Angela Dolganiuc

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Role of lipid rafts in liver health and disease
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, United States
    World J Gastroenterol 17:2520-35. 2011
  2. pmc T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, LRB 270J, 364 Plantation St, Worcester, MA 01605, USA
    J Leukoc Biol 84:614-22. 2008
  3. doi request reprint Dendritic cells in hepatitis C infection: can they (help) win the battle?
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 270 H, Worcester, MA 01605, USA
    J Gastroenterol 46:432-47. 2011
  4. pmc In vitro and in vivo models of acute alcohol exposure
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States
    World J Gastroenterol 15:1168-77. 2009
  5. pmc Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection
    Angela Dolganiuc
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Gastroenterology 133:1627-36. 2007
  6. ncbi request reprint Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins
    Serena Chang
    Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Leukoc Biol 82:479-87. 2007
  7. doi request reprint The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
    Istvan Hritz
    Department of Medicine, University of Massachusetts Medical School, University of Massachusetts, Worcester, MA 01605, USA
    Hepatology 48:1224-31. 2008
  8. pmc MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Alcohol Clin Exp Res 33:1704-10. 2009
  9. ncbi request reprint Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Leukoc Biol 78:1255-64. 2005
  10. ncbi request reprint Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
    Alcohol Clin Exp Res 29:1018-26. 2005

Collaborators

Detail Information

Publications44

  1. pmc Role of lipid rafts in liver health and disease
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, United States
    World J Gastroenterol 17:2520-35. 2011
    ..We have gathered up-to-date information related to the role of LRs in individual types of liver cells, in liver health and diseases, and identified the possibilities of LR-dependent therapeutic targets in liver diseases...
  2. pmc T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, LRB 270J, 364 Plantation St, Worcester, MA 01605, USA
    J Leukoc Biol 84:614-22. 2008
    ..In this review, we summarize the current knowledge about Tregs as they relate to HCV infection...
  3. doi request reprint Dendritic cells in hepatitis C infection: can they (help) win the battle?
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 270 H, Worcester, MA 01605, USA
    J Gastroenterol 46:432-47. 2011
    ....
  4. pmc In vitro and in vivo models of acute alcohol exposure
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States
    World J Gastroenterol 15:1168-77. 2009
    ..The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research...
  5. pmc Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection
    Angela Dolganiuc
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Gastroenterology 133:1627-36. 2007
    ..Persistent inflammation contributes to progression of liver damage in chronic HCV (cHCV) infection. Repeated exposure to toll-like receptor (TLR) ligands results in tolerance, a protective mechanism aimed at limiting inflammation...
  6. ncbi request reprint Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins
    Serena Chang
    Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Leukoc Biol 82:479-87. 2007
    ..These results imply that multiple pattern recognition receptors could participate in cellular activation by HCV proteins...
  7. doi request reprint The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
    Istvan Hritz
    Department of Medicine, University of Massachusetts Medical School, University of Massachusetts, Worcester, MA 01605, USA
    Hepatology 48:1224-31. 2008
    ..However, the induction of IRF7, an IRF3-inducible gene, was found in Kupffer cells of alcohol-fed WT mice. Alcohol feeding also induced nuclear factor-kappaB activation in a TLR4-dependent MyD88-independent manner...
  8. pmc MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Alcohol Clin Exp Res 33:1704-10. 2009
    ..Each miRNA controls the expression of multiple targets; miRNAs have been linked to regulation of lipid metabolism and inflammation...
  9. ncbi request reprint Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Leukoc Biol 78:1255-64. 2005
    ..These results suggest that although P. acnes triggers TLR2-mediated cell activation, TLR2-independent but MyD88-dependent mechanisms mediate in vivo sensitization by P. acnes for LPS-induced liver injury...
  10. ncbi request reprint Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
    Alcohol Clin Exp Res 29:1018-26. 2005
    ....
  11. doi request reprint Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion
    Istvan Hritz
    Department of Medicine, University of Massachusetts, Medical School, Worcester, MA 01605 2324, USA
    Hepatology 48:1342-7. 2008
    ..These results demonstrate that MyD88 in immune cells rather than in liver parenchymal cells plays an important role in inflammatory cell recruitment and liver injury...
  12. pmc Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice
    Timea Csak
    Department of Medicine, University of Massachusetts, Medical School, Worcester, 01605 2324, USA
    Am J Physiol Gastrointest Liver Physiol 300:G433-41. 2011
    ..In conclusion, our results demonstrate a novel, critical role for LPS recognition complex, including MD-2 and TLR4, through NADPH activation in liver steatosis, and fibrosis in a NASH model in mice...
  13. pmc Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells
    Jan Petrasek
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 53:649-60. 2011
    ..Further, parenchymal cell-derived Type I IFNs increase antiinflammatory and suppress proinflammatory cytokines production by LMNC in paracrine manner...
  14. ncbi request reprint Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Gastroenterology 127:1513-24. 2004
    ..The aim of this study was to investigate the role of TLRs in innate immune cell activation by core and NS3 proteins...
  15. pmc Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice
    Timea Csak
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Hepatology 53:1917-31. 2011
    ..Increased expression of MAVS, PSMA7, and RIP3 messenger RNA was also present in human NASH livers...
  16. doi request reprint Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes
    Oxana Norkina
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Alcohol Clin Exp Res 32:1565-73. 2008
    ..Here we aimed to explore the effect of acute alcohol on induction of SOCS1/SOCS3 and regulation of STAT3/STAT1 pathways induced by IL-6 or IFNs in human monocytes...
  17. ncbi request reprint Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, 01605 2324, USA
    Alcohol Clin Exp Res 27:1023-31. 2003
    ..Here we investigated the effects of HCV infection and alcohol on myeloid dendritic cells (DC) that are critical in antiviral immunity...
  18. ncbi request reprint Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver
    Laszlo Romics
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Hepatology 40:376-85. 2004
    ..Thus, an imbalance between PPAR-mediated anti-inflammatory and NF-kappaB-mediated proinflammatory signals may contribute to increased inflammation in the fatty liver...
  19. ncbi request reprint Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection
    Angela Dolganiuc
    University of Massachusetts Medical School, Department of Medicine, Worcester, MA 01605, USA
    J Immunol 177:6758-68. 2006
    ..These mechanisms are likely to contribute to HCV viral escape from immune responses...
  20. ncbi request reprint Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes
    Oxana Norkina
    University of Massachusetts Medical School, Department of Medicine, LRB 215, 364 Plantation Street, Worcester, MA 01605, USA
    J Leukoc Biol 82:752-62. 2007
    ..Our data suggest that acute alcohol activates Src/STAT3 and Src/MAPK/STAT3, AP-1, and Sp-1 pathways as important mechanisms for IL-10-mediated immunomodulation after acute alcohol use...
  21. ncbi request reprint Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury
    Arumugam Velayudham
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Plantation Street, Worcester, MA 01605, USA
    J Hepatol 45:813-24. 2006
    ..Toll-like receptors (TLR) recognize pathogens and regulate innate immune activation. Here, we investigated the roles of TLR9 and the common TLR adaptor, MyD88, in liver injury...
  22. ncbi request reprint Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes
    Yvonne Drechsler
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Immunol 177:2592-600. 2006
    ..Thus, HO-1 activation is a key mediator of the anti-inflammatory effects of acute alcohol on monocytes...
  23. doi request reprint Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
    Timea Csak
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 54:133-44. 2011
    ..These hepatocyte-derived danger signals, in turn, activate inflammasome, IL-1β, and tumor necrosis factor α release in liver mononuclear cells...
  24. ncbi request reprint Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 40:555-64. 2004
    ..In conclusion, P. acnes priming to selective TLR4-mediated liver injury is associated with up-regulation of TLR4 and MD-2 and is likely to involve IFN-gamma and prevent TLR4 desensitization by P. acnes...
  25. ncbi request reprint Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    Immunobiology 210:237-47. 2005
    ..These data demonstrate that both PDC and MDC functions are impaired in patients with chronic HCV infection and DC defects are likely related to interaction of HCV viral products with innate immune cells...
  26. doi request reprint Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes
    Angela Dolganiuc
    University of Massachusetts Medical School, Department of Medicine, Worcester, Massachusetts 01605 2324, USA
    Gastroenterology 135:2119-27. 2008
    ..This study analyzed the activities of myeloid DCs and distinct CD4(+) T-cell populations in samples collected from patients with HCV...
  27. pmc Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e44915. 2012
    ..We hypothesized that IFN-λ have immunomodulatory effects in HCV- infected individuals...
  28. ncbi request reprint Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 173:3398-407. 2004
    ..Taken together, alcohol both in vitro and in vivo can impair generation of Th1 immune responses via inhibition of DC differentiation and accessory cell function through mechanisms that involve decreased IL-12 induction...
  29. ncbi request reprint Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Alcohol Clin Exp Res 30:76-85. 2006
    ..Alcohol, a substance that is most frequently abused, suppresses innate immune responses to microbial pathogens. The host senses pathogens via Toll-like receptors (TLRs). Recent studies indicate that alcohol affects TLR signaling...
  30. pmc VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice
    Arumugam Velayudham
    Department of Medicine, Liver Center, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Hepatology 49:989-97. 2009
    ..The mechanisms of VSL#3-mediated protection from MCD diet-induced liver fibrosis likely include modulation of collagen expression and impaired TGFbeta signaling...
  31. pmc Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice
    Jan Petrasek
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Gastroenterology 140:697-708.e4. 2011
    ..Activation of TLR9 induces type I interferons (IFNs) via the interferon regulatory factor (IRF)-7. We investigated the roles of type I IFNs in TLR9-associated liver injury...
  32. ncbi request reprint Innate immune response and hepatic inflammation
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Semin Liver Dis 27:339-50. 2007
    ..The specificity of Toll-like receptors and the mechanisms of innate immune cell activation are discussed in relation to acute and chronic liver injury including viral, alcoholic, nonalcoholic, and drug-induced hepatitis...
  33. ncbi request reprint Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 170:5615-24. 2003
    ..Our results reveal that HCV core and NS3 proteins activate monocytes and inhibit DC differentiation in the absence of the intact virus and mediate some of the immunoinhibitory effects of HCV via IL-10 induction...
  34. ncbi request reprint Inhibition of antigen-presenting cell functions by alcohol: implications for hepatitis C virus infection
    Gyongyi Szabo
    Liver Center, Division of Gastroenterology, University of Massachusetts Medical School LRB215, 364 Plantation Street, Worcester, MA 01604, USA
    Alcohol 33:241-9. 2004
    ....
  35. doi request reprint Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes
    Terence N Bukong
    University of Massachusetts Medical School, Worcester, MA, USA
    Liver Int 32:732-41. 2012
    ..Here, we aimed to achieve human (h)ESC differentiation into mature hepatocytes using defined recombinant differentiation factors and metabolites...
  36. ncbi request reprint Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection
    Angela Dolganiuc
    University of Massachusetts Medical School, Department of Medicine, 364 Plantation Street, Worcester, MA 01605 2324, United States
    World J Gastroenterol 12:1198-204. 2006
    ..Recent studies suggest that viral and bacterial infections are more common in HCV-infected patients compared to controls. Pathogens are recognized by Toll-like receptors (TLRs) to shape adaptive and innate immune responses...
  37. ncbi request reprint The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunity
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Crit Rev Immunol 28:61-94. 2008
    ..Specifically, we address the mechanisms of IFNalpha induction and the cooperation between PDC, PDC-derived IFNalpha and T cells, B cells, NK, iNKT, and myeloid dendric cells in antiviral immune responses...
  38. pmc Hepatitis C and innate immunity: recent advances
    Gyongyi Szabo
    Department of Medicine LRB215, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Clin Liver Dis 12:675-92, x. 2008
    ..Finally, current and emerging therapeutic approaches targeting innate immune pathways are evaluated...
  39. ncbi request reprint Altered innate immunity in chronic hepatitis C infection: cause or effect?
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 46:1279-90. 2007
  40. ncbi request reprint TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effects
    Gyongyi Szabo
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 178:1243-9. 2007
    ..EtOH provides an example of an immunomodulatory drug that acts at least in part by modifying lipid rafts, and it could represent a model to probe the relationships between rafts, receptor complexes, and signaling...
  41. ncbi request reprint Pattern recognition receptors: a contemporary view on liver diseases
    Gyongyi Szabo
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 44:287-98. 2006
    ..This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated...
  42. ncbi request reprint HCV immunopathogenesis: virus-induced strategies against host immunity
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 215, Worcester, MA 01605 2324, USA
    Clin Liver Dis 10:753-71. 2006
    ..It is believed that both viral and host factors contribute to the inability of the host immune system to clear the initial infection and lead to the high propensity of chronic HCV infection...
  43. ncbi request reprint Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?
    Pranoti Mandrekar
    University of Massachusetts Medical School, Department of Medicine, Worcester 01605 2324, USA
    Alcohol Clin Exp Res 26:1609-14. 2002
    ..Here we investigated whether acute alcohol treatment of human monocytes also inhibits NF-kappaB when induced through activation of the interleukin (IL)-1 or tumor necrosis factor (TNF) receptors...
  44. ncbi request reprint Hepatitis C core protein - the "core" of immune deception?
    Gyongyi Szabo
    J Hepatol 48:8-11. 2008

Research Grants4

  1. Acute alcohol and calcium-dependent LPS-triggered activation of macrophages
    Angela Dolganiuc; Fiscal Year: 2010
    ..This proposal will address our hypothesis in order to unravel the role of Ca2+ in EtOH-induced impairment of TLR4-mediated innate immune activation. ..
  2. Alcohol disrupts TLR4 signaling in lipid rafts
    Angela Dolganiuc; Fiscal Year: 2007
    ..Investigation of the early steps of LPS signaling may identify strategies for interfering with the effects of LPS and design therapeutic approaches for improving immunity against infections. ..
  3. Acute alcohol and calcium-dependent LPS-triggered activation of macrophages
    Angela Dolganiuc; Fiscal Year: 2009
    ..This proposal will address our hypothesis in order to unravel the role of Ca2+ in EtOH-induced impairment of TLR4-mediated innate immune activation. ..