B Dobkin

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Neurobiology of rehabilitation
    Bruce H Dobkin
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Reed Neurologic Research Center, 710 Westwood Plaza Los Angeles, California 90095 1769, USA
    Ann N Y Acad Sci 1038:148-70. 2004
  2. pmc New evidence for therapies in stroke rehabilitation
    Bruce H Dobkin
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Curr Atheroscler Rep 15:331. 2013
  3. doi request reprint Should body weight-supported treadmill training and robotic-assistive steppers for locomotor training trot back to the starting gate?
    Bruce H Dobkin
    Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 26:308-17. 2012
  4. pmc Protocol for the Locomotor Experience Applied Post-stroke (LEAPS) trial: a randomized controlled trial
    Pamela W Duncan
    Division of Doctor of Physical Therapy, Department of Community and Family Medicine, Duke University, Durham, North Carolina, USA
    BMC Neurol 7:39. 2007
  5. ncbi request reprint Rehabilitation and functional neuroimaging dose-response trajectories for clinical trials
    Bruce H Dobkin
    Department of Neurology, University of California Los Angeles, Geffen School of Medicine Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 19:276-82. 2005
  6. doi request reprint Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor Interventions
    Bruce H Dobkin
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, USA
    Neurorehabil Neural Repair 23:197-206. 2009
  7. ncbi request reprint Cellular transplants in China: observational study from the largest human experiment in chronic spinal cord injury
    Bruce H Dobkin
    Department of Neurology, Neurorehabilitation and Research Program, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1769, USA
    Neurorehabil Neural Repair 20:5-13. 2006
  8. ncbi request reprint Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI
    B Dobkin
    Department of Neurology, University of California Los Angeles, Neurologic Rehabilitation and Research Program, Reed Neurologic Research Center, Los Angeles, CA 90095, USA
    Neurology 66:484-93. 2006
  9. ncbi request reprint Short-distance walking speed and timed walking distance: redundant measures for clinical trials?
    Bruce H Dobkin
    Neurologic Rehabilitation and Research Program, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Neurology 66:584-6. 2006
  10. doi request reprint Fatigue versus activity-dependent fatigability in patients with central or peripheral motor impairments
    Bruce H Dobkin
    Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 22:105-10. 2008

Research Grants

Detail Information

Publications50

  1. ncbi request reprint Neurobiology of rehabilitation
    Bruce H Dobkin
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Reed Neurologic Research Center, 710 Westwood Plaza Los Angeles, California 90095 1769, USA
    Ann N Y Acad Sci 1038:148-70. 2004
    ..By determining how much they can influence neural reorganization, clinicians will extend the opportunities for neurorestoration...
  2. pmc New evidence for therapies in stroke rehabilitation
    Bruce H Dobkin
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Curr Atheroscler Rep 15:331. 2013
    ..Recent clinical trials provide evidence for a range of new interventions to manage walking, reach and grasp, aphasia, visual field loss, and hemi-inattention...
  3. doi request reprint Should body weight-supported treadmill training and robotic-assistive steppers for locomotor training trot back to the starting gate?
    Bruce H Dobkin
    Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 26:308-17. 2012
    ..In the absence of evidence for physical therapists to employ these strategies, however, BWSTT and RAST should not be provided routinely to disabled, vulnerable persons in place of OGT outside of a scientifically conducted efficacy trial...
  4. pmc Protocol for the Locomotor Experience Applied Post-stroke (LEAPS) trial: a randomized controlled trial
    Pamela W Duncan
    Division of Doctor of Physical Therapy, Department of Community and Family Medicine, Duke University, Durham, North Carolina, USA
    BMC Neurol 7:39. 2007
    ..The effect of number of treatment sessions will be determined by changes in gait speed taken pre-treatment and post-12, -24, and -36 sessions...
  5. ncbi request reprint Rehabilitation and functional neuroimaging dose-response trajectories for clinical trials
    Bruce H Dobkin
    Department of Neurology, University of California Los Angeles, Geffen School of Medicine Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 19:276-82. 2005
    ..When significant, clinical effectiveness may not be robust enough to alter professional practices...
  6. doi request reprint Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor Interventions
    Bruce H Dobkin
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, USA
    Neurorehabil Neural Repair 23:197-206. 2009
    ....
  7. ncbi request reprint Cellular transplants in China: observational study from the largest human experiment in chronic spinal cord injury
    Bruce H Dobkin
    Department of Neurology, Neurorehabilitation and Research Program, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1769, USA
    Neurorehabil Neural Repair 20:5-13. 2006
    ..In China, fetal brain tissue has been transplanted into the lesions of more than 400 patients with spinal cord injury (SCI). Anecdotal reports have been the only basis for assuming that the procedure is safe and effective...
  8. ncbi request reprint Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI
    B Dobkin
    Department of Neurology, University of California Los Angeles, Neurologic Rehabilitation and Research Program, Reed Neurologic Research Center, Los Angeles, CA 90095, USA
    Neurology 66:484-93. 2006
    ....
  9. ncbi request reprint Short-distance walking speed and timed walking distance: redundant measures for clinical trials?
    Bruce H Dobkin
    Neurologic Rehabilitation and Research Program, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Neurology 66:584-6. 2006
    ..Although speed and endurance did not reflect different domains of efficacy in outpatients whose usual speed was >0.5 m/s, the fastest feasible 15-meter velocity augmented these measures...
  10. doi request reprint Fatigue versus activity-dependent fatigability in patients with central or peripheral motor impairments
    Bruce H Dobkin
    Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 22:105-10. 2008
    ....
  11. doi request reprint Training and exercise to drive poststroke recovery
    Bruce H Dobkin
    University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Nat Clin Pract Neurol 4:76-85. 2008
    ....
  12. pmc Brain-computer interface technology as a tool to augment plasticity and outcomes for neurological rehabilitation
    Bruce H Dobkin
    University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    J Physiol 579:637-42. 2007
    ..Clinical trials with measures of quality of life will be necessary to demonstrate the value of near-term and future BCI applications...
  13. ncbi request reprint The evolution of walking-related outcomes over the first 12 weeks of rehabilitation for incomplete traumatic spinal cord injury: the multicenter randomized Spinal Cord Injury Locomotor Trial
    B Dobkin
    Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 21:25-35. 2007
    ..No previous studies have reported walking-related outcomes during rehabilitation...
  14. ncbi request reprint Behavioral, temporal, and spatial targets for cellular transplants as adjuncts to rehabilitation for stroke
    Bruce H Dobkin
    Reed Neurologic Research Center, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Stroke 38:832-9. 2007
    ..Cell-mediated rehabilitation would then use task-specific therapies in an optimal dose to maximize training-induced reorganization and learning and, most important, reduce unwanted disability...
  15. ncbi request reprint Interpreting the randomized clinical trial of constraint-induced movement therapy
    Bruce H Dobkin
    University of California at Los Angeles, Reed Neurologic Research Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Arch Neurol 64:336-8. 2007
  16. ncbi request reprint Underappreciated statin-induced myopathic weakness causes disability
    Bruce H Dobkin
    University of California Los Angeles, Reed Neurologic Research Center, CA 90095, USA
    Neurorehabil Neural Repair 19:259-63. 2005
    ..No prospective study of statins, however, included tests of strength, so the incidence of weakness, with or without muscle symptoms and elevated enzymes, is unknown, and perhaps overlooked...
  17. ncbi request reprint Clinical practice. Rehabilitation after stroke
    Bruce H Dobkin
    Department of Neurology, the Neurologic Rehabilitation and Research Program, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, USA
    N Engl J Med 352:1677-84. 2005
  18. doi request reprint The promise of mHealth: daily activity monitoring and outcome assessments by wearable sensors
    Bruce H Dobkin
    Department of Neurology, Geffen UCLA School of Medicine, Los Angeles, CA, USA
    Neurorehabil Neural Repair 25:788-98. 2011
    ....
  19. doi request reprint Reliability and validity of bilateral ankle accelerometer algorithms for activity recognition and walking speed after stroke
    Bruce H Dobkin
    Department of Neurology, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Stroke 42:2246-50. 2011
    ....
  20. doi request reprint Recommendations for publishing case studies of cell transplantation for spinal cord injury
    Bruce H Dobkin
    Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 24:687-91. 2010
    ....
  21. ncbi request reprint Methods for a randomized trial of weight-supported treadmill training versus conventional training for walking during inpatient rehabilitation after incomplete traumatic spinal cord injury
    Bruce H Dobkin
    Department of Neurology, Neurologic Rehabilitation and Research Program, University of California Los Angeles, Reed Neurologic, USA
    Neurorehabil Neural Repair 17:153-67. 2003
    ..The trial's methodology offers a model for the feasibility of translating neuroscientific experiments into a RCT to develop evidence-based rehabilitation practices...
  22. ncbi request reprint Confounders in rehabilitation trials of task-oriented training: lessons from the designs of the EXCITE and SCILT multicenter trials
    Bruce H Dobkin
    Department of Neurology, University of California Los Angeles, Los Angeles, California 90095, USA
    Neurorehabil Neural Repair 21:3-13. 2007
    ....
  23. ncbi request reprint Basic advances and new avenues in therapy of spinal cord injury
    Bruce H Dobkin
    Neurologic Rehabilitation and Neural Repair Research Programs, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, California 90095 1769, USA
    Annu Rev Med 55:255-82. 2004
    ..These bench-to-bedside studies are defining the neurobiology of spinal cord injury rehabilitation...
  24. ncbi request reprint Strategies for stroke rehabilitation
    Bruce H Dobkin
    Neurologic Rehabilitation and Research Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, USA
    Lancet Neurol 3:528-36. 2004
    ..Biological strategies for neural repair may augment rehabilitation in the next decade...
  25. ncbi request reprint Ankle dorsiflexion as an fMRI paradigm to assay motor control for walking during rehabilitation
    Bruce H Dobkin
    Department of Neurology, Reed Neurologic Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuroimage 23:370-81. 2004
    ..The ankle paradigm may serve as an ongoing physiological assay of the optimal type, duration, and intensity of rehabilitative gait training...
  26. doi request reprint International randomized clinical trial, stroke inpatient rehabilitation with reinforcement of walking speed (SIRROWS), improves outcomes
    Bruce H Dobkin
    Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Neurorehabil Neural Repair 24:235-42. 2010
    ..Feedback about performance may optimize motor relearning after stroke...
  27. doi request reprint Motor rehabilitation after stroke, traumatic brain, and spinal cord injury: common denominators within recent clinical trials
    Bruce H Dobkin
    Department of Neurology, Geffen UCLA School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Curr Opin Neurol 22:563-9. 2009
    ....
  28. doi request reprint Collaborative models for translational neuroscience and rehabilitation research
    Bruce H Dobkin
    Department of Neurology, University of California, Los Angeles, California 90095, USA
    Neurorehabil Neural Repair 23:633-40. 2009
    ..Problem-oriented collaborations require leadership, incentives, trust, ongoing assessment, and an efficient infrastructure that overcomes barriers. These models are as testable as the hypotheses that drive scientific research...
  29. ncbi request reprint Curiosity and cure: translational research strategies for neural repair-mediated rehabilitation
    Bruce H Dobkin
    Department of Neurology, Reed Neurologic Research Center, University of California Los Angeles, Los Angeles, California 90095, USA
    Dev Neurobiol 67:1133-47. 2007
    ..Collaborations between basic and clinical scientists in the development of translational animal models of injury and repair can propel experiments for ethical bench-to-bedside therapies to augment the rehabilitation of disabled patients...
  30. ncbi request reprint Step training with body weight support: effect of treadmill speed and practice paradigms on poststroke locomotor recovery
    Katherine J Sullivan
    Department of Neurology, University of California, Los Angeles, CA 90095, USA
    Arch Phys Med Rehabil 83:683-91. 2002
    ..To investigate the effect of practice paradigms that varied treadmill speed during step training with body weight support in subjects with chronic hemiparesis after stroke...
  31. ncbi request reprint Evolution of FMRI activation in the perilesional primary motor cortex and cerebellum with rehabilitation training-related motor gains after stroke: a pilot study
    Yun Dong
    Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095 1769, USA
    Neurorehabil Neural Repair 21:412-28. 2007
    ..Previous studies report that motor recovery after partial destruction of the primary motor cortex (M1) may be associated with adaptive functional reorganization within spared M1...
  32. pmc Reliable assessment of lower limb motor representations with fMRI: use of a novel MR compatible device for real-time monitoring of ankle, knee and hip torques
    Jennifer M Newton
    Department of Neurology, University of California, Los Angeles, CA 90095 1769, USA
    Neuroimage 43:136-46. 2008
    ..These findings support the use of this apparatus in serial studies of lower limb function...
  33. ncbi request reprint Immediate and long-term changes in corticomotor output in response to rehabilitation: correlation with functional improvements in chronic stroke
    Lisa Koski
    Ahmanson Lovelace Brain Mapping Center, Neuropsychiatric Institute and Department of Neurology, University of California at Los Angeles, USA
    Neurorehabil Neural Repair 18:230-49. 2004
    ..Methodological differences in the literature, however, currently obscure a full understanding of the potential contributions of TMS to rehabilitation research...
  34. ncbi request reprint Reliability and validity of bilateral thigh and foot accelerometry measures of walking in healthy and hemiparetic subjects
    Kaveh Saremi
    Neurologic Rehabilitation and Research Program, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 20:297-305. 2006
    ..A new integrated system of 5 accelerometers was tested for reliability and compared to a footswitch system to determine if the accelerometers offered a practical option for the acquisition of spatiotemporal gait parameters...
  35. pmc Meaningful gait speed improvement during the first 60 days poststroke: minimal clinically important difference
    Julie K Tilson
    Division of Biokinesiology and Physical Therapy, University of Southern California, 1540 E Alcazar St, CHP 155, Los Angeles, CA 90089, USA
    Phys Ther 90:196-208. 2010
    ..However, the minimal amount of change in gait speed that is clinically meaningful and associated with an important difference in function for people poststroke has not been determined...
  36. doi request reprint Compensatory cerebral adaptations before and evolving changes after surgical decompression in cervical spondylotic myelopathy
    Yun Dong
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosurg Spine 9:538-51. 2008
    ..The goal of this study was to compare cortical sensorimotor adaptations associated with neurological deterioration and then recovery following surgical decompression for cervical spondylotic myelopathy (CSM)...
  37. ncbi request reprint Motor cortex activation during treatment may predict therapeutic gains in paretic hand function after stroke
    Yun Dong
    Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA
    Stroke 37:1552-5. 2006
    ..Functional brain imaging after stroke offers insight into motor network adaptations. This exploratory study examined whether motor cortical activation captured during arm-focused therapy can predict paretic hand functional gains...
  38. doi request reprint Randomized, placebo-controlled, double-blind study of ropinirole in chronic stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine, USA
    Stroke 40:3034-8. 2009
    ..The current study hypothesized that increased dopaminergic tone via the dopamine agonist ropinirole, when combined with physiotherapy (PT), would significantly and safely increase gait velocity...
  39. ncbi request reprint Validity of the walking scale for spinal cord injury and other domains of function in a multicenter clinical trial
    John F Ditunno
    Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Neurorehabil Neural Repair 21:539-50. 2007
    ..To demonstrate criterion (concurrent and predictive) and construct validity of the Walking Index for Spinal Cord Injury (WISCI) scale and other walking measures in the Spinal Cord Injury Locomotor Trial (SCILT)...
  40. ncbi request reprint Do electrically stimulated sensory inputs and movements lead to long-term plasticity and rehabilitation gains?
    Bruce H Dobkin
    Curr Opin Neurol 16:685-91. 2003
    ....
  41. ncbi request reprint Functional MRI: a potential physiologic indicator for stroke rehabilitation interventions
    Bruce H Dobkin
    Stroke 34:e23-8. 2003
  42. ncbi request reprint Brain-computer interface technology: a review of the Second International Meeting
    Theresa M Vaughan
    IEEE Trans Neural Syst Rehabil Eng 11:94-109. 2003
    ..The practical use of BCI technology will be determined by the development of appropriate applications and identification of appropriate user groups, and will require careful attention to the needs and desires of individual users...
  43. pmc Neuroimaging in stroke recovery: a position paper from the First International Workshop on Neuroimaging and Stroke Recovery
    Jean Claude Baron
    Cerebrovasc Dis 18:260-7. 2004
  44. ncbi request reprint An accelerometry-based comparison of 2 robotic assistive devices for treadmill training of gait
    Jean Philippe Regnaux
    Department of Adult Neurologic Rehabilitation, Hopital Raymond Poincare, Garches, France
    Neurorehabil Neural Repair 22:348-54. 2008
    ..Two commercial robotic devices, the Gait Trainer (GT) and the Lokomat (LOKO), assist task-oriented practice of walking. The gait patterns induced by these motor-driven devices have not been characterized and compared...
  45. ncbi request reprint Antimicrobial prophylaxis for urinary tract infection in persons with spinal cord dysfunction
    Sally C Morton
    Southern California Evidence Based Practice Center, Santa Monica, CA, USA
    Arch Phys Med Rehabil 83:129-38. 2002
    ..To assess the benefits and harms of antimicrobial prophylaxis to prevent urinary tract infections (UTIs) in persons with neurogenic bladders caused by spinal cord dysfunction...
  46. ncbi request reprint Standardizing and validating transcranial magnetic stimulation measures for use in stroke rehabilitation research
    Lisa Koski
    Clin Neurophysiol 116:740-1. 2005
  47. ncbi request reprint Statin-related myopathy
    Bruce H Dobkin
    Arch Intern Med 166:1232; author reply 1233. 2006
  48. ncbi request reprint Botulinum toxin for spasticity after stroke
    Bruce H Dobkin
    N Engl J Med 348:258-9; author reply 258-9. 2003
  49. ncbi request reprint A journal for translational neuroscience for rehabilitation
    Bruce H Dobkin
    Neurorehabil Neural Repair 20:3-4. 2006
  50. doi request reprint Emerging subspecialties: neurorehabilitation: training neurologists to retrain the brain
    Michael A Dimyan
    Human Cortical Physiology Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Neurology 70:e52-4. 2008

Research Grants5

  1. LOCOMOTOR THERAPY TRIAL FOR SPINAL CORD INJURY
    Bruce Dobkin; Fiscal Year: 2002
    ..In addition, it will demonstrate the value and feasibility of the RCT for developing evidence-based rehabilitation practices. ..
  2. fMRI Predictor Model for Stroke Locomotor Rehabilitation
    Bruce Dobkin; Fiscal Year: 2007
    ..We will then test a statistically derived predictive model by training a new group of 12 subjects. The study is a step toward using fMRI as a tool to develop theory- and evidencebased practices that lessen disabilities after stroke. ..