G V Doern

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc A pharmacodynamic analysis of resistance trends in pathogens from patients with infection in intensive care units in the United States between 1993 and 2004
    Kathryn J Eagye
    Center for Anti Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
    Ann Clin Microbiol Antimicrob 6:11. 2007
  2. pmc Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999--2000, including a comparison of resistance rates since 1994--1995
    G V Doern
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Antimicrob Agents Chemother 45:1721-9. 2001
  3. ncbi request reprint Antimicrobial resistance among Streptococcus pneumoniae in the United States: have we begun to turn the corner on resistance to certain antimicrobial classes?
    Gary V Doern
    Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Infect Dis 41:139-48. 2005
  4. ncbi request reprint Macrolide and ketolide resistance with Streptococcus pneumoniae
    Gary V Doern
    Clinical Microbiology Laboratories, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Med Clin North Am 90:1109-24. 2006
  5. ncbi request reprint Antimicrobial resistance with Streptococcus pneumoniae: much ado about nothing?
    G V Doern
    Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Semin Respir Infect 16:177-85. 2001
  6. ncbi request reprint Optimizing the management of community-acquired respiratory tract infections in the age of antimicrobial resistance
    Gary V Doern
    University of Iowa, College of Medicine, Iowa City, Iowa, USA
    Expert Rev Anti Infect Ther 4:821-35. 2006
  7. ncbi request reprint Antimicrobial use and the emergence of antimicrobial resistance with Streptococcus pneumoniae in the United States
    G V Doern
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Infect Dis 33:S187-92. 2001
  8. ncbi request reprint Activity of oral beta-lactam antimicrobial agents versus respiratory tract isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the era of antibiotic resistance
    Gary V Doern
    Department of Pathology, University of Iowa Hospitals and Clinics, Clinical Microbiology Laboratories, University of Iowa College of Medicine, USA
    Otolaryngol Head Neck Surg 127:S17-23. 2002
  9. ncbi request reprint Antimicrobial susceptibility among community-acquired respiratory tract pathogens in the USA: data from PROTEKT US 2000-01
    Gary V Doern
    Clinical Microbiology Laboratory, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Infect 48:56-65. 2004
  10. pmc Haemophilus influenzae and Moraxella catarrhalis from patients with community-acquired respiratory tract infections: antimicrobial susceptibility patterns from the SENTRY antimicrobial Surveillance Program (United States and Canada, 1997)
    G V Doern
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Antimicrob Agents Chemother 43:385-9. 1999

Detail Information

Publications72

  1. pmc A pharmacodynamic analysis of resistance trends in pathogens from patients with infection in intensive care units in the United States between 1993 and 2004
    Kathryn J Eagye
    Center for Anti Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
    Ann Clin Microbiol Antimicrob 6:11. 2007
    ..This study's objective was to ascertain whether MICs among major pathogens in the ICU to several commonly used agents have increased enough to significantly impact their ability to achieve bactericidal effect...
  2. pmc Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999--2000, including a comparison of resistance rates since 1994--1995
    G V Doern
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Antimicrob Agents Chemother 45:1721-9. 2001
    ..1%; tetracycline, 9.0%; TMP-SMX, 9.1%; and chloramphenicol, 4.0%, the increase in multiresistance was 13.3%. Despite awareness and prevention efforts, antimicrobial resistance with S. pneumoniae continues to increase in the United States...
  3. ncbi request reprint Antimicrobial resistance among Streptococcus pneumoniae in the United States: have we begun to turn the corner on resistance to certain antimicrobial classes?
    Gary V Doern
    Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Infect Dis 41:139-48. 2005
    ..This study was undertaken to elucidate the current scope and magnitude of this problem in the United States and to assess resistance trends since 1994-1995...
  4. ncbi request reprint Macrolide and ketolide resistance with Streptococcus pneumoniae
    Gary V Doern
    Clinical Microbiology Laboratories, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Med Clin North Am 90:1109-24. 2006
    ..This discussion reviews the current state of resistance to macrolides and ketolides with S pneumoniae in North America...
  5. ncbi request reprint Antimicrobial resistance with Streptococcus pneumoniae: much ado about nothing?
    G V Doern
    Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Semin Respir Infect 16:177-85. 2001
    ....
  6. ncbi request reprint Optimizing the management of community-acquired respiratory tract infections in the age of antimicrobial resistance
    Gary V Doern
    University of Iowa, College of Medicine, Iowa City, Iowa, USA
    Expert Rev Anti Infect Ther 4:821-35. 2006
    ..Ultimately, the single-most important factor will be the judicious use of antibiotics, as fewer antibiotic prescriptions lead to fewer antimicrobial-resistant bacteria...
  7. ncbi request reprint Antimicrobial use and the emergence of antimicrobial resistance with Streptococcus pneumoniae in the United States
    G V Doern
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Infect Dis 33:S187-92. 2001
    ..pneumoniae, given comparable cost, side-effect profile, palatability, convenience of dosing, and accessibility, use of the most potent agent(s) within a particular class is advocated...
  8. ncbi request reprint Activity of oral beta-lactam antimicrobial agents versus respiratory tract isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the era of antibiotic resistance
    Gary V Doern
    Department of Pathology, University of Iowa Hospitals and Clinics, Clinical Microbiology Laboratories, University of Iowa College of Medicine, USA
    Otolaryngol Head Neck Surg 127:S17-23. 2002
    ..We conclude that, notwithstanding diminished beta-lactam activity for many clinical isolates of H influenzae, M catarrhalis, and S pneumoniae, certain agents remain effective in treating outpatient respiratory tract infections...
  9. ncbi request reprint Antimicrobial susceptibility among community-acquired respiratory tract pathogens in the USA: data from PROTEKT US 2000-01
    Gary V Doern
    Clinical Microbiology Laboratory, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Infect 48:56-65. 2004
    ....
  10. pmc Haemophilus influenzae and Moraxella catarrhalis from patients with community-acquired respiratory tract infections: antimicrobial susceptibility patterns from the SENTRY antimicrobial Surveillance Program (United States and Canada, 1997)
    G V Doern
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Antimicrob Agents Chemother 43:385-9. 1999
    ..influenzae were observed only with cefaclor (12.8%) and TMP-SMX (16.2%)...
  11. pmc Antimicrobial resistance with Streptococcus pneumoniae in the United States, 1997 98
    G V Doern
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Emerg Infect Dis 5:757-65. 1999
    ..In 19 of these 24 centers, penicillin resistance rates increased 2.9% to 39.2%. Similar increases were observed with rates of resistance to other antimicrobial drugs...
  12. ncbi request reprint Detection of selected fastidious bacteria
    G V Doern
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Infect Dis 30:166-73. 2000
    ..Situations exist, however, in which culture may be desirable, if not necessary, to establish a definitive diagnosis of infection with these 7 organisms. This review attempts to summarize how best to proceed in those cases...
  13. ncbi request reprint Survey of bloodstream infections due to gram-negative bacilli: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997
    D J Diekema
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Clin Infect Dis 29:595-607. 1999
    ..coli and Klebsiella species from Latin America. Further investigation of the reasons for regional differences in resistance patterns is needed, as is ongoing surveillance to detect resistance trends and to guide antimicrobial use...
  14. pmc International surveillance of bloodstream infections due to Candida species: frequency of occurrence and antifungal susceptibilities of isolates collected in 1997 in the United States, Canada, and South America for the SENTRY Program. The SENTRY Participa
    M A Pfaller
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    J Clin Microbiol 36:1886-9. 1998
    ..9% of C. glabrata isolates (MIC90, 2.0 microg/ml) and 66.6% of C. krusei isolates were resistant to itraconazole. Within each species there were no geographic differences in susceptibility to fluconazole or itraconazole...
  15. pmc Bloodstream infections due to Candida species: SENTRY antimicrobial surveillance program in North America and Latin America, 1997-1998
    M A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Antimicrob Agents Chemother 44:747-51. 2000
    ..4 to 100% susceptible). Isolates from Canada and Latin America were generally more susceptible to both triazoles than U.S. isolates were. Continued surveillance appears necessary to detect these important changes...
  16. ncbi request reprint Activity and spectrum of 22 antimicrobial agents tested against urinary tract infection pathogens in hospitalized patients in Latin America: report from the second year of the SENTRY antimicrobial surveillance program (1998)
    A C Gales
    Medical Microbiology Division, 251 MRC, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Antimicrob Chemother 45:295-303. 2000
    ..The results presented in this report confirm that bacterial resistance continues to be a great problem in Latin American medical institutions...
  17. ncbi request reprint Genetic relatedness of multidrug-resistant, methicillin (oxacillin)-resistant Staphylococcus aureus bloodstream isolates from SENTRY Antimicrobial Resistance Surveillance Centers worldwide, 1998
    D J Diekema
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52246, USA
    Microb Drug Resist 6:213-21. 2000
    ..aureus bloodstream isolates worldwide. Although many MDR-MRSA strains group geographically, a few closely related epidemic strains have wide regional and even global range...
  18. ncbi request reprint The molecular epidemiology of Streptococcus pneumoniae with quinolone resistance mutations
    S S Richter
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City 52242 1009, USA
    Clin Infect Dis 40:225-35. 2005
    ..A second objective was to examine the genetic relatedness of pneumococcal isolates with parC and/or gyrA mutations during the period of 1994-2002...
  19. pmc Bacterial pathogens isolated from patients with bloodstream infection: frequencies of occurrence and antimicrobial susceptibility patterns from the SENTRY antimicrobial surveillance program (United States and Canada, 1997)
    M A Pfaller
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Antimicrob Agents Chemother 42:1762-70. 1998
    ..Antimicrobial resistance continues to increase, and ongoing surveillance of microbial pathogens and resistance profiles is essential on national and international scales...
  20. pmc In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America
    D J Diekema
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Antimicrob Agents Chemother 43:2236-9. 1999
    ..that were dose-dependently fluconazole susceptible and against those that were fluconazole resistant...
  21. ncbi request reprint Macrolide use identified as risk factor for macrolide-resistant Streptococcus pneumoniae in a 17-center case-control study
    S E Beekmann
    Division of Medical Microbiology, Department of Pathology 265 MRC, University of Iowa, Iowa, IA, 52242, USA
    Eur J Clin Microbiol Infect Dis 25:335-9. 2006
    ..pneumoniae. Macrolide resistance was associated with use of any antibiotic during the prior 6 weeks, and was most strongly associated with previous macrolide use...
  22. ncbi request reprint Trends in antimicrobial susceptibility of bacterial pathogens isolated from patients with bloodstream infections in the USA, Canada and Latin America. SENTRY Participants Group
    D J Diekema
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Int J Antimicrob Agents 13:257-71. 2000
    ..Ongoing surveillance remains essential, and will enhance efforts to limit the scope of this worldwide problem...
  23. pmc In vitro susceptibilities of Candida bloodstream isolates to the new triazole antifungal agents BMS-207147, Sch 56592, and voriconazole
    M A Pfaller
    Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Antimicrob Agents Chemother 42:3242-4. 1998
    ..These results suggest that BMS-207147, Sch 56592, and voriconazole all possess promising antifungal activity and that further in vitro and in vivo investigations are warranted to establish the clinical value of this improved potency...
  24. ncbi request reprint Antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and group A beta-haemolytic streptococci in 2002-2003. Results of the multinational GRASP Surveillance Program
    Susan E Beekmann
    Division of Medical Microbiology, Department of Pathology Roy J and Lucille A Carver University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Int J Antimicrob Agents 25:148-56. 2005
    ..influenzae and 80-100% for M. catarrhalis. Antibiotic resistance in S. pneumoniae remains a significant problem world wide...
  25. ncbi request reprint The molecular epidemiology of penicillin-resistant Streptococcus pneumoniae in the United States, 1994-2000
    S S Richter
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Infect Dis 34:330-9. 2002
    ....
  26. ncbi request reprint Antimicrobial activity and spectrum investigation of eight broad-spectrum beta-lactam drugs: a 1997 surveillance trial in 102 medical centers in the United States. Cefepime Study Group
    R N Jones
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Diagn Microbiol Infect Dis 30:215-28. 1998
    ....
  27. pmc Animal and human multidrug-resistant, cephalosporin-resistant salmonella isolates expressing a plasmid-mediated CMY-2 AmpC beta-lactamase
    P L Winokur
    University of Iowa College of Medicine, Iowa City, Iowa, USA
    Antimicrob Agents Chemother 44:2777-83. 2000
    ..between animals and man...
  28. pmc Influence of macrolide susceptibility on efficacies of clarithromycin and azithromycin against Streptococcus pneumoniae in a murine lung infection model
    Holly L Hoffman
    Colleges of Pharmacy, University of Iowa, Iowa City, Iowa, USA
    Antimicrob Agents Chemother 47:739-46. 2003
    ..Animals infected with isolates of S. pneumoniae exhibiting low-level, mefA-mediated macrolide resistance responded to treatment with clarithromycin at rates similar to those observed among mice infected with fully susceptible isolates...
  29. pmc Use of penicillin MICs to predict in vitro activity of other beta-lactam antimicrobial agents against Streptococcus pneumoniae
    A B Brueggemann
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 39:367-9. 2001
    ..It may be possible to test penicillin and use MICs obtained with penicillin to predict MICs of other beta-lactam antimicrobials for Streptococcus pneumoniae...
  30. pmc Comparative bactericidal activities of ciprofloxacin, clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Streptococcus pneumoniae in a dynamic in vitro model
    M E Klepser
    University of Iowa College of Pharmacy, Iowa City, Iowa 52242 1112, USA
    Antimicrob Agents Chemother 45:673-8. 2001
    ..The rank order of the agents with respect to the selection of resistance was ciprofloxacin (most likely) > grepafloxacin, moxifloxacin, and trovafloxacin > levofloxacin > clinafloxacin...
  31. pmc Antimicrobial-drug use and changes in resistance in Streptococcus pneumoniae
    D J Diekema
    University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Emerg Infect Dis 6:552-6. 2000
    ..S. medical centers, we obtained data on outpatient antimicrobial-drug use for the regions surrounding 23 of these centers. We found an association between decreased penicillin susceptibility and use of beta-lactam antimicrobial drugs...
  32. ncbi request reprint The in vitro activity of daptomycin against Staphylococcus aureus and Enterococcus species
    S S Richter
    Department of Pathology, C606 GH, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242 1009, USA
    J Antimicrob Chemother 52:123-7. 2003
    ..aureus (MRSA)...
  33. pmc Epidemiology and outcome of nosocomial and community-onset bloodstream infection
    D J Diekema
    Department of Internal Medicine, Roy J and Lucille A Carver University of Iowa College of Medicine, Iowa City, Iowa, 52242, USA
    J Clin Microbiol 41:3655-60. 2003
    ..0001). Although accounting for about half of all bloodstream infections, nosocomial bloodstream infections account for most of the mortality and costs associated with bloodstream infection...
  34. ncbi request reprint Antimicrobial use in Europe and antimicrobial resistance in Streptococcus pneumoniae
    S Riedel
    Division of Microbiology, Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    Eur J Clin Microbiol Infect Dis 26:485-90. 2007
    ..pneumoniae. There was variation among the different antimicrobial classes as drivers of resistance, with beta-lactams having the strongest association...
  35. pmc Effects of rapid detection of bloodstream infections on length of hospitalization and hospital charges
    S E Beekmann
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:3119-25. 2003
    ..The newest generation of automated continuous-monitoring blood culture systems, which shorten the time required to obtain a positive result, should impact length of hospitalization...
  36. pmc Evaluation of the discriminatory powers of the Dienes test and ribotyping as typing methods for Proteus mirabilis
    M A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 38:1077-80. 2000
    ..mirabilis. The Dienes test is simple, inexpensive, and easy to perform. It can be performed in virtually any laboratory and should be used in the initial epidemiologic characterization of P. mirabilis isolates...
  37. pmc Epidemiology of candidemia: 3-year results from the emerging infections and the epidemiology of Iowa organisms study
    D J Diekema
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    J Clin Microbiol 40:1298-302. 2002
    ..However, C. glabrata has emerged as an important and potentially antifungal resistant cause of candidemia, particularly among the elderly...
  38. pmc Global trends in the antifungal susceptibility of Cryptococcus neoformans (1990 to 2004)
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 43:2163-7. 2005
    ..We conclude that in vitro resistance to antifungal agents used in the treatment of cryptococcosis remains uncommon among isolates of C. neoformans from five broad geographic regions and has not increased over a 15-year period...
  39. ncbi request reprint Antimicrobial resistance with bacterial causes of community-acquired respiratory tract infections in the United States
    Gary V Doern
    University of Iowa College of Medicine, Clinical Microbiology Laboratories, University of Iowa Hospital and Clinics, Iowa City, Iowa 52242, USA
    Treat Respir Med 4:1-4. 2005
  40. pmc Decreasing prevalence of beta-lactamase production among respiratory tract isolates of Haemophilus influenzae in the United States
    Kris P Heilmann
    Division of Medical Microbiology, Department of Pathology, Roy J and Lucille A Carver University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Antimicrob Agents Chemother 49:2561-4. 2005
    ..In comparison to the results of four previous national surveys conducted since 1994, the prevalence of beta-lactamase production with this pathogen appears to be decreasing...
  41. pmc Timing of specimen collection for blood cultures from febrile patients with bacteremia
    Stefan Riedel
    University of Iowa Hospitals and Clinics, Department of Pathology Division of Microbiology, 200 Hawkins Drive, C 606 GH, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 46:1381-5. 2008
    ..A subset analysis based on patient age, gender, white blood cell count and specific cause of bacteremia generally also failed to reveal any associations...
  42. pmc Minimizing the workup of blood culture contaminants: implementation and evaluation of a laboratory-based algorithm
    S S Richter
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 40:2437-44. 2002
    ..6% of 71 isolates. The laboratory-based algorithm provided an acceptably accurate means for assessing the clinical significance of potential contaminants recovered from blood cultures...
  43. doi request reprint Increasing telithromycin resistance among Streptococcus pyogenes in Europe
    Sandra S Richter
    Department of Pathology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    J Antimicrob Chemother 61:603-11. 2008
    ..To assess changes in macrolide and ketolide resistance among Streptococcus pyogenes in Europe and to examine the relationship of resistance to antimicrobial usage...
  44. ncbi request reprint Determining the clinical significance of coagulase-negative staphylococci isolated from blood cultures
    Susan E Beekmann
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Infect Control Hosp Epidemiol 26:559-66. 2005
    ..Our objective was to develop an algorithm to assist in determining the clinical significance of coagulase-negative staphylococci...
  45. ncbi request reprint Evaluation of survival and pharmacodynamic relationships for five fluoroquinolones in a neutropenic murine model of pneumococcal lung infection
    Erika J Ernst
    Colleges of Pharmacy, University of Iowa, Iowa City 52242 1112, USA
    Pharmacotherapy 22:463-70. 2002
    ..To compare the antistreptococcal activity of five fluoroquinolone antibiotics, using a neutropenic murine model of pneumococcal pulmonary infection...
  46. doi request reprint Changing epidemiology of antimicrobial-resistant Streptococcus pneumoniae in the United States, 2004-2005
    Sandra S Richter
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1009, USA
    Clin Infect Dis 48:e23-33. 2009
    ....
  47. ncbi request reprint Macrolide-resistant Streptococcus pyogenes in the United States, 2002-2003
    Sandra S Richter
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1009, USA
    Clin Infect Dis 41:599-608. 2005
    ..pyogenes isolates from throughout the United States and to elucidate the mechanisms of resistance and genetic relatedness of macrolide-resistant isolates...
  48. pmc Multicenter evaluation of the BD Phoenix Automated Microbiology System for antimicrobial susceptibility testing of Streptococcus species
    Sandra S Richter
    Department of Pathology, University of Iowa Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, C606 GH, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 45:2863-71. 2007
    ..5 to 7.1%). The mean times required for organism groups to generate results ranged from 8.4 to 9.4 h. The Phoenix system provided reliable and rapid AST results for most of the organism-antimicrobial agent combinations tested...
  49. pmc Patterns and density of early tracheal colonization in intensive care unit patients
    Lakshmi Durairaj
    Department of Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Crit Care 24:114-21. 2009
    ..The study aimed to describe the patterns and density of early tracheal colonization among intubated patients and to correlate colonization status with levels of antimicrobial peptides and inflammatory cytokines...
  50. pmc Accuracy and appropriateness of antimicrobial susceptibility test reporting for bacteria isolated from blood cultures
    Daniel J Diekema
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52246, USA
    J Clin Microbiol 42:2258-60. 2004
    ..Further study is necessary to determine the impact of testing errors and suboptimal reporting of results on the management of bloodstream infection...
  51. pmc Antimicrobial resistance among Gram-negative bacilli causing infections in intensive care unit patients in the United States between 1993 and 2004
    Shawn R Lockhart
    Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 45:3352-9. 2007
    ..P. aeruginosa, K. pneumoniae, and E. cloacae...
  52. ncbi request reprint Prevention of descending pneumonia in rts with perflubron-delivered tobramycin
    Eric W Dickson
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester MA, USA
    Acad Emerg Med 10:1019-23. 2003
    ..This investigation tested the hypothesis that LiquiVent (Alliance Pharmaceutical, San Diego, CA-LV) delivered antibiotics (via spray-dried microspheres-SDM) would improve survival in a rat model of descending gram-negative pneumonia...
  53. ncbi request reprint Fluoroquinolone resistance in Streptococcus pyogenes
    Sandra S Richter
    Department of Pathology, University of Iowa Healthcare, Iowa City, Iowa 52242, USA
    Clin Infect Dis 36:380-3. 2003
    ..This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance...
  54. pmc Multi-year study of human metapneumovirus infection at a large US Midwestern Medical Referral Center
    Gregory C Gray
    Center for Emerging Infectious Diseases, Department of Epidemiology, University of Iowa College of Public Health, Iowa City, 200 Hawkins Dr, C21 K GH, Iowa City, IA 52242, USA
    J Clin Virol 37:269-76. 2006
    ..Because of its recent identification, few multi-year epidemiologic studies of hMPV infection have been reported...
  55. pmc Comparison of the BACTEC 9240 and BacT/Alert blood culture systems for detection of bacterial contamination in platelet concentrates
    Stefan Riedel
    Division of Clinical Microbiology and Transfusion Medicine, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 44:2262-4. 2006
    ..Among all comparisons, growth was detected, on average, 1.7 h sooner with the BACTEC system. The differences in length of time to detection were statistically significant...
  56. pmc Accuracy of phenotypic methods for identification of Streptococcus pneumoniae isolates included in surveillance programs
    Sandra S Richter
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1009, USA
    J Clin Microbiol 46:2184-8. 2008
    ..9% and 59.3% for optochin susceptibility. Colony morphology was of limited value, as 391 (23.7%) isolates lacked the typical button or mucoid colony appearance of S. pneumoniae...
  57. ncbi request reprint Epidemiology of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus in a rural state
    Philip M Polgreen
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, 52246, USA
    Infect Control Hosp Epidemiol 27:252-6. 2006
    ..Infection control personnel need to understand the epidemiology of MRSA and VRE across the continuum of care, including small rural hospitals, to develop effective control strategies...
  58. pmc BD Phoenix and Vitek 2 detection of mecA-mediated resistance in Staphylococcus aureus with cefoxitin
    Alan D Junkins
    Department of Pathology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 47:2879-82. 2009
    ..The inclusion of cefoxitin in the Phoenix and Vitek 2 panels has optimized the detection of MRSA by both systems...
  59. pmc Detection and treatment of bloodstream infection: laboratory reporting and antimicrobial management
    Erik L Munson
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 55242, USA
    J Clin Microbiol 41:495-7. 2003
    ..Most therapy interventions occurred at the time of phlebotomy and after notification of Gram stain results by telephone. Release of antimicrobial susceptibility data had the least impact on antimicrobial management...
  60. pmc Evidence for transfer of CMY-2 AmpC beta-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans
    P L Winokur
    Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Antimicrob Agents Chemother 45:2716-22. 2001
    ....
  61. pmc Modification of dienes mutual inhibition test for epidemiological characterization of Pseudomonas aeruginosa isolates
    Erik L Munson
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 40:4285-8. 2002
    ..These observations suggest that further studies are warranted to assess the utility of the modified Dienes test as a simple, inexpensive, and reliable means for epidemiological typing of P. aeruginosa...
  62. pmc Comparison of the Bactec 9240 and BacT/Alert blood culture systems for evaluation of placental cord blood for transfusion in neonates
    Stefan Riedel
    The Johns Hopkins University, School of Medicine, Department of Pathology, Division of Microbiology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, A Building, Room 102 B, Baltimore, MD 21224, USA
    J Clin Microbiol 47:1645-9. 2009
    ..In our laboratory, the Bactec system compared to the BacT/Alert system was the superior method for rapid detection of bacterial contaminants in cord blood...
  63. pmc Comparison of three commercial test systems for biotyping Haemophilus influenzae and Haemophilus parainfluenzae
    Erik L Munson
    Division of Medical Microbiology, Department of Pathology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 45:4051-3. 2007
    ..The API NH strip performed best, correctly classifying the biotypes of 371 of 380 (97.6%) different challenge strains...
  64. ncbi request reprint Pharmacodynamic target attainment of oral beta-lactams for the empiric treatment of acute otitis media in children
    Renee M Fallon
    Department of Pharmacy Services, Maine Medical Center, Portland, Maine, USA
    Paediatr Drugs 10:329-35. 2008
    ..To determine the probability of oral beta-lactam regimens achieving bactericidal pharmacodynamic exposure against pathogens causing acute otitis media (AOM) given contemporary prevalence and resistance rates...
  65. ncbi request reprint Oral beta-lactams in the treatment of acute otitis media
    Stan L Block
    Kentucky Pediatric Adult Research, Bardstown, KY, USA
    Diagn Microbiol Infect Dis 57:19S-30S. 2007
    ..influenzae and S. pneumoniae...
  66. ncbi request reprint parE mutations in Streptococcus pneumoniae may reduce bactericidal activity of respiratory fluoroquinolones
    Heather K Sun
    Int J Antimicrob Agents 29:230-2. 2007
  67. pmc Fluoroquinolone resistance in Streptococcus pneumoniae in United States since 1994-1995
    Angela B Brueggemann
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Antimicrob Agents Chemother 46:680-8. 2002
    ....
  68. ncbi request reprint Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia
    Eric W Dickson
    Department of Physiology, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Crit Care Med 30:393-5. 2002
    ..To determine the efficacy of liquid ventilation using a medical-grade perfluorocarbon (perflubron) combined with parenteral or intratracheal antibiotics in a rat model of pneumonia...
  69. ncbi request reprint Health care resource utilization associated with treatment of penicillin-susceptible and -nonsusceptible isolates of Streptococcus pneumoniae
    Michael E Klepser
    Ferris State University College of Pharmacy, Big Rapids, Michigan, USA
    Pharmacotherapy 23:349-59. 2003
    ..Infections caused by penicillin-nonsusceptible pneumococci were not associated with a worse outcome in hospitalized patients but were associated with increased cost of care...
  70. ncbi request reprint Optimal antimicrobial therapy: the balance of potency and exposure
    Glenn S Tillotson
    Expert Opin Investig Drugs 15:335-7. 2006
    ....
  71. ncbi request reprint In vitro exposure of bacteria to antimicrobial impregnated-central venous catheters does not directly lead to the emergence of antimicrobial resistance
    Erik L Munson
    Department of Anesthesiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Chest 126:1628-35. 2004
    ..In this study, we sought to determine if in vitro exposure of four test organisms to catheter segments impregnated with minocycline and rifampin would lead to the development of antibiotic resistance...
  72. ncbi request reprint Multidrug-resistant Enterococcus faecium in a patient with burns
    Sherene S Min
    Clin Infect Dis 36:1210-1. 2003