- Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor functionQing Dong
Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143 0434, USA
J Clin Endocrinol Metab 95:E245-52. 2010..Most mutations are clustered in the N-terminal and Cys-rich regions of the extracellular domain (ECD) and seven-transmembrane domain. Disease-causing mutations are uncommon in the C terminus of ECD...