Zigang Dong

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint NS-398 and piroxicam suppress UVB-induced activator protein 1 activity by mechanisms independent of cyclooxygenase-2
    Guangming Liu
    Hormel Institute, University of Minnesota, Austin 55912, USA
    J Biol Chem 278:2124-30. 2003
  2. ncbi request reprint p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factor
    Zhiwei He
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 278:26435-42. 2003
  3. doi request reprint Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K
    Jong Eun Kim
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 4:582-91. 2011
  4. pmc EBV-encoded LMP1 upregulates Igκ 3'enhancer activity and Igκ expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling
    Haidan Liu
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, China
    PLoS ONE 7:e32624. 2012
  5. pmc Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo
    Hua Xie
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912 3679, USA
    Carcinogenesis 33:1814-21. 2012
  6. pmc UVB-induced COX-2 expression requires histone H3 phosphorylation at Ser10 and Ser28
    Y S Keum
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Oncogene 32:444-52. 2013
  7. pmc Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2
    Haitao Li
    The Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America
    PLoS ONE 8:e76452. 2013
  8. pmc Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods
    Hanyong Chen
    The Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America
    PLoS ONE 7:e38261. 2012
  9. pmc Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity
    Luqing Zhao
    Cancer Research Institute, Xiangya School of Medicine, Central South University Changsha 410078, China
    Carcinogenesis 33:2220-7. 2012
  10. pmc Curcumin suppresses proliferation of colon cancer cells by targeting CDK2
    Tae Gyu Lim
    University of Minnesota, 801 16th Avenue NE, Austin, MN 55912 Phone 507 437 9600 Fax 507 437 9606 and Ki Won Lee, Seoul National University, Seoul, Republic of Korea
    Cancer Prev Res (Phila) 7:466-74. 2014

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint NS-398 and piroxicam suppress UVB-induced activator protein 1 activity by mechanisms independent of cyclooxygenase-2
    Guangming Liu
    Hormel Institute, University of Minnesota, Austin 55912, USA
    J Biol Chem 278:2124-30. 2003
    ..Based on our results, we propose that the inhibition of AP-1 activity by COX-2 inhibitors NS-398 or piroxicam may occur by a mechanism that is independent of COX-2...
  2. ncbi request reprint p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factor
    Zhiwei He
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 278:26435-42. 2003
    ....
  3. doi request reprint Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K
    Jong Eun Kim
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 4:582-91. 2011
    ..Overall, these results indicate that isorhamnetin has potent anticancer activity and it primarily targets MEK and PI3-K, which might contribute to the chemopreventive potential of certain foods...
  4. pmc EBV-encoded LMP1 upregulates Igκ 3'enhancer activity and Igκ expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling
    Haidan Liu
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, China
    PLoS ONE 7:e32624. 2012
    ..Our studies provide evidence for a novel regulatory mechanism of kappa expression, by which virus-encoded proteins activate the kappa 3' enhancer through activating transcription factors in non-B epithelial cancer cells...
  5. pmc Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo
    Hua Xie
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912 3679, USA
    Carcinogenesis 33:1814-21. 2012
    ..Taken together, our results are the first to identify mTOR as a direct antitumor target of 4HPR both in vitro and in vivo, providing a valuable rationale for guiding the clinical uses of 4HPR...
  6. pmc UVB-induced COX-2 expression requires histone H3 phosphorylation at Ser10 and Ser28
    Y S Keum
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Oncogene 32:444-52. 2013
    ....
  7. pmc Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2
    Haitao Li
    The Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America
    PLoS ONE 8:e76452. 2013
    ..Further mechanistic studies revealed that the actions of these phytochemicals were similar to aspirin in that they mainly inhibited COX-1 rather than COX-2, especially at low doses. ..
  8. pmc Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods
    Hanyong Chen
    The Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America
    PLoS ONE 7:e38261. 2012
    ....
  9. pmc Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity
    Luqing Zhao
    Cancer Research Institute, Xiangya School of Medicine, Central South University Changsha 410078, China
    Carcinogenesis 33:2220-7. 2012
    ....
  10. pmc Curcumin suppresses proliferation of colon cancer cells by targeting CDK2
    Tae Gyu Lim
    University of Minnesota, 801 16th Avenue NE, Austin, MN 55912 Phone 507 437 9600 Fax 507 437 9606 and Ki Won Lee, Seoul National University, Seoul, Republic of Korea
    Cancer Prev Res (Phila) 7:466-74. 2014
    ..From these results, we identified CDK2 as a direct target of curcumin in colon cancer cells...
  11. doi request reprint Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1
    Ke Yao
    The Hormel Institute University of Minnesota, 801 16 Ave NE, Austin, MN 55912
    Cancer Prev Res (Phila) 7:139-49. 2014
    ..Therefore, we suggest that because of the critical role of JNK1 in colon cancer and pancreatic carcinogenesis, licochalcone A might have preventive or therapeutic potential against these devastating diseases...
  12. pmc A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1
    Haidan Liu
    University of Minnesota, 801 16th Avenue NE, Austin, MN 55912 Phone 507 437 9600 Fax 507 437 9606 and Bo Yeon Kim, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363 883, Republic of Korea
    Cancer Prev Res (Phila) 7:74-85. 2014
    ....
  13. pmc Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin
    Sung Young Lee
    The Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912
    Cancer Prev Res (Phila) 6:1356-64. 2013
    ..Our data indicate that the interaction between esculetin and β-catenin inhibits the formation of the β-catenin-Tcf complex, which could contribute to esculetin's positive therapeutic and preventive effects against colon carcinogenesis...
  14. pmc Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma
    Nu Ry Song
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912
    Cancer Prev Res (Phila) 6:1293-303. 2013
    ..This insight into the biologic actions of IAA provides a molecular basis for the potential development of a new chemotherapeutic agent...
  15. pmc Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo
    Hua Xie
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Mol Cancer Ther 12:950-8. 2013
    ..The expression of downstream signaling molecules in the mTOR pathway in tumor tissues was also reduced after 3HOI-BA-01 treatment. Taken together, we identified 3HOI-BA-01 as a novel and effective mTOR inhibitor...
  16. pmc Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth
    Mee Hyun Lee
    Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 6:455-65. 2013
    ..Taken together, silybin suppresses melanoma growth by directly targeting MEK- and RSK-mediated signaling pathways...
  17. pmc Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K
    Naomi Oi
    The Hormel Institute, University of Minnesota, 801 16 Ave NE, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 5:1103-14. 2012
    ..These results suggest that taxifolin exerts chemopreventive activity against UV-induced skin carcinogenesis by targeting EGFR and PI3K...
  18. pmc Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells
    Anna L Stratford
    Laboratory for Oncogenomic Research, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    Breast Cancer Res 10:R99. 2008
    ..Using Motifscan we identified p90 ribosomal S6 kinase (RSK) as a potential candidate for activating YB-1...
  19. pmc The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development
    Duo Zheng
    Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 68:3992-8. 2008
    ..These data provide direct evidence indicating that the CB1/2 receptors play a key role in UV-induced inflammation and skin cancer development...
  20. ncbi request reprint Molecular mechanism of the chemopreventive effect of resveratrol
    Zigang Dong
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Mutat Res 523:145-50. 2003
    ..The MAP kinases, ERKs, JNKs, or p38 kinases, are involved in resveratrol-induced activation of p53 and apoptosis...
  21. pmc Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1
    Darya V Urusova
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 4:1366-77. 2011
    ..Overall, these results showed that EGCG directly suppresses the tumor-promoting effect of Pin1...
  22. pmc The molecular mechanisms of arsenic-induced cell transformation and apoptosis
    Zigang Dong
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Environ Health Perspect 110:757-9. 2002
    ..These results suggest that the activation of Erks is required for arsenic-induced cell transformation, whereas the activation of JNKs and NF-kappaB is involved in arsenic-induced apoptosis of JB6 cells...
  23. pmc Breaking the NF-κB and STAT3 alliance inhibits inflammation and pancreatic tumorigenesis
    Young Joon Surh
    The Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912 3679
    Cancer Prev Res (Phila) 3:1379-81. 2010
    ....
  24. ncbi request reprint Dialogue between ERKs and JNKs: friendly or antagonistic?
    Zigang Dong
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Mol Interv 3:306-8. 2003
  25. pmc (3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo
    Dong Joon Kim
    The Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 4:1842-51. 2011
    ..In addition, oral administration of this potent AKT inhibitor suppressed cancer cell growth in an in vivo xenograft mouse model...
  26. pmc Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation
    Zhiwei He
    Hormel Institute, The University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 47:172-83. 2008
    ..Inhibition of Fyn kinase activity is a novel and important mechanism that may be involved in EGCG-induced inhibition of cell transformation...
  27. pmc Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation
    Hong Gyum Kim
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Res 68:2538-47. 2008
    ..Thus, MSK1 is required for tumor promoter-induced cell transformation through its phosphorylation of histone H3 at Ser(10) and AP-1 activation...
  28. ncbi request reprint Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways
    Jin Ping Liu
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Exp Eye Res 79:393-403. 2004
    ..Together, our results for the first time reveal that by regulating multiple signaling pathways the two alpha-crystallins can prevent stress-induced apoptosis through different mechanisms...
  29. ncbi request reprint Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway
    Nam Joo Kang
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    J Biol Chem 282:32856-66. 2007
    ..These findings are the first to reveal a molecular basis for the anticancer action of equol and may partially account for the reported chemopreventive effects of soybean...
  30. pmc Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity
    Kyung Mi Lee
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Biochem Pharmacol 80:2042-9. 2010
    ..Taken together, these results suggest that kaempferol is a potent chemopreventive agent against skin cancer through its inhibitory interaction with Src...
  31. pmc Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase
    Jung Yeon Kwon
    Major in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul 151 742, Republic of Korea
    Carcinogenesis 30:1932-40. 2009
    ..Collectively, our results demonstrated that delphinidin targets MAPKK4 and PI-3K directly to suppress COX-2 overexpression, suggesting a potential protective role for delphinidin against UVB-mediated skin carcinogenesis...
  32. doi request reprint Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer
    Yan Ming Xu
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 70:3218-27. 2010
    ..The interaction between ERK8 and c-Jun seems to increase the tumorigenic properties of HCT15 colorectal cancer cells. Thus, ERK8-regulated signaling might serve as a potential therapeutic target in colorectal cancer...
  33. pmc The resveratrol analogue 3,5,3',4',5'-pentahydroxy-trans-stilbene inhibits cell transformation via MEK
    Ki Won Lee
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Int J Cancer 123:2487-96. 2008
    ....
  34. ncbi request reprint T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation
    Sang Muk Oh
    Hormel Institute, University of Minnesota, Austin, Minnesota
    Cancer Res 67:5186-94. 2007
    ..These studies might also provide a novel molecular mechanism for the role of TOPK in UVB-mediated skin carcinogenesis...
  35. doi request reprint Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation
    Feng Zhu
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 71:393-403. 2011
    ..Thus, the RSK2/H2AX signaling pathway negatively regulates the RSK2/histone H3 pathway and therefore maintains normal cell proliferation...
  36. ncbi request reprint Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha
    Hong Seok Choi
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 280:13545-53. 2005
    ....
  37. ncbi request reprint Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation
    Ke Yao
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 67:8725-35. 2007
    ..Furthermore, knockdown of NFAT3 enhanced Ras-JNK1 or JNK2-induced foci formation in NIH3T3 cells. Taken together, these results provided direct evidence for the anti-oncogenic potential of the NFAT3 transcription factor...
  38. pmc Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine
    Ki Won Lee
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 68:946-55. 2008
    ..Docking data suggested that quercetin, but not resveratrol, formed a hydrogen bond with the backbone amide group of Ser(212), which is the key interaction for stabilizing the inactive conformation of the activation loop of MEK1...
  39. pmc Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation
    Yong Yeon Cho
    The Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
    Cancer Res 69:272-81. 2009
    ..These results showed that the Cdk3/c-Jun signaling axis plays an important role in EGF-stimulated cell proliferation and cell transformation...
  40. pmc A regulatory mechanism for RSK2 NH(2)-terminal kinase activity
    Yong Yeon Cho
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Res 69:4398-406. 2009
    ..These results indicate that targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application...
  41. ncbi request reprint The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 26:331-42. 2005
    ..We also show an inhibitory effect of theaflavins and EGCG on UVB-induced STAT1 (Ser727), ERKs, JNKs, PDK1 and p90RSK2 phosphorylation...
  42. ncbi request reprint The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity
    Bu Young Choi
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, USA
    Nat Struct Mol Biol 12:699-707. 2005
    ..This, in turn, interferes with cell transformation promoted by the H-Ras-JNK-c-Jun-AP-1 signaling axis...
  43. ncbi request reprint Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells
    Feng Zhu
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Gastroenterology 133:219-31. 2007
    ....
  44. ncbi request reprint The intermediate filament protein vimentin is a new target for epigallocatechin gallate
    Svetlana Ermakova
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 280:16882-90. 2005
    ....
  45. doi request reprint Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A₄hydrolase
    Naomi Oi
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 70:9755-64. 2010
    ..Our findings identify LTA(4)H as a functionally important target for mediating the anticancer properties of resveratrol...
  46. doi request reprint Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer
    Sanguine Byun
    Department of Agricultural Biotechnology, Major in Biomodulation, Seoul National University, Seoul, Republic of Korea
    Cancer Res 70:2415-23. 2010
    ..Together, these data suggest that luteolin exerts potent chemopreventive activity against UVB-induced skin cancer mainly by targeting PKC(epsilon)and Src...
  47. pmc RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway
    Cong Peng
    The Hormel Institute, University of Minnesota, 801 16th Ave N E, Austin, MN 55912, USA
    FASEB J 24:3490-9. 2010
    ..The net result is an increased NF-kappaB activity, which serves as a mechanism for RSK2 blockade of TNF-alpha-induced apoptosis and enhanced cell survival...
  48. pmc 7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase
    Dong Eun Lee
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:21458-66. 2010
    ..These insights into the biological actions of 7,3',4'-THIF provide a molecular basis for the possible development of new chemoprotective agents...
  49. ncbi request reprint Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1
    Ki Won Lee
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 28:1918-27. 2007
    ..Overall, these results indicated that myricetin has potent anticancer-promoting activity and mainly targets MEK signaling, which may contribute to the chemopreventive potential of several foods including red wines...
  50. ncbi request reprint Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells
    Feng Zhu
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 25:1847-52. 2004
    ..Overall, our results reveal that MSK1 and ERKs, like p38 kinase and JNKs, are required for ATF2 phosphorylation (Thr71) in the UVC response...
  51. pmc Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis
    Ann M Bode
    The Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 69:905-13. 2009
    ..The data suggest that, although a great deal of interest has focused on TRPV1 as a target for pain relief, the chronic blockade of this pain receptor might increase the risk for cancer development...
  52. pmc COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation
    Feng Zhu
    Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 66:5729-36. 2006
    ..These results indicated that this function of CSK controls cell proliferation under normal growth conditions and may have implications for CSK loss of function in carcinogenesis...
  53. pmc T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:29138-46. 2010
    ..Phosphorylation of Prx1 (Ser-32) by TOPK prevents UVB-induced apoptosis in RPMI7951 melanoma cells through regulation of Prx1 peroxidase activity and blockade of intracellular H(2)O(2) accumulation...
  54. doi request reprint CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth
    Eunjung Lee
    WCU Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul 151 921, Republic of Korea
    Toxicol Appl Pharmacol 272:12-20. 2013
    ..Thus, licorice-derived extracts with high IAA content warrant further clinical investigation for nutritional sources for prostate cancer patients. ..
  55. pmc P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation
    Tingting Li
    The Hormel Institute, University of Minnesota, 801 16th Avenue North East, Austin, MN 55912, USA
    Carcinogenesis 32:659-66. 2011
    ..These results indicated that PAK2/c-Jun signaling plays an important role in EGF-induced cell proliferation and transformation...
  56. ncbi request reprint 5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer
    Kyung Mi Lee
    Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea
    Cancer Prev Res (Phila) 3:454-65. 2010
    ..Taken together, our results indicate that 5-DK holds promise for the treatment of UVB-induced skin cancer by targeting Src, PI3K, and RSK2 signaling...
  57. doi request reprint Myricetin suppresses UVB-induced skin cancer by targeting Fyn
    Sung Keun Jung
    Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea
    Cancer Res 68:6021-9. 2008
    ..Overall, these results indicated that myricetin exerts potent chemopreventive activity mainly by targeting Fyn in skin carcinogenesis...
  58. pmc A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases
    Haidan Liu
    World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363 883, Republic of Korea
    J Biol Chem 288:25924-37. 2013
    ..This study provides new insights for creating a general pharmacophore model to design and develop novel ATP-noncompetitive agents with chemopreventive or chemotherapeutic potency. ..
  59. ncbi request reprint A selective small-molecule inhibitor of c-Jun N-terminal kinase 1
    Ke Yao
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    FEBS Lett 583:2208-12. 2009
    ..These results demonstrate that AV-7 is an isoform selective small-molecule inhibitor of JNK1 activity, which might be developed as a therapeutic against diabetes...
  60. ncbi request reprint Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation
    Qing Bai She
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 277:24039-48. 2002
    ..These data illustrated that UVB-induced phosphorylation of Bad at serine 112 was mediated through MAP kinase signaling pathways in which JNK1, RSK2, and MSK1 served as direct mediators...
  61. pmc Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity
    Hong Seok Choi
    Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    FASEB J 22:113-26. 2008
    ....
  62. pmc Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway
    Cong Peng
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 287:25881-92. 2012
    ..In addition, TRAF2 is overexpressed in colon cancer and required for colon cancer development, suggesting that TRAF2 might be a potential molecular target for cancer prevention and treatment...
  63. pmc T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway
    Shengqing Li
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 286:29601-9. 2011
    ..Notably, the absence of TOPK in mice resulted in a striking increase in skin inflammation. Therefore, we conclude that TOPK has a protective function in solar UV light-induced inflammation...
  64. pmc Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2
    Margarita Malakhova
    Department of Cellular and Molecular Biology, The Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America
    PLoS ONE 4:e8044. 2009
    ..The presence of a unique betaB-sheet insert in the N-lobe suggests a different type of activation mechanism for RSK2...
  65. pmc Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression
    Nam Joo Kang
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 30:321-30. 2009
    ..These results suggested that this compound could act as a potent chemopreventive agent against skin cancer...
  66. ncbi request reprint Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase
    Zhiwei He
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 280:2446-54. 2005
    ..These results indicate that Fyn kinase plays a key role in the UVB-induced phosphorylation of histone H3 at serine 10...
  67. pmc Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation
    Yong Yeon Cho
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Res 67:8104-12. 2007
    ..These results showed that RSK2 is a key regulator for cell transformation induced by tumor promoters such as EGF and TPA...
  68. pmc Theaflavin-3, 3'-digallate induces epidermal growth factor receptor downregulation
    Hideya Mizuno
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 45:204-12. 2006
    ..In addition, TF-3 inhibited EGF-induced anchorage-independent cell transformation. Overall, our results indicate that TF-3 might exert chemopreventive effects through the downregulation of the EGFR...
  69. pmc Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase
    Nam Joo Kang
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    J Biol Chem 283:20664-73. 2008
    ..Notably, procyanidin B2 exerted stronger inhibitory effects compared with PD098059 (a well known pharmacological inhibitor of MEK) on MEK1 activity and neoplastic cell transformation...
  70. ncbi request reprint The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction
    Yong Yeon Cho
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 65:3596-603. 2005
    ..The RSK2-p53-histone H3 complex may likely contribute to chromatin remodeling and cell cycle regulation...
  71. pmc Tpl2 is a key mediator of arsenite-induced signal transduction
    Kyung Mi Lee
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 69:8043-9. 2009
    ..Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells...
  72. pmc MST1 promotes apoptosis through phosphorylation of histone H2AX
    Weihong Wen
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:39108-16. 2010
    ..Taken together, our data indicated that H2AX is a substrate of MST1, which functions to induce apoptotic chromatin condensation and DNA fragmentation...
  73. pmc Involvement of the paxillin pathway in JB6 Cl41 cell transformation
    Yasuaki Tatsumi
    Hormel Institute, University of Minnesota, Austin, Minnesota
    Cancer Res 66:5968-74. 2006
    ..These results clearly provided evidence that paxillin regulates c-Jun protein level and plays a key role in cell transformation most likely through the regulation of c-Jun stability...
  74. pmc Tumor suppressor p16(INK4a) inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction
    Mee Hyun Lee
    The Hormel Institute, University of Minnesota, MN 55912, USA
    J Cell Sci 126:1744-52. 2013
    ..We conclude that the interaction of p16(INK4a) with eEF1A2, and subsequent downregulation of the expression and function of eEF1A2 is a novel mechanism explaining the anti-proliferative effects of p16(INK4a)...
  75. pmc CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo
    Dong Joon Kim
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 34:1134-43. 2013
    ..Overall, these results suggest that these novel MEK inhibitors might be used for chemotherapy or prevention...
  76. pmc Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK
    Nam Joo Kang
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 32:921-8. 2011
    ..These results suggest that coffee and CaA target MEK1 and TOPK to suppress colon cancer metastasis and neoplastic cell transformation...
  77. ncbi request reprint Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1
    Yiguo Zhang
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 25:1165-75. 2004
    ..Overall, our data indicate that phosphorylation of STAT1 at Ser727 occurs through diverse MAPK cascades including MEK1, ERKs, p38 kinase, JNKs and MSK1 in the cellular response to UVA...
  78. doi request reprint Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells
    Chul Ho Jeong
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Stem Cells 28:2141-50. 2010
    ..Overall, our studies provide new insights into the regulatory mechanism of Sox2 in ESCs and also provide a direct link between phosphorylation events and somatic cell reprogramming...
  79. pmc Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3
    Chengrong Lu
    Hormel Institute, University of Minnesota, Austin, 55912, USA
    Mol Cell 23:121-32. 2006
    ....
  80. pmc Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells
    Young Jin Jeon
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:28126-33. 2010
    ....
  81. pmc Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Clin Cancer Res 12:6884-93. 2006
    ..We investigated the role of TOPK in arsenic-induced apoptosis in RPMI7951 human melanoma cells...
  82. ncbi request reprint Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosis
    Sergey N Fedorov
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 67:5914-20. 2007
    ..Therefore, these data showed that application of dactylone and related compounds may lead to decreased malignant cell transformation and/or decreased tumor cell proliferation...
  83. pmc Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation
    Hong Seok Choi
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 65:5818-27. 2005
    ..These results indicate that the phosphorylation of histone H3 at Ser10 is an essential regulatory mechanism for EGF-induced neoplastic cell transformation...
  84. pmc Identification of an Aurora kinase inhibitor specific for the Aurora B isoform
    Hua Xie
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 73:716-24. 2013
    ..The expression of phospho-histone H3, phospho-Aurora B, and Ki-67 was also suppressed in the HOI-07 treatment group. Taken together, we identified HOI-07 as a specific Aurora B inhibitor, which deserves further investigation...
  85. doi request reprint Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth
    Dong Joon Kim
    The Hormel Institute, University of Minnesota, Minneapolis, Minnesota 55912, USA
    Cancer Res 72:3060-8. 2012
    ..Our findings therefore show that HI-TOPK-032 is a specific inhibitor of TOPK both in vitro and in vivo that may be further developed as a potential therapeutic against colorectal cancer...
  86. ncbi request reprint Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3
    Yiguo Zhang
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 278:12650-9. 2003
    ..Additionally, RSK2-mediated phosphorylation of STAT3 (Ser(727)) was further determined to be required for basal and UVA-stimulated STAT3 transcriptional activities...
  87. ncbi request reprint Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells
    Akira Kaji
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 37:138-48. 2003
    ..Thus, we conclude that PFTalpha is not a specific p53 inhibitor in JB6 cells but is a potential activator of p53-mediated signaling and apoptosis...
  88. pmc Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines
    Xiang Li
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 286:22291-9. 2011
    ..Our data indicate that highly expressed PAK2 mediates chemotherapeutic resistance in human breast invasive ductal carcinoma by negatively regulating caspase-7 activity...
  89. doi request reprint Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1
    Jung Hyun Shim
    The Hormel Institute, University of Minnesota, Austin, MN 55912 3679, USA
    Cancer Prev Res (Phila) 3:670-9. 2010
    ..Overall, these results strongly indicate that EGCG suppresses lung tumorigenesis through its binding with G3BP1...
  90. pmc Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling
    Nam Joo Kang
    Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 1:522-31. 2008
    ..Together, these findings suggested that the targeted inhibition of Raf1 and MEK activities and COX-2 expression by delphinidin contribute to the chemopreventive potential of fruits and vegetables...
  91. ncbi request reprint A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development
    Yong Yeon Cho
    Hormel Institute University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 64:3855-64. 2004
    ..These results are the first to indicate that MLTK-alpha plays a key role in neoplastic cell transformation and cancer development...
  92. pmc Phosphorylation of histone H2B serine 32 is linked to cell transformation
    Andy T Y Lau
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 286:26628-37. 2011
    ....
  93. pmc 2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells
    Qing Zhao
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 280:26735-42. 2005
    ..Taken together, our data provide direct evidence suggesting that 2-AG may have a novel role in cell transformation and carcinogenesis in a signaling pathway involving CB1/2 and activation of Fyn, ERKs, and AP-1...
  94. ncbi request reprint Post-translational modification of p53 in tumorigenesis
    Ann M Bode
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, USA
    Nat Rev Cancer 4:793-805. 2004
    ..A thorough understanding of p53 will be extremely useful in the development of new strategies for treating and preventing cancer, including restoration of p53 function and selective killing of tumours with mutant TP53...
  95. ncbi request reprint Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation
    Ming Li
    Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
    Cancer Epidemiol Biomarkers Prev 16:598-605. 2007
    ..Our findings are the first to show that the IGF-IR is a novel binding protein of EGCG and thus may help explain the chemopreventive effect of EGCG on cancer development...
  96. pmc Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation
    Duo Zheng
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 68:7650-60. 2008
    ..These results clearly showed that the cdk3-ATF1 signaling axis is critical for cell proliferation and transformation...
  97. pmc Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation
    Sung Young Lee
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:29525-34. 2010
    ..Taken together, our findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr(16) by Chk1...
  98. ncbi request reprint Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51))
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 28:1543-51. 2007
    ..These data may lead to the use of these signaling molecules as targets to develop more effective chemopreventive agents with fewer side effects to control UV-induced skin cancer...
  99. ncbi request reprint Signal transduction pathways in cancer development and as targets for cancer prevention
    Ann M Bode
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Prog Nucleic Acid Res Mol Biol 79:237-97. 2005
  100. ncbi request reprint The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects
    Ann M Bode
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Crit Rev Oncol Hematol 42:5-24. 2002
    ..The primary purpose of this review is to examine recent findings, from this laboratory and others, that focus on the molecular mechanisms of arsenic's actions in cell transformation and as a therapeutic agent...
  101. ncbi request reprint Signal transduction pathways: targets for green and black tea polyphenols
    Ann M Park
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    J Biochem Mol Biol 36:66-77. 2003
    ..The purpose of this brief review is to present recent research data from other and our laboratory focusing on the tea-induced cellular signal transduction events associated with the MAP kinase, AP-1, and NF-kappaB pathways...

Research Grants34

  1. Study on Ultraviolet-induced Signal Transduction
    Zigang Dong; Fiscal Year: 2010
    ..These preclinical studies are designed to lead to the development of new strategies for the chemoprevention of human skin cancers. ..
  2. Molecular basis of arsenic-induced cell transformation
    Zigang Dong; Fiscal Year: 2007
    ..Such knowledge will facilitate the design of more effective and specific strategies with fewer side effects for chemoprevention of arsenic-induced cancer. ..
  3. Ultraviolet-Induced Signal Trasduction
    Zigang Dong; Fiscal Year: 2007
    ..Such knowledge will lead to a better understanding of human skin carcinogenesis, and facilitate the design of more effective agents for chemoprevention of human skin cancer. ..
  4. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Zigang Dong; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. Anticarcinogenic Mechanisms of Tea Constituents
    Zigang Dong; Fiscal Year: 2007
    ....
  6. Mechanisms of chemopreventive effect of resveratrol
    Zigang Dong; Fiscal Year: 2007
    ..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
  7. Ultraviolet-Induced Signal Trasduction
    Zigang Dong; Fiscal Year: 2008
    ..Such knowledge will lead to a better understanding of human skin carcinogenesis, and facilitate the design of more effective agents for chemoprevention of human skin cancer. ..
  8. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Zigang Dong; Fiscal Year: 2008
    ..abstract_text> ..
  9. Mechanisms of chemopreventive effect of resveratrol
    Zigang Dong; Fiscal Year: 2008
    ..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
  10. The role of histone phosphorylation in arsenic-induced cell transformation and sk
    Zigang Dong; Fiscal Year: 2008
    ..These studies will facilitate the development of more effective agents with fewer side effects for chemoprevention against environmental carcinogens such as arsenic- induced cancer. ..
  11. The role of histone phosphorylation in arsenic-induced cell transformation and sk
    Zigang Dong; Fiscal Year: 2009
    ..These studies will facilitate the development of more effective agents with fewer side effects for chemoprevention against environmental carcinogens such as arsenic- induced cancer. ..
  12. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Zigang Dong; Fiscal Year: 2009
    ..abstract_text> ..
  13. Mechanisms of chemopreventive effect of resveratrol
    Zigang Dong; Fiscal Year: 2009
    ..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
  14. Study on Ultraviolet-induced Signal Transduction
    Zigang Dong; Fiscal Year: 2009
    ..These preclinical studies are designed to lead to the development of new strategies for the chemoprevention of human skin cancers. ..
  15. The role of histone phosphorylation in arsenic-induced cell transformation and sk
    Zigang Dong; Fiscal Year: 2010
    ..These studies will facilitate the development of more effective agents with fewer side effects for chemoprevention against environmental carcinogens such as arsenic- induced cancer. ..
  16. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Zigang Dong; Fiscal Year: 2010
    ..abstract_text> ..
  17. Mechanisms of chemopreventive effect of resveratrol
    Zigang Dong; Fiscal Year: 2006
    ..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
  18. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Zigang Dong; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  19. Anticarcinogenic Mechanisms of Tea Constituents
    Zigang Dong; Fiscal Year: 2003
    ....
  20. Anticarcinogenic Mechanisms of Tea Constituents
    Zigang Dong; Fiscal Year: 2004
    ....
  21. Ultraviolet-Induced Signal Trasduction
    Zigang Dong; Fiscal Year: 2004
    ..Such knowledge will lead to a better understanding of human skin carcinogenesis, and facilitate the design of more effective agents for chemoprevention of human skin cancer. ..
  22. Ultraviolet-Induced Signal Trasduction
    Zigang Dong; Fiscal Year: 2005
    ..Such knowledge will lead to a better understanding of human skin carcinogenesis, and facilitate the design of more effective agents for chemoprevention of human skin cancer. ..
  23. Anticarcinogenic Mechanisms of Tea Constituents
    Zigang Dong; Fiscal Year: 2005
    ....
  24. Mechanisms of chemopreventive effect of resveratrol
    Zigang Dong; Fiscal Year: 2005
    ..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
  25. Ultraviolet-Induced Signal Trasduction
    Zigang Dong; Fiscal Year: 2006
    ..Such knowledge will lead to a better understanding of human skin carcinogenesis, and facilitate the design of more effective agents for chemoprevention of human skin cancer. ..
  26. Molecular basis of arsenic-induced cell transformation
    Zigang Dong; Fiscal Year: 2006
    ..Such knowledge will facilitate the design of more effective and specific strategies with fewer side effects for chemoprevention of arsenic-induced cancer. ..
  27. Anticarcinogenic Mechanisms of Tea Constituents
    Zigang Dong; Fiscal Year: 2006
    ....