Research Topics
Genomes and Genes
| Chen DongSummaryAffiliation: University of Washington Country: USA Publications
| Collaborators
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Detail Information
Publications
Characterization of mouse and human B7-H3 genesMingyi Sun
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
J Immunol 168:6294-7. 2002..B7-H3b is the major isoform expressed in several tissues. This structural information suggests a genetic variation of the B7-H3 gene in mammalian species...- A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responsesSeon Hee Chang
Department of Immunology, MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA
Cell Res 17:435-40. 2007..Thus, IL-17A/F cytokine represents another mechanism whereby T cells regulate inflammatory responses and may serve as a novel target for treating various immune-mediated diseases... - Immune regulation by novel costimulatory moleculesChen Dong
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 7650, USA
Immunol Res 28:39-48. 2003..B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function... - Regulation of immune and autoimmune responses by ICOSChen Dong
Department of Immunology, University of Washington, 1959 NE Pacific Street, H466 HSC, Seattle, WA 98195 7650, USA
J Autoimmun 21:255-60. 2003..Our work not only illustrates the complexity of immune regulation by costimulatory molecules, but also suggests novel therapeutic strategies for various autoimmune diseases... - MAP kinases in the immune responseChen Dong
Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195 7650, USA
Annu Rev Immunol 20:55-72. 2002..In this review, we summarize recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses... - Cutting edge: critical role of inducible costimulator in germinal center reactionsC Dong
Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06514, USA
J Immunol 166:3659-62. 2001..Remarkably, GC formation in response to a secondary recall challenge was completely absent in ICOS knockout mice. These data establish a critical role of ICOS in regulation of humoral immunity... - Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesRoza I Nurieva
Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
Immunity 29:138-49. 2008..This study thus demonstrates that Tfh is a distinct Th cell lineage... - Critical regulation of early Th17 cell differentiation by interleukin-1 signalingYeonseok Chung
Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
Immunity 30:576-87. 2009..Our data thus indicate a critical role of IL-1 in Th17 cell differentiation and this pathway may serve as a unique target for Th17 cell-mediated immunopathology... - Bcl6 mediates the development of T follicular helper cellsRoza I Nurieva
Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
Science 325:1001-5. 2009..Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation... - Molecular antagonism and plasticity of regulatory and inflammatory T cell programsXuexian O Yang
Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
Immunity 29:44-56. 2008..STAT3 regulated Foxp3 downregulation, whereas STAT3, RORgamma, and ROR* were required for IL-17 expression in Treg cells. Our data demonstrate molecular antagonism and plasticity of Treg and Th17 cell programs... - CCR6 regulates the migration of inflammatory and regulatory T cellsTomohide Yamazaki
Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
J Immunol 181:8391-401. 2008..Similarly, CCR6 on Treg cells is also important for their recruitment into inflammatory tissues. Our data indicate an important role of CCR6 in Treg and Th17 cell migration... - Regulation of inflammatory responses by IL-17FXuexian O Yang
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
J Exp Med 205:1063-75. 2008..Our results thus demonstrate that IL-17F is an important regulator of inflammatory responses that seems to function differently than IL-17 in immune responses and diseases... - ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunityJared M Odegard
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
J Exp Med 205:2873-86. 2008.... - ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupusJared M Odegard
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
J Immunol 182:4076-84. 2009..Thus, while dispensable for acquisition of renal trafficking receptor expression, ICOS is strictly required for local inflammatory functions of autoreactive CD4 T cells in murine lupus... - A critical role of costimulation during intrathymic development of invariant NK T cellsYeonseok Chung
Department of Immunology, M D Anderson Cancer Center, 7455 Fannin, Houston, TX 77030, USA
J Immunol 180:2276-83. 2008..Our results thus demonstrate a previously unknown function of costimulation in the intrathymic development of iNKT cells, distinct from that of conventional T cells and regulatory T cells... - T-cell tolerance or function is determined by combinatorial costimulatory signalsRoza Nurieva
Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
EMBO J 25:2623-33. 2006..This work demonstrates that T-cell function or tolerance is controlled by costimulatory signals... - T helper 17 cells promote cytotoxic T cell activation in tumor immunityNatalia Martin-Orozco
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Immunity 31:787-98. 2009..Thus, Th17 cells elicited a protective inflammation that promotes the activation of tumor-specific CD8(+) T cells. These findings have important implications in antitumor immunotherapies... - Essential autocrine regulation by IL-21 in the generation of inflammatory T cellsRoza Nurieva
Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
Nature 448:480-3. 2007..IL-21 is therefore an autocrine cytokine that is sufficient and necessary for T(H)17 differentiation, and serves as a target for treating inflammatory diseases... - Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hostsRoza Nurieva
Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
J Immunol 182:2565-8. 2009..These results, although suggesting the plasticity of Th17 cells, also indicate active maintenance of their program in vivo... - Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitmentXuexian O Yang
Department of Immunology, MD Anderson Cancer Center, Houston, Texas, USA
Nat Immunol 10:1260-6. 2009..As GATA-3 induces Dec2 expression, our findings also indicate a feed-forward regulatory circuit during T(H)2 differentiation... - T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gammaXuexian O Yang
Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
Immunity 28:29-39. 2008..Therefore, Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma... - IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammationJuan Peng
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Cell Res 20:62-71. 2010..Conversely, in the absence of this signal, Th2 cell differentiation was partially inhibited. Therefore, IL-23 signaling may regulate allergic asthma through modulation of Th2 cell differentiation... - Characterization of B7S3 as a novel negative regulator of T cellsYang Yang
Department of Immunology, University of Washington, Seattle, WA 98195, USA
J Immunol 178:3661-7. 2007..This study identifies B7S3 as a novel negative regulator of T cells, and suggests evolutionarily divergent T cell regulation mechanisms in mammals... - Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5Yongliang Zhang
Department of Immunology, University of Washington, Seattle, Washington 98195 7650, USA
Nature 430:793-7. 2004..Therefore, MKP5 has a principal function in both innate and adaptive immune responses, and represents a novel target for therapeutic intervention of immune diseases... - Regulation and function of proinflammatory TH17 cellsGustavo J Martinez
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Ann N Y Acad Sci 1143:188-211. 2008..In this review, we summarize the latest discoveries on the cytokine-mediated regulation and transcriptional programming of TH17 cells and their roles in different immune responses and diseases... - Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cellsNatalia Martin-Orozco
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Eur J Immunol 39:216-24. 2009..These results indicate that islet-reactive Th17 cells promote pancreatic inflammation, but only induce IDDM upon conversion into IFN-gamma producers... - Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactionsYeonseok Chung
Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Nat Med 17:983-8. 2011..These results unveil a Bcl-6-CXCR5 axis in T(reg) cells that drives the development of follicular regulatory T (T(FR)) cells that function to inhibit the germinal center reactions... - A butyrophilin family member critically inhibits T cell activationTomohide Yamazaki
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
J Immunol 185:5907-14. 2010..Therefore, BTNL1 is a critical inhibitory molecule for T cell activation and immune diseases... - A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytesRoza I Nurieva
Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
J Immunol 179:1096-103. 2007..This work demonstrates an important role for costimulatory receptors in sustaining T cell activation programs leading to Nfatc1 gene transcription and has implications in our understanding of the immune response and tolerance... - Regulation of IL-9 expression by IL-25 signalingPornpimon Angkasekwinai
Department of Immunology, University of Texas and MD Anderson Cancer Center, Houston, Texas, USA
Nat Immunol 11:250-6. 2010..In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression... - Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance inductionXikui Liu
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
J Immunol 182:4516-20. 2009..v. Finally, BTLA(-/-) OT-I cells caused autoimmune diabetes in RIP-mOVA recipient mice. Our results thus demonstrate an important role for BTLA in the induction of peripheral tolerance of both CD4(+) and CD8(+) T cells in vivo... - Keeping autoimmunity in check: how to control a Th17 cell controllerRoza I Nurieva
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Immunity 29:841-3. 2008..In this issue of Immunity, Chen et al. (2008) show that IRF-4-binding protein is a critical negative regulator of IRF-4 function, regulating production of the cytokines IL-21 and IL-17... - MKP-1 is necessary for T cell activation and functionYongliang Zhang
Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 284:30815-24. 2009..Our results thus demonstrate that MKP-1 is a critical positive regulator of T cell activation and function and may be targeted in treatment of autoimmune diseases... - The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradationRoza I Nurieva
Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
Immunity 32:670-80. 2010..Our results indicate that GRAIL, by mediating TCR-CD3 degradation, regulates naive T cell tolerance induction and Treg cell function... - IL-23/IL-17 biology and therapeutic considerationsChen Dong
Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77030, USA
J Immunotoxicol 5:43-6. 2008..IL-17 and IL-17-expressing inflammatory T(H) lymphocytes may thus serve as good targets for therapeutic intervention in treatment of patients with inflammatory diseases... - Yin-Yang of costimulation: crucial controls of immune tolerance and functionRoza I Nurieva
Department of Immunology, MD Anderson Cancer Center, Houston, TX, USA
Immunol Rev 229:88-100. 2009..Therefore, positive and negative costimulation are the two sides of the coin to fine tune T-cell receptor signaling to determine the outcome of T-cell receptor engagement-tolerance versus function... - TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune diseaseBhanu P Pappu
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
J Exp Med 205:1049-62. 2008..These observations thus establish an important role of the TL1A-DR3 pathway in promoting Th17 cell function and Th17-mediated autoimmune disease... - Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptorSeon Hee Chang
Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 281:35603-7. 2006..Our study not only for the first time reveals an immediate signaling mechanism downstream of an IL-17 family receptor but also has implications in therapeutic treatment of various immune diseases... - Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthmaSangeeta Goswami
Department of Immunology, Baylor College of Medicine, Houston, Texas, USA
Nat Immunol 10:496-503. 2009..Thus, MMP7 coordinates allergic lung inflammation by activating interleukin 25 while simultaneously inhibiting retinoid-dependent development of regulatory T cells... - A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Heon Park
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 6:1133-41. 2005..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation... - TH17 cells in development: an updated view of their molecular identity and genetic programmingChen Dong
Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77030, USA
Nat Rev Immunol 8:337-48. 2008.... - B7h is required for T cell activation, differentiation, and effector functionRoza I Nurieva
Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
Proc Natl Acad Sci U S A 100:14163-8. 2003..Therefore, B7h is required for proper Th cell activation, differentiation, and effector cytokine expression... - Murine B7-H3 is a negative regulator of T cellsDurbaka V R Prasad
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
J Immunol 173:2500-6. 2004..An antagonistic mAb to B7-H3 enhanced T cell proliferation in vitro and led to exacerbated experimental autoimmune encephalomyelitis in vivo. Therefore, mouse B7-H3 serves as a negative regulator of T cell activation and function... - STAT3 regulates cytokine-mediated generation of inflammatory helper T cellsXuexian O Yang
Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 282:9358-63. 2007..Our data thus demonstrate a pathway whereby cytokines regulate THi differentiation through a selective STAT transcription factor that functions to regulate lineage-specific gene expression... - Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2Xiaohu Wang
Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
Immunity 36:23-31. 2012..CNS2-deficient animals were also shown to be resistant to experimental autoimmune encephalomyelitis (EAE). Our results thus suggest that CNS2 is sufficient and necessary for Il17 and optimal Il17f gene transcription in Th17 cells... - IL-17F: regulation, signaling and function in inflammationSeon Hee Chang
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Cytokine 46:7-11. 2009..However, mice lacking either IL-17 or IL-17F exhibit distinct defects in experimental models of asthma and colitis. These results have laid the basis to understand the role of IL-17F in the pathogenesis of human diseases... - Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiationGustavo J Martinez
Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77054, USA
J Biol Chem 284:35283-6. 2009..These results demonstrate that Smad3 is differentially involved in the reciprocal regulatory and inflammatory T cell generation... - Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosisNobuyuki Tanaka
Section of Immunobiology, Yale University School of Medicine, New Haven CT 06520, USA
EMBO Rep 3:785-91. 2002..In peripheral CD4(+)T cells, MKK3 is induced upon stimulation, whereas MKK6 is downregulated. These results suggest a novel mechanism regulating T-cell apoptosis differentially through the p38MAPK pathway by MKK3 and MKK6... - BTNL2, a butyrophilin-like molecule that functions to inhibit T cell activationThang Nguyen
Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
J Immunol 176:7354-60. 2006..BTNL2 is thus the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy... - Regulation of T cell activation and tolerance by PDL2Yongliang Zhang
Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:11695-700. 2006..In addition, T cell tolerance to an oral antigen was abrogated by the lack of PDL2. Our results thus demonstrate that PDL2 negatively regulates T cells in immune responses and plays an essential role in immune tolerance... - Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytesYeonseok Chung
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Cell Res 16:902-7. 2006..These data demonstrate a novel cytokine expressed by IL-17-producing T cells, and suggest interaction and synergy of IL-22 and IL-17 signaling pathways in tissue inflammation and autoimmune diseases... - Inducible costimulator is essential for collagen-induced arthritisRoza I Nurieva
Department of Immunology, and. Department of Comparative Medicine, University of Washington School of Medicine, Seattle, Washington, USA
J Clin Invest 111:701-6. 2003..These data indicate that ICOS is essential for collagen-induced arthritis and may suggest novel means for treating patients with rheumatoid arthritis... - Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cellsChen Dong
Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77030, USA
Nat Rev Immunol 6:329-33. 2006.... - Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiationAskar M Akimzhanov
Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 282:5969-72. 2007..In summary, our results demonstrate for the first time that THi cell differentiation is associated with epigenetic changes in the IL-17-IL-17F locus, which suggests novel mechanisms in T cell functional regulation... - B7S1, a novel B7 family member that negatively regulates T cell activationDurbaka V R Prasad
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
Immunity 18:863-73. 2003..This study identifies a novel negative regulator of T cell activation and further reveals complex costimulatory regulation of immune responses... - Inhibitory costimulation and anti-tumor immunityNatalia Martin-Orozco
Department of Immunology, The University of Texas M D Anderson Cancer Center, TX, USA
Semin Cancer Biol 17:288-98. 2007..In this article, we summarize recent developments in the field of inhibitory costimulation and discuss the future direction of therapeutic manipulation of inhibitory costimulation in tumor immunotherapy... - The IL-17/IL-23 axis of inflammation in cancer: friend or foe?Natalia Martin-Orozco
MD Anderson Cancer Center, Department of Immunology, 7455 Fannin Street, Houston, TX 77030, USA
Curr Opin Investig Drugs 10:543-9. 2009.... - Highlights of 10 years of immunology in Nature Reviews ImmunologyRuslan Medzhitov
Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Nat Rev Immunol 11:693-702. 2011..We look forward to what the next 10 years of immunology research may bring... - Differentiation and function of pro-inflammatory Th17 cellsChen Dong
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Microbes Infect 11:584-8. 2009.... - Transcriptional regulation of th2 differentiation by inducible costimulatorRoza I Nurieva
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
Immunity 18:801-11. 2003..These data indicate that ICOS, by enhancing TcR signals at an early stage of T cell activation, regulates IL-4 transcription and T cell function in effector cells... - Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cellsNatalia Martin-Orozco
Department of Immunology, The University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
Cancer Res 70:9581-90. 2010..Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion... - Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cellsJeong su Do
Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Immunol 186:4546-50. 2011..Collectively, our results provide a novel function of IL-17(+) γδ T cell subsets in supporting in vivo Th17 differentiation and possibly in fostering the development of intestinal inflammation... - MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascadesXiaofang Wang
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 186:5791-800. 2011..Finally, we found that MEKK3 activation by TCR stimulation requires Rac1/2. Taken together, our study reveals a specific role of MEKK3 in mediating the TCR signals for IFN-γ production... - ICOS co-stimulatory receptor is essential for T-cell activation and functionC Dong
Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 409:97-101. 2001..ICOS-/- mice showed greatly enhanced susceptibility to experimental autoimmune encephalomyelitis, indicating that ICOS has a protective role in inflammatory autoimmune diseases... - Defective antigen processing in GILT-free miceM Maric
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
Science 294:1361-5. 2001..The response to hen egg lysozyme, a model antigen with a compact structure containing four disulfide bonds, was examined in detail... - MAP kinases in immune responsesYong Liang Zhang
Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, 77030, USA
Cell Mol Immunol 2:20-7. 2005..In this review, we summarize recent advances in understanding of the regulation of MAP kinases and the roles of MAP kinases in innate and adaptive immune responses... - Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesisChangchun Xiao
Section of Immunobiology, Howard Hughes Medical Institute, New Haven, CT 06520, USA
Genes Dev 17:2933-49. 2003..Therefore, these results show that Ecsit functions as an essential component in two important signal transduction pathways and establishes a novel role for Ecsit as a cofactor for Smad proteins in the Bmp signaling pathway... - Mouse Th17 cells: current understanding of their generation and regulationChen Dong
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Eur J Immunol 39:640-4. 2009..Considerable progress has been made in understanding the developmental regulation of mouse Th17 cells. Here, I summarize this knowledge and discuss on the relationship of Th17 with regulatory and follicular Th cells... - New battlefields for costimulationNatalia Martin-Orozco
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
J Exp Med 203:817-20. 2006..New evidence shows that negative costimulators expressed by tumors and normal tissues afford local protection from T cell-mediated attack... - Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokinesBhanu P Pappu
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Pharmacol Ther 117:374-84. 2008..From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases... - ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic miceDaniel Hawiger
Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
J Immunol 180:3140-7. 2008..We conclude that ICOS is critically important for the induction of the autoimmune process that leads to diabetes... - Signaling by the JNK group of MAP kinases. c-jun N-terminal KinaseC Dong
Section of Immunobiology, Yale University School of Medicine and Howard Hughes, Medical Institute, New Haven, Connecticut 06520, USA
J Clin Immunol 21:253-7. 2001..In this review, we summarize these advances in understanding the expression, function, and regulation of the JNK pathway in T-lymphocyte activation and differentiation... - Defective T cell differentiation in the absence of Jnk1C Dong
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
Science 282:2092-5. 1998..Thus, the JNK1 signaling pathway plays a key role in T cell receptor-initiated TH cell proliferation, apoptosis, and differentiation... - JNK1 is required for T cell-mediated immunity against Leishmania major infectionS L Constant
Section of Immunobiology, Yale University School of Medicine, and Howard Hughes Medical Institute New Haven, CT 06520, USA
J Immunol 165:2671-6. 2000..These findings demonstrate that the negative regulation of Th2 cytokine production by the JNK1 signaling pathway is essential for generating Th1-polarized immunity against intracellular pathogens, such as Leishmania major... - JNK is required for effector T-cell function but not for T-cell activationC Dong
Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 405:91-4. 2000..However, production of effector T-cell cytokines did require JNK. Thus, JNK is necessary for T-cell differentiation but not for naive T-cell activation... - An NKT-mediated autologous vaccine generates CD4 T-cell dependent potent antilymphoma immunityYeonseok Chung
Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Blood 110:2013-9. 2007..Therefore, NKT ligand-loaded lymphoma elicits long-lasting and effective antitumor immunity, which can be further developed as patient- and tumor-specific immunotherapy against human lymphomas... - Regulation and pro-inflammatory function of interleukin-17 family cytokinesChen Dong
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Immunol Rev 226:80-6. 2008..From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases... - Th1 and Th2 cellsC Dong
Department of Immunology, University of Washington School of Medicine, Seattle, USA
Curr Opin Hematol 8:47-51. 2001..Transcription factors and signaling pathways that are selectively expressed or activated in Th1 and Th2 cells to regulate cytokine gene expression are discussed... - ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naïve CD4+ T cellsRiccardo Mesturini
Interdisciplinary Research Center of Autoimmune Diseases and Department of Medical Sciences, A. Avogadro University of Eastern Piedmont at Novara, Novara, Italy
Eur J Immunol 36:2601-12. 2006.... - CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'Jose M Rojo
Departamento de Inmunologia, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, E 28040 Madrid, Spain
Int Immunol 20:577-89. 2008..Thus, naturally occurring CD4+ICOS+ cells, expanded or not in vitro, are functionally relevant cells able of protecting ICOS-deficient mice from severe EAE... - ICOS is essential for the development of experimental autoimmune myasthenia gravisBenjamin G Scott
Department of Microbiology and Immunology, The University of Texas Medical Branch, 301 University Boulevard, 3.142 MRB, Galveston, TX 77555-1070, USA
J Neuroimmunol 153:16-25. 2004..ICOS-mediated lymphocyte costimulation is thus vital to the induction of T cell-mediated humoral immunity to AChR and the development of clinical EAMG... - Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivoMeixia Zhou
Department of Pediatrics, Stanford University, 300 Pasteur Drive, Palo Alto, CA 94305, USA
J Immunol 178:5496-504. 2007..Furthermore, EMSA and luciferase reporter assays demonstrated that KLF13 binds to multiple sites within the Bcl-X(L) promoter and results in decreased Bcl-X(L) promoter activity, making KLF13 a negative regulator of BCL-X(L)... - Novel function of IFN-gamma: negative regulation of dendritic cell migration and T cell primingXiaodong Wu
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences CAS, 320 Yueyang Road, Shanghai 200031, China
J Immunol 177:934-43. 2006..Taken together, IFN-gamma appears to play a negative regulatory role on in vivo DC function, resulting in suppression of Ag-specific T cell priming... - Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritisBing Wan
Joint Immunology Laboratory, Institute of Health Sciences and Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
J Immunol 177:8844-50. 2006..Our data indicate a novel pathogenic pathway in which overexpression of negative costimulatory molecules to restrict synovial inflammation in RA is overruled by the excessive production of soluble costimulatory molecules... - Interleukin 25 promotes the initiation of proallergic type 2 responsesPornpimon Angkasekwinai
University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Exp Med 204:1509-17. 2007..Thus, IL-25 is a critical factor regulating the initiation of innate and adaptive proallergic responses... - Cutting Edge: Programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigensNatalia Martin-Orozco
University of Texas M D Anderson Cancer Center, 7455 Fannin, Houston, TX 77030, USA
J Immunol 177:8291-5. 2006..Thus, during the presentation of tissue Ags to CD8+ T cells, PD-1/PD-L1 interaction crucially controls the effector differentiation of autoreactive T cells to maintain self-tolerance... - Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cellsXue Zhong Yu
Immunology and Blood and Marrow Transplantation Programs, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
J Immunol 176:7394-401. 2006..Our findings indicate that ICOS has paradoxical effects on the regulation of alloreactive CD4(+) and CD8(+) T cells in GVHD... - Measurement of interleukin-17Bhanu P Pappu
M D Anderson Cancer Center, Houston, Texas, USA
Curr Protoc Immunol . 2007..Detection of IL-17 in cell culture and tissue samples helps in monitoring inflammatory diseases and determining efficacy of therapeutic interventions... - CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activationBrian C Grabiner
Department of Molecular and Cellular Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
Genes Dev 21:984-96. 2007..Consistently, we found TRAF6 deficiency also abrogates GPCR-induced NF-kappaB activation. Together, our results provide the genetic evidence that CARMA3 is required for GPCR-induced NF-kappaB activation... - The adaptor protein CARD9 is required for innate immune responses to intracellular pathogensYen Michael S Hsu
Department of Molecular and Cellular Oncology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
Nat Immunol 8:198-205. 2007..Our data demonstrate that CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens... - Temporal expression of estrogen receptor alpha in rat bone marrow mesenchymal stem cellsQi Wang
Department of Orthodontics, College of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
Biochem Biophys Res Commun 347:117-23. 2006..Thus, the observed developmental expression of ERalpha mRNA correlates with progressive BMSCs growth and osteogenic differentiation and BMSCs may be a primary target cell for estrogen in maintaining bone formation... - A critical role of neural-specific JNK3 for ischemic apoptosisChia Yi Kuan
Department of Pediatrics, Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 100:15184-9. 2003..The downstream mechanism of JNK3-mediated apoptosis may include the induction of Bim and Fas and the mitochondrial release of cytochrome c. These results suggest that JNK3 is a potential target for neuroprotection therapies in stroke... - CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditisAlan Valaperti
Experimental Critical Care Medicine, Department of Research, University Hospital, Petersgraben 4, Basel, Switzerland
J Immunol 180:2686-95. 2008..In conclusion, CD11b(+) monocytes play a dual role in EAM: as a major cellular substrate of IL-17-induced inflammation and as mediators of an IFN-gamma-dependent negative feedback loop confining disease progression...