Nicholas J Donato

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancer
    Anupama Pal
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Breast Cancer Res 16:461. 2014
  2. doi request reprint Targets and effectors of the cellular response to aurora kinase inhibitor MK-0457 (VX-680) in imatinib sensitive and resistant chronic myelogenous leukemia
    Nicholas J Donato
    University of Michigan, Department of Internal Medicine, 1500 E Medical Center Dr, Room CC4306, Ann Arbor, MI 48109, USA
    Biochem Pharmacol 79:688-97. 2010
  3. doi request reprint Chronic myeloid leukemia stem cells and developing therapies
    Nicholas J Donato
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    Leuk Lymphoma 52:60-80. 2011
  4. doi request reprint Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis
    Hanshi Sun
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Blood 117:3151-62. 2011
  5. doi request reprint A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination
    Vaibhav Kapuria
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Cell Signal 23:2076-85. 2011
  6. pmc Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response
    Jeffrey W Perry
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA
    PLoS Pathog 8:e1002783. 2012
  7. pmc A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing
    Kristin M Burkholder
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Infect Immun 79:4850-7. 2011
  8. pmc Small molecule deubiquitinase inhibitors promote macrophage anti-infective capacity
    Marie Eve Charbonneau
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 9:e104096. 2014
  9. doi request reprint Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity
    Vaibhav Kapuria
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan, Ann Arbor, MI, USA
    Biochem Pharmacol 82:341-9. 2011
  10. pmc Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses
    Marta J Gonzalez-Hernandez
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 9:e94491. 2014

Collaborators

  • Vaibhav Kapuria
  • Mary X D O'Riordan
  • Kyeong Ok Chang
  • Alexander Levitzki
  • Anupama Pal
  • Hollis D Showalter
  • Christiane E Wobus
  • Marie Eve Charbonneau
  • Marta J Gonzalez-Hernandez
  • Jeffrey W Perry
  • Harish Potu
  • Moshe Talpaz
  • Luke F Peterson
  • Kristin M Burkholder
  • Hanshi Sun
  • Monique Verhaegen
  • Juxiang Cao
  • Kofi E Gyan
  • Mohammad Ahmed
  • Dexing Fang
  • William G Bornmann
  • Geoffrey Bartholomeusz

Detail Information

Publications12

  1. ncbi request reprint Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancer
    Anupama Pal
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Breast Cancer Res 16:461. 2014
    ..In this report, we summarize the involvement of this class of enzymes in breast cancer signaling and cell regulation and illustrate the potential for additional studies to define novel targets and approaches in breast cancer therapy...
  2. doi request reprint Targets and effectors of the cellular response to aurora kinase inhibitor MK-0457 (VX-680) in imatinib sensitive and resistant chronic myelogenous leukemia
    Nicholas J Donato
    University of Michigan, Department of Internal Medicine, 1500 E Medical Center Dr, Room CC4306, Ann Arbor, MI 48109, USA
    Biochem Pharmacol 79:688-97. 2010
    ....
  3. doi request reprint Chronic myeloid leukemia stem cells and developing therapies
    Nicholas J Donato
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    Leuk Lymphoma 52:60-80. 2011
    ....
  4. doi request reprint Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis
    Hanshi Sun
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Blood 117:3151-62. 2011
    ..This approach may be a therapeutic option for kinase inhibitor-resistant CML patients...
  5. doi request reprint A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination
    Vaibhav Kapuria
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Cell Signal 23:2076-85. 2011
    ..We conclude that chemical modification of AG490 resulted in development of a DUB inhibitor with activity against a DUB capable of modulating Jak2 ubiquitination, trafficking and signal transduction...
  6. pmc Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response
    Jeffrey W Perry
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA
    PLoS Pathog 8:e1002783. 2012
    ....
  7. pmc A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing
    Kristin M Burkholder
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Infect Immun 79:4850-7. 2011
    ....
  8. pmc Small molecule deubiquitinase inhibitors promote macrophage anti-infective capacity
    Marie Eve Charbonneau
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 9:e104096. 2014
    ..This small molecule inhibitor may provide a chemical platform for further development of therapeutic deubiquitinase inhibitors with broad-spectrum anti-infective activity. ..
  9. doi request reprint Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity
    Vaibhav Kapuria
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan, Ann Arbor, MI, USA
    Biochem Pharmacol 82:341-9. 2011
    ....
  10. pmc Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses
    Marta J Gonzalez-Hernandez
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 9:e94491. 2014
    ..Thus, altering structural characteristics of WP1130 can maintain effective broad-spectrum antiviral activity while increasing aqueous solubility. ..
  11. pmc Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway
    Harish Potu
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
    Oncotarget 5:5559-69. 2014
    ..These results suggest that Usp5 inhibition can provide an alternate approach in recovery of diminished p53 (or p73) function in melanoma and can add to the targeted therapies already used in the treatment of melanoma...
  12. doi request reprint Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis
    Vaibhav Kapuria
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Cancer Res 70:9265-76. 2010
    ..Our results show that chemical modification of a previously described JAK2 inhibitor results in the unexpected discovery of a novel DUB inhibitor with a unique antitumor mechanism...