Research Topics
| B DobkinSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Neurobiology of rehabilitationBruce H Dobkin
Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Reed Neurologic Research Center, 710 Westwood Plaza Los Angeles, California 90095 1769, USA
Ann N Y Acad Sci 1038:148-70. 2004..By determining how much they can influence neural reorganization, clinicians will extend the opportunities for neurorestoration...
Should body weight-supported treadmill training and robotic-assistive steppers for locomotor training trot back to the starting gate?Bruce H Dobkin
Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA
Neurorehabil Neural Repair 26:308-17. 2012..In the absence of evidence for physical therapists to employ these strategies, however, BWSTT and RAST should not be provided routinely to disabled, vulnerable persons in place of OGT outside of a scientifically conducted efficacy trial...
Protocol for the Locomotor Experience Applied Post-stroke (LEAPS) trial: a randomized controlled trialPamela W Duncan
Division of Doctor of Physical Therapy, Department of Community and Family Medicine, Duke University, Durham, North Carolina, USA
BMC Neurol 7:39. 2007..The effect of number of treatment sessions will be determined by changes in gait speed taken pre-treatment and post-12, -24, and -36 sessions...- Short-distance walking speed and timed walking distance: redundant measures for clinical trials?Bruce H Dobkin
Neurologic Rehabilitation and Research Program, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
Neurology 66:584-6. 2006..Although speed and endurance did not reflect different domains of efficacy in outpatients whose usual speed was >0.5 m/s, the fastest feasible 15-meter velocity augmented these measures... - Brain-computer interface technology as a tool to augment plasticity and outcomes for neurological rehabilitationBruce H Dobkin
University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
J Physiol 579:637-42. 2007..Clinical trials with measures of quality of life will be necessary to demonstrate the value of near-term and future BCI applications... - Confounders in rehabilitation trials of task-oriented training: lessons from the designs of the EXCITE and SCILT multicenter trialsBruce H Dobkin
Department of Neurology, University of California Los Angeles, Los Angeles, California 90095, USA
Neurorehabil Neural Repair 21:3-13. 2007.... - The evolution of walking-related outcomes over the first 12 weeks of rehabilitation for incomplete traumatic spinal cord injury: the multicenter randomized Spinal Cord Injury Locomotor TrialB Dobkin
Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
Neurorehabil Neural Repair 21:25-35. 2007..No previous studies have reported walking-related outcomes during rehabilitation... - Behavioral, temporal, and spatial targets for cellular transplants as adjuncts to rehabilitation for strokeBruce H Dobkin
Reed Neurologic Research Center, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Stroke 38:832-9. 2007..Cell-mediated rehabilitation would then use task-specific therapies in an optimal dose to maximize training-induced reorganization and learning and, most important, reduce unwanted disability... - Interpreting the randomized clinical trial of constraint-induced movement therapyBruce H Dobkin
University of California at Los Angeles, Reed Neurologic Research Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
Arch Neurol 64:336-8. 2007 - Curiosity and cure: translational research strategies for neural repair-mediated rehabilitationBruce H Dobkin
Department of Neurology, Reed Neurologic Research Center, University of California Los Angeles, Los Angeles, California 90095, USA
Dev Neurobiol 67:1133-47. 2007..Collaborations between basic and clinical scientists in the development of translational animal models of injury and repair can propel experiments for ethical bench-to-bedside therapies to augment the rehabilitation of disabled patients... - The promise of mHealth: daily activity monitoring and outcome assessments by wearable sensorsBruce H Dobkin
Department of Neurology, Geffen UCLA School of Medicine, Los Angeles, CA, USA
Neurorehabil Neural Repair 25:788-98. 2011.... - Training and exercise to drive poststroke recoveryBruce H Dobkin
University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
Nat Clin Pract Neurol 4:76-85. 2008.... - Fatigue versus activity-dependent fatigability in patients with central or peripheral motor impairmentsBruce H Dobkin
Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
Neurorehabil Neural Repair 22:105-10. 2008.... - Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor InterventionsBruce H Dobkin
Department of Neurology, Geffen School of Medicine, University of California Los Angeles, USA
Neurorehabil Neural Repair 23:197-206. 2009.... - Collaborative models for translational neuroscience and rehabilitation researchBruce H Dobkin
Department of Neurology, University of California, Los Angeles, California 90095, USA
Neurorehabil Neural Repair 23:633-40. 2009..Problem-oriented collaborations require leadership, incentives, trust, ongoing assessment, and an efficient infrastructure that overcomes barriers. These models are as testable as the hypotheses that drive scientific research... - International randomized clinical trial, stroke inpatient rehabilitation with reinforcement of walking speed (SIRROWS), improves outcomesBruce H Dobkin
Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
Neurorehabil Neural Repair 24:235-42. 2010..Feedback about performance may optimize motor relearning after stroke... - Recommendations for publishing case studies of cell transplantation for spinal cord injuryBruce H Dobkin
Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
Neurorehabil Neural Repair 24:687-91. 2010.... - Reliability and validity of bilateral ankle accelerometer algorithms for activity recognition and walking speed after strokeBruce H Dobkin
Department of Neurology, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Stroke 42:2246-50. 2011.... - Weight-supported treadmill vs over-ground training for walking after acute incomplete SCIB Dobkin
Department of Neurology, University of California Los Angeles, Neurologic Rehabilitation and Research Program, Reed Neurologic Research Center, Los Angeles, CA 90095, USA
Neurology 66:484-93. 2006.... - Cellular transplants in China: observational study from the largest human experiment in chronic spinal cord injuryBruce H Dobkin
Department of Neurology, Neurorehabilitation and Research Program, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1769, USA
Neurorehabil Neural Repair 20:5-13. 2006..In China, fetal brain tissue has been transplanted into the lesions of more than 400 patients with spinal cord injury (SCI). Anecdotal reports have been the only basis for assuming that the procedure is safe and effective... - Strategies for stroke rehabilitationBruce H Dobkin
Neurologic Rehabilitation and Research Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, USA
Lancet Neurol 3:528-36. 2004..Biological strategies for neural repair may augment rehabilitation in the next decade... - Ankle dorsiflexion as an fMRI paradigm to assay motor control for walking during rehabilitationBruce H Dobkin
Department of Neurology, Reed Neurologic Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA
Neuroimage 23:370-81. 2004..The ankle paradigm may serve as an ongoing physiological assay of the optimal type, duration, and intensity of rehabilitative gait training... - Motor rehabilitation after stroke, traumatic brain, and spinal cord injury: common denominators within recent clinical trialsBruce H Dobkin
Department of Neurology, Geffen UCLA School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Curr Opin Neurol 22:563-9. 2009.... - Clinical practice. Rehabilitation after strokeBruce H Dobkin
Department of Neurology, the Neurologic Rehabilitation and Research Program, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, USA
N Engl J Med 352:1677-84. 2005 - Underappreciated statin-induced myopathic weakness causes disabilityBruce H Dobkin
University of California Los Angeles, Reed Neurologic Research Center, CA 90095, USA
Neurorehabil Neural Repair 19:259-63. 2005..No prospective study of statins, however, included tests of strength, so the incidence of weakness, with or without muscle symptoms and elevated enzymes, is unknown, and perhaps overlooked... - Methods for a randomized trial of weight-supported treadmill training versus conventional training for walking during inpatient rehabilitation after incomplete traumatic spinal cord injuryBruce H Dobkin
Department of Neurology, Neurologic Rehabilitation and Research Program, University of California Los Angeles, Reed Neurologic, USA
Neurorehabil Neural Repair 17:153-67. 2003..The trial's methodology offers a model for the feasibility of translating neuroscientific experiments into a RCT to develop evidence-based rehabilitation practices... - Rehabilitation and functional neuroimaging dose-response trajectories for clinical trialsBruce H Dobkin
Department of Neurology, University of California Los Angeles, Geffen School of Medicine Los Angeles, CA 90095, USA
Neurorehabil Neural Repair 19:276-82. 2005..When significant, clinical effectiveness may not be robust enough to alter professional practices... - Basic advances and new avenues in therapy of spinal cord injuryBruce H Dobkin
Neurologic Rehabilitation and Neural Repair Research Programs, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, California 90095 1769, USA
Annu Rev Med 55:255-82. 2004..These bench-to-bedside studies are defining the neurobiology of spinal cord injury rehabilitation... - Step training with body weight support: effect of treadmill speed and practice paradigms on poststroke locomotor recoveryKatherine J Sullivan
Department of Neurology, University of California, Los Angeles, CA 90095, USA
Arch Phys Med Rehabil 83:683-91. 2002..75) and variable groups (ES=.73). CONCLUSIONS: Training at speeds comparable with normal walking velocity was more effective in improving SSV than training at speeds at or below the patient's typical overground walking velocity... - Immediate and long-term changes in corticomotor output in response to rehabilitation: correlation with functional improvements in chronic strokeLisa Koski
Ahmanson Lovelace Brain Mapping Center, Neuropsychiatric Institute and Department of Neurology, University of California at Los Angeles, USA
Neurorehabil Neural Repair 18:230-49. 2004..Methodological differences in the literature, however, currently obscure a full understanding of the potential contributions of TMS to rehabilitation research... - Evolution of FMRI activation in the perilesional primary motor cortex and cerebellum with rehabilitation training-related motor gains after stroke: a pilot studyYun Dong
Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095 1769, USA
Neurorehabil Neural Repair 21:412-28. 2007..Previous studies report that motor recovery after partial destruction of the primary motor cortex (M1) may be associated with adaptive functional reorganization within spared M1... - Reliable assessment of lower limb motor representations with fMRI: use of a novel MR compatible device for real-time monitoring of ankle, knee and hip torquesJennifer M Newton
Department of Neurology, University of California, Los Angeles, CA 90095 1769, USA
Neuroimage 43:136-46. 2008..These findings support the use of this apparatus in serial studies of lower limb function... - Reliability and validity of bilateral thigh and foot accelerometry measures of walking in healthy and hemiparetic subjectsKaveh Saremi
Neurologic Rehabilitation and Research Program, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Neurorehabil Neural Repair 20:297-305. 2006..CONCLUSIONS: The accelerometry system provided reliable and valid spatiotemporal measures of gait for the upper range of speeds likely to be targeted for rehabilitation interventions in ambulatory subjects... - Compensatory cerebral adaptations before and evolving changes after surgical decompression in cervical spondylotic myelopathyYun Dong
Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1769, USA
J Neurosurg Spine 9:538-51. 2008..The goal of this study was to compare cortical sensorimotor adaptations associated with neurological deterioration and then recovery following surgical decompression for cervical spondylotic myelopathy (CSM)... - Motor cortex activation during treatment may predict therapeutic gains in paretic hand function after strokeYun Dong
Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA
Stroke 37:1552-5. 2006..CONCLUSIONS: The relationship between brain activation during treatment and functional gains suggests a use for serial fMRI in predicting the success and optimal duration for a focused therapeutic intervention... - Meaningful gait speed improvement during the first 60 days poststroke: minimal clinically important differenceJulie K Tilson
Division of Biokinesiology and Physical Therapy, University of Southern California, 1540 E Alcazar St, CHP 155, Los Angeles, CA 90089, USA
Phys Ther 90:196-208. 2010..However, the minimal amount of change in gait speed that is clinically meaningful and associated with an important difference in function for people poststroke has not been determined... - Randomized, placebo-controlled, double-blind study of ropinirole in chronic strokeSteven C Cramer
Department of Neurology, University of California, Irvine, USA
Stroke 40:3034-8. 2009..The current study hypothesized that increased dopaminergic tone via the dopamine agonist ropinirole, when combined with physiotherapy (PT), would significantly and safely increase gait velocity... - Functional MRI: a potential physiologic indicator for stroke rehabilitation interventionsBruce H Dobkin
Stroke 34:e23-8. 2003 - Brain-computer interface technology: a review of the Second International MeetingTheresa M Vaughan
IEEE Trans Neural Syst Rehabil Eng 11:94-109. 2003..The practical use of BCI technology will be determined by the development of appropriate applications and identification of appropriate user groups, and will require careful attention to the needs and desires of individual users... - Neuroimaging in stroke recovery: a position paper from the First International Workshop on Neuroimaging and Stroke RecoveryJean-Claude Baron
Cerebrovasc Dis 18:260-7. 2004 - Do electrically stimulated sensory inputs and movements lead to long-term plasticity and rehabilitation gains?Bruce H Dobkin
Curr Opin Neurol 16:685-91. 2003.... - Validity of the walking scale for spinal cord injury and other domains of function in a multicenter clinical trialJohn F Ditunno
Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Neurorehabil Neural Repair 21:539-50. 2007..To demonstrate criterion (concurrent and predictive) and construct validity of the Walking Index for Spinal Cord Injury (WISCI) scale and other walking measures in the Spinal Cord Injury Locomotor Trial (SCILT)... - An accelerometry-based comparison of 2 robotic assistive devices for treadmill training of gaitJean Philippe Regnaux
Department of Adult Neurologic Rehabilitation, Hopital Raymond Poincare, Garches, France
Neurorehabil Neural Repair 22:348-54. 2008..Two commercial robotic devices, the Gait Trainer (GT) and the Lokomat (LOKO), assist task-oriented practice of walking. The gait patterns induced by these motor-driven devices have not been characterized and compared... - Botulinum toxin for spasticity after strokeBruce H Dobkin
N Engl J Med 348:258-9; author reply 258-9. 2003 - Antimicrobial prophylaxis for urinary tract infection in persons with spinal cord dysfunctionSally C Morton
Southern California Evidence Based Practice Center, Santa Monica, CA, USA
Arch Phys Med Rehabil 83:129-38. 2002..To assess the benefits and harms of antimicrobial prophylaxis to prevent urinary tract infections (UTIs) in persons with neurogenic bladders caused by spinal cord dysfunction... - A journal for translational neuroscience for rehabilitationBruce H Dobkin
Neurorehabil Neural Repair 20:3-4. 2006 - Standardizing and validating transcranial magnetic stimulation measures for use in stroke rehabilitation researchLisa Koski
Clin Neurophysiol 116:740-1. 2005 - Statin-related myopathyBruce H Dobkin
Arch Intern Med 166:1232; author reply 1233. 2006 - Emerging subspecialties: neurorehabilitation: training neurologists to retrain the brainMichael A Dimyan
Human Cortical Physiology Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA
Neurology 70:e52-4. 2008
Research Grants
- LOCOMOTOR THERAPY TRIAL FOR SPINAL CORD INJURYBruce Dobkin; Fiscal Year: 2002..In addition, it will demonstrate the value and feasibility of the RCT for developing evidence-based rehabilitation practices. ..
- fMRI Predictor Model for Stroke Locomotor RehabilitationBruce Dobkin; Fiscal Year: 2007..We will then test a statistically derived predictive model by training a new group of 12 subjects. The study is a step toward using fMRI as a tool to develop theory- and evidencebased practices that lessen disabilities after stroke. ..