David Dinges

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Sleep deprivation and vigilant attention
    Julian Lim
    Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1129:305-22. 2008
  2. ncbi request reprint Cocoa flavanols, cerebral blood flow, cognition, and health: going forward
    David F Dinges
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Cardiovasc Pharmacol 47:S221-3. 2006
  3. ncbi request reprint Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss
    David F Dinges
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Curr Med Res Opin 22:159-67. 2006
  4. ncbi request reprint Critical research issues in development of biomathematical models of fatigue and performance
    David F Dinges
    Division of Sleep and Chronobiology, Department of Psychiatry, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Aviat Space Environ Med 75:A181-91. 2004
  5. ncbi request reprint Effects of modafinil on sustained attention performance and quality of life in OSA patients with residual sleepiness while being treated with nCPAP
    David F Dinges
    Division of Sleep and Chronobiology, Department of Psychiatry, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 1013 Blockley Hall, Philadelphia, PA 19104 6021, USA
    Sleep Med 4:393-402. 2003
  6. ncbi request reprint Optical computer recognition of facial expressions associated with stress induced by performance demands
    David F Dinges
    Unit for Experimental Psychiatry, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Aviat Space Environ Med 76:B172-82. 2005
  7. pmc Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery
    Siobhan Banks
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Sleep 33:1013-26. 2010
  8. ncbi request reprint Circadian eating and sleeping patterns in the night eating syndrome
    John P O'Reardon
    Weight and Eating Disorder Program, Department of Psychiatry, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obes Res 12:1789-96. 2004
  9. ncbi request reprint Assessment of sleep in women with night eating syndrome
    Naomi L Rogers
    Division of Sleep and Chronobiology, Department of Psychiatry, The University of Pennsylvania School of Medicine, Philadelphia 19104 021, USA
    Sleep 29:814-9. 2006
  10. ncbi request reprint Sleep, circadian rhythms, and psychomotor vigilance
    Hans P A Van Dongen
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, 10 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Clin Sports Med 24:237-49, vii-viii. 2005

Research Grants

Detail Information

Publications69

  1. doi request reprint Sleep deprivation and vigilant attention
    Julian Lim
    Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1129:305-22. 2008
    ..A theme that links these findings is the interplay of "top-down" and "bottom-up" attention in producing the unstable and unpredictable patterns of behavior that are the hallmark of the sleep-deprived state...
  2. ncbi request reprint Cocoa flavanols, cerebral blood flow, cognition, and health: going forward
    David F Dinges
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Cardiovasc Pharmacol 47:S221-3. 2006
  3. ncbi request reprint Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss
    David F Dinges
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Curr Med Res Opin 22:159-67. 2006
    ..To assess the pharmacodynamics of armodafinil compared with modafinil and placebo on measures of alertness in healthy volunteers undergoing sleep loss...
  4. ncbi request reprint Critical research issues in development of biomathematical models of fatigue and performance
    David F Dinges
    Division of Sleep and Chronobiology, Department of Psychiatry, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Aviat Space Environ Med 75:A181-91. 2004
    ..Research is needed on how best to scale and interpret metrics of behavioral capability, and incorporate factors that amplify or diminish the relationship between model predictions of performance and risk outcomes...
  5. ncbi request reprint Effects of modafinil on sustained attention performance and quality of life in OSA patients with residual sleepiness while being treated with nCPAP
    David F Dinges
    Division of Sleep and Chronobiology, Department of Psychiatry, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 1013 Blockley Hall, Philadelphia, PA 19104 6021, USA
    Sleep Med 4:393-402. 2003
    ....
  6. ncbi request reprint Optical computer recognition of facial expressions associated with stress induced by performance demands
    David F Dinges
    Unit for Experimental Psychiatry, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Aviat Space Environ Med 76:B172-82. 2005
    ....
  7. pmc Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery
    Siobhan Banks
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Sleep 33:1013-26. 2010
    ..Establish the dose-response relationship between increasing sleep durations in a single night and recovery of neurobehavioral functions following chronic sleep restriction...
  8. ncbi request reprint Circadian eating and sleeping patterns in the night eating syndrome
    John P O'Reardon
    Weight and Eating Disorder Program, Department of Psychiatry, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obes Res 12:1789-96. 2004
    ..To compare the eating and sleep-wake patterns of persons with the night eating syndrome (NES) with those of matched control subjects...
  9. ncbi request reprint Assessment of sleep in women with night eating syndrome
    Naomi L Rogers
    Division of Sleep and Chronobiology, Department of Psychiatry, The University of Pennsylvania School of Medicine, Philadelphia 19104 021, USA
    Sleep 29:814-9. 2006
    ..Evaluation of sleep in subjects with night eating syndrome (NES)...
  10. ncbi request reprint Sleep, circadian rhythms, and psychomotor vigilance
    Hans P A Van Dongen
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, 10 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Clin Sports Med 24:237-49, vii-viii. 2005
    ..There are also considerable individual differences in the degree of vulnerability to performance impairment from sleep loss, and these differences represent a trait...
  11. pmc Effects of night work, sleep loss and time on task on simulated threat detection performance
    Mathias Basner
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Sleep 31:1251-9. 2008
    ..To investigate the effects of night work and sleep loss on a simulated luggage screening task (SLST) that mimicked the x-ray system used by airport luggage screeners...
  12. ncbi request reprint Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome
    Kelly C Allison
    University of Pennsylvania School of Medicine, Department of Psychiatry, Weight and Eating Disorders Program, 3535 Market Street, Suite 3021, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 90:6214-7. 2005
    ..Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable...
  13. ncbi request reprint Individual differences in adult human sleep and wakefulness: Leitmotif for a research agenda
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Sleep 28:479-96. 2005
    ..This paper gives suggestions for a research agenda focusing on individual differences in sleep research and sleep medicine...
  14. pmc Sleep deprivation impairs object-selective attention: a view from the ventral visual cortex
    Julian Lim
    Neuroscience and Behavioral Disorders Program, Duke NUS Graduate Medical School, Singapore, Singapore
    PLoS ONE 5:e9087. 2010
    ..Here, we evaluated the effects of SD on the top-down biasing of activation of ventral visual cortex and on functional connectivity between cognitive control and other brain regions...
  15. pmc American time use survey: sleep time and its relationship to waking activities
    Mathias Basner
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Sleep 30:1085-95. 2007
    ..To gain some insight into how various behavioral (lifestyle) factors influence sleep duration, by investigation of the relationship of sleep time to waking activities using the American Time Use Survey (ATUS)...
  16. pmc Behavioral and physiological consequences of sleep restriction
    Siobhan Banks
    Division of Sleep and Chronobiology, Department ofPsychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Sleep Med 3:519-28. 2007
    ....
  17. pmc Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:17804-9. 2005
    ..Our results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress response...
  18. pmc Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning
    Terri E Weaver
    Biobehavioral and Health Sciences Division, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    Sleep 30:711-9. 2007
    ..This study, employing probit analyses and piecewise regression to estimate dose-response functions, estimated likelihoods of return to normal levels of sleepiness and daily functioning relative to nightly duration of CPAP...
  19. pmc Impaired performance in commercial drivers: role of sleep apnea and short sleep duration
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 174:446-54. 2006
    ..5%, were similar in terms of their impact on objective sleepiness. Thus, addressing impairment in commercial drivers requires addressing both insufficient sleep and sleep apnea, the former being more common...
  20. ncbi request reprint Risk factors for excessive sleepiness in older adults
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, Philadelphia, PA 19104 3403, USA
    Ann Neurol 59:893-904. 2006
    ..To determine risk factors for excessive daytime sleepiness in older adults...
  21. pmc Circadian rhythm profiles in women with night eating syndrome
    Namni Goel
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Biol Rhythms 24:85-94. 2009
    ..Indeed, bright light therapy has shown efficacy in reducing night eating in case studies and should be evaluated in controlled clinical trials...
  22. pmc PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation
    Namni Goel
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    PLoS ONE 4:e5874. 2009
    ..We evaluated whether the PER3 VNTR polymorphism contributed to cumulative neurobehavioral deficits and sleep homeostatic responses during PSD...
  23. ncbi request reprint The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, and Centerfor Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Sleep 26:117-26. 2003
    ....
  24. ncbi request reprint Investigating the interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioural performance
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Sleep Res 12:181-7. 2003
    ..The results provided evidence of an actual non-linear interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioural performance...
  25. ncbi request reprint Sleep, waking and neurobehavioural performance
    Naomi L Rogers
    The University of Pennsylvania School of Medicine, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, 1013 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Front Biosci 8:s1056-67. 2003
    ..Much research has in fact concentrated not on understanding the nature of these deficits, but rather in counteracting them, via the use of countermeasures, such as naps and wake promoting compounds...
  26. ncbi request reprint Self-efficacy in sleep apnea: instrument development and patient perceptions of obstructive sleep apnea risk, treatment benefit, and volition to use continuous positive airway pressure
    Terri E Weaver
    School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    Sleep 26:727-32. 2003
    ..The purpose of this study was to evaluate the Self-Efficacy Measure for Sleep Apnea (SEMSA) designed to assess adherence-related cognitions...
  27. ncbi request reprint Potential action of melatonin in insomnia
    Naomi L Rogers
    The University of Pennsylvania School of Medicine, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Philadelphia 19104 6021, USA
    Sleep 26:1058-9. 2003
  28. ncbi request reprint Consequences of comorbid insomnia symptoms and sleep-related breathing disorder in elderly subjects
    Nalaka S Gooneratne
    Division of Geriatric Medicine, Center for Sleep and Respiratory Neurobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Intern Med 166:1732-8. 2006
    ..The prevalence of sleep-related breathing disorder (SRBD) and insomnia symptoms increases considerably with advancing age, but little is known about their cooccurrence and their effects on daytime functioning when present together...
  29. ncbi request reprint Time of day effects on neurobehavioral performance during chronic sleep restriction
    Daniel J Mollicone
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Aviat Space Environ Med 81:735-44. 2010
    ..The purpose of this study was to determine whether time of day modulates the effects of sleep restriction on objective daytime performance deficits and subjective sleepiness across days of chronic sleep restriction...
  30. pmc A meta-analysis of the impact of short-term sleep deprivation on cognitive variables
    Julian Lim
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Psychol Bull 136:375-89. 2010
    ..The theoretical implications of these findings for the study of SD and cognition are discussed...
  31. ncbi request reprint Dealing with inter-individual differences in the temporal dynamics of fatigue and performance: importance and techniques
    Hans P A Van Dongen
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Aviat Space Environ Med 75:A147-54. 2004
    ....
  32. ncbi request reprint Mixed-model regression analysis and dealing with interindividual differences
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, University of Pennsylvania School of Medicine, Pennsylvania, Philadelphia 19104 6021, USA
    Methods Enzymol 384:139-71. 2004
  33. ncbi request reprint Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Sleep 27:423-33. 2004
    ....
  34. ncbi request reprint The working hours of hospital staff nurses and patient safety
    Ann E Rogers
    School of Nursing, Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia, USA
    Health Aff (Millwood) 23:202-12. 2004
    ..The risks of making an error were significantly increased when work shifts were longer than twelve hours, when nurses worked overtime, or when they worked more than forty hours per week...
  35. pmc Neurocognitive consequences of sleep deprivation
    Namni Goel
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Semin Neurol 29:320-39. 2009
    ..Thus, cognitive deficits believed to be a function of the severity of clinical sleep disturbance may be a product of genetic alleles associated with differential cognitive vulnerability to sleep loss...
  36. pmc Dubious bargain: trading sleep for Leno and Letterman
    Mathias Basner
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Sleep 32:747-52. 2009
    ..We sought to identify waking activities under discretionary control and adjacent to the sleep period that would be a more feasible source for increasing sleep time...
  37. pmc DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue
    Namni Goel
    Division of Sleep and Chronobiology, Unit for Experimental Psychiatry, Department of Psychiatry, University of Pennsylvania School of Medicine, 1013 Blockley Hall, Philadelphia, PA 19104 6021, USA
    Neurology 75:1509-19. 2010
    ....
  38. ncbi request reprint Sleep and inflammation
    Norah Simpson
    Division of Sleep and Chronobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nutr Rev 65:S244-52. 2007
    ..Thus, maintaining adequate sleep duration and quality through good sleep habits and treatment of sleep disorders may reduce inflammatory processes associated with aging and increase the wellness phenotype...
  39. doi request reprint Predictors of continuous positive airway pressure use during the first week of treatment
    Lichuan Ye
    Boston College William F Connell School of Nursing, Chestnut Hill, MA, USA
    J Sleep Res 21:419-26. 2012
    ..Assessing the presence of residual respiratory events may be important in promoting CPAP adherence. The association of race and CPAP use needs to be explored further by including more socioeconomic information...
  40. doi request reprint Emotional expressiveness in sleep-deprived healthy adults
    Jared Minkel
    Department of Psychology, University of Pennsylvania, Philadelphia, 19104, USA
    Behav Sleep Med 9:5-14. 2011
    ..Subjective responses were not significantly different between the sleep-deprived and control groups. These preliminary results suggest that sleep deprivation is associated with attenuated emotional expressiveness in healthy adults...
  41. pmc Outcome of CPAP treatment on intimate and sexual relationships in men with obstructive sleep apnea
    Judith L Reishtein
    College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA
    J Clin Sleep Med 6:221-6. 2010
    ..To examine intimate and sexual relationships in patients with obstructive sleep apnea (OSA), the association with daytime sleepiness, and the change in these outcomes with continuous positive airway pressure treatment (CPAP)...
  42. ncbi request reprint The neural basis of the psychomotor vigilance task
    Sean P A Drummond
    University of California San Diego, Department of Psychiatry, 92161, USA
    Sleep 28:1059-68. 2005
    ..To identify brain regions underlying the fastest and slowest reaction times on the Psychomotor Vigilance task (PVT) under well-rested conditions, as well as brain regions related to particularly poor performance after sleep deprivation...
  43. pmc Imaging brain fatigue from sustained mental workload: an ASL perfusion study of the time-on-task effect
    Julian Lim
    Unit for Experimental Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 49:3426-35. 2010
    ....
  44. ncbi request reprint Sleepiness and relationships in obstructive sleep apnea
    Judith L Reishtein
    School of Nursing, and Division of Sleep Medicine and Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6096, USA
    Issues Ment Health Nurs 27:319-30. 2006
    ..Intrapersonal themes included embarrassment and poor mood. This report adds specific details to previous reports of impaired relationships in OSA, and stresses the importance of assessing this critical area...
  45. ncbi request reprint The cognitive interview: does it successfully avoid the dangers of forensic hypnosis?
    Wayne G Whitehouse
    Unit for Experimental Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Psychol 118:213-34. 2005
    ..This suggests that some CI mnemonics may invoke hypnotic-like processes in hypnotizable people...
  46. doi request reprint Extreme cognitive interviewing: a blueprint for false memories through imagination inflation
    Wayne G Whitehouse
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Int J Clin Exp Hypn 58:269-87. 2010
    ..In this case, the prolonged cognitive interview is perilously hypnotic-like, yielding evidence that must be regarded as a product of imagination inflation--defective for sustaining veridical testimony...
  47. ncbi request reprint Summary of the key features of seven biomathematical models of human fatigue and performance
    Melissa M Mallis
    Fatigue Countermeasures Group, NASA Ames Research Center Human Factors Research and Technology Division, Systems Safety Research Branch, MS 262 4 Moffett Field, CA 94035 1000, USA
    Aviat Space Environ Med 75:A4-14. 2004
    ..S. Department of Defense, U.S. Army Medical Research and Materiel Command, Office of Naval Research, Air Force Office of Scientific Research, and U.S. Department of Transportation...
  48. ncbi request reprint Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
    Hans K Meier-Ewert
    Department of Cardiology, Lahey Clinic Medical Center, Burlington, Boston, Massachusetts, USA
    J Am Coll Cardiol 43:678-83. 2004
    ..We sought to investigate the effects of sleep loss on high-sensitivity C-reactive protein (CRP) levels...
  49. ncbi request reprint Subjective surrogates of performance during night work
    Naomi L Rogers
    Sleep 26:790-1. 2003
  50. ncbi request reprint Sleep debt and scientific evidence
    David F Dinges
    Sleep 27:1050-2. 2004
  51. ncbi request reprint Controlled breaks as a fatigue countermeasure on the flight deck
    David F Neri
    Fatigue Countermeasures Group, NASA Ames Research Center, Moffett Field, CA, USA
    Aviat Space Environ Med 73:654-64. 2002
    ..No system currently exists to assist in managing alertness, and countermeasure options are limited. Surveys reveal many pilots use breaks as an in-flight countermeasure, but there have been no controlled studies of their effectiveness...
  52. ncbi request reprint Claustrophobia and adherence to CPAP treatment
    Eileen R Chasens
    School of Nursing, University of Pittsburgh, USA
    West J Nurs Res 27:307-21. 2005
    ..Identification of persons with increased claustrophobia tendencies and targeted interventions may increase adherence...
  53. ncbi request reprint Caffeine: implications for alertness in athletes
    Naomi L Rogers
    Woolcock Institute of Medical Research, P O Box M77, Missenden Road, Camperdown, NSW 2050, Australia
    Clin Sports Med 24:e1-13, x-xi. 2005
    ..This paper outlines the known sites of caffeine activity in the body,and discusses these with respect to the effects of caffeine observed during performance assessments...
  54. ncbi request reprint Nonlinear mixed-effects modeling: individualization and prediction
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Aviat Space Environ Med 75:A134-40. 2004
    ..The results serve to demonstrate the usefulness of mixed-effects modeling for data-driven development of individualized predictive models of fatigue and performance...
  55. ncbi request reprint Modafinil for excessive sleepiness associated with shift-work sleep disorder
    Charles A Czeisler
    Division of Sleep Medicine, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 353:476-86. 2005
    ..Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. We evaluated the use of modafinil for treating sleepiness in patients with this disorder...
  56. ncbi request reprint The neural basis of interindividual variability in inhibitory efficiency after sleep deprivation
    Y M Lisa Chuah
    Cognitive Neuroscience Laboratory, Singapore Health Services, Singapore, 169611
    J Neurosci 26:7156-62. 2006
    ..These persons also showed a larger rise in such activation both here and in the right insula after sleep deprivation relative to those whose inhibitory efficiency declined...
  57. ncbi request reprint The state of sleep deprivation: From functional biology to functional consequences
    David F Dinges
    Sleep Med Rev 10:303-5. 2006
  58. ncbi request reprint Editorial: the critical role of behavioral research for improving adherence to continuous positive airway pressure therapies for sleep apnea
    David F Dinges
    Behav Sleep Med 5:79-82. 2007
  59. ncbi request reprint Trait interindividual differences in the sleep physiology of healthy young adults
    Adrienne M Tucker
    Sleep and Performance Research Center, Washington State University, Spokane, WA 99210 1495, USA
    J Sleep Res 16:170-80. 2007
    ..Any independent functional significance of these sleep physiologic phenotypes remains to be determined...
  60. ncbi request reprint Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance
    Michael W L Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, 7 Hospital Drive, 01 11, Singapore 169611, Singapore
    Neuroimage 31:419-28. 2006
    ....
  61. doi request reprint Lapsing during sleep deprivation is associated with distributed changes in brain activation
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke National University of Singapore Graduate Medical School, Singapore
    J Neurosci 28:5519-28. 2008
    ..These findings reveal for the first time some of the neural consequences of the interaction between efforts to maintain wakefulness and processes that initiate involuntary sleep in sleep-deprived persons...
  62. ncbi request reprint The use of stimulants to modify performance during sleep loss: a review by the sleep deprivation and Stimulant Task Force of the American Academy of Sleep Medicine
    Michael H Bonnet
    Dayton Department of Veterans Affairs Medical Center, Wright State University, and Kettering Medical Center, Dayton, OH 45428, USA
    Sleep 28:1163-87. 2005
  63. pmc Optimization of biomathematical model predictions for cognitive performance impairment in individuals: accounting for unknown traits and uncertain states in homeostatic and circadian processes
    Hans P A Van Dongen
    Sleep and Performance Research Center, Washington State University, Spokane, WA 99210 1495, USA
    Sleep 30:1129-43. 2007
    ....
  64. pmc Sleep-disordered breathing and psychomotor vigilance in a community-based sample
    Hyon Kim
    Department of Population Health Sciences, Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Sleep 30:1309-16. 2007
    ..This study investigated the association between SDB and psychomotor vigilance with cross-sectional data from the Wisconsin Sleep Cohort Study...
  65. pmc The relationship between nurse work schedules, sleep duration, and drowsy driving
    Linda D Scott
    Kirkhof College of Nursing, Grand Valley State University, 312 Cook Devos Center for Health Sciences, 301 Michigan Avenue NE, Grand Rapids, MI 49503, USA
    Sleep 30:1801-7. 2007
    ..The purpose of this study is to describe the prevalence of drowsy driving episodes and the relationship between drowsy driving and nurse work hours, alertness on duty, working at night, and sleep duration...
  66. ncbi request reprint Neurocognitive consequences of sleep deprivation
    Jeffrey S Durmer
    Program in Sleep Medicine, Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Neurol 25:117-29. 2005
    ....
  67. ncbi request reprint Interfering with theories of sleep and memory: sleep, declarative memory, and associative interference
    Jeffrey M Ellenbogen
    Center for Sleep and Cognition, Harvard Medical School, 330 Brookline Avenue, Feldberg 861, Boston, Massachusetts 02215, USA
    Curr Biol 16:1290-4. 2006
    ..This is the first study to demonstrate that sleep protects declarative memories from subsequent associative interference, and it has important implications for understanding the neurobiology of memory consolidation...
  68. ncbi request reprint Symposium resident work-hour guidelines. A sentence or an opportunity for orthopaedic education?
    Vincent D Pellegrini
    Department of Orthopaedics, University of Maryland School of Medicine, 22 South Greene Street, Suite S 11 B, Baltimore, MD 21201, USA
    J Bone Joint Surg Am 87:2576-86. 2005
  69. ncbi request reprint Can habitual sleep duration harbor sleep debt?
    David F Dinges
    Sleep 28:1209-10. 2005

Research Grants15

  1. NEUROBEHAVIORAL EFFECTS OF PARTIAL SLEEP DEPRIVATION
    David Dinges; Fiscal Year: 2007
    ..The scientific data to be generated will advance theoretical understanding of sleep homeostasis; improve mathematical models of sleep-wake regulation; and inform questions of sleep need relative to public health. ..
  2. NEUROBEHAVIORAL EFFECTS OF PARTIAL SLEEP DEPRIVATION
    David Dinges; Fiscal Year: 2003
    ..abstract_text> ..
  3. NEUROBEHAVIORAL EFFECTS OF PARTIAL SLEEP DEPRIVATION
    David F Dinges; Fiscal Year: 2010
    ..This project seeks to find optimal ways to use prolonged sleep opportunities as an intervention to promote cognitive recovery from, and resistance to, the effects of chronic intermittent sleep restriction. ..