P R Dobner

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Multitasking with neurotensin in the central nervous system
    P R Dobner
    Department of Molecular Genetics and Microbiology, Program in Neuroscience, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts, 01655, USA
    Cell Mol Life Sci 62:1946-63. 2005
  2. ncbi request reprint Neurotensin and pain modulation
    Paul R Dobner
    Department of Molecular Genetics and Microbiology, Program in Neuroscience, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Peptides 27:2405-14. 2006
  3. ncbi request reprint Neurotensin: dual roles in psychostimulant and antipsychotic drug responses
    Paul R Dobner
    Department of Molecular Genetics and Microbiology, Program in Neuroscience, University of Massachusetts Medical School, 55 Lake Ave North, Worcester 01655, USA
    Life Sci 73:801-11. 2003
  4. pmc Neurotensin-deficient mice show altered responses to antipsychotic drugs
    P R Dobner
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 98:8048-53. 2001
  5. ncbi request reprint Endogenous neurotensin facilitates visceral nociception and is required for stress-induced antinociception in mice and rats
    X Gui
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Neuroscience 126:1023-32. 2004
  6. doi request reprint Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells
    Robert E Carraway
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, 55 Lake Avenue North Worcester, MA, 01655, United States
    Regul Pept 147:96-109. 2008
  7. ncbi request reprint Endogenous neurotensin facilitates enterohepatic bile acid circulation by enhancing intestinal uptake in rats
    X Gui
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655-0127, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1413-22. 2001
  8. ncbi request reprint Sequences required for induction of neurotensin receptor gene expression during neuronal differentiation of N1E-115 neuroblastoma cells
    D Tavares
    Department of Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 274:30066-79. 1999
  9. ncbi request reprint Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells
    Sazzad Hassan
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester 01655 0127, USA
    Regul Pept 120:155-66. 2004
  10. ncbi request reprint Synergistic activation of neurotensin/neuromedin N gene expression by c-Jun and glucocorticoids: novel effects of Fos family proteins
    R J Harrison
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester 01655, USA
    Mol Endocrinol 9:981-93. 1995

Collaborators

  • Robert Carraway
  • Jim Fadel
  • ARIEL DEUTCH
  • Charles B Nemeroff CB
  • X Gui
  • Xianyong Gui
  • Adrian M Piliponsky
  • Becky Kinkead
  • Sazzad Hassan
  • Etsuko Wada
  • Martin Metz
  • Grace Guzman
  • Sherma Zacharias
  • Keiji Wada
  • Mindy Tsai
  • Toshihiko Nishimura
  • Shrihari S Kadkol
  • Ronald G Pearl
  • James D Faix
  • D Tavares
  • Gunnar Pejler
  • Uma M Mohanasundaram
  • Magnus Abrink
  • Eon J Rios
  • Stephen J Galli
  • Ching Cheng Chen
  • Tiesha Murray
  • Vasili Egnatashvili
  • Charles B Nemeroff
  • Nancy Deitemeyer
  • R J Harrison
  • K Tully
  • G P McNeil
  • E Kislauskis
  • B Bullock
  • S McNeil

Detail Information

Publications15

  1. ncbi request reprint Multitasking with neurotensin in the central nervous system
    P R Dobner
    Department of Molecular Genetics and Microbiology, Program in Neuroscience, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts, 01655, USA
    Cell Mol Life Sci 62:1946-63. 2005
    ..There is now substantial evidence indicating that NT is required for certain antipsychotic drug actions and that the peptide plays a key role in stress-induced analgesia...
  2. ncbi request reprint Neurotensin and pain modulation
    Paul R Dobner
    Department of Molecular Genetics and Microbiology, Program in Neuroscience, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Peptides 27:2405-14. 2006
    ..This review focuses on recent advances that have provided insights into the role of NT in pain modulation...
  3. ncbi request reprint Neurotensin: dual roles in psychostimulant and antipsychotic drug responses
    Paul R Dobner
    Department of Molecular Genetics and Microbiology, Program in Neuroscience, University of Massachusetts Medical School, 55 Lake Ave North, Worcester 01655, USA
    Life Sci 73:801-11. 2003
    ..This review integrates these new findings with previous evidence implicating NT in both APD and psychostimulant responses...
  4. pmc Neurotensin-deficient mice show altered responses to antipsychotic drugs
    P R Dobner
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 98:8048-53. 2001
    ..These results are consistent with the hypothesis that endogenous NT mediates a specific subset of APD actions...
  5. ncbi request reprint Endogenous neurotensin facilitates visceral nociception and is required for stress-induced antinociception in mice and rats
    X Gui
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Neuroscience 126:1023-32. 2004
    ..NT was also required for acetic acid-induced hyperalgesia. These results indicate that endogenous NT normally facilitates visceral pain responses, is required for irritant-induced hyperalgesia, and plays a critical role in SIAN...
  6. doi request reprint Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells
    Robert E Carraway
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, 55 Lake Avenue North Worcester, MA, 01655, United States
    Regul Pept 147:96-109. 2008
    ..Since NT can activate PKC upon binding to its receptor, it is possible that NT receptor is also subject to homologous regulation by PKC...
  7. ncbi request reprint Endogenous neurotensin facilitates enterohepatic bile acid circulation by enhancing intestinal uptake in rats
    X Gui
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655-0127, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1413-22. 2001
    ..These results suggest that NT or a similar peptide is an endogenous regulator of enterohepatic BA cycling, which acts by enhancing BA uptake in the intestine...
  8. ncbi request reprint Sequences required for induction of neurotensin receptor gene expression during neuronal differentiation of N1E-115 neuroblastoma cells
    D Tavares
    Department of Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 274:30066-79. 1999
    ....
  9. ncbi request reprint Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells
    Sazzad Hassan
    Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester 01655 0127, USA
    Regul Pept 120:155-66. 2004
    ..We conclude that NT stimulated mitogenesis in PC3 cells by a PKC-dependent ligand-mediated transactivation of EGFR, which led to stimulation of the Raf-MEK-ERK pathway in a PI3 kinase-dependent manner...
  10. ncbi request reprint Synergistic activation of neurotensin/neuromedin N gene expression by c-Jun and glucocorticoids: novel effects of Fos family proteins
    R J Harrison
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester 01655, USA
    Mol Endocrinol 9:981-93. 1995
    ....
  11. ncbi request reprint The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences
    E Kislauskis
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester 01655
    J Biol Chem 263:4963-8. 1988
    ....
  12. ncbi request reprint Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice
    Jim Fadel
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Neurosci Lett 402:97-101. 2006
    ..These data suggest that NT is required for the full activation by AMP of medial striatal neurons...
  13. ncbi request reprint Neurotensin-deficient mice have deficits in prepulse inhibition: restoration by clozapine but not haloperidol, olanzapine, or quetiapine
    Becky Kinkead
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 315:256-64. 2005
    ..These results provide evidence that the effects of antipsychotic drugs (APDs) may be differentially affected by the state of NT neurotransmission and, moreover, that APDs differ in their dependence on an intact NT system...
  14. pmc Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Med 14:392-8. 2008
    ....
  15. doi request reprint Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma
    Xianyong Gui
    Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA
    Peptides 29:1609-15. 2008
    ..NTSR1 may thus be a potential target for preventive or therapeutic strategies in colon cancer...