DIRK DITTMER

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Faster quantitative real-time PCR protocols may lose sensitivity and show increased variability
    Chelsey Hilscher
    Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, NC, USA
    Nucleic Acids Res 33:e182. 2005
  2. pmc Liposomal daunorubicin as treatment for Kaposi's sarcoma
    Christin E Petre
    Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599 7290, USA
    Int J Nanomedicine 2:277-88. 2007
  3. pmc Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Pathog 5:e1000389. 2009
  4. pmc Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins
    Wuguo Chen
    Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 8:e1003048. 2012
  5. pmc Efficiency clustering for low-density microarrays and its application to QPCR
    Eric F Lock
    Department of Statistics and Operations Research, University of North Carolina, Chapel Hill, NC, USA
    BMC Bioinformatics 11:386. 2010
  6. pmc Restricted Kaposi's sarcoma (KS) herpesvirus transcription in KS lesions from patients on successful antiretroviral therapy
    Dirk P Dittmer
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, University of North Carolina, Chapel Hill, North Carolina, USA
    MBio 2:e00138-11. 2011
  7. ncbi request reprint Rapalogs in viral cancers
    Dirk P Dittmer
    The University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, CB 7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7290, USA 919 966 7960 919 962 8103
    Expert Opin Investig Drugs 21:135-8. 2012
  8. ncbi request reprint Kaposi's sarcoma in the era of HAART-an update on mechanisms, diagnostics and treatment
    Dirk P Dittmer
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599 7290, USA
    AIDS Rev 7:56-61. 2005
  9. pmc Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma
    Dirk P Dittmer
    Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA
    Int J Cancer 123:2105-12. 2008
  10. ncbi request reprint Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arrays
    Dirk P Dittmer
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Cancer Res 63:2010-5. 2003

Research Grants

  1. Human gamma herpes virus DNA vaccines
    DIRK DITTMER; Fiscal Year: 2000
  2. ART Modulation of Viral Pathogenesis in Oral Epithelia
    Dirk P Dittmer; Fiscal Year: 2010
  3. ART Modulation of Viral Pathogenesis in Oral Epithelia
    DIRK DITTMER; Fiscal Year: 2009
  4. Regulation of the KSHV latent promoter
    DIRK DITTMER; Fiscal Year: 2006
  5. ART Modulation of Viral Pathogenesis in Oral Epithelia
    DIRK DITTMER; Fiscal Year: 2007
  6. Regulation of the KSHV latent promoter
    DIRK DITTMER; Fiscal Year: 2007
  7. Regulation of the KSHV latent promoter
    DIRK DITTMER; Fiscal Year: 2006
  8. Primate Model for Viral Pathogenesis in the Oral Cavity
    DIRK DITTMER; Fiscal Year: 2006
  9. Unified high throughput diagnostics
    DIRK DITTMER; Fiscal Year: 2003
  10. In situ real-time PCR arrays for viral-associated canc*
    DIRK DITTMER; Fiscal Year: 2005

Collaborators

  • Blossom A Damania
  • B J Dezube
  • Margaret L Gulley
  • Susan E Krown
  • Denise Whitby
  • Shou Jiang Gao
  • Glen Barber
  • J J Goedert
  • Ling Wang
  • Edward Gershburg
  • Wuguo Chen
  • Andrea J O'Hara
  • William J Harrington
  • Michelle R Staudt
  • Sang Hoon Sin
  • Chelsey Hilscher
  • Wolfgang Vahrson
  • Eric F Lock
  • Fu Zhang Wang
  • Sean M Gregory
  • Debasmita Roy
  • Tianli Xia
  • Agata D Agostino Mutlu
  • Christin E Petre
  • Ngoc L Toomey
  • Farnaz D Fakhari
  • Juan Carlos Ramos
  • Feng Qi An
  • Motoki Kurokawa
  • Rolf Renne
  • Tomas Kalina
  • Heesoon Chang
  • German P Horn
  • James Papin
  • Joseph H Jeong
  • Kwun Wah Wen
  • Christin E Burd
  • Isaac B Hilton
  • Js Marron
  • Ryan Ziemiecke
  • Pauline Chugh
  • Estrella Luz
  • Patrick J Dillon
  • John A West
  • Christopher B Whitehurst
  • Eduardo M Netto
  • Joseph S Pagano
  • Carlos Brites
  • Jose Barreto
  • Estela Luz
  • Iguaracyra Araujo
  • Celia Pedroso
  • Eny Carvalho
  • Jose Bahia Sapucaia
  • Michele Manrique
  • Andrea O'Hara
  • David Henry
  • Chelsey Hilsher
  • Lucas E Cavallin
  • Krista M D La Perle
  • Loic Vincent
  • Shahin Rafii
  • Dhavalkumar D Patel
  • Enrique A Mesri
  • Pilar Eroles
  • Andrea T Hooper
  • Elda M Duran
  • Zahra Asgari
  • Chiara Chiozzini
  • Stanton L Gerson
  • Nicole Compitello
  • Keith R McCrae
  • Hope Merlene Folarin
  • Justin Roth
  • Shin Young Chul
  • Evelyn Kornmann
  • Hailing Lu
  • Earl Blewett
  • Zhao Zhao
  • Julie Randolph-Habecker
  • Hans Peter Kiem
  • Rebecca Hines-Boykin
  • Roberto Cattaneo
  • Young C Shin
  • Matthias Dobbelstein
  • Youngkwon Hong
  • Sompong Vongpunsawad
  • Robert G Andrews
  • Abdul M Mian
  • David G Maloney

Detail Information

Publications33

  1. pmc Faster quantitative real-time PCR protocols may lose sensitivity and show increased variability
    Chelsey Hilscher
    Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, NC, USA
    Nucleic Acids Res 33:e182. 2005
    ..Fast PCR was associated with a loss of sensitivity as well as higher variability, but not with a loss of specificity or with a higher false positive rate...
  2. pmc Liposomal daunorubicin as treatment for Kaposi's sarcoma
    Christin E Petre
    Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599 7290, USA
    Int J Nanomedicine 2:277-88. 2007
    ....
  3. pmc Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Pathog 5:e1000389. 2009
    ..Mir-140 and Kaposi sarcoma-associated herpesvirus viral miRNAs increased linearly with the degree of transformation. Mir-24 emerged as a biomarker specific for KS...
  4. pmc Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins
    Wuguo Chen
    Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 8:e1003048. 2012
    ..This provides a rationale for clinical testing of Hsp90 inhibitors in KSHV-associated cancers and in the eradication of latent KSHV reservoirs...
  5. pmc Efficiency clustering for low-density microarrays and its application to QPCR
    Eric F Lock
    Department of Statistics and Operations Research, University of North Carolina, Chapel Hill, NC, USA
    BMC Bioinformatics 11:386. 2010
    ..To achieve reliable quantification all primer pairs or array probes must perform with the same efficiency...
  6. pmc Restricted Kaposi's sarcoma (KS) herpesvirus transcription in KS lesions from patients on successful antiretroviral therapy
    Dirk P Dittmer
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, University of North Carolina, Chapel Hill, North Carolina, USA
    MBio 2:e00138-11. 2011
    ..With one exception, only the canonical viral latency mRNAs were detectable. In contrast, early AIDS KS lesions expressed many more viral mRNAs, including, for instance, the viral G protein-coupled receptor (vGPCR)...
  7. ncbi request reprint Rapalogs in viral cancers
    Dirk P Dittmer
    The University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, CB 7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7290, USA 919 966 7960 919 962 8103
    Expert Opin Investig Drugs 21:135-8. 2012
    ..We also speculate how the molecular makeup of viral cancers could guide the selection and use of known and novel mTOR inhibitors to treat virus-associated malignancies...
  8. ncbi request reprint Kaposi's sarcoma in the era of HAART-an update on mechanisms, diagnostics and treatment
    Dirk P Dittmer
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599 7290, USA
    AIDS Rev 7:56-61. 2005
    ..Today we know a lot about KSHV and can begin to understand, diagnose and treat KS as a viral disease rather than another sarcoma...
  9. pmc Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma
    Dirk P Dittmer
    Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA
    Int J Cancer 123:2105-12. 2008
    ..The conceptual insights provided by our quantitative analysis should aid our understanding of mammalian episomes, as well as lead to designs to cure latent viral infection...
  10. ncbi request reprint Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arrays
    Dirk P Dittmer
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Cancer Res 63:2010-5. 2003
    ..Stratification by KSHV lytic transcription can identify lesions with a high percentage of lytically infected cells, which may respond to antiviral drugs...
  11. pmc Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
    Wuguo Chen
    University of North Carolina at Chapel Hill, CB 7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7290, USA
    J Virol 85:9495-505. 2011
    ..The fact that RPS6 has a well-established nuclear function beyond its role in ribosome assembly suggests that RPS6 (and by extension other ribosomal proteins) contributes to the extraordinary stability of LANA...
  12. ncbi request reprint KSHV-associated disease in the AIDS patient
    Dirk P Dittmer
    Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
    Cancer Treat Res 133:129-39. 2007
  13. ncbi request reprint Real-time quantitative PCR analysis of viral transcription
    James Papin
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Methods Mol Biol 292:449-80. 2005
    ..Because these arrays are RT-PCR-based, they are inherently more sensitive and robust than current hybridization-based approaches and are ideally suited to query viral gene expression in models of pathogenesis...
  14. pmc Toll-like receptor signaling controls reactivation of KSHV from latency
    Sean M Gregory
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 106:11725-30. 2009
    ..Our findings have broad implications for physiological triggers of latent viral infections, such as herpesviral reactivation and persistence in the host...
  15. pmc Maribavir inhibits epstein-barr virus transcription in addition to viral DNA replication
    Fu Zhang Wang
    Departments of Microbiology and Immunology and Medicine, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    J Virol 83:12108-17. 2009
    ..The results emphasize the different modes of action of the two drugs and suggest that the action of MBV may be linked to indirect effects on the transcription of EBV genes through the interaction of BGLF4 with multiple viral proteins...
  16. pmc Gene alteration and precursor and mature microRNA transcription changes contribute to the miRNA signature of primary effusion lymphoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, and Curriculum in Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Blood 111:2347-53. 2008
    ..This defines the miRNA signature of PEL and shows that transcriptional regulation of pre-miRNA as well as mature miRNA levels contribute nonredundant information that can be used for the classification of human tumors...
  17. pmc Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus Lymphomas
    Wuguo Chen
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, CB no 7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7290, USA
    J Virol 84:3898-908. 2010
    ..If p53 is activated by DNA damage or nutlin-3a, the complex falls apart easily, and p53 exercises its role as guardian of the genome...
  18. pmc Targeted therapy for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus
    Dirk P Dittmer
    Department of Microbiology and Immunology, Center for AIDS Research and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Curr Opin Oncol 19:452-7. 2007
    ..To summarize major recent findings on the biology of human herpesvirus-8, i.e. Kaposi's sarcoma-associated herpesvirus, and the implications of these findings for Kaposi's sarcoma treatment...
  19. ncbi request reprint Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
    Joseph H Jeong
    University of Oklahoma Health Sciences Center, Department of Microbiology and Immunology, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 279:16822-31. 2004
    ..Furthermore, we demonstrate that LANA regulates its own promoter via its C-terminal domain and does bind to a defined site within the core promoter...
  20. pmc Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling
    Sang Hoon Sin
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, NC 27599 7290, USA
    Blood 109:2165-73. 2007
    ..This validates sirolimus as a new treatment option for PEL...
  21. ncbi request reprint Viral latent proteins as targets for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) induced lymphoma
    Michelle R Staudt
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Curr Drug Targets Infect Disord 3:129-35. 2003
    ..In particular Rta/orf50 is necessary and sufficient for lytic replication and deserves serious consideration as a target for KSHV-specific antivirals...
  22. pmc Whole-genome transcription profiling of rhesus monkey rhadinovirus
    Dirk P Dittmer
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    J Virol 79:8637-50. 2005
    ..Using this assay, we demonstrate that the genome-wide transcription profile for RRV closely parallels the genome-wide transcription profile for KSHV...
  23. pmc Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma
    Andrea J O'Hara
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research at University of North Carolina at Chapel Hill, NC 27599 7290, USA
    Blood 113:5938-41. 2009
    ..Because many tumor suppressor proteins are wild-type in KS and PEL, down-regulation of multiple tumor suppressor miRNAs provides a novel, alternative mechanism of transformation...
  24. pmc Novel Kaposi's sarcoma-associated herpesvirus homolog in baboons
    Denise Whitby
    Viral Epidemiology Section, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    J Virol 77:8159-65. 2003
    ..This establishes baboons as a novel resource to investigate rhadinovirus biology, which can be developed into an animal model system for KSHV-associated human diseases, vaccine development, and therapy evaluation...
  25. ncbi request reprint De novo generation of CD4 T cells against viruses present in the host during immune reconstitution
    Tomas Kalina
    Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA, USA
    Blood 105:2410-4. 2005
    ..This finding provides a strong rationale to improve thymopoiesis in recipients of hematopoietic cell transplants and, perhaps, in other persons lacking de novo-generated CD4 T cells, such as AIDS patients and elderly persons...
  26. pmc EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3
    Tianli Xia
    The Viral Oncology Program, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cancer Res 68:1436-42. 2008
    ..Targeted suppression of CXCL-11/I-TAC by a viral-encoded miRNA may serve as an immunomodulatory mechanism in these tumors...
  27. pmc More on HIV-associated Kaposi's sarcoma
    Susan E Krown
    N Engl J Med 358:535-6; author reply 536. 2008
  28. pmc Enhanced cytotoxicity without internuclear spread of adenovirus upon cell fusion by measles virus glycoproteins
    German P Horn
    Institut fur Virologie, Klinikum der Philipps, Universitat Marburg, Marburg, Germany
    J Virol 79:1911-7. 2005
    ..Most notably, the virus genomes did not spread through fusion-generated multinuclear cells. Hence, adenovirus replication in syncytia remains largely restricted to initially transduced nuclei...
  29. pmc Azidothymidine inhibits NF-kappaB and induces Epstein-Barr virus gene expression in Burkitt lymphoma
    Motoki Kurokawa
    Department of Dermatology, Medical College, University of Miyazaki, Japan
    Blood 106:235-40. 2005
    ..AZT inhibits NF-kappaB and up-regulates EBV gene expression in primary EBV+ BLs. AZT with hydroxyurea may represent an inexpensive, targeted regimen for endemic BL...
  30. pmc In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma
    Agata D Agostino Mutlu
    Laboratory of Viral Oncogenesis, Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cancer Cell 11:245-58. 2007
    ..These results show that KSHV malignancy is in vivo growth restricted and reversible, defining mECK36 as a biologically sensitive animal model of KSHV-dependent KS...
  31. pmc Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regions
    Denise Whitby
    Viral Epidemiology Section, AIDS Vaccine Program, SAIC Frederick, NCI Frederick, Frederick, MD 21702, USA
    Int J Cancer 120:321-8. 2007
    ..These in vitro data provide support for the "oncoweed" hypothesis by demonstrating basic biological plausibility...
  32. pmc Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo
    Feng Qi An
    Department of Molecular Genetics and Microbiology, University of Florida, Shands Cancer Center, Gainesville, FL 32610 0232, USA
    J Virol 80:4833-46. 2006
    ..KSHV-infected LTCs represent the first xenograft model for KS and should be of use to study KS pathogenesis and for the validation of anti-KS drug candidates...
  33. pmc Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression
    Heesoon Chang
    Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 79:14371-82. 2005
    ....

Research Grants19

  1. Human gamma herpes virus DNA vaccines
    DIRK DITTMER; Fiscal Year: 2000
    ..This experience and the immunologic evaluations performed will hopefully be preparatory for a successful trial of one or more of these gamma herpes virus vaccines in man. ..
  2. ART Modulation of Viral Pathogenesis in Oral Epithelia
    Dirk P Dittmer; Fiscal Year: 2010
    ..e. TLR signaling by using our recently developed NF-kappaB real-time QPCR array to compare both clinical samples and experimental models of buccal and gingival epithelium. ..
  3. ART Modulation of Viral Pathogenesis in Oral Epithelia
    DIRK DITTMER; Fiscal Year: 2009
    ..e. TLR signaling by using our recently developed NF-kappaB real-time QPCR array to compare both clinical samples and experimental models of buccal and gingival epithelium. ..
  4. Regulation of the KSHV latent promoter
    DIRK DITTMER; Fiscal Year: 2006
    ....
  5. ART Modulation of Viral Pathogenesis in Oral Epithelia
    DIRK DITTMER; Fiscal Year: 2007
    ..e. TLR signaling by using our recently developed NF-kappaB real-time QPCR array to compare both clinical samples and experimental models of buccal and gingival epithelium. ..
  6. Regulation of the KSHV latent promoter
    DIRK DITTMER; Fiscal Year: 2007
    ....
  7. Regulation of the KSHV latent promoter
    DIRK DITTMER; Fiscal Year: 2006
    ....
  8. Primate Model for Viral Pathogenesis in the Oral Cavity
    DIRK DITTMER; Fiscal Year: 2006
    ..abstract_text> ..
  9. Unified high throughput diagnostics
    DIRK DITTMER; Fiscal Year: 2003
    ..It utilizes the established capability in bacterial genomics at the University of Oklahoma Health Sciences Center and is greatly motivated by Oklahoma City's unfortunate experience with a large-scale terrorist attack. ..
  10. In situ real-time PCR arrays for viral-associated canc*
    DIRK DITTMER; Fiscal Year: 2005
    ..In KS lesions tumor progression depends on and responds to viral gene expression. This study will provide a road map for a better understanding of KS biology and clinical classification of KS tumors. ..
  11. Regulation of the KSHV latent promoter
    DIRK DITTMER; Fiscal Year: 2005
    ....
  12. Real-time high throughput PCR for microbial pathogens
    DIRK DITTMER; Fiscal Year: 2003
    ..Heuristic computations would increase or decrease the degeneracy of primers to reduce false positive and increase the possibility to amplify more distantly related sequences. ..
  13. Regulation of the KSHV latent promoter
    DIRK DITTMER; Fiscal Year: 2004
    ....
  14. Human gamma herpes virus DNA vaccines
    DIRK DITTMER; Fiscal Year: 2002
    ..This experience and the immunologic evaluations performed will hopefully be preparatory for a successful trial of one or more of these gamma herpes virus vaccines in man. ..
  15. Human gamma herpes virus DNA vaccines
    DIRK DITTMER; Fiscal Year: 2001
    ..This experience and the immunologic evaluations performed will hopefully be preparatory for a successful trial of one or more of these gamma herpes virus vaccines in man. ..
  16. Human gamma herpes virus DNA vaccines
    DIRK DITTMER; Fiscal Year: 2001
    ..This experience and the immunologic evaluations performed will hopefully be preparatory for a successful trial of one or more of these gamma herpes virus vaccines in man. ..
  17. Regulation of the KSHV latent promoter
    Dirk P Dittmer; Fiscal Year: 2010
    ..Understanding their regulation will help unravel the biology of cancers caused by KSHV and, we hope, provide novel targets for intervention. ..