Dirk P Dittmer

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCR
    Farnaz D Fakhari
    Department of Microbiology and Immunology, The University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Virol 76:6213-23. 2002
  2. ncbi request reprint Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arrays
    Dirk P Dittmer
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Cancer Res 63:2010-5. 2003
  3. pmc Whole-genome transcription profiling of rhesus monkey rhadinovirus
    Dirk P Dittmer
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    J Virol 79:8637-50. 2005
  4. ncbi request reprint The tumor microenvironment controls primary effusion lymphoma growth in vivo
    Michelle R Staudt
    Graduate Program in Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Cancer Res 64:4790-9. 2004
  5. pmc Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Pathog 5:e1000389. 2009
  6. pmc Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research at University of North Carolina at Chapel Hill, NC 27599 7290, USA
    Blood 113:5938-41. 2009
  7. pmc Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirus
    Tamara K Nun
    Department of Microbiology and Immunology, Lineberger Cancer Center, University of North Carolina at Chapel Hill, North Carolina, NC 27599, USA
    Mol Cancer Ther 6:2360-70. 2007
  8. pmc Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling
    Sang Hoon Sin
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, NC 27599 7290, USA
    Blood 109:2165-73. 2007
  9. pmc Toll-like receptor signaling controls reactivation of KSHV from latency
    Sean M Gregory
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 106:11725-30. 2009
  10. pmc Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus Lymphomas
    Wuguo Chen
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, CB no 7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7290, USA
    J Virol 84:3898-908. 2010

Collaborators

Detail Information

Publications46

  1. pmc Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCR
    Farnaz D Fakhari
    Department of Microbiology and Immunology, The University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Virol 76:6213-23. 2002
    ..In contrast, every other latent or lytic message was induced. Hence, LANA, v-FLIP, v-cyclin, and LANA-2 constitute a group of uniquely regulated transcripts in the KSHV genome...
  2. ncbi request reprint Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arrays
    Dirk P Dittmer
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Cancer Res 63:2010-5. 2003
    ..Stratification by KSHV lytic transcription can identify lesions with a high percentage of lytically infected cells, which may respond to antiviral drugs...
  3. pmc Whole-genome transcription profiling of rhesus monkey rhadinovirus
    Dirk P Dittmer
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    J Virol 79:8637-50. 2005
    ..Using this assay, we demonstrate that the genome-wide transcription profile for RRV closely parallels the genome-wide transcription profile for KSHV...
  4. ncbi request reprint The tumor microenvironment controls primary effusion lymphoma growth in vivo
    Michelle R Staudt
    Graduate Program in Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Cancer Res 64:4790-9. 2004
    ..These findings underscore the importance of the microenvironment for PEL tumorigenesis and simplify the preclinical evaluation of potential anticancer agents...
  5. pmc Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Pathog 5:e1000389. 2009
    ..Mir-140 and Kaposi sarcoma-associated herpesvirus viral miRNAs increased linearly with the degree of transformation. Mir-24 emerged as a biomarker specific for KS...
  6. pmc Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research at University of North Carolina at Chapel Hill, NC 27599 7290, USA
    Blood 113:5938-41. 2009
    ..Because many tumor suppressor proteins are wild-type in KS and PEL, down-regulation of multiple tumor suppressor miRNAs provides a novel, alternative mechanism of transformation...
  7. pmc Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirus
    Tamara K Nun
    Department of Microbiology and Immunology, Lineberger Cancer Center, University of North Carolina at Chapel Hill, North Carolina, NC 27599, USA
    Mol Cancer Ther 6:2360-70. 2007
    ....
  8. pmc Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling
    Sang Hoon Sin
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, NC 27599 7290, USA
    Blood 109:2165-73. 2007
    ..This validates sirolimus as a new treatment option for PEL...
  9. pmc Toll-like receptor signaling controls reactivation of KSHV from latency
    Sean M Gregory
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 106:11725-30. 2009
    ..Our findings have broad implications for physiological triggers of latent viral infections, such as herpesviral reactivation and persistence in the host...
  10. pmc Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus Lymphomas
    Wuguo Chen
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, CB no 7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7290, USA
    J Virol 84:3898-908. 2010
    ..If p53 is activated by DNA damage or nutlin-3a, the complex falls apart easily, and p53 exercises its role as guardian of the genome...
  11. ncbi request reprint Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
    Joseph H Jeong
    University of Oklahoma Health Sciences Center, Department of Microbiology and Immunology, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 279:16822-31. 2004
    ..Furthermore, we demonstrate that LANA regulates its own promoter via its C-terminal domain and does bind to a defined site within the core promoter...
  12. pmc The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivo
    Sang Hoon Sin
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, CB 7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7290, USA
    J Virol 84:10653-60. 2010
    ..This was dependent upon B-cell receptor since LANA did not restore the GC defect of CD19 knockout mice. However, LANA was able to restore the marginal zone defect in CD19 knockout mice...
  13. ncbi request reprint Viral latent proteins as targets for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) induced lymphoma
    Michelle R Staudt
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Curr Drug Targets Infect Disord 3:129-35. 2003
    ..In particular Rta/orf50 is necessary and sufficient for lytic replication and deserves serious consideration as a target for KSHV-specific antivirals...
  14. ncbi request reprint Real-time quantitative PCR analysis of viral transcription
    James Papin
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Methods Mol Biol 292:449-80. 2005
    ..Because these arrays are RT-PCR-based, they are inherently more sensitive and robust than current hybridization-based approaches and are ideally suited to query viral gene expression in models of pathogenesis...
  15. pmc Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A
    Kristen M Tamburro
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    Virology 433:220-5. 2012
    ..It is the first whole genome KSHV sequence to be determined directly from patient plasma rather than cultured or biopsied tumor material. This case supports KICS as a new clinical entity associated with KSHV...
  16. pmc Comparison of the Rta/Orf50 transactivator proteins of gamma-2-herpesviruses
    Blossom Damania
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 78:5491-9. 2004
    ..These results suggest that the core functionality of Rta/Orf50 is conserved and independent of its host, but the human protein has evolved additional, human-specific capabilities...
  17. pmc Gene alteration and precursor and mature microRNA transcription changes contribute to the miRNA signature of primary effusion lymphoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, and Curriculum in Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Blood 111:2347-53. 2008
    ..This defines the miRNA signature of PEL and shows that transcriptional regulation of pre-miRNA as well as mature miRNA levels contribute nonredundant information that can be used for the classification of human tumors...
  18. pmc Tissue specificity of the Kaposi's sarcoma-associated herpesvirus latent nuclear antigen (LANA/orf73) promoter in transgenic mice
    Joseph H Jeong
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Virol 76:11024-32. 2002
    ..The transgenic-mouse experiments reported here suggest that tissue-restricted LANA gene expression could explain B-cell-specific viral persistence...
  19. ncbi request reprint Methylene blue photoinactivation of RNA viruses
    Robert A Floyd
    Oklahoma Medical Research Foundation, Auburn University, Auburn, AL 36849, USA
    Antiviral Res 61:141-51. 2004
    ..MB photoinactivation of viruses show significant promise because the technology not only offers significant potency but the history of safe MB use in human therapy makes it attractive also...
  20. pmc Latency locus complements MicroRNA 155 deficiency in vivo
    Sang Hoon Sin
    Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Virol 87:11908-11. 2013
    ..Germinal center (GC) formation was rescued in spleen, lymph node, and Peyer's patches. Immunoglobulin levels were restored. This demonstrates that KSHV can complement the normal, physiological function of miR-155. ..
  21. ncbi request reprint Methylene blue photoinactivation abolishes West Nile virus infectivity in vivo
    James F Papin
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, USA
    Antiviral Res 68:84-7. 2005
    ..Since MB is already approved for human use at a dose of 100mg/kg/day, we conjecture that MB+light treatment of blood products for high-risk patients will be efficacious and suitable for use in resource-limited settings...
  22. ncbi request reprint Kaposi's sarcoma in the era of HAART-an update on mechanisms, diagnostics and treatment
    Dirk P Dittmer
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599 7290, USA
    AIDS Rev 7:56-61. 2005
    ..Today we know a lot about KSHV and can begin to understand, diagnose and treat KS as a viral disease rather than another sarcoma...
  23. pmc Restricted Kaposi's sarcoma (KS) herpesvirus transcription in KS lesions from patients on successful antiretroviral therapy
    Dirk P Dittmer
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, University of North Carolina, Chapel Hill, North Carolina, USA
    MBio 2:e00138-11. 2011
    ..With one exception, only the canonical viral latency mRNAs were detectable. In contrast, early AIDS KS lesions expressed many more viral mRNAs, including, for instance, the viral G protein-coupled receptor (vGPCR)...
  24. pmc Targeted therapy for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus
    Dirk P Dittmer
    Department of Microbiology and Immunology, Center for AIDS Research and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Curr Opin Oncol 19:452-7. 2007
    ..To summarize major recent findings on the biology of human herpesvirus-8, i.e. Kaposi's sarcoma-associated herpesvirus, and the implications of these findings for Kaposi's sarcoma treatment...
  25. pmc What lies within: coinfections and immunity
    Blossom Damania
    Department of Microbiology and Immunology, Program in Global Oncology at the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Cell Host Microbe 16:145-7. 2014
    ..2014) demonstrate that helminth infection impacts viral infections by tilting the immune system toward Th2/M2 immune regulatory responses that dampen Th1/M1 antiviral responses as well as promote reactivation of latent herpesviruses. ..
  26. pmc Recent cancer incidence trends in an observational clinical cohort of HIV-infected patients in the US, 2000 to 2011
    Elizabeth L Yanik
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 715 Mary Ellen Jones Building, Chapel Hill, NC, USA
    Infect Agent Cancer 8:18. 2013
    ..We assessed changes in the distribution of cancer types and incidence trends among HIV-infected patients in North Carolina up until 2011...
  27. pmc Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma
    Aadra P Bhatt
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:11818-23. 2012
    ..Our findings suggest that FASN may be a unique candidate for molecular targeted therapy against PEL and other B-NHL...
  28. ncbi request reprint A naturally occurring fatal case of Herpesvirus papio 2 pneumonia in an infant baboon (Papio hamadryas anubis)
    Roman F Wolf
    Division of Animal Resources, Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    J Am Assoc Lab Anim Sci 45:64-8. 2006
    ..This case is interesting because the age at onset suggests perinatal transmission at or immediately after birth, and the disease course suggests inoculation of the virus into the respiratory tract...
  29. pmc SYBR green-based real-time quantitative PCR assay for detection of West Nile Virus circumvents false-negative results due to strain variability
    James F Papin
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Clin Microbiol 42:1511-8. 2004
    ....
  30. pmc Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regions
    Denise Whitby
    Viral Epidemiology Section, AIDS Vaccine Program, SAIC Frederick, NCI Frederick, Frederick, MD 21702, USA
    Int J Cancer 120:321-8. 2007
    ..These in vitro data provide support for the "oncoweed" hypothesis by demonstrating basic biological plausibility...
  31. ncbi request reprint Promoter switching allows simultaneous transcription of LANA and K14/vGPCR of Kaposi's sarcoma-associated herpesvirus
    Michelle R Staudt
    Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 804 Mary Ellen Jones, CB 7290, Chapel Hill, NC 27599 7290, USA
    Virology 350:192-205. 2006
    ..In sum, cis-elements within the LANAp were selected to ensure faithful expression of LANA and other genes regulated by LANAp during all stages of the KSHV lifecycle despite potential interference from K14/vGPCRp activity...
  32. pmc In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma
    Agata D Agostino Mutlu
    Laboratory of Viral Oncogenesis, Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cancer Cell 11:245-58. 2007
    ..These results show that KSHV malignancy is in vivo growth restricted and reversible, defining mECK36 as a biologically sensitive animal model of KSHV-dependent KS...
  33. pmc EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3
    Tianli Xia
    The Viral Oncology Program, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cancer Res 68:1436-42. 2008
    ..Targeted suppression of CXCL-11/I-TAC by a viral-encoded miRNA may serve as an immunomodulatory mechanism in these tumors...
  34. pmc The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma
    Farnaz D Fakhari
    Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7290, USA
    J Clin Invest 116:735-42. 2006
    ..We also observed lymphomas, implying that LANA can activate B cells and provide the first step toward lymphomagenesis...
  35. pmc Novel Kaposi's sarcoma-associated herpesvirus homolog in baboons
    Denise Whitby
    Viral Epidemiology Section, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    J Virol 77:8159-65. 2003
    ..This establishes baboons as a novel resource to investigate rhadinovirus biology, which can be developed into an animal model system for KSHV-associated human diseases, vaccine development, and therapy evaluation...
  36. pmc Azidothymidine inhibits NF-kappaB and induces Epstein-Barr virus gene expression in Burkitt lymphoma
    Motoki Kurokawa
    Department of Dermatology, Medical College, University of Miyazaki, Japan
    Blood 106:235-40. 2005
    ..AZT inhibits NF-kappaB and up-regulates EBV gene expression in primary EBV+ BLs. AZT with hydroxyurea may represent an inexpensive, targeted regimen for endemic BL...
  37. pmc Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression
    Heesoon Chang
    Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 79:14371-82. 2005
    ....
  38. pmc Faster quantitative real-time PCR protocols may lose sensitivity and show increased variability
    Chelsey Hilscher
    Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, NC, USA
    Nucleic Acids Res 33:e182. 2005
    ..Fast PCR was associated with a loss of sensitivity as well as higher variability, but not with a loss of specificity or with a higher false positive rate...
  39. pmc Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma
    Dirk P Dittmer
    Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA
    Int J Cancer 123:2105-12. 2008
    ..The conceptual insights provided by our quantitative analysis should aid our understanding of mammalian episomes, as well as lead to designs to cure latent viral infection...
  40. pmc More on HIV-associated Kaposi's sarcoma
    Susan E Krown
    N Engl J Med 358:535-6; author reply 536. 2008
  41. ncbi request reprint Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus
    Ling Wang
    Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cancer Res 66:3658-66. 2006
    ..We also report that K1 enhances angiogenesis in vivo and increases tumor vasculature and tumor size...
  42. pmc Liposomal daunorubicin as treatment for Kaposi's sarcoma
    Christin E Petre
    Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599 7290, USA
    Int J Nanomedicine 2:277-88. 2007
    ....
  43. ncbi request reprint KSHV-associated disease in the AIDS patient
    Dirk P Dittmer
    Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
    Cancer Treat Res 133:129-39. 2007
  44. pmc Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy
    Christin E Petre
    Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Virol 81:1912-22. 2007
    ....
  45. pmc Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo
    Feng Qi An
    Department of Molecular Genetics and Microbiology, University of Florida, Shands Cancer Center, Gainesville, FL 32610 0232, USA
    J Virol 80:4833-46. 2006
    ..KSHV-infected LTCs represent the first xenograft model for KS and should be of use to study KS pathogenesis and for the validation of anti-KS drug candidates...
  46. ncbi request reprint Baboon model for West Nile virus infection and vaccine evaluation
    Roman F Wolf
    Department of Comparative Medicine Science, University of Oklahoma Health Sciences Center, USA
    Virology 355:44-51. 2006
    ..This report is the first to describe the development of the baboon model for WNV experimental infection and the utility of this model to characterize the immunologic response against WNV and a candidate WNV vaccine...