Research Topics
Genomes and Genes
Species | Zigang DongSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiationGuangming Liu
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 277:8810-6. 2002..The p38/MSK1 pathway, but not PI3-kinase or Akt, is required for mediating the UVB-induced 4E-BP1 phosphorylation...- Involvement of c-jun NH(2)-terminal kinases in resveratrol-induced activation of p53 and apoptosisQing-Bai She
The Hormel Institute, University of Minnesota, Austin 55912, USA
Mol Carcinog 33:244-50. 2002..These data suggested that JNKs act as mediators of resveratrol-induced activation of p53 and apoptosis, which may occur partially through p53 phosphorylation... - NS-398 and piroxicam suppress UVB-induced activator protein 1 activity by mechanisms independent of cyclooxygenase-2Guangming Liu
Hormel Institute, University of Minnesota, Austin 55912, USA
J Biol Chem 278:2124-30. 2003..Based on our results, we propose that the inhibition of AP-1 activity by COX-2 inhibitors NS-398 or piroxicam may occur by a mechanism that is independent of COX-2... - p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factorZhiwei He
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 278:26435-42. 2003.... 
Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-KJong Eun Kim
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Cancer Prev Res (Phila) 4:582-91. 2011..Overall, these results indicate that isorhamnetin has potent anticancer activity and it primarily targets MEK and PI3-K, which might contribute to the chemopreventive potential of certain foods...
Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell GrowthMee Hyun Lee
The Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912
Cancer Prev Res (Phila) 6:455-65. 2013..Taken together, silybin suppresses melanoma growth by directly targeting MEK- and RSK-mediated signaling pathways. Cancer Prev Res; 6(5); 455-65. ©2013 AACR...- Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3KNaomi Oi
The Hormel Institute, University of Minnesota, 801 16 Ave NE, Austin, MN 55912, USA
Cancer Prev Res (Phila) 5:1103-14. 2012..These results suggest that taxifolin exerts chemopreventive activity against UV-induced skin carcinogenesis by targeting EGFR and PI3K... - Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cellsAnna L Stratford
Laboratory for Oncogenomic Research, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
Breast Cancer Res 10:R99. 2008..Using Motifscan we identified p90 ribosomal S6 kinase (RSK) as a potential candidate for activating YB-1... - Breaking the NF-κB and STAT3 alliance inhibits inflammation and pancreatic tumorigenesisYoung Joon Surh
The Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912 3679
Cancer Prev Res (Phila) 3:1379-81. 2010.... - The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer developmentDuo Zheng
Hormel Institute, University of Minnesota, Austin, Minnesota, USA
Cancer Res 68:3992-8. 2008..These data provide direct evidence indicating that the CB1/2 receptors play a key role in UV-induced inflammation and skin cancer development... - The molecular mechanisms of arsenic-induced cell transformation and apoptosisZigang Dong
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Environ Health Perspect 110:757-9. 2002..These results suggest that the activation of Erks is required for arsenic-induced cell transformation, whereas the activation of JNKs and NF-kappaB is involved in arsenic-induced apoptosis of JB6 cells... - Molecular mechanism of the chemopreventive effect of resveratrolZigang Dong
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Mutat Res 523:145-50. 2003..The MAP kinases, ERKs, JNKs, or p38 kinases, are involved in resveratrol-induced activation of p53 and apoptosis... - Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1Darya V Urusova
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Cancer Prev Res (Phila) 4:1366-77. 2011..Overall, these results showed that EGCG directly suppresses the tumor-promoting effect of Pin1... - Dialogue between ERKs and JNKs: friendly or antagonistic?Zigang Dong
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Mol Interv 3:306-8. 2003 - (3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivoDong Joon Kim
The Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
Cancer Prev Res (Phila) 4:1842-51. 2011..In addition, oral administration of this potent AKT inhibitor suppressed cancer cell growth in an in vivo xenograft mouse model... - Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformationHong Gyum Kim
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Cancer Res 68:2538-47. 2008..Thus, MSK1 is required for tumor promoter-induced cell transformation through its phosphorylation of histone H3 at Ser(10) and AP-1 activation... - Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformationZhiwei He
Hormel Institute, The University of Minnesota, Austin, Minnesota 55912, USA
Mol Carcinog 47:172-83. 2008..Inhibition of Fyn kinase activity is a novel and important mechanism that may be involved in EGCG-induced inhibition of cell transformation... - Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformationKe Yao
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 67:8725-35. 2007..Furthermore, knockdown of NFAT3 enhanced Ras-JNK1 or JNK2-induced foci formation in NIH3T3 cells. Taken together, these results provided direct evidence for the anti-oncogenic potential of the NFAT3 transcription factor... - The resveratrol analogue 3,5,3',4',5'-pentahydroxy-trans-stilbene inhibits cell transformation via MEKKi Won Lee
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Int J Cancer 123:2487-96. 2008.... - Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathwaysJin-Ping Liu
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Exp Eye Res 79:393-403. 2004..Together, our results for the first time reveal that by regulating multiple signaling pathways the two alpha-crystallins can prevent stress-induced apoptosis through different mechanisms... - T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformationSang Muk Oh
Hormel Institute, University of Minnesota, Austin, Minnesota
Cancer Res 67:5186-94. 2007..These studies might also provide a novel molecular mechanism for the role of TOPK in UVB-mediated skin carcinogenesis... - Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alphaHong Seok Choi
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 280:13545-53. 2005.... - Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformationFeng Zhu
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 71:393-403. 2011..Thus, the RSK2/H2AX signaling pathway negatively regulates the RSK2/histone H3 pathway and therefore maintains normal cell proliferation... - The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenolsTatyana A Zykova
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Carcinogenesis 26:331-42. 2005..We also show an inhibitory effect of theaflavins and EGCG on UVB-induced STAT1 (Ser727), ERKs, JNKs, PDK1 and p90RSK2 phosphorylation... - Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activityHong Seok Choi
Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
FASEB J 22:113-26. 2008.... - Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathwayNam Joo Kang
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
J Biol Chem 282:32856-66. 2007..These findings are the first to reveal a molecular basis for the anticancer action of equol and may partially account for the reported chemopreventive effects of soybean... - Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformationYong Yeon Cho
The Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
Cancer Res 69:272-81. 2009..These results showed that the Cdk3/c-Jun signaling axis plays an important role in EGF-stimulated cell proliferation and cell transformation... - Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiationQing Bai She
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 277:24039-48. 2002..These data illustrated that UVB-induced phosphorylation of Bad at serine 112 was mediated through MAP kinase signaling pathways in which JNK1, RSK2, and MSK1 served as direct mediators... - A regulatory mechanism for RSK2 NH(2)-terminal kinase activityYong Yeon Cho
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Cancer Res 69:4398-406. 2009..These results indicate that targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application... - Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancerYan Ming Xu
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 70:3218-27. 2010..The interaction between ERK8 and c-Jun seems to increase the tumorigenic properties of HCT15 colorectal cancer cells. Thus, ERK8-regulated signaling might serve as a potential therapeutic target in colorectal cancer... - Transient receptor potential type vanilloid 1 suppresses skin carcinogenesisAnn M Bode
The Hormel Institute, University of Minnesota, Austin, Minnesota, USA
Cancer Res 69:905-13. 2009..The data suggest that, although a great deal of interest has focused on TRPV1 as a target for pain relief, the chronic blockade of this pain receptor might increase the risk for cancer development... - Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wineKi Won Lee
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 68:946-55. 2008..Docking data suggested that quercetin, but not resveratrol, formed a hydrogen bond with the backbone amide group of Ser(212), which is the key interaction for stabilizing the inactive conformation of the activation loop of MEK1... - Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cellsFeng Zhu
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Gastroenterology 133:219-31. 2007.... - T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activityTatyana A Zykova
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 285:29138-46. 2010..Phosphorylation of Prx1 (Ser-32) by TOPK prevents UVB-induced apoptosis in RPMI7951 melanoma cells through regulation of Prx1 peroxidase activity and blockade of intracellular H(2)O(2) accumulation... - Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformationYong Yeon Cho
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Cancer Res 67:8104-12. 2007..These results showed that RSK2 is a key regulator for cell transformation induced by tumor promoters such as EGF and TPA... - Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinaseZhiwei He
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 280:2446-54. 2005..These results indicate that Fyn kinase plays a key role in the UVB-induced phosphorylation of histone H3 at serine 10... - COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformationFeng Zhu
Hormel Institute, University of Minnesota, Austin, Minnesota, USA
Cancer Res 66:5729-36. 2006..These results indicated that this function of CSK controls cell proliferation under normal growth conditions and may have implications for CSK loss of function in carcinogenesis... - Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathwayCong Peng
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 287:25881-92. 2012..In addition, TRAF2 is overexpressed in colon cancer and required for colon cancer development, suggesting that TRAF2 might be a potential molecular target for cancer prevention and treatment... - Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activityKyung Mi Lee
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Biochem Pharmacol 80:2042-9. 2010..Taken together, these results suggest that kaempferol is a potent chemopreventive agent against skin cancer through its inhibitory interaction with Src... - 7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinaseDong Eun Lee
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 285:21458-66. 2010..These insights into the biological actions of 7,3',4'-THIF provide a molecular basis for the possible development of new chemoprotective agents... - T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathwayShengqing Li
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 286:29601-9. 2011..Notably, the absence of TOPK in mice resulted in a striking increase in skin inflammation. Therefore, we conclude that TOPK has a protective function in solar UV light-induced inflammation... - Theaflavin-3, 3'-digallate induces epidermal growth factor receptor downregulationHideya Mizuno
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Mol Carcinog 45:204-12. 2006..In addition, TF-3 inhibited EGF-induced anchorage-independent cell transformation. Overall, our results indicate that TF-3 might exert chemopreventive effects through the downregulation of the EGFR... - Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2Margarita Malakhova
Department of Cellular and Molecular Biology, The Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America
PLoS ONE 4:e8044. 2009..The presence of a unique betaB-sheet insert in the N-lobe suggests a different type of activation mechanism for RSK2... - The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activityBu Young Choi
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, USA
Nat Struct Mol Biol 12:699-707. 2005..This, in turn, interferes with cell transformation promoted by the H-Ras-JNK-c-Jun-AP-1 signaling axis... - RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathwayCong Peng
The Hormel Institute, University of Minnesota, 801 16th Ave N E, Austin, MN 55912, USA
FASEB J 24:3490-9. 2010..The net result is an increased NF-kappaB activity, which serves as a mechanism for RSK2 blockade of TNF-alpha-induced apoptosis and enhanced cell survival... - The intermediate filament protein vimentin is a new target for epigallocatechin gallateSvetlana Ermakova
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 280:16882-90. 2005.... - Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cellsFeng Zhu
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Carcinogenesis 25:1847-52. 2004..Overall, our results reveal that MSK1 and ERKs, like p38 kinase and JNKs, are required for ATF2 phosphorylation (Thr71) in the UVC response... - Tpl2 is a key mediator of arsenite-induced signal transductionKyung Mi Lee
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 69:8043-9. 2009..Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells... - Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1Ki Won Lee
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Carcinogenesis 28:1918-27. 2007..Overall, these results indicated that myricetin has potent anticancer-promoting activity and mainly targets MEK signaling, which may contribute to the chemopreventive potential of several foods including red wines... - Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinaseNam Joo Kang
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
J Biol Chem 283:20664-73. 2008..Notably, procyanidin B2 exerted stronger inhibitory effects compared with PD098059 (a well known pharmacological inhibitor of MEK) on MEK1 activity and neoplastic cell transformation... - MST1 promotes apoptosis through phosphorylation of histone H2AXWeihong Wen
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 285:39108-16. 2010..Taken together, our data indicated that H2AX is a substrate of MST1, which functions to induce apoptotic chromatin condensation and DNA fragmentation... - Involvement of the paxillin pathway in JB6 Cl41 cell transformationYasuaki Tatsumi
Hormel Institute, University of Minnesota, Austin, Minnesota
Cancer Res 66:5968-74. 2006..These results clearly provided evidence that paxillin regulates c-Jun protein level and plays a key role in cell transformation most likely through the regulation of c-Jun stability... - The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interactionYong-Yeon Cho
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 65:3596-603. 2005..The RSK2-p53-histone H3 complex may likely contribute to chromatin remodeling and cell cycle regulation... - Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1Yiguo Zhang
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Carcinogenesis 25:1165-75. 2004..Overall, our data indicate that phosphorylation of STAT1 at Ser727 occurs through diverse MAPK cascades including MEK1, ERKs, p38 kinase, JNKs and MSK1 in the cellular response to UVA... - Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cellsChul Ho Jeong
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Stem Cells 28:2141-50. 2010..Overall, our studies provide new insights into the regulatory mechanism of Sox2 in ESCs and also provide a direct link between phosphorylation events and somatic cell reprogramming... - A selective small-molecule inhibitor of c-Jun N-terminal kinase 1Ke Yao
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
FEBS Lett 583:2208-12. 2009..These results demonstrate that AV-7 is an isoform selective small-molecule inhibitor of JNK1 activity, which might be developed as a therapeutic against diabetes... - Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A₄hydrolaseNaomi Oi
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 70:9755-64. 2010..Our findings identify LTA(4)H as a functionally important target for mediating the anticancer properties of resveratrol... - P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformationTingting Li
The Hormel Institute, University of Minnesota, 801 16th Avenue North East, Austin, MN 55912, USA
Carcinogenesis 32:659-66. 2011..These results indicated that PAK2/c-Jun signaling plays an important role in EGF-induced cell proliferation and transformation... - Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expressionNam Joo Kang
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Carcinogenesis 30:321-30. 2009..These results suggested that this compound could act as a potent chemopreventive agent against skin cancer... - Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosisSergey N Fedorov
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 67:5914-20. 2007..Therefore, these data showed that application of dactylone and related compounds may lead to decreased malignant cell transformation and/or decreased tumor cell proliferation... - Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cellsYoung Jin Jeon
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 285:28126-33. 2010.... - Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformationHong Seok Choi
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 65:5818-27. 2005..These results indicate that the phosphorylation of histone H3 at Ser10 is an essential regulatory mechanism for EGF-induced neoplastic cell transformation... - Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3Chengrong Lu
Hormel Institute, University of Minnesota, Austin, 55912, USA
Mol Cell 23:121-32. 2006.... - Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cellsTatyana A Zykova
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Clin Cancer Res 12:6884-93. 2006..We investigated the role of TOPK in arsenic-induced apoptosis in RPMI7951 human melanoma cells... - Identification of an Aurora kinase inhibitor specific for the Aurora B isoformHua Xie
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 73:716-24. 2013..The expression of phospho-histone H3, phospho-Aurora B, and Ki-67 was also suppressed in the HOI-07 treatment group. Taken together, we identified HOI-07 as a specific Aurora B inhibitor, which deserves further investigation... - Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growthDong Joon Kim
The Hormel Institute, University of Minnesota, Minneapolis, Minnesota 55912, USA
Cancer Res 72:3060-8. 2012..Our findings therefore show that HI-TOPK-032 is a specific inhibitor of TOPK both in vitro and in vivo that may be further developed as a potential therapeutic against colorectal cancer... - Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signalingNam Joo Kang
Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
Cancer Prev Res (Phila) 1:522-31. 2008..Together, these findings suggested that the targeted inhibition of Raf1 and MEK activities and COX-2 expression by delphinidin contribute to the chemopreventive potential of fruits and vegetables... - A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor developmentYong Yeon Cho
Hormel Institute University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 64:3855-64. 2004..These results are the first to indicate that MLTK-alpha plays a key role in neoplastic cell transformation and cancer development... - Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1Jung Hyun Shim
The Hormel Institute, University of Minnesota, Austin, MN 55912 3679, USA
Cancer Prev Res (Phila) 3:670-9. 2010..Overall, these results strongly indicate that EGCG suppresses lung tumorigenesis through its binding with G3BP1... - Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3Yiguo Zhang
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 278:12650-9. 2003..Additionally, RSK2-mediated phosphorylation of STAT3 (Ser(727)) was further determined to be required for basal and UVA-stimulated STAT3 transcriptional activities... - Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cellsAkira Kaji
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Mol Carcinog 37:138-48. 2003..Thus, we conclude that PFTalpha is not a specific p53 inhibitor in JB6 cells but is a potential activator of p53-mediated signaling and apoptosis... - Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell linesXiang Li
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 286:22291-9. 2011..Our data indicate that highly expressed PAK2 mediates chemotherapeutic resistance in human breast invasive ductal carcinoma by negatively regulating caspase-7 activity... - Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPKNam Joo Kang
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Carcinogenesis 32:921-8. 2011..These results suggest that coffee and CaA target MEK1 and TOPK to suppress colon cancer metastasis and neoplastic cell transformation... - Phosphorylation of histone H2B serine 32 is linked to cell transformationAndy T Y Lau
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 286:26628-37. 2011.... - Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformationMing Li
Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
Cancer Epidemiol Biomarkers Prev 16:598-605. 2007..Our findings are the first to show that the IGF-IR is a novel binding protein of EGCG and thus may help explain the chemopreventive effect of EGCG on cancer development... - Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformationDuo Zheng
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 68:7650-60. 2008..These results clearly showed that the cdk3-ATF1 signaling axis is critical for cell proliferation and transformation... - Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylationSung Young Lee
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 285:29525-34. 2010..Taken together, our findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr(16) by Chk1... - 2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cellsQing Zhao
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 280:26735-42. 2005..Taken together, our data provide direct evidence suggesting that 2-AG may have a novel role in cell transformation and carcinogenesis in a signaling pathway involving CB1/2 and activation of Fyn, ERKs, and AP-1... - Post-translational modification of p53 in tumorigenesisAnn M Bode
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, USA
Nat Rev Cancer 4:793-805. 2004..A thorough understanding of p53 will be extremely useful in the development of new strategies for treating and preventing cancer, including restoration of p53 function and selective killing of tumours with mutant TP53... - Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51))Tatyana A Zykova
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Carcinogenesis 28:1543-51. 2007..These data may lead to the use of these signaling molecules as targets to develop more effective chemopreventive agents with fewer side effects to control UV-induced skin cancer... - Signal transduction pathways in cancer development and as targets for cancer preventionAnn M Bode
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Prog Nucleic Acid Res Mol Biol 79:237-97. 2005 - The functional contrariety of JNKAnn M Bode
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Mol Carcinog 46:591-8. 2007..Specifically in this review, we examine evidence regarding whether the JNKs proteins might play distinctive roles in cellular processes associated with carcinogenesis... - Signal transduction pathways: targets for green and black tea polyphenolsAnn M Park
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
J Biochem Mol Biol 36:66-77. 2003..The purpose of this brief review is to present recent research data from other and our laboratory focusing on the tea-induced cellular signal transduction events associated with the MAP kinase, AP-1, and NF-kappaB pathways... - Update on Cancer Prevention Research in the United States and China: the 2009 China--U.S. Forum on Frontiers of Cancer ResearchAnn M Bode
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Cancer Prev Res (Phila) 3:1630-7. 2010..This perspective presents an overview of the progress being made in cancer prevention in China and the United States... - The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effectsAnn M Bode
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Crit Rev Oncol Hematol 42:5-24. 2002..The primary purpose of this review is to examine recent findings, from this laboratory and others, that focus on the molecular mechanisms of arsenic's actions in cell transformation and as a therapeutic agent... - The enigmatic effects of caffeine in cell cycle and cancerAnn M Bode
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Cancer Lett 247:26-39. 2007.... - Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activationDavid Wan Cheng Li
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Mol Biol Cell 16:4437-53. 2005..Together, our results provide 1) a partial explanation for the lack of spontaneous tumor in the lens, 2) a novel signaling pathway for calcium-induced apoptosis, and 3) a novel antiapoptotic mechanism for alphaB-crystallin... - Inducible covalent posttranslational modification of histone H3Ann M Bode
Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
Sci STKE 2005:re4. 2005..In addition, the interdependence of phosphorylation and acetylation will be discussed in light of data showing patterns of inducible modification at specific genes... - Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathwaysJin-Ping Liu
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin 55912, USA
Exp Eye Res 79:393-403. 2004..Together, our results for the first time reveal that by regulating multiple signaling pathways the two alpha-crystallins can prevent stress-induced apoptosis through different mechanisms... - Signal transduction molecules as targets for cancer preventionAnn M Bode
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Sci Signal 2:mr2. 2009.... - Inhibition of cell transformation by resveratrol and its derivatives: differential effects and mechanisms involvedQing-Bai She
The Hormel Institute, University of Minnesota, Austin 55912, USA
Oncogene 22:2143-50. 2003..Collectively, these data suggested that the higher antitumor effect of the compound compared to resveratrol, may act through a different mechanism by mainly targeting PI-3K/Akt signaling pathways... - Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathwaysZhiwei He
Hormel Institute, University of Minnesota, 801 16th Avenue N.E, Austin, MN 55912, USA
Cancer Res 63:4396-401. 2003..Cleaved caspase 3 was also increased in a time- and dose-dependent manner. These data show that a low concentration of caffeine can induce p53-dependent apoptosis in JB6 cells through the Bax and caspase 3 pathways... - Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin AShuping Zhong
The Hormel Institute, University of Minnesota, 801, 16th Avenue NE, Austin, MN 55912, USA
Oncogene 22:5291-7. 2003..The facilitation of phosphorylation and acetylation of histone H3 induced by TSA may play a critical regulatory role in chromatin remodeling and gene expression... - Requirement of ATM in UVA-induced signaling and apoptosisYiguo Zhang
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 277:3124-31. 2002..Therefore, these results suggest that ATM, like p53, is involved in the UVA-induced apoptosis to suppress carcinogenesis... - Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20Qing-Bai She
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota, MN 55912, USA
Oncogene 21:1580-9. 2002..These findings strongly suggest that JNKs are the major direct signaling mediators of UVB-induced p53 phosphorylation at serine 20... - The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformationZigang Dong
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Mol Carcinog 45:416-21. 2006.... - Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetateQing Bai She
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 62:1343-8. 2002..These results suggest that JNK1 is a crucial suppressor of skin tumor development... - Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cellsTakashi Hashimoto
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Res 64:3344-9. 2004..The inhibitory mechanism may be due to the inhibition of cell growth signal-induced activation of cdk4, which may be involved in the inhibition of carcinogenesis in vivo... - Mitogen-activated protein kinase activation in UV-induced signal transductionAnn M Bode
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Sci STKE 2003:RE2. 2003..Progress in understanding the mechanisms of UV-induced signal transduction could lead to the use of these protein kinases as specific targets for the prevention and control of skin cancer... - Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeineMasaaki Nomura
Department of Hospital Pharmacy, School of Medicine, Kanazawa University, Kanazawa, Japan
Mol Carcinog 44:67-76. 2005..Because Akt plays a key role in signal transduction pathways leading to cell proliferation and apoptosis, our results provide novel insight into possible mechanisms of the chemotherapeutic effect of caffeine... - Inhibitory effects of caffeine analogues on neoplastic transformation: structure-activity relationshipEvgeny A Rogozin
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Carcinogenesis 29:1228-34. 2008..2 or 62.0%, respectively. Collectively, these results indicated that the number of carbons at R1 and R3 is important for the antitumor-promoting activity of the trialkylxanthines and xanthine 70 might be a promising anticancer agent...
Research Grants
- Study on Ultraviolet-induced Signal TransductionZigang Dong; Fiscal Year: 2010..These preclinical studies are designed to lead to the development of new strategies for the chemoprevention of human skin cancers. ..
- Molecular basis of arsenic-induced cell transformationZigang Dong; Fiscal Year: 2007..Such knowledge will facilitate the design of more effective and specific strategies with fewer side effects for chemoprevention of arsenic-induced cancer. ..
- Ultraviolet-Induced Signal TrasductionZigang Dong; Fiscal Year: 2007..Such knowledge will lead to a better understanding of human skin carcinogenesis, and facilitate the design of more effective agents for chemoprevention of human skin cancer. ..
- INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTSZigang Dong; Fiscal Year: 2007....
- Anticarcinogenic Mechanisms of Tea ConstituentsZigang Dong; Fiscal Year: 2007....
- Mechanisms of chemopreventive effect of resveratrolZigang Dong; Fiscal Year: 2007..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
- The role of histone phosphorylation in arsenic-induced cell transformation and skZigang Dong; Fiscal Year: 2009..These studies will facilitate the development of more effective agents with fewer side effects for chemoprevention against environmental carcinogens such as arsenic- induced cancer. ..
- INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTSZigang Dong; Fiscal Year: 2009..abstract_text> ..
- Mechanisms of chemopreventive effect of resveratrolZigang Dong; Fiscal Year: 2009..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
- The role of histone phosphorylation in arsenic-induced cell transformation and skZigang Dong; Fiscal Year: 2010..These studies will facilitate the development of more effective agents with fewer side effects for chemoprevention against environmental carcinogens such as arsenic- induced cancer. ..
- INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTSZigang Dong; Fiscal Year: 2010..abstract_text> ..