Zbigniew Dominski

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Genes Dev 16:58-71. 2002
  2. pmc A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100
    Zbigniew Dominski
    Program in Molecular Biology and Biotechnology, CB 3280, University of North Carolina, Chapel Hill, NC 27599
    Mol Cell Biol 25:1489-500. 2005
  3. pmc Differences and similarities between Drosophila and mammalian 3' end processing of histone pre-mRNAs
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    RNA 11:1835-47. 2005
  4. ncbi request reprint An RNA end tied to the cell cycle: new ties to apoptosis and microRNA formation?
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Cell Cycle 9:1308-12. 2010
  5. doi request reprint The hunt for the 3' endonuclease
    Zbigniew Dominski
    Department of Biochemistry and Biophysics and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Wiley Interdiscip Rev RNA 1:325-40. 2010
  6. ncbi request reprint A 3' exonuclease that specifically interacts with the 3' end of histone mRNA
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell 12:295-305. 2003
  7. pmc Cloning and characterization of the Drosophila U7 small nuclear RNA
    Zbigniew Dominski
    Department of Biochemistry and Biophysics and Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 100:9422-7. 2003
  8. ncbi request reprint Nucleases of the metallo-beta-lactamase family and their role in DNA and RNA metabolism
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Crit Rev Biochem Mol Biol 42:67-93. 2007
  9. pmc Formation of the 3' end of histone mRNA: getting closer to the end
    Zbigniew Dominski
    Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Gene 396:373-90. 2007
  10. ncbi request reprint The polyadenylation factor CPSF-73 is involved in histone-pre-mRNA processing
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 123:37-48. 2005

Collaborators

Detail Information

Publications27

  1. pmc A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Genes Dev 16:58-71. 2002
    ..Antibodies to hZFP100 precipitate U7 snRNA, and expression of hZFP100 in Xenopus oocytes stimulates processing of histone pre-mRNA, showing that hZFP100 is a component of the processing machinery...
  2. pmc A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100
    Zbigniew Dominski
    Program in Molecular Biology and Biotechnology, CB 3280, University of North Carolina, Chapel Hill, NC 27599
    Mol Cell Biol 25:1489-500. 2005
    ..RC-68 is highly conserved from plants to humans and may function in conjunction with RC-74 in the 3' end processing of a distinct subset of cellular pre-mRNAs encoding proteins required for G(1) progression and entry into S phase...
  3. pmc Differences and similarities between Drosophila and mammalian 3' end processing of histone pre-mRNAs
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    RNA 11:1835-47. 2005
    ....
  4. ncbi request reprint An RNA end tied to the cell cycle: new ties to apoptosis and microRNA formation?
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Cell Cycle 9:1308-12. 2010
    ..This finding may uncover important and unanticipated links between the biogenesis of replication-dependent histone mrNAs and microrNAs...
  5. doi request reprint The hunt for the 3' endonuclease
    Zbigniew Dominski
    Department of Biochemistry and Biophysics and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Wiley Interdiscip Rev RNA 1:325-40. 2010
    ..It thus seems likely that these two processing reactions evolved from a common mechanism, with CPSF-73 as the endonuclease...
  6. ncbi request reprint A 3' exonuclease that specifically interacts with the 3' end of histone mRNA
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell 12:295-305. 2003
    ..These features make 3'hExo a primary candidate for the exonuclease that initiates rapid decay of histone mRNA upon completion and/or inhibition of DNA replication...
  7. pmc Cloning and characterization of the Drosophila U7 small nuclear RNA
    Zbigniew Dominski
    Department of Biochemistry and Biophysics and Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 100:9422-7. 2003
    ..Changes in the HDE that abolish or decrease processing efficiency result in a reduced ability to recruit U7 snRNA to the pre-mRNA...
  8. ncbi request reprint Nucleases of the metallo-beta-lactamase family and their role in DNA and RNA metabolism
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Crit Rev Biochem Mol Biol 42:67-93. 2007
    ..This article reviews the cellular roles of nucleases of the metallo-beta-lactamase family and the recent advances in studying these proteins...
  9. pmc Formation of the 3' end of histone mRNA: getting closer to the end
    Zbigniew Dominski
    Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Gene 396:373-90. 2007
    ..The greatest challenge that lies ahead is to determine how all these factors interact with each other to form a catalytically competent processing complex capable of cleaving histone pre-mRNAs...
  10. ncbi request reprint The polyadenylation factor CPSF-73 is involved in histone-pre-mRNA processing
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 123:37-48. 2005
    ..These studies suggest that CPSF-73 is both the endonuclease and 5'-3' exonuclease in histone-pre-mRNA processing and reveal an evolutionary link between 3' end formation of histone mRNAs and polyadenylated mRNAs...
  11. pmc Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase
    Lianxing Zheng
    Department of Biochemistry and Biophysics Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 23:1590-601. 2003
    ..Nuclear extracts from G1 and G2 cells are deficient in histone pre-mRNA processing, which is restored by addition of recombinant SLBP, indicating that SLBP is the only cell cycle-regulated factor required for histone pre-mRNA processing...
  12. pmc Drosophila stem-loop binding protein intracellular localization is mediated by phosphorylation and is required for cell cycle-regulated histone mRNA expression
    David J Lanzotti
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Biol Cell 15:1112-23. 2004
    ..The T230A protein is concentrated in the cytoplasm, suggesting that it is defective in nuclear targeting, and accounting for its failure to function in histone pre-mRNA processing in vivo...
  13. pmc FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs
    Xiao cui Yang
    Department of Biochemistry and Biophysics and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell 36:267-78. 2009
    ..These results demonstrate that FLASH is an essential factor required for 3' end maturation of histone mRNAs in both vertebrates and invertebrates and suggest a potential link between this process and apoptosis...
  14. pmc Combined top-down and bottom-up proteomics identifies a phosphorylation site in stem-loop-binding proteins that contributes to high-affinity RNA binding
    Christoph H Borchers
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, 27599, USA
    Proc Natl Acad Sci U S A 103:3094-9. 2006
    ..Removal of the phosphoryl group from T230 by either dephosphorylation or mutation results in a 7-fold reduction in the affinity of SLBP for the stem-loop RNA...
  15. pmc 3' end processing of Drosophila melanogaster histone pre-mRNAs: requirement for phosphorylated Drosophila stem-loop binding protein and coevolution of the histone pre-mRNA processing system
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 27599, USA
    Mol Cell Biol 22:6648-60. 2002
    ..20 nucleotides downstream from the stem, and an Sm-reactive factor, most likely the Drosophila counterpart of vertebrate U7 snRNP...
  16. pmc A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing
    Xiao cui Yang
    Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Mol Cell Biol 33:28-37. 2013
    ....
  17. pmc Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila
    Brandon D Burch
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    RNA 17:1132-47. 2011
    ..Together, these studies demonstrate that direct interaction between dFLASH and dLsm11 is essential for histone pre-mRNA processing in vivo and for proper development and viability in flies...
  18. pmc Drosophila histone locus bodies form by hierarchical recruitment of components
    Anne E White
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Biol 193:677-94. 2011
    ....
  19. pmc Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA
    Xiao cui Yang
    Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 29:4045-56. 2009
    ..These proteins likely rigidify the substrate and function as the molecular ruler in determining the site of cleavage...
  20. pmc Studies of the 5' exonuclease and endonuclease activities of CPSF-73 in histone pre-mRNA processing
    Xiao cui Yang
    Program in Molecular Biology and Biotechnology, CB 3280, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 29:31-42. 2009
    ..RNA interference experiments with HeLa cells indicate that degradation of the DCP does not depend on the Xrn2 5' exonuclease, suggesting that CPSF-73 degrades the DCP both in vitro and in vivo...
  21. pmc U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis
    Ashley C Godfrey
    Department of Biology, CB 3280, University of North Carolina, Chapel Hill, NC 27599, USA
    RNA 12:396-409. 2006
    ..These data suggest that SLBP and U7 snRNP cooperate in the production of histone mRNA in vivo, and that disruption of histone pre-mRNA processing is detrimental to development...
  22. pmc SLBP is associated with histone mRNA on polyribosomes as a component of the histone mRNP
    Michael L Whitfield
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 32:4833-42. 2004
    ..SLBP remains active both in RNA binding and histone pre-mRNA processing when DNA replication is inhibited...
  23. pmc The sea urchin stem-loop-binding protein: a maternally expressed protein that probably functions in expression of multiple classes of histone mRNA
    Anthony J Robertson
    Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill 27599, USA
    Nucleic Acids Res 32:811-8. 2004
    ..SuSLBP expressed by in vitro translation does not bind the stem-loop RNA, suggesting that suSLBP is modified to activate RNA binding in sea urchin embryos...
  24. ncbi request reprint Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA
    Xiao cui Yang
    Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 281:30447-54. 2006
    ..3'hExo removes 3' overhangs of small interfering RNAs, whereas the double-stranded region is resistant to the enzymatic activity...
  25. pmc FLASH is required for the endonucleolytic cleavage of histone pre-mRNAs but is dispensable for the 5' exonucleolytic degradation of the downstream cleavage product
    Xiao cui Yang
    Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, CB 3280, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 31:1492-502. 2011
    ..These results suggest that CPSF-73, the catalytic component in both reactions, can be recruited to histone pre-mRNA largely in a manner independent of FLASH, possibly by a separate domain in Lsm11...
  26. doi request reprint Emergence of the β-CASP ribonucleases: highly conserved and ubiquitous metallo-enzymes involved in messenger RNA maturation and degradation
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA
    Biochim Biophys Acta 1829:532-51. 2013
    ..This article is part of a Special Issue entitled: RNA Decay mechanisms...
  27. ncbi request reprint Direct MALDI-MS/MS of phosphopeptides affinity-bound to immobilized metal ion affinity chromatography beads
    Christina S Raska
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 27599, USA
    Anal Chem 74:3429-33. 2002
    ..Direct analysis of phosphorylated peptides on IMAC beads does not adversely affect the high-mass accuracy of an orthogonal injection QqTOF mass spectrometer, making it a suitable technique for phosphoproteomics...