Research Topics
| Dirk P DittmerSummaryAffiliation: University of Oklahoma Health Sciences Center Country: USA Publications
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Detail Information
Publications
Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCRFarnaz D Fakhari
Department of Microbiology and Immunology, The University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
J Virol 76:6213-23. 2002..In contrast, every other latent or lytic message was induced. Hence, LANA, v-FLIP, v-cyclin, and LANA-2 constitute a group of uniquely regulated transcripts in the KSHV genome...
Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arraysDirk P Dittmer
Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
Cancer Res 63:2010-5. 2003..Stratification by KSHV lytic transcription can identify lesions with a high percentage of lytically infected cells, which may respond to antiviral drugs...- Whole-genome transcription profiling of rhesus monkey rhadinovirusDirk P Dittmer
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, North Carolina 27599, USA
J Virol 79:8637-50. 2005..Using this assay, we demonstrate that the genome-wide transcription profile for RRV closely parallels the genome-wide transcription profile for KSHV... - The tumor microenvironment controls primary effusion lymphoma growth in vivoMichelle R Staudt
Graduate Program in Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Cancer Res 64:4790-9. 2004..These findings underscore the importance of the microenvironment for PEL tumorigenesis and simplify the preclinical evaluation of potential anticancer agents... - Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcomaAndrea J O'Hara
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research at University of North Carolina at Chapel Hill, NC 27599 7290, USA
Blood 113:5938-41. 2009..Because many tumor suppressor proteins are wild-type in KS and PEL, down-regulation of multiple tumor suppressor miRNAs provides a novel, alternative mechanism of transformation... - Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcomaAndrea J O'Hara
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
PLoS Pathog 5:e1000389. 2009..Mir-140 and Kaposi sarcoma-associated herpesvirus viral miRNAs increased linearly with the degree of transformation. Mir-24 emerged as a biomarker specific for KS... - Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus LymphomasWuguo Chen
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, CB no 7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7290, USA
J Virol 84:3898-908. 2010..If p53 is activated by DNA damage or nutlin-3a, the complex falls apart easily, and p53 exercises its role as guardian of the genome... - Toll-like receptor signaling controls reactivation of KSHV from latencySean M Gregory
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 106:11725-30. 2009..Our findings have broad implications for physiological triggers of latent viral infections, such as herpesviral reactivation and persistence in the host... - Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirusTamara K Nun
Department of Microbiology and Immunology, Lineberger Cancer Center, University of North Carolina at Chapel Hill, North Carolina, NC 27599, USA
Mol Cancer Ther 6:2360-70. 2007.... - Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirusJoseph H Jeong
University of Oklahoma Health Sciences Center, Department of Microbiology and Immunology, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 279:16822-31. 2004..Furthermore, we demonstrate that LANA regulates its own promoter via its C-terminal domain and does bind to a defined site within the core promoter... - Real-time quantitative PCR analysis of viral transcriptionJames Papin
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Methods Mol Biol 292:449-80. 2005..Because these arrays are RT-PCR-based, they are inherently more sensitive and robust than current hybridization-based approaches and are ideally suited to query viral gene expression in models of pathogenesis... - Viral latent proteins as targets for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) induced lymphomaMichelle R Staudt
Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Curr Drug Targets Infect Disord 3:129-35. 2003..In particular Rta/orf50 is necessary and sufficient for lytic replication and deserves serious consideration as a target for KSHV-specific antivirals... - The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivoSang Hoon Sin
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, CB 7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7290, USA
J Virol 84:10653-60. 2010..This was dependent upon B-cell receptor since LANA did not restore the GC defect of CD19 knockout mice. However, LANA was able to restore the marginal zone defect in CD19 knockout mice... - Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signalingSang Hoon Sin
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, NC 27599 7290, USA
Blood 109:2165-73. 2007..This validates sirolimus as a new treatment option for PEL... - Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6AKristen M Tamburro
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
Virology 433:220-5. 2012..It is the first whole genome KSHV sequence to be determined directly from patient plasma rather than cultured or biopsied tumor material. This case supports KICS as a new clinical entity associated with KSHV... - Tissue specificity of the Kaposi's sarcoma-associated herpesvirus latent nuclear antigen (LANA/orf73) promoter in transgenic miceJoseph H Jeong
Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Virol 76:11024-32. 2002..The transgenic-mouse experiments reported here suggest that tissue-restricted LANA gene expression could explain B-cell-specific viral persistence... - Comparison of the Rta/Orf50 transactivator proteins of gamma-2-herpesvirusesBlossom Damania
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Virol 78:5491-9. 2004..These results suggest that the core functionality of Rta/Orf50 is conserved and independent of its host, but the human protein has evolved additional, human-specific capabilities... - Gene alteration and precursor and mature microRNA transcription changes contribute to the miRNA signature of primary effusion lymphomaAndrea J O'Hara
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, and Curriculum in Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Blood 111:2347-53. 2008..This defines the miRNA signature of PEL and shows that transcriptional regulation of pre-miRNA as well as mature miRNA levels contribute nonredundant information that can be used for the classification of human tumors... - Methylene blue photoinactivation of RNA virusesRobert A Floyd
Oklahoma Medical Research Foundation, Auburn University, Auburn, AL 36849, USA
Antiviral Res 61:141-51. 2004..MB photoinactivation of viruses show significant promise because the technology not only offers significant potency but the history of safe MB use in human therapy makes it attractive also... - Methylene blue photoinactivation abolishes West Nile virus infectivity in vivoJames F Papin
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, USA
Antiviral Res 68:84-7. 2005..Since MB is already approved for human use at a dose of 100mg/kg/day, we conjecture that MB+light treatment of blood products for high-risk patients will be efficacious and suitable for use in resource-limited settings... - Kaposi's sarcoma in the era of HAART-an update on mechanisms, diagnostics and treatmentDirk P Dittmer
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599 7290, USA
AIDS Rev 7:56-61. 2005..Today we know a lot about KSHV and can begin to understand, diagnose and treat KS as a viral disease rather than another sarcoma... - Restricted Kaposi's sarcoma (KS) herpesvirus transcription in KS lesions from patients on successful antiretroviral therapyDirk P Dittmer
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, University of North Carolina, Chapel Hill, North Carolina, USA
MBio 2:e00138-11. 2011..This implies a novel mode of pathogenesis (tightly latent KS), which may inform KS cancer treatment options in the post-ART era... - Targeted therapy for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirusDirk P Dittmer
Department of Microbiology and Immunology, Center for AIDS Research and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Curr Opin Oncol 19:452-7. 2007..To summarize major recent findings on the biology of human herpesvirus-8, i.e. Kaposi's sarcoma-associated herpesvirus, and the implications of these findings for Kaposi's sarcoma treatment... - Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphomaAadra P Bhatt
Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 109:11818-23. 2012..Our findings suggest that FASN may be a unique candidate for molecular targeted therapy against PEL and other B-NHL... - SYBR green-based real-time quantitative PCR assay for detection of West Nile Virus circumvents false-negative results due to strain variabilityJames F Papin
Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Clin Microbiol 42:1511-8. 2004.... - A naturally occurring fatal case of Herpesvirus papio 2 pneumonia in an infant baboon (Papio hamadryas anubis)Roman F Wolf
Division of Animal Resources, Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
J Am Assoc Lab Anim Sci 45:64-8. 2006..This case is interesting because the age at onset suggests perinatal transmission at or immediately after birth, and the disease course suggests inoculation of the virus into the respiratory tract... - Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regionsDenise Whitby
Viral Epidemiology Section, AIDS Vaccine Program, SAIC Frederick, NCI Frederick, Frederick, MD 21702, USA
Int J Cancer 120:321-8. 2007..These in vitro data provide support for the "oncoweed" hypothesis by demonstrating basic biological plausibility... - In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcomaAgata D Agostino Mutlu
Laboratory of Viral Oncogenesis, Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
Cancer Cell 11:245-58. 2007..These results show that KSHV malignancy is in vivo growth restricted and reversible, defining mECK36 as a biologically sensitive animal model of KSHV-dependent KS... - The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphomaFarnaz D Fakhari
Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7290, USA
J Clin Invest 116:735-42. 2006..We also observed lymphomas, implying that LANA can activate B cells and provide the first step toward lymphomagenesis... - EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3Tianli Xia
The Viral Oncology Program, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Cancer Res 68:1436-42. 2008..Targeted suppression of CXCL-11/I-TAC by a viral-encoded miRNA may serve as an immunomodulatory mechanism in these tumors... - Promoter switching allows simultaneous transcription of LANA and K14/vGPCR of Kaposi's sarcoma-associated herpesvirusMichelle R Staudt
Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 804 Mary Ellen Jones, CB 7290, Chapel Hill, NC 27599 7290, USA
Virology 350:192-205. 2006..In sum, cis-elements within the LANAp were selected to ensure faithful expression of LANA and other genes regulated by LANAp during all stages of the KSHV lifecycle despite potential interference from K14/vGPCRp activity... - Liposomal daunorubicin as treatment for Kaposi's sarcomaChristin E Petre
Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599 7290, USA
Int J Nanomedicine 2:277-88. 2007.... - Azidothymidine inhibits NF-kappaB and induces Epstein-Barr virus gene expression in Burkitt lymphomaMotoki Kurokawa
Department of Dermatology, Medical College, University of Miyazaki, Japan
Blood 106:235-40. 2005..AZT inhibits NF-kappaB and up-regulates EBV gene expression in primary EBV+ BLs. AZT with hydroxyurea may represent an inexpensive, targeted regimen for endemic BL... - Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expressionHeesoon Chang
Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 79:14371-82. 2005.... - Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapyChristin E Petre
Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Virol 81:1912-22. 2007.... - Novel Kaposi's sarcoma-associated herpesvirus homolog in baboonsDenise Whitby
Viral Epidemiology Section, AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute, Frederick, MD 21702, USA
J Virol 77:8159-65. 2003..This establishes baboons as a novel resource to investigate rhadinovirus biology, which can be developed into an animal model system for KSHV-associated human diseases, vaccine development, and therapy evaluation... - Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivoFeng-Qi An
Department of Molecular Genetics and Microbiology, University of Florida, Shands Cancer Center, Gainesville, FL 32610-0232, USA
J Virol 80:4833-46. 2006..KSHV-infected LTCs represent the first xenograft model for KS and should be of use to study KS pathogenesis and for the validation of anti-KS drug candidates... - Faster quantitative real-time PCR protocols may lose sensitivity and show increased variabilityChelsey Hilscher
Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, NC, USA
Nucleic Acids Res 33:e182. 2005..Fast PCR was associated with a loss of sensitivity as well as higher variability, but not with a loss of specificity or with a higher false positive rate... - KSHV-associated disease in the AIDS patientDirk P Dittmer
Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
Cancer Treat Res 133:129-39. 2007 - Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinomaDirk P Dittmer
Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA
Int J Cancer 123:2105-12. 2008..The conceptual insights provided by our quantitative analysis should aid our understanding of mammalian episomes, as well as lead to designs to cure latent viral infection... - Baboon model for West Nile virus infection and vaccine evaluationRoman F Wolf
Department of Comparative Medicine Science, University of Oklahoma Health Sciences Center, USA
Virology 355:44-51. 2006..This report is the first to describe the development of the baboon model for WNV experimental infection and the utility of this model to characterize the immunologic response against WNV and a candidate WNV vaccine... - Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirusLing Wang
Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Cancer Res 66:3658-66. 2006..We also report that K1 enhances angiogenesis in vivo and increases tumor vasculature and tumor size... - More on HIV-associated Kaposi's sarcomaSusan E Krown
N Engl J Med 358:535-6; author reply 536. 2008