Research Topics
Species | Frederick DomannSummaryAffiliation: University of Iowa Country: USA Publications
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Publications
Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseasesFrederick E Domann
Departments of Radiation Oncology, Surgery, and Pathology Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Int J Mol Sci 14:8491-5. 2013..Together with this deeper understanding, opportunities will arise to devise rational therapeutic interventions to decrease the incidence and severity of these diseases and positively impact the human healthspan...
Epigenetic silencing of DSC3 is a common event in human breast cancerMarc M Oshiro
Department of Pharmacology, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
Breast Cancer Res 7:R669-80. 2005..In this study, we examined the prevalence of epigenetic silencing of DSC3 gene expression in primary breast tumor specimens...- Flipping the epigenetic switchFrederick E Domann
Department of Radiation Oncology, Carver College of Medicine and Holden Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA
Am J Pathol 164:1883-6. 2004 
Epigenetic silencing of maspin gene expression in human breast cancersF E Domann
Free Radical and Radiation Biology Program, Department of Radiology, College of Medicine, University of Iowa and the Iowa Cancer Center, Iowa City, IA 52242, USA
Int J Cancer 85:805-10. 2000..Thus, aberrant cytosine methylation and heterochromatinization of the maspin promoter may silence maspin gene expression, thereby contributing to the progression of human mammary cancer...- Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasisMelissa L T Teoh-Fitzgerald
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine and The Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA
Mol Cancer Res 10:40-51. 2012.... - Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxidesWei Ying Yue
Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Neuro Oncol 13:961-73. 2011..Taken together, these results indicate that persistent JNK activity enhances VS cell survival, at least in part, by suppressing accumulation of mitochondrial superoxides... - Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapyH P Wang
Free Radical and Radiation Biology Program, Department of Radiology, College of Medicine, The University of Iowa, Iowa City, 52242-1101, USA
Free Radic Biol Med 30:825-35. 2001..Thus, PhGPx activity could contribute to the resistance of tumor cells to PDT... - Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cellsB W Darbro
Interdisciplinary Program in Molecular Biology and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
Oncogene 25:7421-33. 2006.... - Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoterC H Zhu
Free Radical and Radiation Biology Program, Department of Radiology, The University of Iowa, Iowa City, IA 52242, USA
Biochim Biophys Acta 1519:85-91. 2001..Our results suggest that transcriptional activation of AP-2 alpha in the SV40-transformed cells is mediated, at least in part, by site-specific methylation of a negative regulatory cis-element in the AP-2 alpha promoter... - AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cellsH Li
Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
Oncogene 25:5405-15. 2006.... - AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cellsHualei Li
Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA
Neoplasia 8:568-77. 2006..In summary, expression of either AP-2gamma or AP-2alpha inhibited breast carcinoma cell growth; thus, these genes may be therapeutic targets for breast cancer... - Dual-expressing adenoviral vectors encoding the sodium iodide symporter for use in noninvasive radiological imaging of therapeutic gene transferGang Niu
Free Radical and Radiation Biology Program, The University of Iowa, Iowa City, IA 52242, USA
Nucl Med Biol 33:391-8. 2006..CONCLUSIONS: Radiological detection of hNIS derived from dual-expressing adenoviral vectors is a highly effective method to monitor therapeutic gene transfer and expression in a noninvasive manner... - Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cellsRui Zhao
Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53792, USA
Cancer Res 66:2296-304. 2006..Activation of p53 in turn synergistically enhances superoxide production and apoptosis induced by selenite... - v-Ha-ras mitogenic signaling through superoxide and derived reactive oxygen speciesJi-Qin Yang
Free Radical and Radiation Biology Program, Department of Radiation Oncology, B180 Medical Laboratories, University of Iowa, Iowa City, Iowa, USA
Mol Carcinog 33:206-18. 2002..This finding suggests that peroxides removed by GPx1, but not by CAT, are also involved in ras-induced transformation... - Epigenetic regulation of the cell type-specific gene 14-3-3sigmaMarc M Oshiro
Pharmacology and Toxicology, University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA
Neoplasia 7:799-808. 2005..These findings extend the spectrum of cell type-specific genes controlled, partly, by normal epigenetic mechanisms, and suggest that this subset of genes may represent important targets of epigenetic dysregulation in human cancer... - RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinomaGeeta Lal
Department of Surgery, Division of Surgical Oncology, University of Iowa, Iowa City, Iowa, USA
Cancer 107:2752-9. 2006..RIZ1 expression is lost in a variety of tumors, primarily by means of epigenetic mechanisms that involve promoter hypermethylation... - A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stabilityVan S Tompkins
Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, 52242 1109, USA, and the Laboratoire de Genetique Cellulaire et Moleculaire, UPRES EA2622, Centre Hospitalier Universitaire de Poitiers, France
J Biol Chem 282:1322-33. 2007..This study identifies a novel protein with tumor suppressor-like behaviors and functional links to ARF-MDM2-p53 signaling... - Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cellsRui Zhao
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, K4/868, Clinical Science Center, Box 8550, 600 Highland Avenue, Madison, WI 53792, USA
Mol Cancer Ther 5:3275-84. 2006..Our study shows that apoptosis induced by SeMet plus METase is superoxide mediated and p53 dependent via mitochondrial pathway(s). These results suggest that superoxide and p53 may play a role in cancer chemoprevention by selenium... - Human glioblastoma U87MG cells transduced with a dominant negative p53 (TP53) adenovirus construct undergo radiation-induced mitotic catastropheFiorenza Ianzini
Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
Radiat Res 168:183-92. 2007.... - An epigenetic perspective on the free radical theory of developmentMichael J Hitchler
Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
Free Radic Biol Med 43:1023-36. 2007..Moreover, the recent discovery of histone demethylases that require oxygen as a cofactor directly links epigenetic processes to oxygen gradients during development... - Epigenetic regulation of manganese superoxide dismutase expression in human breast cancer cellsMichael J Hitchler
Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, Iowa 52242, USA
Epigenetics 1:163-71. 2006..These findings indicate that epigenetic silencing of SOD2 constitutes one mechanism leading to the decreased expression of MnSOD observed in many breast cancers... - Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC)Matthew J Provenzano
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA, USA
Otolaryngol Head Neck Surg 137:722-8. 2007..To determine if epigenetic-modifying drugs can increase iodine uptake in thyroid carcinoma cell lines... - 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stressIman M Ahmad
Department of Radiography, The Hashemite University, Al Zarqa, Jordan
Free Radic Biol Med 44:826-34. 2008.... - Regulation of 14-3-3sigma expression in human thyroid carcinoma is epigenetically regulated by aberrant cytosine methylationGeeta Lal
Department of Surgery, Division of Surgical Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 4641 JCP, Iowa City, IA 52242, USA
Cancer Lett 267:165-74. 2008..In addition, 5-aza-dC treatment increased 14-3-3sigma expression in the FTC-238 and NPA cell lines, which had low baseline expression. We conclude 14-3-3sigma expression in thyroid carcinomas is regulated by CpG island hypermethylation... - Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutaseSarita G Menon
Department of Microbiology and Immunology, State University of New York at Buffalo School of Medicine, Buffalo, New York, USA
Cancer Res 67:6392-9. 2007..Scavenging of O(2)(*-) with Tiron reversed the NAC-induced G(1) arrest. These results show that an O(2)(*-) signaling pathway regulates NAC-induced G(1) arrest by decreasing cyclin D1 protein levels and increasing MnSOD activity... - Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factorMin Wang
Department of Radiation Oncology, Free Radical and Radiation Biology Program, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242 1181, USA
Oncogene 24:8154-66. 2005..These observations demonstrated that HIF-1alpha accumulation and VEGF expression could be modulated by the antioxidant enzyme MnSOD... - Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanismJoseph J Cullen
Department of Surgery, University of Iowa College of Medicine, Iowa City, IA, USA
Cancer Res 63:5513-20. 2003..These mechanisms suggest that altering the intracellular redox environment of pancreatic cancer cells may inhibit growth and delineate a potential strategy directed against pancreatic cancer... - Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic controlMatthew Fitzgerald
Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
Neoplasia 5:427-36. 2003..Thus, human pancreatic carcinoma cells acquire maspin expression through epigenetic derepression of the maspin locus, and in so doing appear to co-opt a normal cellular mechanism for the regulation of this gene... - MnSOD up-regulates maspin tumor suppressor gene expression in human breast and prostate cancer cellsHong Duan
Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
Antioxid Redox Signal 5:677-88. 2003..Our findings identify a mechanism underlying MnSOD antitumor effects and provide evidence to support MnSOD as a genetic therapy in the treatment of human breast and prostate cancers... - Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growthYing Zhang
Free Radical and Radiation Biology Program, Department of Radiation Oncology, B180 Medical Laboratories, College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
Cancer Res 62:1205-12. 2002.... - Multimodality noninvasive imaging of gene transfer using the human sodium iodide symporterGang Niu
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USA
J Nucl Med 45:445-9. 2004..This preliminary study demonstrates the feasibility of using hNIS for monitoring the location and magnitude of expression of genes delivered during gene therapy... - The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cellsGeorge S Watts
Bone Marrow Transplant Program, Arizona Cancer Center and Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85724, USA
Neoplasia 6:187-94. 2004..Taken together, the results show that PCAF expression can be induced by wild-type p53... - Dominant negative interference of transcription factor AP-2 causes inhibition of ErbB-3 expression and suppresses malignant cell growthChun Hong Zhu
Free Radical and Radiation Biology Program, Department of Radiation Oncology, and Holden Comprehensive Cancer Center, The University of Iowa, Iowa City 52242, USA
Breast Cancer Res Treat 71:47-57. 2002..Interference with the function of transcription factor AP-2 might provide a potential strategy for modulation of the malignant phenotype... - The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinomaJoseph J Cullen
Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Cancer Res 63:1297-303. 2003..Overexpression of MnSOD may be effective in growth suppression of pancreatic cancer... - Redox factor-1 contributes to the regulation of progression from G0/G1 to S by PDGF in vascular smooth muscle cellsTongrong He
Free Radical and Radiation Biology Program, Dept of Radiation Oncology, The University of Iowa, Iowa City, IA 52242 1181, USA
Am J Physiol Heart Circ Physiol 285:H804-12. 2003..These results suggest that Ref-1 contributes to the regulation of PDGF-BB-stimulated cell cycle progression from G0/G1 to S in SMCs, with one of the possible steps being redox-regulation of AP-1 by Ref-1 protein... - AP-2 participates in the transcriptional control of the amyloid precursor protein (APP) gene in oral squamous cell carcinomaMatthew J Provenzano
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242 1181, USA
Exp Mol Pathol 83:277-82. 2007..Taken together, these findings demonstrate a role for the transcription factor AP-2alpha in the regulation of APP gene expression in human keratinocytes... - A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patternsMatthew J Provenzano
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242 1181, United States
Hear Res 233:1-13. 2007..We then examine the evidence of a role for epigenetics in hearing related processes and hearing loss. The article concludes with a discussion of areas of epigenetic research that could be applied to hearing research... - Editorial: maspin as a molecular target for cancer therapyFrederick E Domann
J Urol 169:1162-4. 2003 - Role for DNA methylation in the control of cell type specific maspin expressionBernard W Futscher
Department of Pharmacology and Toxicology, Bone Marrow Transplant Program, Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
Nat Genet 31:175-9. 2002..These findings indicate that cytosine methylation is important in the establishment and maintenance of cell type restricted gene expression... - Acetaldehyde activates Jun/AP-1 expression and DNA binding activity in human oral keratinocytesSherry R Timmons
Oral Sciences Graduate Program, B180ML, The University of Iowa, Iowa City, IA 52242, USA
Oral Oncol 38:281-90. 2002..Taken together, these results suggest that acetaldehyde may participate, at least in part, in the promotion stage of oral carcinogenesis... - Redox regulation of adenovirus-induced AP-1 activation by overexpression of manganese-containing superoxide dismutaseHannah J Zhang
Department of Exercise Science, Free Radical and Radiation Biology Program. Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa 52242, USA
J Virol 76:355-63. 2002..Furthermore, our results suggest that MnSOD overexpression decreases AP-1 DNA binding activity by regulating intracellular redox status, with the possible involvement of Ref-1 in this redox-sensitive pathway... - Mutant p53 and aberrant cytosine methylation cooperate to silence gene expressionMarc M Oshiro
Bone Marrow Transplant Program, Arizona Cancer Center and Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
Oncogene 22:3624-34. 2003..These results suggest that cancer treatments that target both genetic and epigenetic facets of gene regulation may be a useful strategy towards the therapeutic transcriptional reprogramming of cancer cells... - L-PhGPx expression can be suppressed by antisense oligodeoxynucleotidesLingjie Zhao
Free Radical and Radiation Biology, EMRB 68, The University of Iowa, Iowa City, IA 52242-1101, USA
Arch Biochem Biophys 417:212-8. 2003..These data demonstrate that PhGPx expression can be manipulated by antisense techniques... - Relative non-steroidal anti-inflammatory drug (NSAID) antiproliferative activity is mediated through p21-induced G1 arrest and E2F inhibitionJonathan M Bock
Department of Otolaryngology Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Mol Carcinog 46:857-64. 2007..These data demonstrate the wide range of activity of various NSAID agents, and reveal a mechanism of action through cell cycle inhibition and induction of apoptosis... - Noninvasive radiological imaging of pulmonary gene transfer and expression using the human sodium iodide symporterGang Niu
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, B 180 Med Labs, Iowa City, IA 52242, USA
Eur J Nucl Med Mol Imaging 32:534-40. 2005..The ability to noninvasively visualize gene expression tomographically in real time has significant translational implications in human gene therapy... - Epigenetic regulation of maspin expression in human ovarian carcinoma cellsStephen L Rose
Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, The Holden Comprehensive Cancer Center, 4630 John Colloton Pavilion, 200 Hawkins Drive, Iowa City, IA 52242, USA
Gynecol Oncol 102:319-24. 2006..Deregulation of maspin expression in ovarian cancer is due to loss of epigenetic control as has been shown in other cancers. This observation provides further evidence of the strict epigenetic control of the maspin gene... - Genetically targeted radiotherapy of head and neck squamous cell carcinoma using the sodium-iodide symporter (NIS)Andrew W Gaut
Department of Otolaryngology-Head and Neck Surgery, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Head Neck 26:265-71. 2004..CONCLUSIONS: Our data demonstrate the feasibility of genetically targeted radiotherapy by use of the NIS gene as a possible therapeutic intervention in head and neck cancer... - Intrinsic radiation resistance in human chondrosarcoma cellsFarid Moussavi-Harami
Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, 52242, USA
Biochem Biophys Res Commun 346:379-85. 2006..These results support the hypothesis that p16(ink4a) plays a role in the radiation resistance of chondrosarcoma cell lines and suggests that restoring p16 expression will improve the radiation sensitivity of human chondrosarcomas... - Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucoseKelly K Andringa
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Cancer Res 66:1605-10. 2006..These results support the hypothesis that drug combinations capable of inhibiting both glucose and hydroperoxide metabolism may provide an effective biochemical strategy for sensitizing human cancer cells to metabolic oxidative stress... - Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomasAnna C M Chaves
Faculdade de Odontologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Int J Oncol 24:295-303. 2004..We conclude that p53 mutations are common among oral cavity cancers in this population, and stress the significance of this study since it is the first analysis of p53 mutation in oral cancer in a southern Brazilian population... - Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instabilityBenjamin G Slane
Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA
Cancer Res 66:7615-20. 2006..These results also allow for the speculation that DNA damage to genes coding for electron transport chain proteins could result in a "mutator phenotype" by increasing steady-state levels of O2(.-) and H2O2... - Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygenJun Luo
Free Radical and Radiation Biology Graduate Program, Department of Radiation Oncology, The University of Iowa, Iowa City, 52242, USA
Antioxid Redox Signal 8:1307-14. 2006.... - Rapid and direct quantitative RT-PCR method to measure promoter activityLei Yu
Free Radical and Radiation Program, Radiation Oncology Department, B180 ML, The University of Iowa, Iowa City, Iowa 52242, USA
Biotechnol Prog 22:1461-3. 2006..The correlation between the endogenous p21 gene expression in response to p53 and the transfected cis element is remarkable. This method is more direct and potentially faster than traditional promoter-reporter assays... - Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemiaAngela M Devlin
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
J Biol Chem 280:25506-11. 2005..05, r = 0.620). We conclude that hyperhomocysteinemia produces tissue-specific changes in H19 DMD methylation and increased vascular expression of H19 in adult mice... - Celecoxib toxicity is cell cycle phase specificJonathan M Bock
Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
Cancer Res 67:3801-8. 2007..We additionally show that a profound inhibition of nuclear E2F function provides a possible mechanism for this S phase-specific toxicity...
Research Grants
- Epigenetic factors governing SOD2 gene expressionFrederick Domann; Fiscal Year: 2007..abstract_text> ..
- Molecular Species Responsible for Tumor Supressive Effect of MnSODFrederick E Domann; Fiscal Year: 2010..In this way, we hope to be able to develop exciting new cancer therapies. ..