James Dobson

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Beta-adrenergic and antiadrenergic modulation of cardiac adenylyl cyclase is influenced by phosphorylation
    James G Dobson
    Department of Physiology, University Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655 0127, USA
    Am J Physiol Heart Circ Physiol 285:H1471-8. 2003
  2. ncbi request reprint Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling
    James G Dobson
    Genomic Physiology Group, Department of Physiology, University of Massachusetts Medical School, Worcester 01655, USA
    Physiol Genomics 15:142-7. 2003
  3. pmc Adenosine A2A and beta-adrenergic calcium transient and contractile responses in rat ventricular myocytes
    James G Dobson
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 295:H2364-72. 2008
  4. ncbi request reprint Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts
    Eugene I Tikh
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 290:H348-56. 2006
  5. doi request reprint Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart
    Eugene I Tikh
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 216:83-90. 2008
  6. pmc Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol Heart Circ Physiol 297:H718-25. 2009
  7. ncbi request reprint Adenosine A1 and A2A receptor effects on G-protein cycling in beta-adrenergic stimulated ventricular membranes
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 213:785-92. 2007
  8. ncbi request reprint Endogenous adenosine inhibits CNS terminal Ca(2+) currents and exocytosis
    Thomas K Knott
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 210:309-14. 2007
  9. pmc Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27
    Richard A Fenton
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 298:H1671-8. 2010
  10. ncbi request reprint Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Life Sci 77:3375-88. 2005

Research Grants

  1. Myocardial Adenosine Receptors
    James Dobson; Fiscal Year: 2009
  2. ADENOSINE A1 AND A2 RECEPTORS IN THE MYOCARDIUM
    James Dobson; Fiscal Year: 2004
  3. MECHANISMS OF AGING--ENHANCED HEART ADENOSINE
    James Dobson; Fiscal Year: 1993
  4. Myocardial Adenosine Receptors
    James G Dobson; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Beta-adrenergic and antiadrenergic modulation of cardiac adenylyl cyclase is influenced by phosphorylation
    James G Dobson
    Department of Physiology, University Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655 0127, USA
    Am J Physiol Heart Circ Physiol 285:H1471-8. 2003
    ..These results indicate that the cardioprotective effect of adenosine afforded by its antiadrenergic action is facilitated by cardiac membrane phosphorylation...
  2. ncbi request reprint Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling
    James G Dobson
    Genomic Physiology Group, Department of Physiology, University of Massachusetts Medical School, Worcester 01655, USA
    Physiol Genomics 15:142-7. 2003
    ..Although these results do not prove causality, they demonstrate that cardiac aging is associated with changes in the profiles of gene expression and that many of these changes may contribute to reduced adrenergic signaling...
  3. pmc Adenosine A2A and beta-adrenergic calcium transient and contractile responses in rat ventricular myocytes
    James G Dobson
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 295:H2364-72. 2008
    ..Although PKC is important in the A1R antiadrenergic action, it does not seem to play a role in A2AR-elicited Ca transient and contractile events...
  4. ncbi request reprint Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts
    Eugene I Tikh
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 290:H348-56. 2006
    ..In addition, A2AR supports myocardial contractility in a setting of low-flow ischemia...
  5. doi request reprint Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart
    Eugene I Tikh
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 216:83-90. 2008
    ..These data show that A(2A)R and A(1)R regulate PP2A activity, thus suggesting an important mechanism for modulating myocardial contractility...
  6. pmc Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol Heart Circ Physiol 297:H718-25. 2009
    ..In conclusion, A(1)R stimulation of the heart is associated with PLC-initiated PKC-epsilon translocation and association with RACK2...
  7. ncbi request reprint Adenosine A1 and A2A receptor effects on G-protein cycling in beta-adrenergic stimulated ventricular membranes
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 213:785-92. 2007
    ..Together, these results indicate that A1R exert an antiadrenergic action at the level of beta1R stimulated G(s)-protein cycling and that A2AR reduce this action...
  8. ncbi request reprint Endogenous adenosine inhibits CNS terminal Ca(2+) currents and exocytosis
    Thomas K Knott
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 210:309-14. 2007
    ..This could be a general mechanism for controlling transmitter release in these and other CNS terminals...
  9. pmc Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27
    Richard A Fenton
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 298:H1671-8. 2010
    ..Attenuation of beta-adrenergic-induced contractile function by A(1)R may involve the activation of p38 MAPK, but not HSP27...
  10. ncbi request reprint Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart
    Richard A Fenton
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Life Sci 77:3375-88. 2005
    ..In conclusion, aging-induced changes in protein dephosphorylation may be one mechanism reducing the manifestation of preconditioning in the aged heart...
  11. ncbi request reprint Receptors subtypes involved in adenosine-mediated modulation of norepinephrine release from cardiac nerve terminals
    Mojca Lorbar
    Department of Medicine, St Vincent Hospital, Worcester, MA 01608, USA
    Can J Physiol Pharmacol 82:1026-31. 2004
    ..This effect of adenosine was of short duration. Adenosine A2A and A3 receptors were either absent or functionally insignificant in the regulation of norepinephrine release in the rat heart...
  12. ncbi request reprint Protein kinase Cepsilon and the antiadrenergic action of adenosine in rat ventricular myocytes
    Koji Miyazaki
    Dept of Physiology, S4 242, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 287:H1721-9. 2004
    ..These results suggest that the translocation of PKCepsilon to the t-tubular system plays an important role in A(1)R-mediated antiadrenergic actions in the heart...
  13. ncbi request reprint Anoxia-induced changes in purine nucleoside metabolism of in vitro aged human fibroblasts
    Patricia S Reisert
    Department of Natural Sciences, Assumption College, Worcester, MA 01615 0005, USA
    Life Sci 70:1369-82. 2002
    ..Immediately following anoxia (time 0), adenosine release by young AF was 29% greater than for young NF, whereas both the youn..

Research Grants18

  1. Myocardial Adenosine Receptors
    James Dobson; Fiscal Year: 2009
    ..Such information should be instrumental for the development of new therapies and agents to alleviate cardiac dysfunction. ..
  2. ADENOSINE A1 AND A2 RECEPTORS IN THE MYOCARDIUM
    James Dobson; Fiscal Year: 2004
    ..Additionally, the findings should significantly contribute to our basic knowledge of the molecular mechanisms of G protein coupled receptor cross-regulation in the heart. ..
  3. MECHANISMS OF AGING--ENHANCED HEART ADENOSINE
    James Dobson; Fiscal Year: 1993
    ..This project represents a relatively new concept involving adenosine that may be important in explaining the decrement of beta-adrenergic responsiveness of the mammalian heart observed with aging...
  4. Myocardial Adenosine Receptors
    James G Dobson; Fiscal Year: 2010
    ..Such information should be instrumental for the development of new therapies and agents to alleviate cardiac dysfunction. ..