Chen Dong

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Characterization of mouse and human B7-H3 genes
    Mingyi Sun
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Immunol 168:6294-7. 2002
  2. ncbi request reprint A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
    Seon Hee Chang
    Department of Immunology, MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA
    Cell Res 17:435-40. 2007
  3. ncbi request reprint Immune regulation by novel costimulatory molecules
    Chen Dong
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 7650, USA
    Immunol Res 28:39-48. 2003
  4. ncbi request reprint Cutting edge: critical role of inducible costimulator in germinal center reactions
    C Dong
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06514, USA
    J Immunol 166:3659-62. 2001
  5. ncbi request reprint Regulation of immune and autoimmune responses by ICOS
    Chen Dong
    Department of Immunology, University of Washington, 1959 NE Pacific Street, H466 HSC, Seattle, WA 98195 7650, USA
    J Autoimmun 21:255-60. 2003
  6. ncbi request reprint MAP kinases in the immune response
    Chen Dong
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195 7650, USA
    Annu Rev Immunol 20:55-72. 2002
  7. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
  8. pmc Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:44-56. 2008
  9. pmc Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    Yeonseok Chung
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 30:576-87. 2009
  10. pmc Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Characterization of mouse and human B7-H3 genes
    Mingyi Sun
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Immunol 168:6294-7. 2002
    ..B7-H3b is the major isoform expressed in several tissues. This structural information suggests a genetic variation of the B7-H3 gene in mammalian species...
  2. ncbi request reprint A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
    Seon Hee Chang
    Department of Immunology, MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA
    Cell Res 17:435-40. 2007
    ..Thus, IL-17A/F cytokine represents another mechanism whereby T cells regulate inflammatory responses and may serve as a novel target for treating various immune-mediated diseases...
  3. ncbi request reprint Immune regulation by novel costimulatory molecules
    Chen Dong
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 7650, USA
    Immunol Res 28:39-48. 2003
    ..B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function...
  4. ncbi request reprint Cutting edge: critical role of inducible costimulator in germinal center reactions
    C Dong
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06514, USA
    J Immunol 166:3659-62. 2001
    ..Remarkably, GC formation in response to a secondary recall challenge was completely absent in ICOS knockout mice. These data establish a critical role of ICOS in regulation of humoral immunity...
  5. ncbi request reprint Regulation of immune and autoimmune responses by ICOS
    Chen Dong
    Department of Immunology, University of Washington, 1959 NE Pacific Street, H466 HSC, Seattle, WA 98195 7650, USA
    J Autoimmun 21:255-60. 2003
    ..Our work not only illustrates the complexity of immune regulation by costimulatory molecules, but also suggests novel therapeutic strategies for various autoimmune diseases...
  6. ncbi request reprint MAP kinases in the immune response
    Chen Dong
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195 7650, USA
    Annu Rev Immunol 20:55-72. 2002
    ..In this review, we summarize recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses...
  7. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  8. pmc Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:44-56. 2008
    ..STAT3 regulated Foxp3 downregulation, whereas STAT3, RORgamma, and ROR* were required for IL-17 expression in Treg cells. Our data demonstrate molecular antagonism and plasticity of Treg and Th17 cell programs...
  9. pmc Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    Yeonseok Chung
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 30:576-87. 2009
    ..Our data thus indicate a critical role of IL-1 in Th17 cell differentiation and this pathway may serve as a unique target for Th17 cell-mediated immunopathology...
  10. pmc Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009
    ..Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation...
  11. pmc CCR6 regulates the migration of inflammatory and regulatory T cells
    Tomohide Yamazaki
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 181:8391-401. 2008
    ..Similarly, CCR6 on Treg cells is also important for their recruitment into inflammatory tissues. Our data indicate an important role of CCR6 in Treg and Th17 cell migration...
  12. pmc Regulation of inflammatory responses by IL-17F
    Xuexian O Yang
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 205:1063-75. 2008
    ..Our results thus demonstrate that IL-17F is an important regulator of inflammatory responses that seems to function differently than IL-17 in immune responses and diseases...
  13. pmc ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus
    Jared M Odegard
    Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
    J Immunol 182:4076-84. 2009
    ..Thus, while dispensable for acquisition of renal trafficking receptor expression, ICOS is strictly required for local inflammatory functions of autoreactive CD4 T cells in murine lupus...
  14. pmc ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
    Jared M Odegard
    Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
    J Exp Med 205:2873-86. 2008
    ....
  15. ncbi request reprint A critical role of costimulation during intrathymic development of invariant NK T cells
    Yeonseok Chung
    Department of Immunology, M D Anderson Cancer Center, 7455 Fannin, Houston, TX 77030, USA
    J Immunol 180:2276-83. 2008
    ..Our results thus demonstrate a previously unknown function of costimulation in the intrathymic development of iNKT cells, distinct from that of conventional T cells and regulatory T cells...
  16. ncbi request reprint Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 448:480-3. 2007
    ..IL-21 is therefore an autocrine cytokine that is sufficient and necessary for T(H)17 differentiation, and serves as a target for treating inflammatory diseases...
  17. pmc T helper 17 cells promote cytotoxic T cell activation in tumor immunity
    Natalia Martin-Orozco
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 31:787-98. 2009
    ..Thus, Th17 cells elicited a protective inflammation that promotes the activation of tumor-specific CD8(+) T cells. These findings have important implications in antitumor immunotherapies...
  18. pmc T-cell tolerance or function is determined by combinatorial costimulatory signals
    Roza Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 25:2623-33. 2006
    ..This work demonstrates that T-cell function or tolerance is controlled by costimulatory signals...
  19. pmc Bcl6 expression specifies the T follicular helper cell program in vivo
    Xindong Liu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 209:1841-52, S1-24. 2012
    ..Once Bcl6 is highly expressed, Tfh cells can persist in vivo and some of them develop into memory cells. Together, our results indicate Bcl6 as a bona fide marker for Tfh polarized program...
  20. pmc Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 182:2565-8. 2009
    ..These results, although suggesting the plasticity of Th17 cells, also indicate active maintenance of their program in vivo...
  21. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
    ..Therefore, Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma...
  22. pmc Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
    Xuexian O Yang
    Department of Immunology, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 10:1260-6. 2009
    ..As GATA-3 induces Dec2 expression, our findings also indicate a feed-forward regulatory circuit during T(H)2 differentiation...
  23. pmc IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation
    Juan Peng
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Res 20:62-71. 2010
    ..Conversely, in the absence of this signal, Th2 cell differentiation was partially inhibited. Therefore, IL-23 signaling may regulate allergic asthma through modulation of Th2 cell differentiation...
  24. ncbi request reprint Characterization of B7S3 as a novel negative regulator of T cells
    Yang Yang
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 178:3661-7. 2007
    ..This study identifies B7S3 as a novel negative regulator of T cells, and suggests evolutionarily divergent T cell regulation mechanisms in mammals...
  25. ncbi request reprint Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5
    Yongliang Zhang
    Department of Immunology, University of Washington, Seattle, Washington 98195 7650, USA
    Nature 430:793-7. 2004
    ..Therefore, MKP5 has a principal function in both innate and adaptive immune responses, and represents a novel target for therapeutic intervention of immune diseases...
  26. pmc USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex
    Xikui Liu
    Department of Immunology, Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 210:1575-90. 2013
    ..Our findings thus demonstrate a previously uncharacterized negative regulation of TAK1 activity during Th17 differentiation, suggesting that USP18 may be targeted to treat autoimmune diseases. ..
  27. doi request reprint Regulation and function of proinflammatory TH17 cells
    Gustavo J Martinez
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann N Y Acad Sci 1143:188-211. 2008
    ..In this review, we summarize the latest discoveries on the cytokine-mediated regulation and transcriptional programming of TH17 cells and their roles in different immune responses and diseases...
  28. pmc Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
    Natalia Martin-Orozco
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Immunol 39:216-24. 2009
    ..These results indicate that islet-reactive Th17 cells promote pancreatic inflammation, but only induce IDDM upon conversion into IFN-gamma producers...
  29. pmc Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction
    Xikui Liu
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 182:4516-20. 2009
    ..v. Finally, BTLA(-/-) OT-I cells caused autoimmune diabetes in RIP-mOVA recipient mice. Our results thus demonstrate an important role for BTLA in the induction of peripheral tolerance of both CD4(+) and CD8(+) T cells in vivo...
  30. ncbi request reprint A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 179:1096-103. 2007
    ..This work demonstrates an important role for costimulatory receptors in sustaining T cell activation programs leading to Nfatc1 gene transcription and has implications in our understanding of the immune response and tolerance...
  31. doi request reprint Keeping autoimmunity in check: how to control a Th17 cell controller
    Roza I Nurieva
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:841-3. 2008
    ..In this issue of Immunity, Chen et al. (2008) show that IRF-4-binding protein is a critical negative regulator of IRF-4 function, regulating production of the cytokines IL-21 and IL-17...
  32. pmc Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
    Yeonseok Chung
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 17:983-8. 2011
    ..These results unveil a Bcl-6-CXCR5 axis in T(reg) cells that drives the development of follicular regulatory T (T(FR)) cells that function to inhibit the germinal center reactions...
  33. doi request reprint A butyrophilin family member critically inhibits T cell activation
    Tomohide Yamazaki
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 185:5907-14. 2010
    ..Therefore, BTNL1 is a critical inhibitory molecule for T cell activation and immune diseases...
  34. pmc Regulation of IL-9 expression by IL-25 signaling
    Pornpimon Angkasekwinai
    Department of Immunology, University of Texas and MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 11:250-6. 2010
    ..In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression...
  35. pmc Yin-Yang of costimulation: crucial controls of immune tolerance and function
    Roza I Nurieva
    Department of Immunology, MD Anderson Cancer Center, Houston, TX, USA
    Immunol Rev 229:88-100. 2009
    ..Therefore, positive and negative costimulation are the two sides of the coin to fine tune T-cell receptor signaling to determine the outcome of T-cell receptor engagement-tolerance versus function...
  36. pmc TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease
    Bhanu P Pappu
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 205:1049-62. 2008
    ..These observations thus establish an important role of the TL1A-DR3 pathway in promoting Th17 cell function and Th17-mediated autoimmune disease...
  37. doi request reprint IL-23/IL-17 biology and therapeutic considerations
    Chen Dong
    Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Immunotoxicol 5:43-6. 2008
    ..IL-17 and IL-17-expressing inflammatory T(H) lymphocytes may thus serve as good targets for therapeutic intervention in treatment of patients with inflammatory diseases...
  38. pmc The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 32:670-80. 2010
    ..Our results indicate that GRAIL, by mediating TCR-CD3 degradation, regulates naive T cell tolerance induction and Treg cell function...
  39. doi request reprint Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma
    Sangeeta Goswami
    Department of Immunology, Baylor College of Medicine, Houston, Texas, USA
    Nat Immunol 10:496-503. 2009
    ..Thus, MMP7 coordinates allergic lung inflammation by activating interleukin 25 while simultaneously inhibiting retinoid-dependent development of regulatory T cells...
  40. ncbi request reprint Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor
    Seon Hee Chang
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 281:35603-7. 2006
    ..Our study not only for the first time reveals an immediate signaling mechanism downstream of an IL-17 family receptor but also has implications in therapeutic treatment of various immune diseases...
  41. pmc MKP-1 is necessary for T cell activation and function
    Yongliang Zhang
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:30815-24. 2009
    ..Our results thus demonstrate that MKP-1 is a critical positive regulator of T cell activation and function and may be targeted in treatment of autoimmune diseases...
  42. ncbi request reprint Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes
    Yeonseok Chung
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Res 16:902-7. 2006
    ..These data demonstrate a novel cytokine expressed by IL-17-producing T cells, and suggest interaction and synergy of IL-22 and IL-17 signaling pathways in tissue inflammation and autoimmune diseases...
  43. pmc B7h is required for T cell activation, differentiation, and effector function
    Roza I Nurieva
    Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
    Proc Natl Acad Sci U S A 100:14163-8. 2003
    ..Therefore, B7h is required for proper Th cell activation, differentiation, and effector cytokine expression...
  44. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  45. doi request reprint TH17 cells in development: an updated view of their molecular identity and genetic programming
    Chen Dong
    Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:337-48. 2008
    ....
  46. ncbi request reprint Murine B7-H3 is a negative regulator of T cells
    Durbaka V R Prasad
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Immunol 173:2500-6. 2004
    ..An antagonistic mAb to B7-H3 enhanced T cell proliferation in vitro and led to exacerbated experimental autoimmune encephalomyelitis in vivo. Therefore, mouse B7-H3 serves as a negative regulator of T cell activation and function...
  47. ncbi request reprint STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:9358-63. 2007
    ..Our data thus demonstrate a pathway whereby cytokines regulate THi differentiation through a selective STAT transcription factor that functions to regulate lineage-specific gene expression...
  48. doi request reprint Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3
    Bo Zhong
    Department of Immunology, Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054, USA
    Sci Signal 6:ra35. 2013
    ..Thus, by inhibiting the degradation of TRAF3 during TLR4 activation, USP25 enables a balanced innate immune response...
  49. pmc Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2
    Xiaohu Wang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 36:23-31. 2012
    ..CNS2-deficient animals were also shown to be resistant to experimental autoimmune encephalomyelitis (EAE). Our results thus suggest that CNS2 is sufficient and necessary for Il17 and optimal Il17f gene transcription in Th17 cells...
  50. pmc Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation
    Gustavo J Martinez
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77054, USA
    J Biol Chem 284:35283-6. 2009
    ..These results demonstrate that Smad3 is differentially involved in the reciprocal regulatory and inflammatory T cell generation...
  51. pmc BTNL2, a butyrophilin-like molecule that functions to inhibit T cell activation
    Thang Nguyen
    Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
    J Immunol 176:7354-60. 2006
    ..BTNL2 is thus the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy...
  52. pmc Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis
    Nobuyuki Tanaka
    Section of Immunobiology, Yale University School of Medicine, New Haven CT 06520, USA
    EMBO Rep 3:785-91. 2002
    ..In peripheral CD4(+)T cells, MKK3 is induced upon stimulation, whereas MKK6 is downregulated. These results suggest a novel mechanism regulating T-cell apoptosis differentially through the p38MAPK pathway by MKK3 and MKK6...
  53. pmc Regulation of T cell activation and tolerance by PDL2
    Yongliang Zhang
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:11695-700. 2006
    ..In addition, T cell tolerance to an oral antigen was abrogated by the lack of PDL2. Our results thus demonstrate that PDL2 negatively regulates T cells in immune responses and plays an essential role in immune tolerance...
  54. pmc IL-17F: regulation, signaling and function in inflammation
    Seon Hee Chang
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Cytokine 46:7-11. 2009
    ..However, mice lacking either IL-17 or IL-17F exhibit distinct defects in experimental models of asthma and colitis. These results have laid the basis to understand the role of IL-17F in the pathogenesis of human diseases...
  55. pmc Inducible costimulator is essential for collagen-induced arthritis
    Roza I Nurieva
    Department of Immunology, and Department of Comparative Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    J Clin Invest 111:701-6. 2003
    ..These data indicate that ICOS is essential for collagen-induced arthritis and may suggest novel means for treating patients with rheumatoid arthritis...
  56. ncbi request reprint B7S1, a novel B7 family member that negatively regulates T cell activation
    Durbaka V R Prasad
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 18:863-73. 2003
    ..This study identifies a novel negative regulator of T cell activation and further reveals complex costimulatory regulation of immune responses...
  57. ncbi request reprint Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
    Chen Dong
    Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 6:329-33. 2006
    ....
  58. ncbi request reprint Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
    Askar M Akimzhanov
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:5969-72. 2007
    ..In summary, our results demonstrate for the first time that THi cell differentiation is associated with epigenetic changes in the IL-17-IL-17F locus, which suggests novel mechanisms in T cell functional regulation...
  59. pmc Highlights of 10 years of immunology in Nature Reviews Immunology
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Immunol 11:693-702. 2011
    ..We look forward to what the next 10 years of immunology research may bring...
  60. ncbi request reprint The IL-17/IL-23 axis of inflammation in cancer: friend or foe?
    Natalia Martin-Orozco
    MD Anderson Cancer Center, Department of Immunology, 7455 Fannin Street, Houston, TX 77030, USA
    Curr Opin Investig Drugs 10:543-9. 2009
    ....
  61. pmc Inhibitory costimulation and anti-tumor immunity
    Natalia Martin-Orozco
    Department of Immunology, The University of Texas M D Anderson Cancer Center, TX, USA
    Semin Cancer Biol 17:288-98. 2007
    ..In this article, we summarize recent developments in the field of inhibitory costimulation and discuss the future direction of therapeutic manipulation of inhibitory costimulation in tumor immunotherapy...
  62. pmc Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells
    Natalia Martin-Orozco
    Department of Immunology, The University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 70:9581-90. 2010
    ..Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion...
  63. ncbi request reprint Transcriptional regulation of th2 differentiation by inducible costimulator
    Roza I Nurieva
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 18:801-11. 2003
    ..These data indicate that ICOS, by enhancing TcR signals at an early stage of T cell activation, regulates IL-4 transcription and T cell function in effector cells...
  64. pmc Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells
    Jeong su Do
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 186:4546-50. 2011
    ..Collectively, our results provide a novel function of IL-17(+) γδ T cell subsets in supporting in vivo Th17 differentiation and possibly in fostering the development of intestinal inflammation...
  65. pmc MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades
    Xiaofang Wang
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 186:5791-800. 2011
    ..Finally, we found that MEKK3 activation by TCR stimulation requires Rac1/2. Taken together, our study reveals a specific role of MEKK3 in mediating the TCR signals for IFN-γ production...
  66. pmc Differentiation and function of pro-inflammatory Th17 cells
    Chen Dong
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Microbes Infect 11:584-8. 2009
    ....
  67. ncbi request reprint Defective antigen processing in GILT-free mice
    M Maric
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 294:1361-5. 2001
    ..The response to hen egg lysozyme, a model antigen with a compact structure containing four disulfide bonds, was examined in detail...
  68. ncbi request reprint ICOS co-stimulatory receptor is essential for T-cell activation and function
    C Dong
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 409:97-101. 2001
    ..ICOS-/- mice showed greatly enhanced susceptibility to experimental autoimmune encephalomyelitis, indicating that ICOS has a protective role in inflammatory autoimmune diseases...
  69. ncbi request reprint MAP kinases in immune responses
    Yong Liang Zhang
    Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, 77030, USA
    Cell Mol Immunol 2:20-7. 2005
    ..In this review, we summarize recent advances in understanding of the regulation of MAP kinases and the roles of MAP kinases in innate and adaptive immune responses...
  70. pmc Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokines
    Bhanu P Pappu
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Pharmacol Ther 117:374-84. 2008
    ..From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases...
  71. pmc Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis
    Changchun Xiao
    Section of Immunobiology, Howard Hughes Medical Institute, New Haven, CT 06520, USA
    Genes Dev 17:2933-49. 2003
    ..Therefore, these results show that Ecsit functions as an essential component in two important signal transduction pathways and establishes a novel role for Ecsit as a cofactor for Smad proteins in the Bmp signaling pathway...
  72. doi request reprint Mouse Th17 cells: current understanding of their generation and regulation
    Chen Dong
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Immunol 39:640-4. 2009
    ..Considerable progress has been made in understanding the developmental regulation of mouse Th17 cells. Here, I summarize this knowledge and discuss on the relationship of Th17 with regulatory and follicular Th cells...
  73. pmc New battlefields for costimulation
    Natalia Martin-Orozco
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 203:817-20. 2006
    ..New evidence shows that negative costimulators expressed by tumors and normal tissues afford local protection from T cell-mediated attack...
  74. ncbi request reprint ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice
    Daniel Hawiger
    Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 180:3140-7. 2008
    ..We conclude that ICOS is critically important for the induction of the autoimmune process that leads to diabetes...
  75. ncbi request reprint Defective T cell differentiation in the absence of Jnk1
    C Dong
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 282:2092-5. 1998
    ..Thus, the JNK1 signaling pathway plays a key role in T cell receptor-initiated TH cell proliferation, apoptosis, and differentiation...
  76. ncbi request reprint JNK is required for effector T-cell function but not for T-cell activation
    C Dong
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 405:91-4. 2000
    ..However, production of effector T-cell cytokines did require JNK. Thus, JNK is necessary for T-cell differentiation but not for naive T-cell activation...
  77. ncbi request reprint JNK1 is required for T cell-mediated immunity against Leishmania major infection
    S L Constant
    Section of Immunobiology, Yale University School of Medicine, and Howard Hughes Medical Institute New Haven, CT 06520, USA
    J Immunol 165:2671-6. 2000
    ..These findings demonstrate that the negative regulation of Th2 cytokine production by the JNK1 signaling pathway is essential for generating Th1-polarized immunity against intracellular pathogens, such as Leishmania major...
  78. ncbi request reprint Signaling by the JNK group of MAP kinases. c-jun N-terminal Kinase
    C Dong
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes, Medical Institute, New Haven, Connecticut 06520, USA
    J Clin Immunol 21:253-7. 2001
    ..In this review, we summarize these advances in understanding the expression, function, and regulation of the JNK pathway in T-lymphocyte activation and differentiation...
  79. pmc Regulation and pro-inflammatory function of interleukin-17 family cytokines
    Chen Dong
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunol Rev 226:80-6. 2008
    ..From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases...
  80. pmc An NKT-mediated autologous vaccine generates CD4 T-cell dependent potent antilymphoma immunity
    Yeonseok Chung
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 110:2013-9. 2007
    ..Therefore, NKT ligand-loaded lymphoma elicits long-lasting and effective antitumor immunity, which can be further developed as patient- and tumor-specific immunotherapy against human lymphomas...
  81. ncbi request reprint Th1 and Th2 cells
    C Dong
    Department of Immunology, University of Washington School of Medicine, Seattle, USA
    Curr Opin Hematol 8:47-51. 2001
    ..Transcription factors and signaling pathways that are selectively expressed or activated in Th1 and Th2 cells to regulate cytokine gene expression are discussed...
  82. ncbi request reprint ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naïve CD4+ T cells
    Riccardo Mesturini
    Interdisciplinary Research Center of Autoimmune Diseases and Department of Medical Sciences, A Avogadro University of Eastern Piedmont at Novara, Novara, Italy
    Eur J Immunol 36:2601-12. 2006
    ....
  83. ncbi request reprint ICOS is essential for the development of experimental autoimmune myasthenia gravis
    Benjamin G Scott
    Department of Microbiology and Immunology, The University of Texas Medical Branch, 301 University Boulevard, 3 142 MRB, Galveston, TX 77555 1070, USA
    J Neuroimmunol 153:16-25. 2004
    ..ICOS-mediated lymphocyte costimulation is thus vital to the induction of T cell-mediated humoral immunity to AChR and the development of clinical EAMG...
  84. doi request reprint CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'
    Jose M Rojo
    Departamento de Inmunologia, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, E 28040 Madrid, Spain
    Int Immunol 20:577-89. 2008
    ..Thus, naturally occurring CD4+ICOS+ cells, expanded or not in vitro, are functionally relevant cells able of protecting ICOS-deficient mice from severe EAE...
  85. ncbi request reprint Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis
    Bing Wan
    Joint Immunology Laboratory, Institute of Health Sciences and Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Immunol 177:8844-50. 2006
    ..Our data indicate a novel pathogenic pathway in which overexpression of negative costimulatory molecules to restrict synovial inflammation in RA is overruled by the excessive production of soluble costimulatory molecules...
  86. pmc Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo
    Meixia Zhou
    Department of Pediatrics, Stanford University, 300 Pasteur Drive, Palo Alto, CA 94305, USA
    J Immunol 178:5496-504. 2007
    ..Furthermore, EMSA and luciferase reporter assays demonstrated that KLF13 binds to multiple sites within the Bcl-X(L) promoter and results in decreased Bcl-X(L) promoter activity, making KLF13 a negative regulator of BCL-X(L)...
  87. ncbi request reprint Novel function of IFN-gamma: negative regulation of dendritic cell migration and T cell priming
    Xiaodong Wu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences CAS, 320 Yueyang Road, Shanghai 200031, China
    J Immunol 177:934-43. 2006
    ..Taken together, IFN-gamma appears to play a negative regulatory role on in vivo DC function, resulting in suppression of Ag-specific T cell priming...
  88. pmc A critical role of neural-specific JNK3 for ischemic apoptosis
    Chia Yi Kuan
    Department of Pediatrics, Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 100:15184-9. 2003
    ..The downstream mechanism of JNK3-mediated apoptosis may include the induction of Bim and Fas and the mitochondrial release of cytochrome c. These results suggest that JNK3 is a potential target for neuroprotection therapies in stroke...
  89. ncbi request reprint Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells
    Xue Zhong Yu
    Immunology and Blood and Marrow Transplantation Programs, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Immunol 176:7394-401. 2006
    ..Our findings indicate that ICOS has paradoxical effects on the regulation of alloreactive CD4(+) and CD8(+) T cells in GVHD...
  90. ncbi request reprint Temporal expression of estrogen receptor alpha in rat bone marrow mesenchymal stem cells
    Qi Wang
    Department of Orthodontics, College of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Biochem Biophys Res Commun 347:117-23. 2006
    ..Thus, the observed developmental expression of ERalpha mRNA correlates with progressive BMSCs growth and osteogenic differentiation and BMSCs may be a primary target cell for estrogen in maintaining bone formation...
  91. ncbi request reprint Cutting Edge: Programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens
    Natalia Martin-Orozco
    University of Texas M D Anderson Cancer Center, 7455 Fannin, Houston, TX 77030, USA
    J Immunol 177:8291-5. 2006
    ..Thus, during the presentation of tissue Ags to CD8+ T cells, PD-1/PD-L1 interaction crucially controls the effector differentiation of autoreactive T cells to maintain self-tolerance...
  92. ncbi request reprint The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
    Yen Michael S Hsu
    Department of Molecular and Cellular Oncology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Immunol 8:198-205. 2007
    ..Our data demonstrate that CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens...
  93. pmc CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation
    Brian C Grabiner
    Department of Molecular and Cellular Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 21:984-96. 2007
    ..Consistently, we found TRAF6 deficiency also abrogates GPCR-induced NF-kappaB activation. Together, our results provide the genetic evidence that CARMA3 is required for GPCR-induced NF-kappaB activation...
  94. pmc Interleukin 25 promotes the initiation of proallergic type 2 responses
    Pornpimon Angkasekwinai
    University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1509-17. 2007
    ..Thus, IL-25 is a critical factor regulating the initiation of innate and adaptive proallergic responses...
  95. ncbi request reprint CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis
    Alan Valaperti
    Experimental Critical Care Medicine, Department of Research, University Hospital, Petersgraben 4, Basel, Switzerland
    J Immunol 180:2686-95. 2008
    ..In conclusion, CD11b(+) monocytes play a dual role in EAM: as a major cellular substrate of IL-17-induced inflammation and as mediators of an IFN-gamma-dependent negative feedback loop confining disease progression...
  96. ncbi request reprint Measurement of interleukin-17
    Bhanu P Pappu
    M D Anderson Cancer Center, Houston, Texas, USA
    Curr Protoc Immunol . 2007
    ..Detection of IL-17 in cell culture and tissue samples helps in monitoring inflammatory diseases and determining efficacy of therapeutic interventions...