Research Topics
| A DjamaliSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosisAparna Vidyasagar
Nephrology Section, Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI 53713, USA
Am J Physiol Renal Physiol 295:F707-16. 2008..HSP27 overexpression may delay injury by upregulating E-cadherin through downregulation of Snail...- Nox2 is a mediator of chronic CsA nephrotoxicityA Djamali
Division of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Am J Transplant 12:1997-2007. 2012..In conclusion, specific Nox2 inhibition strategies may improve chronic CNI nephrotoxicity in solid organ transplantation... - Heat shock protein 27 (HSP27): biomarker of disease and therapeutic targetAparna Vidyasagar
Nephrology Division, Department of Medicine, University of Wisconsin, H4 564 CSC, 600 Highland Avenue, Madison, WI, 53792, USA
Fibrogenesis Tissue Repair 5:7. 2012..The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target... 
Potential of emerging immunosuppressive strategies to improve the posttransplant cardiovascular risk profileArjang Djamali
Department of Medicine, University of Wisconsin, Madison, Wisconsin 53793, USA
Kidney Int 78:S15-21. 2010..Surveillance for new adverse events must be an integral part of the long-term management strategy...- The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion modelShannon Reese
Departments of Medicine and Surgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
Fibrogenesis Tissue Repair 3:1. 2010.... 
Increase in proteinuria >200 mg/g after late rejection is associated with poor graft survivalArjang Djamali
University of Wisconsin Madison SMPH, Department of Medicine, Wisconsin, USA
Nephrol Dial Transplant 25:1300-6. 2010..There is no information on the effects of proteinuria on outcomes following rejection...- Nox-2 is a modulator of fibrogenesis in kidney allograftsA Djamali
Nephrology Section, Department of Medicine, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
Am J Transplant 9:74-82. 2009..In aggregate, these studies suggest that Nox-2 is involved in the pathogenesis of allograft tubulointerstitial fibrosis via activation transcription factor Smad2, EMT and myofibroblasts... - [Can the renal transplant patient be really considered as a patient with chronic renal insufficiency?]A Djamali
Nephrology Research, University of Wisconsin Madison, 3034 Fish Hatchery Rd, B, Madison, WI 53713, USA
Nephrol Ther 4:S36-S39. 2008..The general application of the KDOQI and KDIGO guidelines to kidney transplant recipients requires therefore further evaluation... - Medical care of kidney transplant recipients after the first posttransplant yearArjang Djamali
Department of Medicine, Nephrology Section, University of Wisconsin Madison, School of Medicine, 3034 Fish Hatchery Road, Suite B, Madison, WI 53713, USA
Clin J Am Soc Nephrol 1:623-40. 2006..This article reviews the contemporary aspects of care for these patients... - Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allograftsArjang Djamali
Department of Medicine, University of Wisconsin, Madison, Madison, WI 53713, USA
Am J Physiol Renal Physiol 293:F445-55. 2007..These questions may be answered by prospective randomized placebo-control trials examining the role of select antioxidants in the prevention of chronic allograft TA/IF... - Noninvasive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imagingArjang Djamali
Department of Medicine, University of Wisconsin Madison, Madison, WI, USA
Transplantation 82:621-8. 2006..We hypothesized that BOLD-MRI could accurately discriminate different types of rejection early after kidney transplantation... - BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunctionArjang Djamali
Department of Medicine, University of Wisconsin Madison, Madison, WI 53713, USA
Am J Physiol Renal Physiol 292:F513-22. 2007..BOLD-MRI demonstrated significant changes in medullary and cortical oxygen bioavailability in allografts with CAN. These correlated with serum/urine biomarkers of OS, suggesting an association between intrarenal oxygenation and OS... - Mycophenolic acid may delay allograft fibrosis by inhibiting transforming growth factor-beta1-induced activation of Nox-2 through the nuclear factor-kappaB pathwayArjang Djamali
Department of Medicine, University of Wisconsin Madison SMPH, Madison, WI, USA
Transplantation 90:387-93. 2010..We evaluated the role of renal tubular Nox-2 in the pathogenesis of epithelial-to-mesenchymal transition (EMT) in kidney allografts... - Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosisSurmeet Bedi
Department of Medicine, Nephrology Section, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI 53713, USA
Transplant Rev (Orlando) 22:1-5. 2008..Furthermore, additional data are required to determine whether EMT may be used as a surrogate marker of disease progression in kidney transplant recipients... - Heat shock protein 27 in chronic allograft nephropathy: a local stress responseArjang Djamali
Department of Medicine, University of Wisconsin Madison, Madison, WI, USA
Transplantation 79:1645-57. 2005..The authors hypothesized that HSP27 is involved in chronic allograft nephropathy (CAN), a chronic state of inflammation and stress... - Outcomes in kidney transplantationArjang Djamali
Department of Medicine and Surgery, University of Wisconsin Medical School, Madison, WI 53792, USA
Semin Nephrol 23:306-16. 2003..In addition, we review the current management and intervention for the comorbidities associated with the long-term clinical management of the kidney transplant recipient... - Epithelial-to-mesenchymal transition and oxidative stress in chronic allograft nephropathyArjang Djamali
Department of Medicine, University of Wisconsin, Madison, WI 53713, USA
Am J Transplant 5:500-9. 2005..In conclusion, these observations suggest that CAN-associated EMT may be a link between oxidative stress and allograft fibrosis... - Alemtuzumab induction and antibody-mediated kidney rejection after simultaneous pancreas-kidney transplantationJulio Pascual
Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53713, USA
Transplantation 87:125-32. 2009..Alemtuzumab is effective in preventing acute cellular rejection (ACR) in SPK recipients and has been used to prevent antibody-mediated rejection (AMR) in sensitized kidney transplant candidates... - Fibrogenesis in kidney transplantation: potential targets for prevention and therapyArjang Djamali
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53793, USA
Transplantation 88:1149-56. 2009..Clinical trials are needed to examine the effect of these therapies on long-term outcomes... - Recurrent atypical hemolytic uremic syndrome associated with factor I mutation in a living related renal transplant recipientMicah R Chan
Department of Medicine, Section of Nephrology, University of Wisconsin Hospitals and Clinics, Madison, WI, USA
Am J Kidney Dis 53:321-6. 2009..This report reemphasizes the importance of screening patients with atypical hemolytic uremic syndrome for mutations in these genes before renal transplantation and shows the challenges in the management of these patients... - Alemtuzumab induction and recurrence of glomerular disease after kidney transplantationJulio Pascual
Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI 53713, USA
Transplantation 83:1429-34. 2007..An increase in the incidence of autoimmune diseases has been described in patients receiving alemtuzumab... - Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging: initial experienceElizabeth A Sadowski
Department of Radiology, Medical Physics, Nephrology, and Biostatistics, University of Wisconsin, 600 Highland Ave, E3 311 CSC, Madison, WI 53792, USA
Radiology 236:911-9. 2005.... - Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cellsSusan H McKiernan
Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
Am J Physiol Renal Physiol 292:F1751-60. 2007..Renal tubular epithelial cells with mitochondrial abnormalities presented cellular characteristics indicative of physiological dysfunction... - Measurement and comparison of T1 relaxation times in native and transplanted kidney cortex and medullaYin Huang
Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705 2275, USA
J Magn Reson Imaging 33:1241-7. 2011..To measure and compare cortical and medullary T1 values in native and transplanted kidneys with a wide range of function as measured by estimated glomerular filtration rate (eGFR)... - Low serum magnesium is associated with decreased graft survival in patients with chronic cyclosporin nephrotoxicityRyan Holzmacher
Department of Medicine, University of Wisconsin, Madison, WI, USA
Nephrol Dial Transplant 20:1456-62. 2005..This suggests that hypomagnesaemia could potentiate CsA-mediated nephropathy... - Collapsing focal segmental glomerulosclerosis in a liver transplant recipient on alendronateJ Pascual
Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Osteoporos Int 18:1435-8. 2007..In view of the increasing incidence of chronic kidney disease in long-term liver transplant patients, bisphosphonate need to be used with caution in patients with a low glomerular filtration rate... - Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneysElizabeth A Sadowski
Department of Radiology, University of Wisconsin, Madison, WI 53792, USA
Magn Reson Imaging 28:56-64. 2010.... - Drug insight: maintenance immunosuppression in kidney transplant recipientsMillie Samaniego
Nephrology Section, Department of Medicine, University of Wisconsin Madison, 3034 Fish Hatchery Road, Suite B, Madison, WI 53713, USA
Nat Clin Pract Nephrol 2:688-99. 2006.... - CKD stage-to-stage progression in native and transplant kidney diseaseAleksandra Kukla
Department of Medicine, Nephrology Section, University of Wisconsin School of Medicine and Public Health, 3034 Fish Hatchery Road, Madison, WI 53713, USA
Nephrol Dial Transplant 23:693-700. 2008..Kidney half-life and inter-stage progression rates in native chronic kidney disease (CKD) and CKD-transplant (CKD-T) remain unknown... - Disease progression and outcomes in chronic kidney disease and renal transplantationArjang Djamali
Department of Medicine, Nephrology Section, University of Wisconsin-Madison Medical School, Madison, Wisconsin 53713-3125, USA
Kidney Int 64:1800-7. 2003..These data suggest that RTR are a unique subset of patients with CKD whose comorbid conditions likely offset the potential benefits of slower rates of progression... - Disease progression and outcomes in type 1 diabetic kidney transplant recipients based on posttransplantation CKD stagingChanigan Smavatkul
Department of Medicine, Nephrology Section, University of Wisconsin School of Medicine and Public Health, Madison, WI 53713, USA
Am J Kidney Dis 50:631-40. 2007..Disease progression rates and outcomes per stage of kidney disease in kidney transplant recipients with type 1 diabetes mellitus are unknown... - Intrathymic injection of anti-Fas monoclonal antibody prolongs murine non-vascularized cardiac allograft survivalArjang Djamali
Department of Medicine, Nephrology Section, Division of Organ Transplantation, University of Wisconsin-Madison Medical School, Madison, Wisconsin 53792, USA
Transpl Int 17:301-9. 2004.... - Quantitative MR measures of intrarenal perfusion in the assessment of transplanted kidneys: initial experienceAndrew L Wentland
Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705 2275, USA
Acad Radiol 16:1077-85. 2009.... - Antibody-mediated rejection of the kidney after simultaneous pancreas-kidney transplantationJulio Pascual
Department of Surgery, Division of Transplantation, University of Wisconsin Hospital and Clinics, H4 772 CSC, 600 Highland Avenue, Madison, WI 53792 7375, USA
J Am Soc Nephrol 19:812-24. 2008.... - Mitral annular calcification is associated with reduced left ventricular function and inflammation in patients with chronic kidney diseaseAnupama K Rao
University of Wisconsin School of Medicine and Public Health, Division of Cardiovascular Medicine and Section of Nephrology, Madison, Wisconsin 53792, USA
J Am Soc Echocardiogr 21:747-50. 2008.... - Chronic kidney disease stage progression in liver transplant recipientsJohn C LaMattina
Department of Medicine, University of Wisconsin, H4 564 CSC, 600 Highland Avenue, Madison, WI 53792, USA
Clin J Am Soc Nephrol 6:1851-7. 2011..There is little information on chronic kidney disease (CKD) stage progression rates and outcomes in liver transplant recipients. Identifying modifiable risk factors may help prevent CKD progression in liver transplant recipients... - Do statins delay the incidence of ESRD in diabetic patients with moderate CKD?James Conley
Nephrology Section, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53793, USA
J Nephrol 23:321-7. 2010..There is little information on whether statins and LDL cholesterol are associated with the onset of end-stage renal disease (ESRD) in at-risk populations... - Increasing hematocrit reduces early posttransplant cardiovascular risk in diabetic transplant recipientsArjang Djamali
Department of Medicine, University of Wisconsin, Madison, USA
Transplantation 76:816-20. 2003..Prospective studies of anemia management therapy in this setting are warranted to determine whether this will reduce early posttransplant CV risk... - Nephrogenic systemic fibrosis: risk factors and incidence estimationElizabeth A Sadowski
Department of Radiology, University of Wisconsin, Madison, WI 53792 3252, USA
Radiology 243:148-57. 2007..To retrospectively review data in 13 patients with biopsy-confirmed nephrogenic systemic fibrosis (NSF), assess the associated risk factors, and report the incidence of NSF at the authors' institution... - Bisphosphonates and bone fractures in long-term kidney transplant recipientsEmily Conley
Department of Medicine, University of Wisconsin Madison, Madison, WI, USA
Transplantation 86:231-7. 2008..There is little information on the role of bisphosphonates and bone mineral density (BMD) measurements for the follow-up and management of bone loss and fractures in long-term kidney transplant recipients... - ATR blockade reduces IFN-gamma production in lymphocytes in vivo and in vitroJon A Weidanz
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
Kidney Int 67:2134-42. 2005..AT(1)R blocker treatment furthermore also inhibited IFN-gamma production in the cytotoxic T-lymphocyte line. CONCLUSION: AT(1)R blockers may have a clinically relevant immunomodulatory role by blocking IFN-gamma production in T cells...
Research Grants
- HSP27 in Kidney Epithelial to Mesenchymal TransformationArjang Djamali; Fiscal Year: 2007..Overexpression of HSP27 will be obtained by recombinant virus-mediated HSP27 gene transfer. This proposal would allow us to determine whether HSP27 overexpression can prevent/delay EMT. ..