Ranjan Dohil

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Treatment of cystinosis with delayed-release cysteamine: 6-year follow-up
    Ranjan Dohil
    Department of Pediatrics, Rady Children s Hospital San Diego, University of California San Diego, 3030 Children s Way, San Diego, CA 92123, USA
    Pediatr Nephrol 28:507-10. 2013
  2. doi request reprint Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitis
    Ranjan Dohil
    Departments of Pediatrics and Pathology, University of California, San Diego, La Jolla, CA, USA
    Dig Dis Sci 57:1413-9. 2012
  3. ncbi request reprint The evaluation and treatment of gastrointestinal disease in children with cystinosis receiving cysteamine
    Ranjan Dohil
    Department of Pediatrics, University of California San Diego, UCSD Medical Center, Hillcrest, 200 West Arbor Drive, San Diego, CA 92103 8450, USA
    J Pediatr 143:224-30. 2003
  4. doi request reprint Long-term treatment of cystinosis in children with twice-daily cysteamine
    Ranjan Dohil
    Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Pediatr 156:823-7. 2010
  5. doi request reprint Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial
    Ranjan Dohil
    Departments of Pediatrics and Pathology, University of California, San Diego, La Jolla, California and Rady Children s Hospital San Diego, San Diego, California 92103 8450, USA
    Gastroenterology 139:418-29. 2010
  6. doi request reprint Twice-daily cysteamine bitartrate therapy for children with cystinosis
    Ranjan Dohil
    Department of Pediatrics, University of California San Diego, La Jolla, CA 92103 8450, USA
    J Pediatr 156:71-75.e1-3. 2010
  7. ncbi request reprint Understanding intestinal cysteamine bitartrate absorption
    Ranjan Dohil
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92103 8450, USA
    J Pediatr 148:764-9. 2006
  8. ncbi request reprint Esomeprazole therapy for gastric acid hypersecretion in children with cystinosis
    Ranjan Dohil
    UCSD Medical Center, San Diego, CA 92103 8450, USA
    Pediatr Nephrol 20:1786-93. 2005
  9. pmc Pharmacokinetics of enteric-coated cysteamine bitartrate in healthy adults: a pilot study
    Jon A Gangoiti
    Department of Paediatrics, University of California, San Diego, La Jolla, California, USA
    Br J Clin Pharmacol 70:376-82. 2010
  10. pmc Pharmacokinetics of cysteamine bitartrate following gastrointestinal infusion
    Meredith C Fidler
    Department of Paediatrics and Family, University of California at San Diego, La Jolla, California, USA
    Br J Clin Pharmacol 63:36-40. 2007

Collaborators

  • Seema S Aceves
  • Joel E Lavine
  • Susan A Phillips
  • Ajai Khanna
  • Lewis Rubin
  • Berent Prakken
  • D Broide
  • Jon A Gangoiti
  • Iris M Otani
  • Meredith Fidler
  • Gisella L Puga Yung
  • Bruce A Barshop
  • Jerry A Schneider
  • Meredith C Fidler
  • Ahmed Laving
  • Silvia Buratti
  • Lisa Y Beppu
  • Arjun A Anilkumar
  • Monica Bhagat
  • Robert O Newbury
  • Betty L Cabrera
  • Theo van den Broek
  • Rosario Billetta
  • Robert Newbury
  • Naomi Spermon
  • Erika Albani
  • Nicole Schechter
  • Salvatore Albani
  • Gijs Teklenburg
  • Reena Deutsch
  • Michael Martin
  • Frank Ing
  • David Collins
  • Rose Kamenwa

Detail Information

Publications20

  1. doi request reprint Treatment of cystinosis with delayed-release cysteamine: 6-year follow-up
    Ranjan Dohil
    Department of Pediatrics, Rady Children s Hospital San Diego, University of California San Diego, 3030 Children s Way, San Diego, CA 92123, USA
    Pediatr Nephrol 28:507-10. 2013
    ..Enteric-coated cysteamine bitartrate (EC-cysteamine) was developed as a "proof-of-concept" formulation for twice-daily ingestion. Previous reports have shown this therapy to be effective up to a mean of 14 months...
  2. doi request reprint Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitis
    Ranjan Dohil
    Departments of Pediatrics and Pathology, University of California, San Diego, La Jolla, CA, USA
    Dig Dis Sci 57:1413-9. 2012
    ..The mechanisms of PPIRee and whether this represents a sub-phenotype of GERD, a sub-phenotype of EoE, or its own distinct entity remain unclear...
  3. ncbi request reprint The evaluation and treatment of gastrointestinal disease in children with cystinosis receiving cysteamine
    Ranjan Dohil
    Department of Pediatrics, University of California San Diego, UCSD Medical Center, Hillcrest, 200 West Arbor Drive, San Diego, CA 92103 8450, USA
    J Pediatr 143:224-30. 2003
    ..Cysteamine prevents organ damage in children with cystinosis, but may cause gastrointestinal (GI) symptoms. In this study we evaluated the nature of GI disease, and the value of omeprazole in controlling GI symptoms in these children...
  4. doi request reprint Long-term treatment of cystinosis in children with twice-daily cysteamine
    Ranjan Dohil
    Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Pediatr 156:823-7. 2010
    ..A recent study showed that an enteric-release cysteamine required less frequent daily dosing. This report describes the long-term use of enteric-coated (EC) cysteamine bitartrate (Cystagon) in children with cystinosis...
  5. doi request reprint Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial
    Ranjan Dohil
    Departments of Pediatrics and Pathology, University of California, San Diego, La Jolla, California and Rady Children s Hospital San Diego, San Diego, California 92103 8450, USA
    Gastroenterology 139:418-29. 2010
    ..The diagnosis is considered if >or=15 eosinophils per high-powered field (eos/hpf) are detected in mucosal biopsies. Placebo-controlled studies have not been conducted to evaluate the safety and efficacy of oral viscous budesonide (OVB)...
  6. doi request reprint Twice-daily cysteamine bitartrate therapy for children with cystinosis
    Ranjan Dohil
    Department of Pediatrics, University of California San Diego, La Jolla, CA 92103 8450, USA
    J Pediatr 156:71-75.e1-3. 2010
    ..A formulation of cysteamine requiring less frequent dosing may improve compliance and possibly patient outcome...
  7. ncbi request reprint Understanding intestinal cysteamine bitartrate absorption
    Ranjan Dohil
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92103 8450, USA
    J Pediatr 148:764-9. 2006
    ..To test the hypothesis that a controlled-release preparation of cysteamine, with fewer daily administrations, would improve the quality of life for patients with cystinosis...
  8. ncbi request reprint Esomeprazole therapy for gastric acid hypersecretion in children with cystinosis
    Ranjan Dohil
    UCSD Medical Center, San Diego, CA 92103 8450, USA
    Pediatr Nephrol 20:1786-93. 2005
    ..Cysteamine-induced gastric acid-hypersecretion and GI symptoms are dramatically reduced with esomeprazole therapy. Esomeprazole does not alter cysteamine absorption and is very well tolerated in children...
  9. pmc Pharmacokinetics of enteric-coated cysteamine bitartrate in healthy adults: a pilot study
    Jon A Gangoiti
    Department of Paediatrics, University of California, San Diego, La Jolla, California, USA
    Br J Clin Pharmacol 70:376-82. 2010
    ..Recent studies using cysteamine for for other diseases such as neurodegenerative disorders adopt the same dosing regimen for cysteamine. Regular cysteamine bitartrate (Cystagon) may cause upper gastrointestinal symptoms in some patients...
  10. pmc Pharmacokinetics of cysteamine bitartrate following gastrointestinal infusion
    Meredith C Fidler
    Department of Paediatrics and Family, University of California at San Diego, La Jolla, California, USA
    Br J Clin Pharmacol 63:36-40. 2007
    ..The aim of te study was to understand the pharmacokinetics of cysteamine bitartrate following gastrointestinal infusion...
  11. pmc Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis
    Iris M Otani
    Division of Allergy and Immunology, University of California, San Diego, Rady Children s Hospital, San Diego, Calif, USA
    J Allergy Clin Immunol 131:1576-82. 2013
    ..IL-5 is essential for eosinophil trafficking, and anti-IL-5 therapy decreases esophageal eosinophilia. EoE is associated with prominent mast cell infiltration...
  12. doi request reprint A potential new method to estimate tissue cystine content in nephropathic cystinosis
    Ranjan Dohil
    Departments of Pediatrics and Pathology, University of California, San Diego, La Jolla, CA, USA
    J Pediatr 161:531-535.e1. 2012
    ..To evaluate intestinal mucosal cystine crystal (CC) load as a way to estimate tissue cystine content in children with cystinosis...
  13. doi request reprint Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction
    Seema S Aceves
    Division of Allergy and Immunology, University of California and Rady Children s Hospital, San Diego, USA
    J Allergy Clin Immunol 126:1198-204.e4. 2010
    ..However, mast cell infiltration into the esophageal lamina propria (LP) and smooth muscle (SM) and the effects of their products on SM function has not been determined...
  14. ncbi request reprint Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in children
    Seema S Aceves
    Division of Allergy and Immunology, Children s Hospital, San Diego, La Jolla, California, USA
    Am J Gastroenterol 102:2271-9; quiz 2280. 2007
    ..Eosinophilic esophagitis (EE) is a disorder characterized typically by pan-esophageal eosinophilia. We evaluate a palatable, long-acting topical corticosteroid preparation for the treatment of EE...
  15. ncbi request reprint Distinguishing eosinophilic esophagitis in pediatric patients: clinical, endoscopic, and histologic features of an emerging disorder
    Seema S Aceves
    Division of Allergy, Rady Children s Hospital San Diego, University of California, San Diego, CA 92123, USA
    J Clin Gastroenterol 41:252-6. 2007
    ..To determine the clinical, endoscopic, and histologic criteria that distinguish children with eosinophilic esophagitis (EE) from those with non-EE diagnoses...
  16. ncbi request reprint Esophageal remodeling in pediatric eosinophilic esophagitis
    Seema S Aceves
    Division of Allergy, Immunology, Children s Hospital, San Diego, and the University of California, San Diego, CA 92123, USA
    J Allergy Clin Immunol 119:206-12. 2007
    ..Eosinophils are associated with airway remodeling in asthma, but studies have not yet determined whether eosinophilic esophagitis (EE) is associated with esophageal remodeling...
  17. doi request reprint The effect of cysteamine bitartrate on adiponectin multimerization in non-alcoholic fatty liver disease and healthy subjects
    Ranjan Dohil
    Department of Pediatrics, University of California, San Diego, San Diego, CA 92103 8450, USA
    J Pediatr 161:639-45.e1. 2012
    ..To determine the effects of cysteamine on adiponectin multimerization in sera of patients with nonalcoholic fatty liver disease (NAFLD)...
  18. ncbi request reprint Esophagogastric disconnection following failed fundoplication for the treatment of gastroesophageal reflux disease (GERD) in children with severe neurological impairment
    Silvia Buratti
    Division of Pediatric Gastroenterology and Nutrition, University of California San Diego and Children s Hospital, 200 West Arbor Drive, San Diego, CA 92103 8450, USA
    Pediatr Surg Int 20:786-90. 2004
    ..Esophagogastric disconnection for the treatment of GERD in neurologically impaired children is associated with major complications and should be considered after more conservative procedures fail...
  19. pmc Heat shock protein-derived T-cell epitopes contribute to autoimmune inflammation in pediatric Crohn's disease
    Gisella L Puga Yung
    Department of Medicine Pediatrics, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 4:e7714. 2009
    ..The responses correlated positively with clinical and histological measurements of disease activity, thus suggesting a contribution of immune responses to HSP in pediatric CD site-specific mucosal inflammation...
  20. ncbi request reprint Successful liver transplantation in a child with severe portopulmonary hypertension treated with epoprostenol
    Ahmed Laving
    Division of Pediatric Gastroenterology and Nutrition, University of California, San Diego, California 92103, USA
    J Pediatr Gastroenterol Nutr 41:466-8. 2005