A Djamali

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Potential of emerging immunosuppressive strategies to improve the posttransplant cardiovascular risk profile
    Arjang Djamali
    Department of Medicine, University of Wisconsin, Madison, Wisconsin 53793, USA
    Kidney Int 78:S15-21. 2010
  2. pmc HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis
    Aparna Vidyasagar
    Nephrology Section, Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI 53713, USA
    Am J Physiol Renal Physiol 295:F707-16. 2008
  3. pmc Tubular expression of heat-shock protein 27 inhibits fibrogenesis in obstructive nephropathy
    Aparna Vidyasagar
    Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Kidney Int 83:84-92. 2013
  4. pmc Increased C4d in post-reperfusion biopsies and increased donor specific antibodies at one-week post transplant are risk factors for acute rejection in mild to moderately sensitized kidney transplant recipients
    Arjang Djamali
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 51703, USA
    Kidney Int 83:1185-92. 2013
  5. pmc Nox2 is a mediator of chronic CsA nephrotoxicity
    A Djamali
    Division of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Am J Transplant 12:1997-2007. 2012
  6. pmc Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target
    Aparna Vidyasagar
    Nephrology Division, Department of Medicine, University of Wisconsin, H4 564 CSC, 600 Highland Avenue, Madison, WI, 53792, USA
    Fibrogenesis Tissue Repair 5:7. 2012
  7. ncbi request reprint Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allografts
    Arjang Djamali
    Department of Medicine, University of Wisconsin, Madison, Madison, WI 53713, USA
    Am J Physiol Renal Physiol 293:F445-55. 2007
  8. ncbi request reprint [Can the renal transplant patient be really considered as a patient with chronic renal insufficiency?]
    A Djamali
    Nephrology Research, University of Wisconsin Madison, 3034 Fish Hatchery Rd, B, Madison, WI 53713, USA
    Nephrol Ther 4:S36-S39. 2008
  9. doi request reprint Increase in proteinuria >200 mg/g after late rejection is associated with poor graft survival
    Arjang Djamali
    University of Wisconsin Madison SMPH, Department of Medicine, Wisconsin, USA
    Nephrol Dial Transplant 25:1300-6. 2010
  10. pmc The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model
    Shannon Reese
    Departments of Medicine and Surgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Fibrogenesis Tissue Repair 3:1. 2010

Research Grants

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Potential of emerging immunosuppressive strategies to improve the posttransplant cardiovascular risk profile
    Arjang Djamali
    Department of Medicine, University of Wisconsin, Madison, Wisconsin 53793, USA
    Kidney Int 78:S15-21. 2010
    ..Surveillance for new adverse events must be an integral part of the long-term management strategy...
  2. pmc HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis
    Aparna Vidyasagar
    Nephrology Section, Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI 53713, USA
    Am J Physiol Renal Physiol 295:F707-16. 2008
    ..HSP27 overexpression may delay injury by upregulating E-cadherin through downregulation of Snail...
  3. pmc Tubular expression of heat-shock protein 27 inhibits fibrogenesis in obstructive nephropathy
    Aparna Vidyasagar
    Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Kidney Int 83:84-92. 2013
    ..Thus, tubular HSP27 inhibits fibrogenesis in obstructive nephropathy. Further studies are needed to determine pathways regulating the interactions between HSP27 and the E-cadherin-β-catenin complex...
  4. pmc Increased C4d in post-reperfusion biopsies and increased donor specific antibodies at one-week post transplant are risk factors for acute rejection in mild to moderately sensitized kidney transplant recipients
    Arjang Djamali
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 51703, USA
    Kidney Int 83:1185-92. 2013
    ..8-fold risk of rejection. Thus, C4d staining in post-reperfusion biopsies and an early rise in donor specific antibodies after transplantation are risk factors for rejection in moderately sensitized patients...
  5. pmc Nox2 is a mediator of chronic CsA nephrotoxicity
    A Djamali
    Division of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Am J Transplant 12:1997-2007. 2012
    ..In conclusion, specific Nox2 inhibition strategies may improve chronic CNI nephrotoxicity in solid organ transplantation...
  6. pmc Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target
    Aparna Vidyasagar
    Nephrology Division, Department of Medicine, University of Wisconsin, H4 564 CSC, 600 Highland Avenue, Madison, WI, 53792, USA
    Fibrogenesis Tissue Repair 5:7. 2012
    ..The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target...
  7. ncbi request reprint Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allografts
    Arjang Djamali
    Department of Medicine, University of Wisconsin, Madison, Madison, WI 53713, USA
    Am J Physiol Renal Physiol 293:F445-55. 2007
    ..These questions may be answered by prospective randomized placebo-control trials examining the role of select antioxidants in the prevention of chronic allograft TA/IF...
  8. ncbi request reprint [Can the renal transplant patient be really considered as a patient with chronic renal insufficiency?]
    A Djamali
    Nephrology Research, University of Wisconsin Madison, 3034 Fish Hatchery Rd, B, Madison, WI 53713, USA
    Nephrol Ther 4:S36-S39. 2008
    ..The general application of the KDOQI and KDIGO guidelines to kidney transplant recipients requires therefore further evaluation...
  9. doi request reprint Increase in proteinuria >200 mg/g after late rejection is associated with poor graft survival
    Arjang Djamali
    University of Wisconsin Madison SMPH, Department of Medicine, Wisconsin, USA
    Nephrol Dial Transplant 25:1300-6. 2010
    ..There is no information on the effects of proteinuria on outcomes following rejection...
  10. pmc The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model
    Shannon Reese
    Departments of Medicine and Surgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Fibrogenesis Tissue Repair 3:1. 2010
    ....
  11. ncbi request reprint Noninvasive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imaging
    Arjang Djamali
    Department of Medicine, University of Wisconsin Madison, Madison, WI, USA
    Transplantation 82:621-8. 2006
    ..We hypothesized that BOLD-MRI could accurately discriminate different types of rejection early after kidney transplantation...
  12. ncbi request reprint BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction
    Arjang Djamali
    Department of Medicine, University of Wisconsin Madison, Madison, WI 53713, USA
    Am J Physiol Renal Physiol 292:F513-22. 2007
    ..BOLD-MRI demonstrated significant changes in medullary and cortical oxygen bioavailability in allografts with CAN. These correlated with serum/urine biomarkers of OS, suggesting an association between intrarenal oxygenation and OS...
  13. pmc Mycophenolic acid may delay allograft fibrosis by inhibiting transforming growth factor-beta1-induced activation of Nox-2 through the nuclear factor-kappaB pathway
    Arjang Djamali
    Department of Medicine, University of Wisconsin Madison SMPH, Madison, WI, USA
    Transplantation 90:387-93. 2010
    ..We evaluated the role of renal tubular Nox-2 in the pathogenesis of epithelial-to-mesenchymal transition (EMT) in kidney allografts...
  14. pmc Nox-2 is a modulator of fibrogenesis in kidney allografts
    A Djamali
    Nephrology Section, Department of Medicine, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Am J Transplant 9:74-82. 2009
    ..In aggregate, these studies suggest that Nox-2 is involved in the pathogenesis of allograft tubulointerstitial fibrosis via activation transcription factor Smad2, EMT and myofibroblasts...
  15. ncbi request reprint Medical care of kidney transplant recipients after the first posttransplant year
    Arjang Djamali
    Department of Medicine, Nephrology Section, University of Wisconsin Madison, School of Medicine, 3034 Fish Hatchery Road, Suite B, Madison, WI 53713, USA
    Clin J Am Soc Nephrol 1:623-40. 2006
    ..This article reviews the contemporary aspects of care for these patients...
  16. ncbi request reprint Heat shock protein 27 in chronic allograft nephropathy: a local stress response
    Arjang Djamali
    Department of Medicine, University of Wisconsin Madison, Madison, WI, USA
    Transplantation 79:1645-57. 2005
    ..The authors hypothesized that HSP27 is involved in chronic allograft nephropathy (CAN), a chronic state of inflammation and stress...
  17. pmc Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis
    Surmeet Bedi
    Department of Medicine, Nephrology Section, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI 53713, USA
    Transplant Rev (Orlando) 22:1-5. 2008
    ..Furthermore, additional data are required to determine whether EMT may be used as a surrogate marker of disease progression in kidney transplant recipients...
  18. ncbi request reprint Outcomes in kidney transplantation
    Arjang Djamali
    Department of Medicine and Surgery, University of Wisconsin Medical School, Madison, WI 53792, USA
    Semin Nephrol 23:306-16. 2003
    ..In addition, we review the current management and intervention for the comorbidities associated with the long-term clinical management of the kidney transplant recipient...
  19. ncbi request reprint Epithelial-to-mesenchymal transition and oxidative stress in chronic allograft nephropathy
    Arjang Djamali
    Department of Medicine, University of Wisconsin, Madison, WI 53713, USA
    Am J Transplant 5:500-9. 2005
    ..In conclusion, these observations suggest that CAN-associated EMT may be a link between oxidative stress and allograft fibrosis...
  20. ncbi request reprint Alemtuzumab induction and recurrence of glomerular disease after kidney transplantation
    Julio Pascual
    Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI 53713, USA
    Transplantation 83:1429-34. 2007
    ..An increase in the incidence of autoimmune diseases has been described in patients receiving alemtuzumab...
  21. doi request reprint Alemtuzumab induction and antibody-mediated kidney rejection after simultaneous pancreas-kidney transplantation
    Julio Pascual
    Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53713, USA
    Transplantation 87:125-32. 2009
    ..Alemtuzumab is effective in preventing acute cellular rejection (ACR) in SPK recipients and has been used to prevent antibody-mediated rejection (AMR) in sensitized kidney transplant candidates...
  22. pmc Recurrent atypical hemolytic uremic syndrome associated with factor I mutation in a living related renal transplant recipient
    Micah R Chan
    Department of Medicine, Section of Nephrology, University of Wisconsin Hospitals and Clinics, Madison, WI, USA
    Am J Kidney Dis 53:321-6. 2009
    ..This report reemphasizes the importance of screening patients with atypical hemolytic uremic syndrome for mutations in these genes before renal transplantation and shows the challenges in the management of these patients...
  23. pmc Fibrogenesis in kidney transplantation: potential targets for prevention and therapy
    Arjang Djamali
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53793, USA
    Transplantation 88:1149-56. 2009
    ..Clinical trials are needed to examine the effect of these therapies on long-term outcomes...
  24. ncbi request reprint Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cells
    Susan H McKiernan
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    Am J Physiol Renal Physiol 292:F1751-60. 2007
    ..Renal tubular epithelial cells with mitochondrial abnormalities presented cellular characteristics indicative of physiological dysfunction...
  25. ncbi request reprint Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging: initial experience
    Elizabeth A Sadowski
    Department of Radiology, Medical Physics, Nephrology, and Biostatistics, University of Wisconsin, 600 Highland Ave, E3 311 CSC, Madison, WI 53792, USA
    Radiology 236:911-9. 2005
    ....
  26. pmc Measurement and comparison of T1 relaxation times in native and transplanted kidney cortex and medulla
    Yin Huang
    Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705 2275, USA
    J Magn Reson Imaging 33:1241-7. 2011
    ..To measure and compare cortical and medullary T1 values in native and transplanted kidneys with a wide range of function as measured by estimated glomerular filtration rate (eGFR)...
  27. ncbi request reprint Low serum magnesium is associated with decreased graft survival in patients with chronic cyclosporin nephrotoxicity
    Ryan Holzmacher
    Department of Medicine, University of Wisconsin, Madison, WI, USA
    Nephrol Dial Transplant 20:1456-62. 2005
    ..Hypomagnesaemia is a common side effect of cyclosporin A (CsA) therapy. Animal studies suggest that magnesium (Mg) supplementation inhibits chronic CsA nephropathy...
  28. ncbi request reprint Characterization of transfusion-elicited acute antibody-mediated rejection in a rat model of kidney transplantation
    G Huang
    Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI
    Am J Transplant 14:1061-72. 2014
    ..These studies suggest that M1 macrophages and TH 1 cytokines play an important role in the pathogenesis of acute mixed rejection in sensitized allograft recipients...
  29. ncbi request reprint Collapsing focal segmental glomerulosclerosis in a liver transplant recipient on alendronate
    J Pascual
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Osteoporos Int 18:1435-8. 2007
    ..In view of the increasing incidence of chronic kidney disease in long-term liver transplant patients, bisphosphonate need to be used with caution in patients with a low glomerular filtration rate...
  30. ncbi request reprint Drug insight: maintenance immunosuppression in kidney transplant recipients
    Millie Samaniego
    Nephrology Section, Department of Medicine, University of Wisconsin Madison, 3034 Fish Hatchery Road, Suite B, Madison, WI 53713, USA
    Nat Clin Pract Nephrol 2:688-99. 2006
    ....
  31. pmc Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys
    Elizabeth A Sadowski
    Department of Radiology, University of Wisconsin, Madison, WI 53792, USA
    Magn Reson Imaging 28:56-64. 2010
    ....
  32. doi request reprint Diagnosis and management of antibody-mediated rejection: current status and novel approaches
    A Djamali
    Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI
    Am J Transplant 14:255-71. 2014
    ..This review article provides an overview of current thinking and research surrounding the pathophysiology and diagnosis of ABMR, ABMR-related outcomes, ABMR prevention and treatment, as well as possible future directions in treatment. ..
  33. pmc Quantitative MR measures of intrarenal perfusion in the assessment of transplanted kidneys: initial experience
    Andrew L Wentland
    Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705 2275, USA
    Acad Radiol 16:1077-85. 2009
    ....
  34. ncbi request reprint Disease progression and outcomes in chronic kidney disease and renal transplantation
    Arjang Djamali
    Department of Medicine, Nephrology Section, University of Wisconsin Madison Medical School, Madison, Wisconsin 53713 3125, USA
    Kidney Int 64:1800-7. 2003
    ..It is unknown whether renal transplant recipients (RTR) have better outcomes and disease progression rates compared to patients with chronic kidney disease (CKD) when matched for the level of kidney function...
  35. pmc Antibody-mediated rejection of the kidney after simultaneous pancreas-kidney transplantation
    Julio Pascual
    Department of Surgery, Division of Transplantation, University of Wisconsin Hospital and Clinics, H4 772 CSC, 600 Highland Avenue, Madison, WI 53792 7375, USA
    J Am Soc Nephrol 19:812-24. 2008
    ....
  36. ncbi request reprint Intrathymic injection of anti-Fas monoclonal antibody prolongs murine non-vascularized cardiac allograft survival
    Arjang Djamali
    Department of Medicine, Nephrology Section, Division of Organ Transplantation, University of Wisconsin Madison Medical School, Madison, Wisconsin 53792, USA
    Transpl Int 17:301-9. 2004
    ....
  37. doi request reprint Mitral annular calcification is associated with reduced left ventricular function and inflammation in patients with chronic kidney disease
    Anupama K Rao
    University of Wisconsin School of Medicine and Public Health, Division of Cardiovascular Medicine and Section of Nephrology, Madison, Wisconsin 53792, USA
    J Am Soc Echocardiogr 21:747-50. 2008
    ....
  38. ncbi request reprint Disease progression and outcomes in type 1 diabetic kidney transplant recipients based on posttransplantation CKD staging
    Chanigan Smavatkul
    Department of Medicine, Nephrology Section, University of Wisconsin School of Medicine and Public Health, Madison, WI 53713, USA
    Am J Kidney Dis 50:631-40. 2007
    ..Disease progression rates and outcomes per stage of kidney disease in kidney transplant recipients with type 1 diabetes mellitus are unknown...
  39. ncbi request reprint CKD stage-to-stage progression in native and transplant kidney disease
    Aleksandra Kukla
    Department of Medicine, Nephrology Section, University of Wisconsin School of Medicine and Public Health, 3034 Fish Hatchery Road, Madison, WI 53713, USA
    Nephrol Dial Transplant 23:693-700. 2008
    ..Kidney half-life and inter-stage progression rates in native chronic kidney disease (CKD) and CKD-transplant (CKD-T) remain unknown...
  40. pmc Chronic kidney disease stage progression in liver transplant recipients
    John C LaMattina
    Department of Medicine, University of Wisconsin, H4 564 CSC, 600 Highland Avenue, Madison, WI 53792, USA
    Clin J Am Soc Nephrol 6:1851-7. 2011
    ..There is little information on chronic kidney disease (CKD) stage progression rates and outcomes in liver transplant recipients. Identifying modifiable risk factors may help prevent CKD progression in liver transplant recipients...
  41. pmc Bisphosphonates and bone fractures in long-term kidney transplant recipients
    Emily Conley
    Department of Medicine, University of Wisconsin Madison, Madison, WI, USA
    Transplantation 86:231-7. 2008
    ..There is little information on the role of bisphosphonates and bone mineral density (BMD) measurements for the follow-up and management of bone loss and fractures in long-term kidney transplant recipients...
  42. ncbi request reprint Increasing hematocrit reduces early posttransplant cardiovascular risk in diabetic transplant recipients
    Arjang Djamali
    Department of Medicine, University of Wisconsin, Madison, USA
    Transplantation 76:816-20. 2003
    ..Cardiovascular disease remains epidemic in transplant recipients, despite aggressive treatment of cardiovascular risk factors. Thus, novel risk factors could play a role in the genesis of cardiovascular events in this population...
  43. ncbi request reprint Nephrogenic systemic fibrosis: risk factors and incidence estimation
    Elizabeth A Sadowski
    Department of Radiology, University of Wisconsin, Madison, WI 53792 3252, USA
    Radiology 243:148-57. 2007
    ..To retrospectively review data in 13 patients with biopsy-confirmed nephrogenic systemic fibrosis (NSF), assess the associated risk factors, and report the incidence of NSF at the authors' institution...
  44. ncbi request reprint Do statins delay the incidence of ESRD in diabetic patients with moderate CKD?
    James Conley
    Nephrology Section, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53793, USA
    J Nephrol 23:321-7. 2010
    ..There is little information on whether statins and LDL cholesterol are associated with the onset of end-stage renal disease (ESRD) in at-risk populations...
  45. ncbi request reprint ATR blockade reduces IFN-gamma production in lymphocytes in vivo and in vitro
    Jon A Weidanz
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
    Kidney Int 67:2134-42. 2005
    ..We examined the effect of AT(1)R blockade on release of the proinflammatory cytokine, interferon-gamma (IFN-gamma) by human lymphocytes in vivo and in vitro...

Research Grants2

  1. HSP27 in Kidney Epithelial to Mesenchymal Transformation
    Arjang Djamali; Fiscal Year: 2007
    ..Overexpression of HSP27 will be obtained by recombinant virus-mediated HSP27 gene transfer. This proposal would allow us to determine whether HSP27 overexpression can prevent/delay EMT. ..