Yohei Doi

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Genetic environment of 16S rRNA methylase gene rmtD
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 52:2270-2. 2008
  2. pmc Identification of 16S rRNA methylase-producing Acinetobacter baumannii clinical strains in North America
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:4209-10. 2007
  3. pmc High prevalence of metallo-beta-lactamase and 16S rRNA methylase coproduction among imipenem-resistant Pseudomonas aeruginosa isolates in Brazil
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh PA 15213, USA
    Antimicrob Agents Chemother 51:3388-90. 2007
  4. ncbi request reprint 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 45:88-94. 2007
  5. pmc Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:852-6. 2007
  6. pmc Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, S829 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261
    Antimicrob Agents Chemother 52:3837-43. 2008
  7. pmc Simple disk-based method for detection of Klebsiella pneumoniae carbapenemase-type beta-lactamase by use of a boronic acid compound
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Clin Microbiol 46:4083-6. 2008
  8. pmc Mutations of the ompK36 porin gene and promoter impact responses of sequence type 258, KPC-2-producing Klebsiella pneumoniae strains to doripenem and doripenem-colistin
    Cornelius J Clancy
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 57:5258-65. 2013
  9. doi request reprint Interspecies spread of Klebsiella pneumoniae carbapenemase gene in a single patient
    Hanna E Sidjabat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 49:1736-8. 2009
  10. pmc Features of infections due to Klebsiella pneumoniae carbapenemase-producing Escherichia coli: emergence of sequence type 131
    Young Ah Kim
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Clin Infect Dis 55:224-31. 2012

Collaborators

Detail Information

Publications66

  1. pmc Genetic environment of 16S rRNA methylase gene rmtD
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 52:2270-2. 2008
    ..rmtD found in Klebsiella pneumoniae appeared to have been mobilized from P. aeruginosa by an IS26-mediated event...
  2. pmc Identification of 16S rRNA methylase-producing Acinetobacter baumannii clinical strains in North America
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:4209-10. 2007
    ..Two of the isolates coproduced OXA-23 beta-lactamase and were highly resistant to carbapenems as well. The isolates were genetically closely related by pulsed-field gel electrophoresis...
  3. pmc High prevalence of metallo-beta-lactamase and 16S rRNA methylase coproduction among imipenem-resistant Pseudomonas aeruginosa isolates in Brazil
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh PA 15213, USA
    Antimicrob Agents Chemother 51:3388-90. 2007
    ..Of them, 57% and 75% produced SPM-1 and RmtD, respectively. Of note, 51% produced both enzymes, suggesting that their coproduction is already common in this geographic area...
  4. ncbi request reprint 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 45:88-94. 2007
    ..A 2-tiered approach, consisting of disk diffusion tests followed by confirmation with polymerase chain reaction, is recommended for detection of 16S rRNA methylase-mediated resistance...
  5. pmc Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:852-6. 2007
    ..This is also the first report to document coproduction of a metallo-beta-lactamase and a 16S rRNA methylase, a combination that would severely compromise therapeutic options for the infected patients...
  6. pmc Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, S829 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261
    Antimicrob Agents Chemother 52:3837-43. 2008
    ..Fifty-nine percent of the MDR isolates belonged to a single clonal group over the course of the study period, as demonstrated by pulsed-field gel electrophoresis...
  7. pmc Simple disk-based method for detection of Klebsiella pneumoniae carbapenemase-type beta-lactamase by use of a boronic acid compound
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Clin Microbiol 46:4083-6. 2008
    ..When combined with nonsusceptibility to ertapenem, the method was easy to perform and reliably differentiated isolates producing KPC-type beta-lactamases from those producing other types of beta-lactamases...
  8. pmc Mutations of the ompK36 porin gene and promoter impact responses of sequence type 258, KPC-2-producing Klebsiella pneumoniae strains to doripenem and doripenem-colistin
    Cornelius J Clancy
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 57:5258-65. 2013
    ..002). In conclusion, ompK36 genotypes identified ST258 KPC-K. pneumoniae strains that were most likely to respond to doripenem-colistin. ..
  9. doi request reprint Interspecies spread of Klebsiella pneumoniae carbapenemase gene in a single patient
    Hanna E Sidjabat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 49:1736-8. 2009
    ..Molecular typing and plasmid analysis suggested that the KPC gene was acquired by E. coli, most likely from K. pneumoniae, and was subsequently transferred to S. marcescens...
  10. pmc Features of infections due to Klebsiella pneumoniae carbapenemase-producing Escherichia coli: emergence of sequence type 131
    Young Ah Kim
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Clin Infect Dis 55:224-31. 2012
    ..Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become endemic in many US hospitals. On the other hand, KPC-producing Escherichia coli remains rare...
  11. pmc The role of horizontal gene transfer in the dissemination of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates in an endemic setting
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Diagn Microbiol Infect Dis 74:34-8. 2012
    ..HGT among clonally distinct strains contributes to the transmission dynamics of these ESBL-producing Gram-negative bacteria and should be considered when evaluating the spread of these pathogens...
  12. pmc Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens
    Zubair A Qureshi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 56:2108-13. 2012
    ..7% (8/12). The use of combination therapy for definitive therapy appears to be associated with improved survival in bacteremia due to KPC-producing K. pneumoniae...
  13. pmc Clinical characteristics of bloodstream infections due to ampicillin-sulbactam-resistant, non-extended- spectrum-beta-lactamase-producing Escherichia coli and the role of TEM-1 hyperproduction
    Rebecca I Waltner-Toews
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 55:495-501. 2011
    ..These results suggest high-level bla(TEM-1) expression as the predominant cause of ampicillin-sulbactam resistance and also the presence of yet-unidentified factors promoting overexpression of bla(TEM-1) in these isolates...
  14. pmc Clinical features and molecular epidemiology of CMY-type beta-lactamase-producing Escherichia coli
    Hanna E Sidjabat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 48:739-44. 2009
    ..Of the several groups of plasmid-mediated AmpC beta-lactamases, CMY-type beta-lactamase is the most common in the United States...
  15. pmc Colistin-resistant, Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae belonging to the international epidemic clone ST258
    Tatiana Bogdanovich
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 53:373-6. 2011
    ..These cases likely represented both emergence of resistance and transmission of resistant organism. The colistin-resistant isolates were able to persist in the absence of selective pressure in vitro...
  16. pmc Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    J Clin Microbiol 49:3849-54. 2011
    ..S. hospitals constitute part of the global epidemic driven by CC92, but have unique STs other than ST92, which may be spreading by means of patient transfer between health care facilities within the United States...
  17. pmc Molecular epidemiology of CTX-M-producing Escherichia coli isolates at a tertiary medical center in western Pennsylvania
    Hanna E Sidjabat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 53:4733-9. 2009
    ..Our findings underscore the need to further investigate the epidemiology and virulence of CTX-M-producing E. coli in the United States...
  18. pmc Identification of diverse OXA-40 group carbapenemases, including a novel variant, OXA-160, from Acinetobacter baumannii in Pennsylvania
    Guo Bao Tian
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 55:429-32. 2011
    ..The genetic environment of bla(OXA-160) and bla(OXA-40) beyond the putative XerC/XerD recombination sites was distinct from the scaffold reported previously...
  19. pmc Characterization of porin expression in Klebsiella pneumoniae Carbapenemase (KPC)-producing K. pneumoniae identifies isolates most susceptible to the combination of colistin and carbapenems
    Jae H Hong
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 57:2147-53. 2013
    ..In the future, molecular characterization of KPC K. pneumoniae isolates may be a practical tool for identifying effective combination regimens...
  20. pmc Community-associated extended-spectrum β-lactamase-producing Escherichia coli infection in the United States
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, PA 15261, USA
    Clin Infect Dis 56:641-8. 2013
    ..This epidemiologic shift has implications for the empiric management of community-associated infection when involvement of E. coli is suspected...
  21. pmc Extended-spectrum AmpC cephalosporinase in Acinetobacter baumannii: ADC-56 confers resistance to cefepime
    Guo Bao Tian
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Scaife Hall S829, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 55:4922-5. 2011
    ..This permitted cefepime to undergo conformational changes in the active site, with the carboxyl interacting with R340, likely allowing for better binding and turnover...
  22. pmc Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 53:3159-61. 2009
    ..Sequencing of the bla(CMY) genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime...
  23. pmc Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma
    Jessica A O'Hara
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 57:2413-6. 2013
    ..A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization...
  24. pmc Clinical and microbiologic characteristics of cephalosporin-resistant Escherichia coli at three centers in the United States
    Yoon Soo Park
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 56:1870-6. 2012
    ..2% being susceptible due to the predominance of CTX-M-15. These findings have implications in the selection of appropriate empirical therapy when infection due to cephalosporin-resistant E. coli is suspected...
  25. ncbi request reprint Detection of plasmid-mediated class C beta-lactamases
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Int J Infect Dis 11:191-7. 2007
    ....
  26. ncbi request reprint Carbapenem-Resistant Klebsiella pneumoniae Strains Exhibit Diversity in Aminoglycoside-Modifying Enzymes, Which Exert Differing Effects on Plazomicin and Other Agents
    Reem Almaghrabi
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 58:4443-51. 2014
    ..The development of molecular assays that predict antimicrobial responses among carbapenem-resistant K. pneumoniae strains should be a research priority. ..
  27. doi request reprint High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment
    Ryan K Shields
    University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Diagn Microbiol Infect Dis 70:246-52. 2011
    ..Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens...
  28. pmc PME-1, an extended-spectrum β-lactamase identified in Pseudomonas aeruginosa
    Guo Bao Tian
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 55:2710-3. 2011
    ..PME-1 was inhibited well by β-lactamase inhibitors, including clavulanic acid, sulbactam, and tazobactam. The bla(PME-1) gene was carried by an approximately 9-kb plasmid and flanked by tandem ISCR24 elements...
  29. pmc Screening for Acinetobacter baumannii colonization by use of sponges
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Scaife Hall S829, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 49:154-8. 2011
    ..003). The combined sensitivity for the upper arm and leg with a sponge was 89.1%. The novel screening method using sterile sponges was easy to perform and achieved excellent sensitivity for the detection of A. baumannii colonization...
  30. doi request reprint Risk factors and outcome of extended-spectrum β-lactamase-producing Enterobacter cloacae bloodstream infections
    Zubair A Qureshi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Int J Antimicrob Agents 37:26-32. 2011
    ..The majority of isolates produced SHV-type ESBL, whereas two isolates produced CTX-M-type ESBL. Initial therapy with a carbapenem appears to be associated with improved clinical outcome in BSI due to ESBL-producing E. cloacae...
  31. pmc In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem
    Louise M Oleksiuk
    Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 58:1195-9. 2014
    ..Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus -2.43; P = 0.04). ..
  32. ncbi request reprint Molecular Epidemiology of KPC-Producing Escherichia coli: Occurrence of ST131-fimH30 Subclone Harboring pKpQIL-Like IncFIIk Plasmid
    Jessica A O'Hara
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 58:4234-7. 2014
    ..IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Three blaKPC-carrying plasmids (IncA/C and IncN) possessed blaSHV-7/12 and qnrA1 or qnrS1. ..
  33. ncbi request reprint Epidemiology and Clinical Outcomes of Patients with Carbapenem-Resistant Klebsiella pneumoniae Bacteriuria
    Zubair A Qureshi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 58:3100-4. 2014
    ..Factors associated with UTIs included male sex, solid-organ transplantation, and neurogenic bladder. Doxycycline may be an effective therapy for CRKP UTIs. ..
  34. ncbi request reprint Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients
    Yuriko Fukuta
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Am J Infect Control 41:1249-52. 2013
    ..Data regarding multidrug-resistant (MDR) Acinetobacter baumannii infections among cancer patients are limited...
  35. pmc Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae
    Dora Szabo
    Division of Infectious Diseases, University of Pittsburgh Medical Center, PA 15213, USA
    Antimicrob Agents Chemother 50:2833-5. 2006
    ..Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance...
  36. ncbi request reprint Safety and efficacy of long-term outpatient ertapenem therapy
    Zubair A Qureshi
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 58:3437-40. 2014
    ..Of the 6 patients who experienced clinical failure, 2 had adverse events leading to discontinuation of therapy and 4 required additional source control for clinical success. In addition, 2 patients had recurrent infection at 6 months. ..
  37. ncbi request reprint Escherichia coli sequence type 131: epidemiology and challenges in treatment
    Zubair A Qureshi
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Expert Rev Anti Infect Ther 12:597-609. 2014
    ..There is a growing interest in reevaluating oral agents including fosfomycin and pivmecillinam for less serious infections such as uncomplicated cystitis. ..
  38. pmc Rational design of engineered cationic antimicrobial peptides consisting exclusively of arginine and tryptophan, and their activity against multidrug-resistant pathogens
    Berthony Deslouches
    Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 57:2511-21. 2013
    ..The results demonstrate that the rational design of CAPs can lead to a significant reduction in the length and the number of amino acids used in peptide design to achieve optimal potency and selectivity against specific pathogens...
  39. ncbi request reprint [Antimicrobial resistance testing in clinical practice]
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, USA
    Nihon Rinsho 70:272-5. 2012
    ..Antimicrobial resistance testing plays a crucial role in patient management, infection control and monitoring of local as well as national and international epidemiology...
  40. pmc Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class a beta-lactamase, GES-3, in a neonatal intensive care unit in Japan
    Jun ichi Wachino
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 48:1960-7. 2004
    ..These findings suggest that within the NICU setting genetically related K. pneumoniae strains carrying the bla(GES) gene were ambushed with genetic rearrangements that caused the multiplication and translocation of the bla(GES) gene...
  41. pmc Plasmid-mediated 16S rRNA methylase in Serratia marcescens conferring high-level resistance to aminoglycosides
    Yohei Doi
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan
    Antimicrob Agents Chemother 48:491-6. 2004
    ..aeruginosa in Japan. This is a cause for concern since other treatment options are often limited in patients requiring highly potent aminoglycosides such as amikacin and tobramycin...
  42. ncbi request reprint Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa
    Keiko Yokoyama
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Lancet 362:1888-93. 2003
    ..We aimed to clone and characterise the genetic determinant of this resistance...
  43. pmc Characterization of a novel plasmid-mediated cephalosporinase (CMY-9) and its genetic environment in an Escherichia coli clinical isolate
    Yohei Doi
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gauken, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 46:2427-34. 2002
    ..bla(CMY-9) was closely located downstream of the end of the common region. These observations are indicative of the exogenous derivation of bla(CMY-9) from some environmental microorganisms such as aeromonads...
  44. ncbi request reprint [IMP-1 type metalo-beta-lactamase producing Serratia marcescens strains isolated from blood culture between 1991 to 2000]
    Tatsuya Nakamura
    Clinical Central Laboratory, Kansai Medical University Hospital
    Kansenshogaku Zasshi 76:246-53. 2002
    ..It cannot be excluded that the resistant bacteria spread as the amount of carbapenem consumption increased. Prudent use of antibiotics is mandatory to prevent further dissemination of such MBL producers...
  45. pmc Novel plasmid-mediated 16S rRNA methylase, RmtC, found in a proteus mirabilis isolate demonstrating extraordinary high-level resistance against various aminoglycosides
    Jun ichi Wachino
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 50:178-84. 2006
    ..The acceleration of aminoglycoside resistance among gram-negative bacilli by producing plasmid-mediated 16S rRNA methylases, such as RmtC, RmtB, and RmtA, may indeed become an actual clinical hazard in the near future...
  46. ncbi request reprint Characterization of Klebsiella pneumoniae and Escherichia coli strains that produce CTX-M-2-type broad spectrum beta-lactamase isolated from a child with leukemia
    Toshiya Ohkawa
    Department of Pediatrics, Faculty of Medicine, Kagoshima University, Japan
    Pediatr Infect Dis J 21:260-2. 2002
    ..Patients with frequent episodes of neutropenia and prophylactic administration of beta-lactams are at risk of harboring colonizing strains that produce broad spectrum beta-lactamases...
  47. pmc Genetic environments of the rmtA gene in Pseudomonas aeruginosa clinical isolates
    Kunikazu Yamane
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 48:2069-74. 2004
    ....
  48. pmc Spread of novel aminoglycoside resistance gene aac(6')-Iad among Acinetobacter clinical isolates in Japan
    Yohei Doi
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1, Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 48:2075-80. 2004
    ..These results suggest that aac(6')-Iad plays a substantial role in amikacin resistance among Acinetobacter spp. in Japan...
  49. doi request reprint Community-acquired extended-spectrum beta-lactamase producers, United States
    Yohei Doi
    Emerg Infect Dis 13:1121-3. 2007
  50. pmc 16S ribosomal RNA methylase RmtD produced by Klebsiella pneumoniae in Brazil
    Kunikazu Yamane
    J Antimicrob Chemother 61:746-7. 2008
  51. pmc Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil
    Doroti de Oliveira Garcia
    Instituto Adolfo Lutz, Sao Paulo, Brazil
    Antimicrob Agents Chemother 52:1790-3. 2008
    ..Of the 10 pulsotypes identified during the outbreak and follow-up periods, nine produced CTX-M-2 or its new variant CTX-M-59 and one produced SHV-5. bla(CTX-M-2/59) genes were located on closely related plasmids that were transferable...
  52. pmc High prevalence of CTX-M-15-producing Klebsiella pneumoniae among inpatients and outpatients with urinary tract infection in Southern India
    - Muzaheed
    J Antimicrob Chemother 61:1393-4. 2008
  53. pmc Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans
    Yohei Doi
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté deMédecine Paris Sud, Universite Paris XI, 94275 K Bicêtre, France
    Antimicrob Agents Chemother 52:1952-6. 2008
    ..xylosoxidans strains tested (n = 5), indicating that this beta-lactamase is naturally occurring in that species. Induction experiments with imipenem and cefoxitin did not show inducibility of bla(OXA-114) expression...
  54. pmc Nomenclature of plasmid-mediated 16S rRNA methylases responsible for panaminoglycoside resistance
    Yohei Doi
    Antimicrob Agents Chemother 52:2287-8. 2008
  55. pmc Escherichia coli isolate coproducing 16S rRNA Methylase and CTX-M-type extended-spectrum beta-lactamase isolated from an outpatient in the United States
    Yohei Doi
    Antimicrob Agents Chemother 52:1204-5. 2008
  56. pmc Global spread of multiple aminoglycoside resistance genes
    Kunikazu Yamane
    National Institute of Infectious Diseases, Tokyo, Japan
    Emerg Infect Dis 11:951-3. 2005
    ..ArmA, which had been identified exclusively in Europe, was also found in several gram-negative pathogenic bacilli isolated in Japan, suggesting global dissemination of hazardous multiple aminoglycoside resistance genes...
  57. pmc Practical methods using boronic acid compounds for identification of class C beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli
    Tetsuya Yagi
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    J Clin Microbiol 43:2551-8. 2005
    ..These methods will provide useful information needed for targeted antimicrobial therapy and better infection control...
  58. pmc Inhibitor-sensitive AmpC beta-lactamase variant produced by an Escherichia coli clinical isolate resistant to oxyiminocephalosporins and cephamycins
    Yohei Doi
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 48:2652-8. 2004
    ..To our knowledge, this is the first report to have characterized an E. coli ampC that encodes chromosomal AmpC beta-lactamase sensitive to the available beta-lactamase inhibitors...
  59. pmc Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop
    Jun ichi Wachino
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Musashi Murayama, Tokyo, Japan
    Antimicrob Agents Chemother 48:2905-10. 2004
    ....
  60. ncbi request reprint A step closer to extreme drug resistance (XDR) in gram-negative bacilli
    David L Paterson
    Clin Infect Dis 45:1179-81. 2007
  61. ncbi request reprint A novel apoptosis-inducing protein from Helicobacter pylori
    Keigo Shibayama
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Mol Microbiol 47:443-51. 2003
    ..pylori-mediated apoptosis. Our findings provide new insights into H. pylori pathogenicity and reveal a novel aspect of the bacterial gamma-glutamyl transpeptidase function...
  62. pmc PCR typing of genetic determinants for metallo-beta-lactamases and integrases carried by gram-negative bacteria isolated in Japan, with focus on the class 3 integron
    Naohiro Shibata
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 41:5407-13. 2003
    ..In the present study, it was confirmed that strains carrying bla(IMP-1) with a class 1 integron are the most prevalent type in Japan, although several intI3 carriers have also been identified sporadically in this country...
  63. pmc A new TEM-derived extended-spectrum beta-lactamase (TEM-91) with an R164C substitution at the omega-loop confers ceftazidime resistance
    Hiroshi Kurokawa
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan
    Antimicrob Agents Chemother 47:2981-3. 2003
    ..The isoelectric point (pI), K(m), and k(cat) of TEM-91 for ceftazidime were 5.7, 179 microM, and 29.0 s(-1), respectively. The K(i) of clavulanic acid for ceftazidime hydrolysis was 30.3 nM...
  64. pmc KPC type beta-lactamase, rural Pennsylvania
    Jonathan Pope
    Emerg Infect Dis 12:1613-4. 2006
  65. pmc PCR classification of CTX-M-type beta-lactamase genes identified in clinically isolated gram-negative bacilli in Japan
    Naohiro Shibata
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan
    Antimicrob Agents Chemother 50:791-5. 2006
    ..Fifty-seven, 161, and 99 strains harbored bla(CTX-M) genes belonging to the bla(CTX-M-1), bla(CTX-M-2), and bla(CTX-M-9) clusters, respectively...
  66. pmc Escherichia coli producing CTX-M-2 beta-lactamase in cattle, Japan
    Yutaka Shiraki
    Gifu Prefectural Office of Meat Inspection, Gifu, Japan
    Emerg Infect Dis 10:69-75. 2004
    ..coli. Continuous and strategic surveillance of antimicrobial-resistant bacteria in livestock is essential to suppress further dissemination of these bacteria into society at large...