oxygen species and evade neutrophil killing
    Zhihong Xie
    Department of Oral Health and Diagnostic Sciences, Division of Periodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030 1710, USA
    J Infect Dis 206:1936-45. 2012
    ..We conclude that these polymers act as a decoy mechanism to prevent neutrophil activation and that this represents an important innate immune evasion mechanism of C. albicans biofilms...
  13. pmc Synergistic interaction between Candida albicans and commensal oral streptococci in a novel in vitro mucosal model
    Patricia I Diaz
    Division of Periodontology, Department of Oral Health and Diagnostic Sciences, The University of Connecticut Health Center, Farmington, Connecticut, USA
    Infect Immun 80:620-32. 2012
    ..In summary, C. albicans and commensal oral streptococci display a synergistic interaction with implications for the pathogenic potential of C. albicans in the upper gastrointestinal tract...
  14. pmc Characterization of mucosal Candida albicans biofilms
    Anna Dongari-Bagtzoglou
    Division of Periodontology, School of Dental Medicine, University of Connecticut, Farmington, Connecticut, United States of America
    PLoS ONE 4:e7967. 2009
    ....
  15. pmc A quantitative real-time RT-PCR assay for mature C. albicans biofilms
    Zhihong Xie
    Division of Periodontology, School of Dental Medicine, University of Connecticut, Farmington, Connecticut, USA
    BMC Microbiol 11:93. 2011
    ....
  16. doi request reprint Periodontitis and inflammatory markers in transplant recipients
    Murad Shaqman
    Department of Oral Health and Diagnostic Sciences, Division of Periodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA
    J Periodontol 81:666-72. 2010
    ..We hypothesized that transplant subjects have a greater prevalence of severe periodontitis, accompanied by higher levels of serum interleukin-6 (IL-6) and C-reactive protein (CRP), compared to systemically healthy subjects...
  17. pmc Cytotoxic and cytokine-inducing properties of Candida glabrata in single and mixed oral infection models
    Lulu Li
    Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut, 263 Farmington Ave, Farmington, CT 06030 1710, USA
    Microb Pathog 42:138-47. 2007
    ..albicans, is low. Synergy between C. glabrata and C. albicans in cytokine induction and host damage was not observed with the strains tested...
  18. pmc Host cell invasion and virulence mediated by Candida albicans Ssa1
    Jianing N Sun
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, New York, United States of America
    PLoS Pathog 6:e1001181. 2010
    ..albicans to cause maximal damage to host cells and induce disseminated and oropharyngeal disease...
  19. ncbi request reprint Elevated serum interleukin-6 (IL-6) in solid-organ transplant recipients is positively associated with tissue destruction and IL-6 gene expression in the periodontium
    Effie Ioannidou
    Department of Oral Health and Diagnostic Sciences, Division of Periodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030 1710, USA
    J Periodontol 77:1871-8. 2006
    ....
  20. pmc Transplantation-associated long-term immunosuppression promotes oral colonization by potentially opportunistic pathogens without impacting other members of the salivary bacteriome
    Patricia I Diaz
    Division of Periodontology, Department of Oral Health and Diagnostic Sciences, The University of Connecticut Health Center, Farmington, CT, USA
    Clin Vaccine Immunol 20:920-30. 2013
    ..This work demonstrates that immunosuppression aimed at limiting T-cell-mediated responses creates a more permissive oral environment for potentially opportunistic pathogens without affecting other members of the salivary bacteriome...
  21. pmc Redefining the human oral mycobiome with improved practices in amplicon-based taxonomy: discovery of Malassezia as a prominent commensal
    Amanda K Dupuy
    Center for Applied Genetics and Technology and Department of Molecular and Cell Biology, The University of Connecticut, Storrs, Connecticut, United States of America
    PLoS ONE 9:e90899. 2014
    ....
  22. pmc Glucanase induces filamentation of the fungal pathogen Candida albicans
    Hongbin Xu
    Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, Connecticut, USA
    PLoS ONE 8:e63736. 2013
    ..Our data suggest that the natural antifungal agent beta-glucanase may support morphologic transformation of Candida albicans at a wide range of ambient temperatures...

Research Grants11

  1. ORAL EPITHELIAL CELL CYTOKINES--CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2000
    ..Identification of such cytokines may have future therapeutic applications in the treatment of oral candidiasis in the severely immunocompromised host. ..
  2. Oral Epithelial Cells, Candida and PMN Activation
    ANNA I DONGARI BAGTZOGLOU; Fiscal Year: 2010
    ..We envision that our studies in tissue biofilms will lead to the development of new oral anti-mycotic agents which target pathways of biofilm regulation by C. albicans and promote neutrophil antifungal functions. ..
  3. Oral Epithelial Cells, Candida and PMN Activation
    Anna Dongari Bagtzoglou; Fiscal Year: 2009
    ..We envision that our studies in tissue biofilms will lead to the development of new oral anti-mycotic agents which target pathways of biofilm regulation by C. albicans and promote neutrophil antifungal functions. ..
  4. ORAL EPITHELIAL CELL CYTOKINES CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2006
    ..albicans genes which promote invasive infection will provide novel therapeutic targets within the C. albicans-oral mucosal response framework. ..
  5. ORAL EPITHELIAL CELL CYTOKINES CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2005
    ..albicans genes which promote invasive infection will provide novel therapeutic targets within the C. albicans-oral mucosal response framework. ..
  6. Oral infection and inflammation in transplant patients
    Anna Dongari Bagtzoglou; Fiscal Year: 2005
    ....
  7. ORAL EPITHELIAL CELL CYTOKINES CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2004
    ..albicans genes which promote invasive infection will provide novel therapeutic targets within the C. albicans-oral mucosal response framework. ..
  8. ORAL EPITHELIAL CELL CYTOKINES CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2002
    ..Identification of such cytokines may have future therapeutic applications in the treatment of oral candidiasis in the severely immunocompromised host. ..
  9. ORAL EPITHELIAL CELL CYTOKINES CANDIDA & PMN ACTIVATION
    Anna Dongari Bagtzoglou; Fiscal Year: 2001
    ..Identification of such cytokines may have future therapeutic applications in the treatment of oral candidiasis in the severely immunocompromised host. ..
  10. Oral Epithelial Cells, Candida and PMN Activation
    Anna Dongari Bagtzoglou; Fiscal Year: 2009
    ..We envision that our studies in tissue biofilms will lead to the development of new oral anti-mycotic agents which target pathways of biofilm regulation by C. albicans and promote neutrophil antifungal functions. ..