Research Topics
| Ranjan DohilSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Treatment of cystinosis with delayed-release cysteamine: 6-year follow-upRanjan Dohil
Department of Pediatrics, Rady Children s Hospital San Diego, University of California San Diego, 3030 Children s Way, San Diego, CA 92123, USA
Pediatr Nephrol 28:507-10. 2013....- Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitisRanjan Dohil
Departments of Pediatrics and Pathology, University of California, San Diego, La Jolla, CA, USA
Dig Dis Sci 57:1413-9. 2012..The mechanisms of PPIRee and whether this represents a sub-phenotype of GERD, a sub-phenotype of EoE, or its own distinct entity remain unclear... - Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trialRanjan Dohil
Departments of Pediatrics and Pathology, University of California, San Diego, La Jolla, California and Rady Children s Hospital San Diego, San Diego, California 92103 8450, USA
Gastroenterology 139:418-29. 2010..The diagnosis is considered if >or=15 eosinophils per high-powered field (eos/hpf) are detected in mucosal biopsies. Placebo-controlled studies have not been conducted to evaluate the safety and efficacy of oral viscous budesonide (OVB)... - Long-term treatment of cystinosis in children with twice-daily cysteamineRanjan Dohil
Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
J Pediatr 156:823-7. 2010..A recent study showed that an enteric-release cysteamine required less frequent daily dosing. This report describes the long-term use of enteric-coated (EC) cysteamine bitartrate (Cystagon) in children with cystinosis... - Twice-daily cysteamine bitartrate therapy for children with cystinosisRanjan Dohil
Department of Pediatrics, University of California San Diego, La Jolla, CA 92103 8450, USA
J Pediatr 156:71-75.e1-3. 2010..A formulation of cysteamine requiring less frequent dosing may improve compliance and possibly patient outcome... 
The evaluation and treatment of gastrointestinal disease in children with cystinosis receiving cysteamineRanjan Dohil
Department of Pediatrics, University of California San Diego, UCSD Medical Center, Hillcrest, 200 West Arbor Drive, San Diego, CA 92103 8450, USA
J Pediatr 143:224-30. 2003..Cysteamine prevents organ damage in children with cystinosis, but may cause gastrointestinal (GI) symptoms. In this study we evaluated the nature of GI disease, and the value of omeprazole in controlling GI symptoms in these children...- Esomeprazole therapy for gastric acid hypersecretion in children with cystinosisRanjan Dohil
UCSD Medical Center, San Diego, CA 92103 8450, USA
Pediatr Nephrol 20:1786-93. 2005..Cysteamine-induced gastric acid-hypersecretion and GI symptoms are dramatically reduced with esomeprazole therapy. Esomeprazole does not alter cysteamine absorption and is very well tolerated in children... - Understanding intestinal cysteamine bitartrate absorptionRanjan Dohil
Department of Pediatrics, University of California, San Diego, La Jolla, California 92103 8450, USA
J Pediatr 148:764-9. 2006..To test the hypothesis that a controlled-release preparation of cysteamine, with fewer daily administrations, would improve the quality of life for patients with cystinosis... 
Pharmacokinetics of enteric-coated cysteamine bitartrate in healthy adults: a pilot studyJon A Gangoiti
Department of Paediatrics, University of California, San Diego, La Jolla, California, USA
Br J Clin Pharmacol 70:376-82. 2010..Recent studies using cysteamine for for other diseases such as neurodegenerative disorders adopt the same dosing regimen for cysteamine. Regular cysteamine bitartrate (Cystagon) may cause upper gastrointestinal symptoms in some patients...- Pharmacokinetics of cysteamine bitartrate following gastrointestinal infusionMeredith C Fidler
Department of Paediatrics and Family, University of California at San Diego, La Jolla, California, USA
Br J Clin Pharmacol 63:36-40. 2007..The aim of te study was to understand the pharmacokinetics of cysteamine bitartrate following gastrointestinal infusion... - Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contractionSeema S Aceves
Division of Allergy and Immunology, University of California and Rady Children s Hospital, San Diego, USA
J Allergy Clin Immunol 126:1198-204.e4. 2010..However, mast cell infiltration into the esophageal lamina propria (LP) and smooth muscle (SM) and the effects of their products on SM function has not been determined... - Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in childrenSeema S Aceves
Division of Allergy and Immunology, Children s Hospital, San Diego, La Jolla, California, USA
Am J Gastroenterol 102:2271-9; quiz 2280. 2007..Eosinophilic esophagitis (EE) is a disorder characterized typically by pan-esophageal eosinophilia. We evaluate a palatable, long-acting topical corticosteroid preparation for the treatment of EE... - Distinguishing eosinophilic esophagitis in pediatric patients: clinical, endoscopic, and histologic features of an emerging disorderSeema S Aceves
Division of Allergy, Rady Children s Hospital San Diego, University of California, San Diego, CA 92123, USA
J Clin Gastroenterol 41:252-6. 2007..To determine the clinical, endoscopic, and histologic criteria that distinguish children with eosinophilic esophagitis (EE) from those with non-EE diagnoses... - Esophageal remodeling in pediatric eosinophilic esophagitisSeema S Aceves
Division of Allergy, Immunology, Children s Hospital, San Diego, and the University of California, San Diego, CA 92123, USA
J Allergy Clin Immunol 119:206-12. 2007..Eosinophils are associated with airway remodeling in asthma, but studies have not yet determined whether eosinophilic esophagitis (EE) is associated with esophageal remodeling... - A potential new method to estimate tissue cystine content in nephropathic cystinosisRanjan Dohil
Departments of Pediatrics and Pathology, University of California, San Diego, La Jolla, CA, USA
J Pediatr 161:531-535.e1. 2012..To evaluate intestinal mucosal cystine crystal (CC) load as a way to estimate tissue cystine content in children with cystinosis... - The effect of cysteamine bitartrate on adiponectin multimerization in non-alcoholic fatty liver disease and healthy subjectsRanjan Dohil
Department of Pediatrics, University of California, San Diego, San Diego, CA 92103 8450, USA
J Pediatr 161:639-45.e1. 2012..To determine the effects of cysteamine on adiponectin multimerization in sera of patients with nonalcoholic fatty liver disease (NAFLD)... - Esophagogastric disconnection following failed fundoplication for the treatment of gastroesophageal reflux disease (GERD) in children with severe neurological impairmentSilvia Buratti
Division of Pediatric Gastroenterology and Nutrition, University of California San Diego and Children's Hospital, 200 West Arbor Drive, San Diego, CA 92103-8450, USA
Pediatr Surg Int 20:786-90. 2004..Esophagogastric disconnection for the treatment of GERD in neurologically impaired children is associated with major complications and should be considered after more conservative procedures fail... - Heat shock protein-derived T-cell epitopes contribute to autoimmune inflammation in pediatric Crohn's diseaseGisella L Puga Yung
Department of Medicine Pediatrics, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 4:e7714. 2009..The responses correlated positively with clinical and histological measurements of disease activity, thus suggesting a contribution of immune responses to HSP in pediatric CD site-specific mucosal inflammation... - Successful liver transplantation in a child with severe portopulmonary hypertension treated with epoprostenolAhmed Laving
Division of Pediatric Gastroenterology and Nutrition, University of California, San Diego, California 92103, USA
J Pediatr Gastroenterol Nutr 41:466-8. 2005