Xi Qin Ding

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Exploration of cone cyclic nucleotide-gated channel-interacting proteins using affinity purification and mass spectrometry
    Xi Qin Ding
    Departments of Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, BMSB 553, 73104, Oklahoma City, OK, USA
    Adv Exp Med Biol 801:57-65. 2014
  2. pmc Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism
    Xi Qin Ding
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Hum Mol Genet 18:4770-80. 2009
  3. pmc Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina
    Xi Qin Ding
    The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 4:e7410. 2009
  4. pmc Molecular pathogenesis of achromatopsia associated with mutations in the cone cyclic nucleotide-gated channel CNGA3 subunit
    Xi Qin Ding
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Adv Exp Med Biol 664:245-53. 2010
  5. doi request reprint Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains
    Xi Qin Ding
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Dean A McGee Eye Institute, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 47:3677-87. 2008
  6. ncbi request reprint The R172W mutation in peripherin/rds causes a cone-rod dystrophy in transgenic mice
    Xi Qin Ding
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Hum Mol Genet 13:2075-87. 2004
  7. pmc Modulating expression of peripherin/rds in transgenic mice: critical levels and the effect of overexpression
    May Nour
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Invest Ophthalmol Vis Sci 45:2514-21. 2004
  8. pmc cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function
    Jianhua Xu
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, Center for Integrated Protein Science Munich and Department of Pharmacy Center for Drug Research, Ludwig Maximilians Universitat Munchen, 80539 Munich, Germany, John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, and Department of Basic Sciences and Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania 19027
    J Neurosci 33:14939-48. 2013
  9. pmc Role of the second intradiscal loop of peripherin/rds in homo and hetero associations
    Xi Qin Ding
    The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 44:4897-904. 2005
  10. pmc Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- mice
    Alexander V Matveev
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 106:2042-55. 2008

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Exploration of cone cyclic nucleotide-gated channel-interacting proteins using affinity purification and mass spectrometry
    Xi Qin Ding
    Departments of Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, BMSB 553, 73104, Oklahoma City, OK, USA
    Adv Exp Med Biol 801:57-65. 2014
    ..Results of this study provide insight into our understanding of cone CNG channel-interacting proteins and the functional modulations. ..
  2. pmc Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism
    Xi Qin Ding
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Hum Mol Genet 18:4770-80. 2009
    ..Hence, we show that loss of CNGB3 reduces biosynthesis of CNGA3 and impairs cone CNG channel function. We suggest that down-regulation of CNGA3 contributes to the pathogenic mechanism by which CNGB3 mutations lead to human cone disease...
  3. pmc Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina
    Xi Qin Ding
    The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 4:e7410. 2009
    ..These investigations show no signs of local inflammatory responses associated with subretinal injection of compacted DNA nanoparticles, indicating that the retina may be a suitable target for clinical nanoparticle-based interventions...
  4. pmc Molecular pathogenesis of achromatopsia associated with mutations in the cone cyclic nucleotide-gated channel CNGA3 subunit
    Xi Qin Ding
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Adv Exp Med Biol 664:245-53. 2010
    ..Therapeutic supplementation of the wild type transgene may help correct the visual disorders caused by these two mutations...
  5. doi request reprint Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains
    Xi Qin Ding
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Dean A McGee Eye Institute, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 47:3677-87. 2008
    ....
  6. ncbi request reprint The R172W mutation in peripherin/rds causes a cone-rod dystrophy in transgenic mice
    Xi Qin Ding
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Hum Mol Genet 13:2075-87. 2004
    ....
  7. pmc Modulating expression of peripherin/rds in transgenic mice: critical levels and the effect of overexpression
    May Nour
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Invest Ophthalmol Vis Sci 45:2514-21. 2004
    ..Gene therapy-directed approaches have been hindered by the haploinsufficiency phenotype, which dictates well-regulated expression of peripherin/rds protein levels...
  8. pmc cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function
    Jianhua Xu
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, Center for Integrated Protein Science Munich and Department of Pharmacy Center for Drug Research, Ludwig Maximilians Universitat Munchen, 80539 Munich, Germany, John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, and Department of Basic Sciences and Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania 19027
    J Neurosci 33:14939-48. 2013
    ..Our results indicate that cGMP accumulation in photoreceptors can itself exert cytotoxic effect in cones, independently of CNG channel activity and Ca(2+) influx. ..
  9. pmc Role of the second intradiscal loop of peripherin/rds in homo and hetero associations
    Xi Qin Ding
    The Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 44:4897-904. 2005
    ..Elucidation of the molecular mechanisms behind the protein-protein associations of P/rds and its partners may reveal the pathogenic defects arising from the most common mutations in this gene...
  10. pmc Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- mice
    Alexander V Matveev
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 106:2042-55. 2008
    ..This may implicate a distinct modulatory mechanism for Ca(2+) homeostasis in cones compared to rods...
  11. ncbi request reprint Retinal abnormalities associated with the G90D mutation in opsin
    Muna I Naash
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Comp Neurol 478:149-63. 2004
    ..These findings suggest that much of the ERG sensitivity loss derives from the reduced quantal absorption that results from a failure of G90D opsin to bind to its chromophore and form a normal complement of light-sensitive visual pigment...
  12. pmc The Cys214-->Ser mutation in peripherin/rds causes a loss-of-function phenotype in transgenic mice
    Heidi M Stricker
    Department of Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, BSMB 781, Oklahoma City, OK 73104, USA
    Biochem J 388:605-13. 2005
    ....
  13. pmc CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration
    Jianhua Xu
    Department of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Invest Ophthalmol Vis Sci 53:1117-29. 2012
    ..To investigate rod function and survival after cone dysfunction and degeneration in a mouse model of cone cyclic nucleotide-gated (CNG) channel deficiency...
  14. pmc Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice
    Elaine Tan
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Invest Ophthalmol Vis Sci 45:764-8. 2004
    ..To examine an immortalized mouse retinal cell line (661W) for markers characteristic of photoreceptor cells and validate its photoreceptor origin...
  15. pmc Transgenic animal studies of human retinal disease caused by mutations in peripherin/rds
    Xi Qin Ding
    Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Adv Exp Med Biol 572:141-6. 2006
  16. pmc Outer segment oligomerization of Rds: evidence from mouse models and subcellular fractionation
    Dibyendu Chakraborty
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126, USA
    Biochemistry 47:1144-56. 2008
    ..These results suggest that Rds mutations that interfere with tetramer formation can block Rds trafficking to the OS, leading to loss-of-function defects...
  17. pmc RDS in cones does not interact with the beta subunit of the cyclic nucleotide gated channel
    Shannon M Conley
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma, OK 73104, USA
    Adv Exp Med Biol 664:63-70. 2010
    ..cones...
  18. ncbi request reprint Peripherin/rds in skate retina
    Muna I Naash
    Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Adv Exp Med Biol 533:377-83. 2003
  19. pmc Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency
    Arjun Thapa
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 287:18018-29. 2012
    ..Taken together, our findings suggest a crucial role of endoplasmic reticulum stress in cone degeneration associated with CNG channel deficiency...
  20. pmc Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration
    Hongwei Ma
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104
    Proc Natl Acad Sci U S A 111:3602-7. 2014
    ..This work demonstrates that suppressing TH signaling in retina dystrophy mouse models is protective of cones, providing insights into cone preservation and therapeutic interventions. ..
  21. pmc The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change
    Alexander V Matveev
    Department of Cell Biology, University ofOklahoma Health Sciences Center, 940 Stanton L Young Boulevard, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 49:1628-39. 2010
    ..The observed alterations in the local secondary structure and active conformational change may confer an adverse effect on the channel's activity and cellular processing...
  22. doi request reprint Functional expression of cone cyclic nucleotide-gated channel in cone photoreceptor-derived 661W cells
    J Browning Fitzgerald
    Department of Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Adv Exp Med Biol 613:327-34. 2008
  23. pmc Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones
    Dibyendu Chakraborty
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Hum Mol Genet 18:797-808. 2009
    ..The apparent OS structural differences between rods and cones may cause cones to be more susceptible to the elimination of higher-order Rds/Rom-1 oligomers (e.g. as mediated by mutation of the Rds C150 residue)...
  24. pmc Early-onset, slow progression of cone photoreceptor dysfunction and degeneration in CNG channel subunit CNGB3 deficiency
    Jianhua Xu
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Invest Ophthalmol Vis Sci 52:3557-66. 2011
    ..To investigate the progression of cone dysfunction and degeneration in CNG channel subunit CNGB3 deficiency...
  25. pmc Molecular characterization of the skate peripherin/rds gene: relationship to its orthologues and paralogues
    Chibo Li
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA
    Invest Ophthalmol Vis Sci 44:2433-41. 2003
    ..This study was designed to identify evolutionarily conserved domains of the photoreceptor disc membrane protein peripherin/rds by analysis of the homologue in a primitive vertebrate, the skate...

Research Grants2

  1. Using Nanotechnology to Rescue Visual Loss in A Model of Human Blinding Disorder
    Xi Qin Ding; Fiscal Year: 2007
    ..Information obtained from the proposed study will open a new pathway for therapeutic interventions of retinal degeneration and will have significant impact on the clinical treatment of human retinal diseases. ..
  2. Mechanism of Cone Degeneration Resulting from CNG Channel Deficiency
    Xi Qin Ding; Fiscal Year: 2010
    ..This knowledge is essential for developing therapeutic interventions to treat cone diseases and retard or rescue vision loss. ..