Gorth D, Martin J, Dodge G, Elliott D, Malhotra N, Mauck R, et al. In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation. J Exp Orthop. 2014;1:15 pubmed publisher
..Microspheres can successfully be delivered to the disc in vivo and retained for a clinically relevant time frame. IL-1ra released from microspheres can effectively prevent IL-1Î²-induced NP glycosaminoglycan loss in vivo. ..
Gorth D, Mauck R, Chiaro J, Mohanraj B, Hebela N, Dodge G, et al. IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1?-mediated degradation of nucleus pulposus in vitro. Arthritis Res Ther. 2012;14:R179 pubmed publisher
..Ongoing studies are focusing on testing IL-1ra microspheres in an in vivo model of disc degeneration, as a prelude to clinical translation. ..