Frederick Domann

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation
    Suwit Duangmano
    School of Allied Health Science and Public Health, Walailak University, Bangkok, Thailand
    BMC Complement Altern Med 12:185. 2012
  2. pmc Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseases
    Frederick E Domann
    Departments of Radiation Oncology, Surgery, and Pathology Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Int J Mol Sci 14:8491-5. 2013
  3. pmc Epigenetic silencing of DSC3 is a common event in human breast cancer
    Marc M Oshiro
    Department of Pharmacology, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Breast Cancer Res 7:R669-80. 2005
  4. ncbi request reprint Epigenetic silencing of maspin gene expression in human breast cancers
    F E Domann
    Free Radical and Radiation Biology Program, Department of Radiology, College of Medicine, University of Iowa and the Iowa Cancer Center, Iowa City, IA 52242, USA
    Int J Cancer 85:805-10. 2000
  5. pmc Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis
    Melissa L T Teoh-Fitzgerald
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine and The Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Cancer Res 10:40-51. 2012
  6. pmc Flipping the epigenetic switch
    Frederick E Domann
    Department of Radiation Oncology, Carver College of Medicine and Holden Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA
    Am J Pathol 164:1883-6. 2004
  7. pmc Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides
    Wei Ying Yue
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Neuro Oncol 13:961-73. 2011
  8. ncbi request reprint Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy
    H P Wang
    Free Radical and Radiation Biology Program, Department of Radiology, College of Medicine, The University of Iowa, Iowa City, 52242-1101, USA
    Free Radic Biol Med 30:825-35. 2001
  9. ncbi request reprint AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells
    H Li
    Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
    Oncogene 25:5405-15. 2006
  10. pmc Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells
    B W Darbro
    Interdisciplinary Program in Molecular Biology and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
    Oncogene 25:7421-33. 2006

Research Grants

Collaborators

Detail Information

Publications56

  1. pmc Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation
    Suwit Duangmano
    School of Allied Health Science and Public Health, Walailak University, Bangkok, Thailand
    BMC Complement Altern Med 12:185. 2012
    ..Cucurbitacin B is great of interest because of its biological activity. This agent inhibits growth of various types of human cancer cells lines...
  2. pmc Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseases
    Frederick E Domann
    Departments of Radiation Oncology, Surgery, and Pathology Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Int J Mol Sci 14:8491-5. 2013
    ..Together with this deeper understanding, opportunities will arise to devise rational therapeutic interventions to decrease the incidence and severity of these diseases and positively impact the human healthspan...
  3. pmc Epigenetic silencing of DSC3 is a common event in human breast cancer
    Marc M Oshiro
    Department of Pharmacology, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Breast Cancer Res 7:R669-80. 2005
    ..In this study, we examined the prevalence of epigenetic silencing of DSC3 gene expression in primary breast tumor specimens...
  4. ncbi request reprint Epigenetic silencing of maspin gene expression in human breast cancers
    F E Domann
    Free Radical and Radiation Biology Program, Department of Radiology, College of Medicine, University of Iowa and the Iowa Cancer Center, Iowa City, IA 52242, USA
    Int J Cancer 85:805-10. 2000
    ..Thus, aberrant cytosine methylation and heterochromatinization of the maspin promoter may silence maspin gene expression, thereby contributing to the progression of human mammary cancer...
  5. pmc Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis
    Melissa L T Teoh-Fitzgerald
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine and The Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Cancer Res 10:40-51. 2012
    ....
  6. pmc Flipping the epigenetic switch
    Frederick E Domann
    Department of Radiation Oncology, Carver College of Medicine and Holden Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA
    Am J Pathol 164:1883-6. 2004
  7. pmc Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides
    Wei Ying Yue
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Neuro Oncol 13:961-73. 2011
    ..Taken together, these results indicate that persistent JNK activity enhances VS cell survival, at least in part, by suppressing accumulation of mitochondrial superoxides...
  8. ncbi request reprint Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy
    H P Wang
    Free Radical and Radiation Biology Program, Department of Radiology, College of Medicine, The University of Iowa, Iowa City, 52242-1101, USA
    Free Radic Biol Med 30:825-35. 2001
    ..Thus, PhGPx activity could contribute to the resistance of tumor cells to PDT...
  9. ncbi request reprint AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells
    H Li
    Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
    Oncogene 25:5405-15. 2006
    ....
  10. pmc Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells
    B W Darbro
    Interdisciplinary Program in Molecular Biology and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
    Oncogene 25:7421-33. 2006
    ....
  11. ncbi request reprint Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter
    C H Zhu
    Free Radical and Radiation Biology Program, Department of Radiology, The University of Iowa, Iowa City, IA 52242, USA
    Biochim Biophys Acta 1519:85-91. 2001
    ..Our results suggest that transcriptional activation of AP-2 alpha in the SV40-transformed cells is mediated, at least in part, by site-specific methylation of a negative regulatory cis-element in the AP-2 alpha promoter...
  12. ncbi request reprint Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase
    Sarita G Menon
    Department of Microbiology and Immunology, State University of New York at Buffalo School of Medicine, Buffalo, New York, USA
    Cancer Res 67:6392-9. 2007
    ..Scavenging of O(2)(*-) with Tiron reversed the NAC-induced G(1) arrest. These results show that an O(2)(*-) signaling pathway regulates NAC-induced G(1) arrest by decreasing cyclin D1 protein levels and increasing MnSOD activity...
  13. pmc Epigenetic regulation of the cell type-specific gene 14-3-3sigma
    Marc M Oshiro
    Pharmacology and Toxicology, University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA
    Neoplasia 7:799-808. 2005
    ..These findings extend the spectrum of cell type-specific genes controlled, partly, by normal epigenetic mechanisms, and suggest that this subset of genes may represent important targets of epigenetic dysregulation in human cancer...
  14. ncbi request reprint Epigenetic regulation of manganese superoxide dismutase expression in human breast cancer cells
    Michael J Hitchler
    Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, Iowa 52242, USA
    Epigenetics 1:163-71. 2006
    ..These findings indicate that epigenetic silencing of SOD2 constitutes one mechanism leading to the decreased expression of MnSOD observed in many breast cancers...
  15. pmc Regulation of 14-3-3sigma expression in human thyroid carcinoma is epigenetically regulated by aberrant cytosine methylation
    Geeta Lal
    Department of Surgery, Division of Surgical Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 4641 JCP, Iowa City, IA 52242, USA
    Cancer Lett 267:165-74. 2008
    ..In addition, 5-aza-dC treatment increased 14-3-3sigma expression in the FTC-238 and NPA cell lines, which had low baseline expression. We conclude 14-3-3sigma expression in thyroid carcinomas is regulated by CpG island hypermethylation...
  16. pmc Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells
    Rui Zhao
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53792, USA
    Cancer Res 66:2296-304. 2006
    ..Activation of p53 in turn synergistically enhances superoxide production and apoptosis induced by selenite...
  17. ncbi request reprint Dual-expressing adenoviral vectors encoding the sodium iodide symporter for use in noninvasive radiological imaging of therapeutic gene transfer
    Gang Niu
    Free Radical and Radiation Biology Program, The University of Iowa, Iowa City, IA 52242, USA
    Nucl Med Biol 33:391-8. 2006
    ..To image p53 and MnSOD gene transfer noninvasively, we used radiologically detectable dual-expressing adenoviral vectors with the human sodium iodide symporter (hNIS) as the reporter gene...
  18. pmc 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress
    Iman M Ahmad
    Department of Radiography, The Hashemite University, Al Zarqa, Jordan
    Free Radic Biol Med 44:826-34. 2008
    ....
  19. ncbi request reprint Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC)
    Matthew J Provenzano
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA, USA
    Otolaryngol Head Neck Surg 137:722-8. 2007
    ..To determine if epigenetic-modifying drugs can increase iodine uptake in thyroid carcinoma cell lines...
  20. pmc AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cells
    Hualei Li
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA
    Neoplasia 8:568-77. 2006
    ..In summary, expression of either AP-2gamma or AP-2alpha inhibited breast carcinoma cell growth; thus, these genes may be therapeutic targets for breast cancer...
  21. ncbi request reprint RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma
    Geeta Lal
    Department of Surgery, Division of Surgical Oncology, University of Iowa, Iowa City, Iowa, USA
    Cancer 107:2752-9. 2006
    ..RIZ1 expression is lost in a variety of tumors, primarily by means of epigenetic mechanisms that involve promoter hypermethylation...
  22. pmc An epigenetic perspective on the free radical theory of development
    Michael J Hitchler
    Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
    Free Radic Biol Med 43:1023-36. 2007
    ..Moreover, the recent discovery of histone demethylases that require oxygen as a cofactor directly links epigenetic processes to oxygen gradients during development...
  23. pmc Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells
    Rui Zhao
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, K4 868, Clinical Science Center, Box 8550, 600 Highland Avenue, Madison, WI 53792, USA
    Mol Cancer Ther 5:3275-84. 2006
    ..Our study shows that apoptosis induced by SeMet plus METase is superoxide mediated and p53 dependent via mitochondrial pathway(s). These results suggest that superoxide and p53 may play a role in cancer chemoprevention by selenium...
  24. ncbi request reprint Human glioblastoma U87MG cells transduced with a dominant negative p53 (TP53) adenovirus construct undergo radiation-induced mitotic catastrophe
    Fiorenza Ianzini
    Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
    Radiat Res 168:183-92. 2007
    ....
  25. ncbi request reprint A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability
    Van S Tompkins
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, 52242 1109, USA, and the Laboratoire de Genetique Cellulaire et Moleculaire, UPRES EA2622, Centre Hospitalier Universitaire de Poitiers, France
    J Biol Chem 282:1322-33. 2007
    ..This study identifies a novel protein with tumor suppressor-like behaviors and functional links to ARF-MDM2-p53 signaling...
  26. ncbi request reprint Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor
    Min Wang
    Department of Radiation Oncology, Free Radical and Radiation Biology Program, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242 1181, USA
    Oncogene 24:8154-66. 2005
    ..These observations demonstrated that HIF-1alpha accumulation and VEGF expression could be modulated by the antioxidant enzyme MnSOD...
  27. pmc Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control
    Matthew Fitzgerald
    Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
    Neoplasia 5:427-36. 2003
    ..Thus, human pancreatic carcinoma cells acquire maspin expression through epigenetic derepression of the maspin locus, and in so doing appear to co-opt a normal cellular mechanism for the regulation of this gene...
  28. ncbi request reprint Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism
    Joseph J Cullen
    Department of Surgery, University of Iowa College of Medicine, Iowa City, IA, USA
    Cancer Res 63:5513-20. 2003
    ..These mechanisms suggest that altering the intracellular redox environment of pancreatic cancer cells may inhibit growth and delineate a potential strategy directed against pancreatic cancer...
  29. ncbi request reprint v-Ha-ras mitogenic signaling through superoxide and derived reactive oxygen species
    Ji Qin Yang
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, B180 Medical Laboratories, University of Iowa, Iowa City, Iowa, USA
    Mol Carcinog 33:206-18. 2002
    ..This finding suggests that peroxides removed by GPx1, but not by CAT, are also involved in ras-induced transformation...
  30. ncbi request reprint Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth
    Ying Zhang
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, B180 Medical Laboratories, College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Res 62:1205-12. 2002
    ....
  31. ncbi request reprint Multimodality noninvasive imaging of gene transfer using the human sodium iodide symporter
    Gang Niu
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
    J Nucl Med 45:445-9. 2004
    ....
  32. pmc The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells
    George S Watts
    Bone Marrow Transplant Program, Arizona Cancer Center and Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85724, USA
    Neoplasia 6:187-94. 2004
    ..Taken together, the results show that PCAF expression can be induced by wild-type p53...
  33. ncbi request reprint Dominant negative interference of transcription factor AP-2 causes inhibition of ErbB-3 expression and suppresses malignant cell growth
    Chun Hong Zhu
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, and Holden Comprehensive Cancer Center, The University of Iowa, Iowa City 52242, USA
    Breast Cancer Res Treat 71:47-57. 2002
    ..Interference with the function of transcription factor AP-2 might provide a potential strategy for modulation of the malignant phenotype...
  34. ncbi request reprint The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma
    Joseph J Cullen
    Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Cancer Res 63:1297-303. 2003
    ..Overexpression of MnSOD may be effective in growth suppression of pancreatic cancer...
  35. ncbi request reprint MnSOD up-regulates maspin tumor suppressor gene expression in human breast and prostate cancer cells
    Hong Duan
    Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
    Antioxid Redox Signal 5:677-88. 2003
    ..Our findings identify a mechanism underlying MnSOD antitumor effects and provide evidence to support MnSOD as a genetic therapy in the treatment of human breast and prostate cancers...
  36. pmc AP-2 participates in the transcriptional control of the amyloid precursor protein (APP) gene in oral squamous cell carcinoma
    Matthew J Provenzano
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242 1181, USA
    Exp Mol Pathol 83:277-82. 2007
    ..Taken together, these findings demonstrate a role for the transcription factor AP-2alpha in the regulation of APP gene expression in human keratinocytes...
  37. pmc A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns
    Matthew J Provenzano
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242 1181, United States
    Hear Res 233:1-13. 2007
    ..We then examine the evidence of a role for epigenetics in hearing related processes and hearing loss. The article concludes with a discussion of areas of epigenetic research that could be applied to hearing research...
  38. ncbi request reprint Editorial: maspin as a molecular target for cancer therapy
    Frederick E Domann
    J Urol 169:1162-4. 2003
  39. ncbi request reprint Epigenetic regulation of maspin expression in human ovarian carcinoma cells
    Stephen L Rose
    Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, The Holden Comprehensive Cancer Center, 4630 John Colloton Pavilion, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Gynecol Oncol 102:319-24. 2006
    ..The objective of this study was to determine whether gain of maspin expression in ovarian cancer is governed by epigenetic mechanisms...
  40. ncbi request reprint Role for DNA methylation in the control of cell type specific maspin expression
    Bernard W Futscher
    Department of Pharmacology and Toxicology, Bone Marrow Transplant Program, Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Nat Genet 31:175-9. 2002
    ..These findings indicate that cytosine methylation is important in the establishment and maintenance of cell type restricted gene expression...
  41. ncbi request reprint Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia
    Angela M Devlin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 280:25506-11. 2005
    ..05, r = 0.620). We conclude that hyperhomocysteinemia produces tissue-specific changes in H19 DMD methylation and increased vascular expression of H19 in adult mice...
  42. pmc Redox regulation of adenovirus-induced AP-1 activation by overexpression of manganese-containing superoxide dismutase
    Hannah J Zhang
    Department of Exercise Science, Free Radical and Radiation Biology Program Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa 52242, USA
    J Virol 76:355-63. 2002
    ..Furthermore, our results suggest that MnSOD overexpression decreases AP-1 DNA binding activity by regulating intracellular redox status, with the possible involvement of Ref-1 in this redox-sensitive pathway...
  43. ncbi request reprint Redox factor-1 contributes to the regulation of progression from G0/G1 to S by PDGF in vascular smooth muscle cells
    Tongrong He
    Free Radical and Radiation Biology Program, Dept of Radiation Oncology, The University of Iowa, Iowa City, IA 52242 1181, USA
    Am J Physiol Heart Circ Physiol 285:H804-12. 2003
    ..These results suggest that Ref-1 contributes to the regulation of PDGF-BB-stimulated cell cycle progression from G0/G1 to S in SMCs, with one of the possible steps being redox-regulation of AP-1 by Ref-1 protein...
  44. ncbi request reprint Celecoxib toxicity is cell cycle phase specific
    Jonathan M Bock
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Cancer Res 67:3801-8. 2007
    ..We additionally show that a profound inhibition of nuclear E2F function provides a possible mechanism for this S phase-specific toxicity...
  45. ncbi request reprint Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose
    Kelly K Andringa
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Cancer Res 66:1605-10. 2006
    ..These results support the hypothesis that drug combinations capable of inhibiting both glucose and hydroperoxide metabolism may provide an effective biochemical strategy for sensitizing human cancer cells to metabolic oxidative stress...
  46. ncbi request reprint Noninvasive radiological imaging of pulmonary gene transfer and expression using the human sodium iodide symporter
    Gang Niu
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, Roy J and Lucille A Carver College of Medicine, University of Iowa, B 180 Med Labs, Iowa City, IA 52242, USA
    Eur J Nucl Med Mol Imaging 32:534-40. 2005
    ..In this study we investigated the application of the human sodium iodide symporter (hNIS) as a reporter gene to noninvasively image in vivo gene transfer and expression in lung tissue in real time...
  47. ncbi request reprint Genetically targeted radiotherapy of head and neck squamous cell carcinoma using the sodium-iodide symporter (NIS)
    Andrew W Gaut
    Department of Otolaryngology Head and Neck Surgery, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Head Neck 26:265-71. 2004
    ..Gene therapy that uses delivery of the sodium-iodide symporter (NIS) gene followed by radioiodide administration has been proposed as a novel form of radiotherapy for nonthyroidal cancers...
  48. ncbi request reprint Intrinsic radiation resistance in human chondrosarcoma cells
    Farid Moussavi-Harami
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, 52242, USA
    Biochem Biophys Res Commun 346:379-85. 2006
    ..These results support the hypothesis that p16(ink4a) plays a role in the radiation resistance of chondrosarcoma cell lines and suggests that restoring p16 expression will improve the radiation sensitivity of human chondrosarcomas...
  49. ncbi request reprint Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas
    Anna C M Chaves
    Faculdade de Odontologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Int J Oncol 24:295-303. 2004
    ..We conclude that p53 mutations are common among oral cavity cancers in this population, and stress the significance of this study since it is the first analysis of p53 mutation in oral cancer in a southern Brazilian population...
  50. ncbi request reprint Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability
    Benjamin G Slane
    Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA
    Cancer Res 66:7615-20. 2006
    ..These results also allow for the speculation that DNA damage to genes coding for electron transport chain proteins could result in a "mutator phenotype" by increasing steady-state levels of O2(.-) and H2O2...
  51. ncbi request reprint Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen
    Jun Luo
    Free Radical and Radiation Biology Graduate Program, Department of Radiation Oncology, The University of Iowa, Iowa City, 52242, USA
    Antioxid Redox Signal 8:1307-14. 2006
    ....
  52. ncbi request reprint Rapid and direct quantitative RT-PCR method to measure promoter activity
    Lei Yu
    Free Radical and Radiation Program, Radiation Oncology Department, B180 ML, The University of Iowa, Iowa City, Iowa 52242, USA
    Biotechnol Prog 22:1461-3. 2006
    ..The correlation between the endogenous p21 gene expression in response to p53 and the transfected cis element is remarkable. This method is more direct and potentially faster than traditional promoter-reporter assays...
  53. ncbi request reprint Acetaldehyde activates Jun/AP-1 expression and DNA binding activity in human oral keratinocytes
    Sherry R Timmons
    Oral Sciences Graduate Program, B180ML, The University of Iowa, Iowa City, IA 52242, USA
    Oral Oncol 38:281-90. 2002
    ..Taken together, these results suggest that acetaldehyde may participate, at least in part, in the promotion stage of oral carcinogenesis...
  54. ncbi request reprint L-PhGPx expression can be suppressed by antisense oligodeoxynucleotides
    Lingjie Zhao
    Free Radical and Radiation Biology, EMRB 68, The University of Iowa, Iowa City, IA 52242 1101, USA
    Arch Biochem Biophys 417:212-8. 2003
    ..These data demonstrate that PhGPx expression can be manipulated by antisense techniques...
  55. ncbi request reprint Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression
    Marc M Oshiro
    Bone Marrow Transplant Program, Arizona Cancer Center and Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
    Oncogene 22:3624-34. 2003
    ..These results suggest that cancer treatments that target both genetic and epigenetic facets of gene regulation may be a useful strategy towards the therapeutic transcriptional reprogramming of cancer cells...
  56. ncbi request reprint Relative non-steroidal anti-inflammatory drug (NSAID) antiproliferative activity is mediated through p21-induced G1 arrest and E2F inhibition
    Jonathan M Bock
    Department of Otolaryngology Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Mol Carcinog 46:857-64. 2007
    ..These data demonstrate the wide range of activity of various NSAID agents, and reveal a mechanism of action through cell cycle inhibition and induction of apoptosis...

Research Grants8

  1. Epigenetic factors governing SOD2 gene expression
    Frederick Domann; Fiscal Year: 2007
    ..abstract_text> ..
  2. Molecular Species Responsible for Tumor Supressive Effect of MnSOD
    Frederick E Domann; Fiscal Year: 2010
    ..In this way, we hope to be able to develop exciting new cancer therapies. ..