Kimberly L Dodge-Kafka

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3
    Kimberly L Dodge-Kafka
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 285:11078-86. 2010
  2. ncbi request reprint Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins
    Kimberly L Dodge-Kafka
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 98:993-1001. 2006
  3. ncbi request reprint The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways
    Kimberly L Dodge-Kafka
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Eur J Cell Biol 85:593-602. 2006
  4. doi request reprint Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms
    John M Redden
    Pat and Jim Calhoun Center for Cardiovascular Research, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Biochem J 446:301-9. 2012
  5. pmc AKAP phosphatase complexes in the heart
    John M Redden
    Department of Cell Biology, Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Cardiovasc Pharmacol 58:354-62. 2011
  6. pmc Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation
    Maximilian A X Vargas
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06030, United States
    Cell Signal 24:1496-503. 2012
  7. pmc The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity
    Arpita Singh
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06032, USA
    Mol Pharmacol 79:533-40. 2011
  8. pmc Identification of AKAP79 as a protein phosphatase 1 catalytic binding protein
    Andrew V Le
    University of Connecticut Health Center, Farmington, CT 06030, USA
    Biochemistry 50:5279-91. 2011
  9. ncbi request reprint The mAKAP signalosome and cardiac myocyte hypertrophy
    Andrea L Bauman
    Department of Pediatrics, Heart Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    IUBMB Life 59:163-9. 2007
  10. ncbi request reprint The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling
    Genevieve C Pare
    Department of Pediatrics, Heart Research Center, Oregon Health and Science University, NRC5 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 118:5637-46. 2005

Collaborators

Detail Information

Publications12

  1. pmc cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3
    Kimberly L Dodge-Kafka
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 285:11078-86. 2010
    ..In general, PKA.PP2A.mAKAP complexes exemplify how protein kinases and phosphatases may participate in molecular signaling complexes to dynamically regulate localized intracellular signaling...
  2. ncbi request reprint Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins
    Kimberly L Dodge-Kafka
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 98:993-1001. 2006
    ..For cAMP signaling, A-kinase anchoring proteins (AKAPs) provide a molecular mechanism for cAMP compartmentation, allowing for the precise control of PKA-mediated phosphorylation events. (cAMP, PKA, AKAP, PKG)...
  3. ncbi request reprint The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways
    Kimberly L Dodge-Kafka
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Eur J Cell Biol 85:593-602. 2006
    ....
  4. doi request reprint Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms
    John M Redden
    Pat and Jim Calhoun Center for Cardiovascular Research, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Biochem J 446:301-9. 2012
    ..Collectively, the results of the present study suggests that AKAP7 could play an integral role in dictating PKC localization and function in tissues where the two proteins are co-expressed...
  5. pmc AKAP phosphatase complexes in the heart
    John M Redden
    Department of Cell Biology, Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Cardiovasc Pharmacol 58:354-62. 2011
    ..The focus of this review is on the emerging role of AKAPs in regulating the 3 main cardiac phosphatases: Protein Phosphatase 1 by AKAP18 and Yotiao, and Protein Phosphatases 2A and 2B by muscle specific A-kinase anchoring protein...
  6. pmc Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation
    Maximilian A X Vargas
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06030, United States
    Cell Signal 24:1496-503. 2012
    ..This study expands our understanding of the regulation of MEF2 in skeletal muscle and identifies the mAKAP scaffold as a facilitator of MEF2 transcription and myogenic differentiation...
  7. pmc The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity
    Arpita Singh
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06032, USA
    Mol Pharmacol 79:533-40. 2011
    ....
  8. pmc Identification of AKAP79 as a protein phosphatase 1 catalytic binding protein
    Andrew V Le
    University of Connecticut Health Center, Farmington, CT 06030, USA
    Biochemistry 50:5279-91. 2011
    ..These combined observations suggest that AKAP79 acts as a PP1 regulatory subunit that can direct PP1 activity toward specific targets in the AKAP79 complex...
  9. ncbi request reprint The mAKAP signalosome and cardiac myocyte hypertrophy
    Andrea L Bauman
    Department of Pediatrics, Heart Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    IUBMB Life 59:163-9. 2007
    ..The mAKAPbeta signalosome is important for the control of NFATc transcription factor activity and for the overall induction of myocyte hypertrophy...
  10. ncbi request reprint The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling
    Genevieve C Pare
    Department of Pediatrics, Heart Research Center, Oregon Health and Science University, NRC5 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 118:5637-46. 2005
    ..These data reveal a novel function of the mAKAP complex involving the integration of cAMP and Ca2+ signals that promote myocyte hypertrophy...
  11. ncbi request reprint Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha
    Jennifer J Carlisle Michel
    Howard Hughes Medical Institute and Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, USA
    Mol Cell 20:661-72. 2005
    ..The assembly of tissue-specific signaling complexes provides an efficient mechanism to integrate and relay lipid-mediated and mitogenic activated signals to the nucleus...
  12. pmc The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
    Kimberly L Dodge-Kafka
    Howard Hughes Medical Institute, Oregon Health and Sciences University, Portland, Oregon 97239, USA
    Nature 437:574-8. 2005
    ..Thus, two coupled cAMP-dependent feedback loops are coordinated within the context of the mAKAP complex, suggesting that local control of cAMP signalling by AKAP proteins is more intricate than previously appreciated...

Research Grants5

  1. mAKAP-orchestrated phosphorylation events: regulation of PDE4D3
    KIMBERLY DODGE; Fiscal Year: 2006
    ..This study will further our understanding of the molecular mechanism of cardiac hypertrophy and help to identify novel targets for drug design to aid in the treatment of hypertrophy. ..
  2. mAKAP-orchestrated phosphorylation events: regulation of PDE4D3
    KIMBERLY DODGE; Fiscal Year: 2007
    ..This study will further our understanding of the molecular mechanism of cardiac hypertrophy and help to identify novel targets for drug design to aid in the treatment of hypertrophy. ..
  3. mAKAP-orchestrated phosphorylation events: regulation of PDE4D3
    Kimberly Dodge Kafka; Fiscal Year: 2009
    ..This study will further our understanding of the molecular mechanism of cardiac hypertrophy and help to identify novel targets for drug design to aid in the treatment of hypertrophy. ..
  4. mAKAP-orchestrated phosphorylation events: regulation of PDE4D3
    Kimberly L Dodge Kafka; Fiscal Year: 2010
    ..This study will further our understanding of the molecular mechanism of cardiac hypertrophy and help to identify novel targets for drug design to aid in the treatment of hypertrophy. ..