DAN ALAN DIXON

Summary

Affiliation: University of South Carolina
Country: USA

Publications

  1. pmc The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase
    Sandhya Sanduja
    Department of Biological Sciences and Cancer Research Center, University of South Carolina, Columbia, SC 29203, USA
    Aging (Albany NY) 1:803-17. 2009
  2. pmc The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2
    Lisa E Young
    Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Mol Cancer Res 10:167-80. 2012
  3. pmc Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling
    Dan A Dixon
    Department of Biological Sciences and South Carolina Cancer Center, University of South Carolina, Columbia, South Carolina 29203, USA
    J Clin Invest 116:2727-38. 2006
  4. pmc The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis
    Lisa E Young
    Department of Biological Sciences and Cancer Research Center, University of South Carolina, Columbia, South Carolina 29203, USA
    Gastroenterology 136:1669-79. 2009
  5. ncbi Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis
    Guang Peng
    Department of Pathology and Microbiology, School of Medicine, The University of South Carolina, and South Carolina Cancer Center, Columbia, South Carolina 29203, USA
    Mol Carcinog 45:309-19. 2006
  6. pmc Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells
    Zongxian Cao
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Cell Signal 19:1542-53. 2007
  7. ncbi Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells
    Alexandra Thiel
    Department of Pathology, Helsinki University Central Hospital, and Molecular and Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland
    J Biol Chem 281:4564-9. 2006
  8. ncbi Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates
    Andrew S Weyrich
    Department of Internal Medicine, Human Molecular Biology and Genetics, Bldg 533, Room 4220, University of Utah, Salt Lake City, UT 84112, USA
    Circulation 111:633-42. 2005
  9. ncbi Dysregulated post-transcriptional control of COX-2 gene expression in cancer
    Dan A Dixon
    Surgical Oncology Research Laboratory, Departments of Surgery and Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2733, USA
    Curr Pharm Des 10:635-46. 2004
  10. pmc Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1
    Dan A Dixon
    Surgical Oncology Research Laboratory, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2733, USA
    J Exp Med 198:475-81. 2003

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase
    Sandhya Sanduja
    Department of Biological Sciences and Cancer Research Center, University of South Carolina, Columbia, SC 29203, USA
    Aging (Albany NY) 1:803-17. 2009
    ..These findings demonstrate the ability of TTP to act as a tumor suppressor by inhibiting the E6-AP pathway and indicate TTP loss to be a critical event during HPV-mediated carcinogenesis...
  2. pmc The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2
    Lisa E Young
    Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Mol Cancer Res 10:167-80. 2012
    ..Along with insight into altered ARE-mediated mRNA decay observed in colorectal cancer, these findings provide a new explanation for tumor-derived loss of miR-16...
  3. pmc Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling
    Dan A Dixon
    Department of Biological Sciences and South Carolina Cancer Center, University of South Carolina, Columbia, South Carolina 29203, USA
    J Clin Invest 116:2727-38. 2006
    ..These checkpoints may be altered in disease and therefore useful as targets for antiinflammatory intervention...
  4. pmc The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis
    Lisa E Young
    Department of Biological Sciences and Cancer Research Center, University of South Carolina, Columbia, South Carolina 29203, USA
    Gastroenterology 136:1669-79. 2009
    ..We examined the functions of HuR and TTP during colon tumorigenesis and their ability to regulate cyclooxygenase (COX-2), a mediator of prostaglandin synthesis that increases in the colon tumor microenvironment...
  5. ncbi Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis
    Guang Peng
    Department of Pathology and Microbiology, School of Medicine, The University of South Carolina, and South Carolina Cancer Center, Columbia, South Carolina 29203, USA
    Mol Carcinog 45:309-19. 2006
    ..In conclusion, these data suggest that inhibition of COX-2 is a mechanism for the anti-proliferative effect of green tea and emphasizes the role that dietary factors have as anti-cancer agents...
  6. pmc Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells
    Zongxian Cao
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Cell Signal 19:1542-53. 2007
    ....
  7. ncbi Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells
    Alexandra Thiel
    Department of Pathology, Helsinki University Central Hospital, and Molecular and Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland
    J Biol Chem 281:4564-9. 2006
    ..Our data show that inhibition of GSK-3beta stimulates COX-2 expression in gastric cancer cells, which seems to be primarily facilitated via an increase in mRNA stability and to a lesser extent through enhanced transcription...
  8. ncbi Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates
    Andrew S Weyrich
    Department of Internal Medicine, Human Molecular Biology and Genetics, Bldg 533, Room 4220, University of Utah, Salt Lake City, UT 84112, USA
    Circulation 111:633-42. 2005
    ..Here, we determined whether dipyridamole and aspirin, a combination therapy used to prevent recurrent stroke, regulates gene expression in platelet-monocyte inflammatory model systems...
  9. ncbi Dysregulated post-transcriptional control of COX-2 gene expression in cancer
    Dan A Dixon
    Surgical Oncology Research Laboratory, Departments of Surgery and Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2733, USA
    Curr Pharm Des 10:635-46. 2004
    ....
  10. pmc Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1
    Dan A Dixon
    Surgical Oncology Research Laboratory, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2733, USA
    J Exp Med 198:475-81. 2003
    ..These findings implicate that TIA-1 functions as a translational silencer of COX-2 expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia...
  11. ncbi Regulation of cyclooxgenase-2 mRNA stability by taxanes: evidence for involvement of p38, MAPKAPK-2, and HuR
    Kotha Subbaramaiah
    Department of Medicine Division of Gastroenterology and Hepatology, New York Presbyterian Hospital, New York, New York 10021, USA
    J Biol Chem 278:37637-47. 2003
    ..To the best of our knowledge, this is the first evidence that taxanes can promote stabilization of mRNA in addition to modulating gene transcription...
  12. ncbi Regulation of COX-2 expression in human cancers
    Dan A Dixon
    Surgical Oncology Research Laboratory, Departments of Surgery and Cancer Biology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Prog Exp Tumor Res 37:52-71. 2003
  13. ncbi Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site
    Hitoshi Sawaoka
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 278:13928-35. 2003
    ..However, the truncated transcript escaped tristetraprolin binding and downregulation...
  14. ncbi Change in protein phenotype without a nucleus: translational control in platelets
    Andrew S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    Semin Thromb Hemost 30:491-8. 2004
    ..We highlight the molecular machinery and pathways used by platelets to translate mRNA into protein and offer insight into how these synthesized products may regulate thrombotic and inflammatory events...
  15. ncbi Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta
    Sheng Ru Shiou
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2730, USA
    J Biol Chem 281:33971-81. 2006
    ....
  16. pmc Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition
    Cindy L Kanies
    Department of Surgery, Vanderbilt University Medical Center, D 4316 Medical Center North, Nashville, TN 37232 2730, USA
    Mol Cancer Res 6:1124-36. 2008
    ....
  17. ncbi Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cells
    Olivier Boutaud
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Adv Exp Med Biol 525:157-60. 2003

Research Grants2

  1. Post-Transcriptional Regulation in Colorectal Cancer
    DAN ALAN DIXON; Fiscal Year: 2010
    ....