Gina M Donato

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles
    Gina M Donato
    Department of Medicine, Division of Infectious Diseases, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    FEBS Lett 586:459-65. 2012
  2. ncbi Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis
    Joshua C Eby
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Infect Immun 80:850-9. 2012
  3. ncbi Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP!
    Erik L Hewlett
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Box 800419, Charlottesville, 22908, USA
    Mol Microbiol 59:447-59. 2006
  4. ncbi Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells
    Joshua C Eby
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 285:10662-70. 2010
  5. ncbi Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control
    Kevin M D'Auria
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    BMC Syst Biol 6:2. 2012
  6. ncbi Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis
    Gina M Donato
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, 22908, USA
    J Bacteriol 187:7579-88. 2005

Collaborators

Detail Information

Publications6

  1. ncbi Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles
    Gina M Donato
    Department of Medicine, Division of Infectious Diseases, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    FEBS Lett 586:459-65. 2012
    ..Thus OMV-ACT can deliver ACT by processes distinct from those of ACT alone...
  2. ncbi Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis
    Joshua C Eby
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Infect Immun 80:850-9. 2012
    ..In addition to characterizing the effects of CR3 on the actions of ACT, these data show that ATP consumption is yet another concentration-dependent activity of ACT that must be considered when studying how ACT affects target cells...
  3. ncbi Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP!
    Erik L Hewlett
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Box 800419, Charlottesville, 22908, USA
    Mol Microbiol 59:447-59. 2006
    ....
  4. ncbi Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells
    Joshua C Eby
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 285:10662-70. 2010
    ..Thus, elements of the basolateral membrane render epithelial cells highly sensitive to the entry of ACT in the absence of a specific receptor for toxin binding...
  5. ncbi Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control
    Kevin M D'Auria
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    BMC Syst Biol 6:2. 2012
    ..To better understand their effects in a susceptible cell line, we analyzed the transciptome-wide gene expression response of human ileocecal epithelial cells (HCT-8) after 2, 6, and 24 hr of toxin exposure...
  6. ncbi Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis
    Gina M Donato
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, 22908, USA
    J Bacteriol 187:7579-88. 2005
    ..pertussis ACT. These results demonstrate the expression of ACT by B. hinzii and represent the first characterization of a potential virulence factor of this organism...