Scott H Donaldson

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Regulation of the epithelial sodium channel by serine proteases in human airways
    Scott H Donaldson
    Cystic Fibrosis Research and Treatment Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 277:8338-45. 2002
  2. ncbi request reprint Sodium channels and cystic fibrosis
    Scott H Donaldson
    Cystic Fibrosis Research and Treatment Center, 6007B Thurston Bowles Building, CB 7248, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Chest 132:1631-6. 2007
  3. ncbi request reprint Mucociliary clearance as an outcome measure for cystic fibrosis clinical research
    Scott H Donaldson
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Proc Am Thorac Soc 4:399-405. 2007
  4. ncbi request reprint Mucus clearance and lung function in cystic fibrosis with hypertonic saline
    Scott H Donaldson
    University of North Carolina at Chapel Hill Cystic Fibrosis Research and Treatment Center, Chapel Hill 27599, USA
    N Engl J Med 354:241-50. 2006
  5. ncbi request reprint Update on pathogenesis of cystic fibrosis lung disease
    Scott H Donaldson
    Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Curr Opin Pulm Med 9:486-91. 2003
  6. ncbi request reprint Secreted and cell-associated adenylate kinase and nucleoside diphosphokinase contribute to extracellular nucleotide metabolism on human airway surfaces
    Scott H Donaldson
    Cystic Fibrosis Research and Treatment Center, Department of Medicine, 6019 Thurston Bowles Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Respir Cell Mol Biol 26:209-15. 2002
  7. pmc SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage
    Agustin Garcia-Caballero
    Cystic Fibrosis Pulmonary Research and Treatment Center, Thurston Bowles Building, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Proc Natl Acad Sci U S A 106:11412-7. 2009
  8. pmc Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia
    Robert Tarran
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina, Chapel Hill 27599, USA
    J Gen Physiol 127:591-604. 2006
  9. pmc A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system
    Brett M Rollins
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Respir Cell Mol Biol 39:190-7. 2008
  10. ncbi request reprint CFTR regulation of ENaC
    Scott H Donaldson
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Med 70:343-64. 2002

Research Grants

  1. Regulation of ENaC by Serine Proteases in Airways
    Scott Donaldson; Fiscal Year: 2006

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Regulation of the epithelial sodium channel by serine proteases in human airways
    Scott H Donaldson
    Cystic Fibrosis Research and Treatment Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 277:8338-45. 2002
    ..These data, therefore, suggest that protease-mediated regulation of sodium absorption is a function of human airway epithelia, and prostasin is a likely candidate for this activity...
  2. ncbi request reprint Sodium channels and cystic fibrosis
    Scott H Donaldson
    Cystic Fibrosis Research and Treatment Center, 6007B Thurston Bowles Building, CB 7248, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Chest 132:1631-6. 2007
    ..The development of treatment strategies that address this defect is a logical and promising means of preventing or delaying the onset of this lethal lung disease...
  3. ncbi request reprint Mucociliary clearance as an outcome measure for cystic fibrosis clinical research
    Scott H Donaldson
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Proc Am Thorac Soc 4:399-405. 2007
    ..The resulting data may then be used to select those candidates that should be rapidly advanced into larger clinical trials...
  4. ncbi request reprint Mucus clearance and lung function in cystic fibrosis with hypertonic saline
    Scott H Donaldson
    University of North Carolina at Chapel Hill Cystic Fibrosis Research and Treatment Center, Chapel Hill 27599, USA
    N Engl J Med 354:241-50. 2006
    ..Through osmotic forces, hypertonic saline may increase the volume of airway surface liquid, restore mucus clearance, and improve lung function...
  5. ncbi request reprint Update on pathogenesis of cystic fibrosis lung disease
    Scott H Donaldson
    Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Curr Opin Pulm Med 9:486-91. 2003
    ..Various hypotheses have attempted to explain the apparent breach of innate defenses in CF, although a definitive explanation has been elusive...
  6. ncbi request reprint Secreted and cell-associated adenylate kinase and nucleoside diphosphokinase contribute to extracellular nucleotide metabolism on human airway surfaces
    Scott H Donaldson
    Cystic Fibrosis Research and Treatment Center, Department of Medicine, 6019 Thurston Bowles Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Respir Cell Mol Biol 26:209-15. 2002
    ....
  7. pmc SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage
    Agustin Garcia-Caballero
    Cystic Fibrosis Pulmonary Research and Treatment Center, Thurston Bowles Building, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Proc Natl Acad Sci U S A 106:11412-7. 2009
    ..Thus, we propose that SPLUNC1 is secreted onto mucosal surfaces as a soluble volume sensor whose concentration and dilution can regulate ENaC activity and mucosal volumes, including that of airway surface liquid...
  8. pmc Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia
    Robert Tarran
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina, Chapel Hill 27599, USA
    J Gen Physiol 127:591-604. 2006
    ..Interestingly, the amount of ASL/Cl- secretion elicited by ATP/ADO was influenced by the level of CAP-induced Na+ absorption, suggesting that there are important interactions between the soluble regulators which finely tune ASL volume...
  9. pmc A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system
    Brett M Rollins
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Respir Cell Mol Biol 39:190-7. 2008
    ..A(2B)-R are required for ASL volume homeostasis in human airways, and therapies directed at inhibiting A(2B)-R may lead to a cystic fibrosis-like phenotype with depleted ASL volume and mucus stasis...
  10. ncbi request reprint CFTR regulation of ENaC
    Scott H Donaldson
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Med 70:343-64. 2002
  11. doi request reprint Safety and tolerability of inhaled hypertonic saline in young children with cystic fibrosis
    Elisabeth P Dellon
    Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7217, USA
    Pediatr Pulmonol 43:1100-6. 2008
    ..Initiating therapies in young patients has potential to preserve lung function. Before conducting a therapeutic trial of HS in this population, its safety must be evaluated and protocols for monitoring response must be tested...
  12. pmc Comparison of 133 xenon ventilation equilibrium scan (XV) and 99m technetium transmission (TT) scan for use in regional lung analysis by 2D Gamma scintigraphy in healthy and cystic fibrosis lungs
    Kirby L Zeman
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    J Aerosol Med Pulm Drug Deliv 26:94-100. 2013
    ..In various laboratories, the reference image is made by a transmission scan ((57)Co or (99m)Tc) or gas ventilation scan ((133)Xe or (81)Kr). There has not been a direct comparison of measures from the two methods...
  13. pmc Progress in cystic fibrosis and the CF Therapeutics Development Network
    Steven M Rowe
    Department of Medicine, University of Alabama at Birmingham, 1819 University Boulevard MCLM 768, Birmingham, AL 35294, USA
    Thorax 67:882-90. 2012
    ..Efforts to advance CF biomarkers, necessary to accelerate the therapeutic goals of the network, are also summarised...
  14. ncbi request reprint Burkholderia gladioli: five year experience in a cystic fibrosis and lung transplantation center
    Marcus P Kennedy
    Department of Pulmonary Medicine, Unit 403, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Cyst Fibros 6:267-73. 2007
    ..The impact of infection with Burkholderia gladioli in cystic fibrosis, other chronic airway diseases and immunosuppressed patients is unknown...

Research Grants1

  1. Regulation of ENaC by Serine Proteases in Airways
    Scott Donaldson; Fiscal Year: 2006
    ..The PI's long term goals are to provide important new insights into the basic elements of airway defense, CF lung disease, and to bring these findings to the development of novel therapies for CF lung disease. ..