Steven E Domino

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Interdisciplinary research career development: building interdisciplinary research careers in women's health program best practices
    Steven E Domino
    Department of Obstetrics and Gynecology, L4100 Von Voigtlander Women s Hospital, 1500 East Medical Center Drive, University of Michigan, Ann Arbor, MI 48109 5276, USA
    J Womens Health (Larchmt) 20:1587-601. 2011
  2. ncbi Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract
    S E Domino
    Department of Obstetrics and Gynecology, Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0650, USA
    J Biol Chem 276:23748-56. 2001
  3. pmc Deficiency of reproductive tract alpha(1,2)fucosylated glycans and normal fertility in mice with targeted deletions of the FUT1 or FUT2 alpha(1,2)fucosyltransferase locus
    S E Domino
    Department of Obstetrics and Gynecology, 6428 Medical Science Bldg 1, The University of Michigan Medical School, 1150 West Medical Center Dr, Ann Arbor, MI 48109, USA
    Mol Cell Biol 21:8336-45. 2001
  4. pmc LacZ expression in Fut2-LacZ reporter mice reveals estrogen-regulated endocervical glandular expression during estrous cycle, hormone replacement, and pregnancy
    Steven E Domino
    Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, 6428 Medical Science I Box 0617, University of Michigan Medical Center, Ann Arbor, MI 48109 0617, USA
    Glycobiology 14:169-75. 2004
  5. pmc Cervical mucins carry alpha(1,2)fucosylated glycans that partly protect from experimental vaginal candidiasis
    Steven E Domino
    Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA
    Glycoconj J 26:1125-34. 2009
  6. pmc Opportunities and challenges of interdisciplinary research career development: implementation of a women's health research training program
    Steven E Domino
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109 0617, USA
    J Womens Health (Larchmt) 16:256-61. 2007
  7. pmc Cell surface fucosylation does not affect development of colon tumors in mice with germline Smad3 mutation
    Steven E Domino
    Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, Mich, USA
    Tumour Biol 28:77-83. 2007
  8. pmc Gastrointestinal mucins of Fut2-null mice lack terminal fucosylation without affecting colonization by Candida albicans
    Elizabeth A Hurd
    Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, 6428 Medical Science I Box 0617, University of Michigan Medical Center, Ann Arbor, MI 48109 0617, USA
    Glycobiology 15:1002-7. 2005
  9. pmc Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells
    S E Domino
    Department of Obstetrics and Gynecology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0650, USA
    Biochem J 327:105-15. 1997
  10. ncbi Fucosyltransferase 1 mediates angiogenesis in rheumatoid arthritis
    Takeo Isozaki
    University of Michigan, Ann Arbor
    Arthritis Rheumatol 66:2047-58. 2014

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc Interdisciplinary research career development: building interdisciplinary research careers in women's health program best practices
    Steven E Domino
    Department of Obstetrics and Gynecology, L4100 Von Voigtlander Women s Hospital, 1500 East Medical Center Drive, University of Michigan, Ann Arbor, MI 48109 5276, USA
    J Womens Health (Larchmt) 20:1587-601. 2011
    ..As of 2010, 407 scholars have been supported in interdisciplinary women's health research and a total of 63 BIRCWH program awards have been made to 41 institutions across the U.S...
  2. ncbi Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract
    S E Domino
    Department of Obstetrics and Gynecology, Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0650, USA
    J Biol Chem 276:23748-56. 2001
    ..FUT2 expression localizes to luminal uterine epithelium by in situ hybridization, implying that this gene determines expression of cell surface Fucalpha1-->2Galbeta epitopes proposed to mediate blastocyst adhesion...
  3. pmc Deficiency of reproductive tract alpha(1,2)fucosylated glycans and normal fertility in mice with targeted deletions of the FUT1 or FUT2 alpha(1,2)fucosyltransferase locus
    S E Domino
    Department of Obstetrics and Gynecology, 6428 Medical Science Bldg 1, The University of Michigan Medical School, 1150 West Medical Center Dr, Ann Arbor, MI 48109, USA
    Mol Cell Biol 21:8336-45. 2001
    ....
  4. pmc LacZ expression in Fut2-LacZ reporter mice reveals estrogen-regulated endocervical glandular expression during estrous cycle, hormone replacement, and pregnancy
    Steven E Domino
    Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, 6428 Medical Science I Box 0617, University of Michigan Medical Center, Ann Arbor, MI 48109 0617, USA
    Glycobiology 14:169-75. 2004
    ..Endocervical expression of Fut2 in estrus and pregnancy may modify cervical mucus barrier properties from microbial infection analogous to the potential role of mucosal glycans in humans...
  5. pmc Cervical mucins carry alpha(1,2)fucosylated glycans that partly protect from experimental vaginal candidiasis
    Steven E Domino
    Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA
    Glycoconj J 26:1125-34. 2009
    ..Intravaginal instillation of recombinant MUC1 glycanpolymer partially reduced experimental yeast vaginitis suggesting that a large glycanpolymer, with different glycan epitopes, may affect fungal burden...
  6. pmc Opportunities and challenges of interdisciplinary research career development: implementation of a women's health research training program
    Steven E Domino
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109 0617, USA
    J Womens Health (Larchmt) 16:256-61. 2007
    ..A second cohort of 12 centers, called BIRCWH II, was funded in 2002...
  7. pmc Cell surface fucosylation does not affect development of colon tumors in mice with germline Smad3 mutation
    Steven E Domino
    Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, Mich, USA
    Tumour Biol 28:77-83. 2007
    ..Spontaneous colorectal tumors from mice with a germline null mutation of transforming growth factor-beta signaling gene Smad3 (Madh3) were tested for alpha(1,2)fucosylated glycan expression...
  8. pmc Gastrointestinal mucins of Fut2-null mice lack terminal fucosylation without affecting colonization by Candida albicans
    Elizabeth A Hurd
    Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, 6428 Medical Science I Box 0617, University of Michigan Medical Center, Ann Arbor, MI 48109 0617, USA
    Glycobiology 15:1002-7. 2005
    ..albicans-host interaction in the intestine, highlighting that infections caused by the same organism at different mucosal surfaces are not equal...
  9. pmc Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells
    S E Domino
    Department of Obstetrics and Gynecology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0650, USA
    Biochem J 327:105-15. 1997
    ..Hybridization analyses in situ localize expression of FUT1 transcripts to thymic medullary and epididymal epithelial cells, implying that this gene determines the expression of cell surface Fucalpha(1-2)Galbeta epitopes in these tissues...
  10. ncbi Fucosyltransferase 1 mediates angiogenesis in rheumatoid arthritis
    Takeo Isozaki
    University of Michigan, Ann Arbor
    Arthritis Rheumatol 66:2047-58. 2014
    ..To determine the role of α(1,2)-linked fucosylation of proteins by fucosyltransferase 1 (FUT1) in rheumatoid arthritis (RA) angiogenesis...
  11. pmc Increased susceptibility of secretor factor gene Fut2-null mice to experimental vaginal candidiasis
    Elizabeth A Hurd
    Department of Obstetrics and Gynecology, 6428 Medical Science I, Box 0617, University of Michigan, Ann Arbor, MI 48109 0617, USA
    Infect Immun 72:4279-81. 2004
    ..However, the lack of significant effect of competitive inhibition by exogenous neoglycoproteins in this study emphasizes the complexity of Candida-epithelial cell adhesion events...
  12. doi A key role for Fut1-regulated angiogenesis and ICAM-1 expression in K/BxN arthritis
    Mohammad A Amin
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Ann Rheum Dis . 2014
    ..Angiogenesis contributes to the pathogenesis of rheumatoid arthritis. Fucosyltransferases (Futs) are involved in angiogenesis and tumour growth. Here, we examined the role of Fut1 in angiogenesis and K/BxN serum transfer arthritis...
  13. doi A novel role for inducible Fut2 in angiogenesis
    Pei Suen Tsou
    Department of Medicine, University of Michigan Medical School, Ann Arbor, 48109, USA
    Angiogenesis 16:195-205. 2013
    ..Angiogenesis plays an important role in wound healing and tumor growth. Fucosyltransferases synthesize fucosylated glycans and may play a major role in vascular biology...
  14. ncbi Polarity proteins control ciliogenesis via kinesin motor interactions
    Shuling Fan
    Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Curr Biol 14:1451-61. 2004
    ..Retinitis pigmentosa can be caused by loss-of-function mutations in the polarity protein Crumbs1 (CRB1), but the exact role of CRB1 in retinal function is unclear...
  15. ncbi Genetic manipulation of blood group carbohydrates alters development and pathfinding of primary sensory axons of the olfactory systems
    James A St John
    Brain Growth and Regeneration Laboratory, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Queensland, Australia
    Dev Biol 298:470-84. 2006
    ..These results provide in vivo evidence for a role of specific cell surface carbohydrates during development of the olfactory nerve pathways...
  16. pmc Tissue-specific loss of fucosylated glycolipids in mice with targeted deletion of alpha(1,2)fucosyltransferase genes
    Masao Iwamori
    Department of Biochemistry, Faculty of Science and Technology, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Biochem J 380:75-81. 2004
    ..Ileum, epididymis, and testis retained specific fucosylated glycolipids, irrespective of targeted deletion of either gene, indicating either compensation for or redundancy of the alpha(1,2)fucosyltransferase genes in these tissues...
  17. pmc Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucalpha1-2 glycosyltransferase
    Kristina A Thomsson
    Department of Medical Biochemistry, Goteborg University, Medicinaregatan 9A, 41390 Gothenburg, Sweden
    Biochem J 367:609-16. 2002
    ..The reason for this up-regulation could be a direct or indirect effect of a non-functional CF transmembrane conductance regulator (CFTR) caused by the absence of CFTR channel...

Research Grants1

  1. Fucosylated cell surface molecules in tumor invasion
    STEVEN DOMINO; Fiscal Year: 2005
    ..and in 1,2-dimethylhydrazine-induced tumors, in the presence and absence of cell surface alpha(1,2)fucose by crossing mice into the Fut1 and Fut2 null background. ..