Wen Xing Ding


Affiliation: University of Kansas Medical Center
Country: USA


  1. Wang H, Ni H, Chao X, Ma X, Rodriguez Y, Chavan H, et al. Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice. Redox Biol. 2019;22:101148 pubmed publisher
    ..In conclusion, our results demonstrated that PINK1-Parkin signaling pathway plays a critical role in APAP-induced mitophagy and liver injury. ..
  2. Li Y, Chao X, Yang L, Lu Q, Li T, Ding W, et al. Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation. Am J Pathol. 2018;188:1833-1846 pubmed publisher
  3. Chao X, Wang S, Zhao K, Li Y, Williams J, Li T, et al. Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice. Gastroenterology. 2018;155:865-879.e12 pubmed publisher
    ..Strategies to block mTOR activity or increase levels of TFEB might be developed to protect the liver from ethanol-induced damage. ..
  4. Ni H, Williams J, Ding W. Mitochondrial dynamics and mitochondrial quality control. Redox Biol. 2015;4:6-13 pubmed publisher
    ..We also discuss multiple pathways leading to the quality control of mitochondria in addition to the traditional mitophagy pathway under different conditions. ..
  5. Williams J, Ni H, Haynes A, Manley S, Li Y, Jaeschke H, et al. Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice. J Biol Chem. 2015;290:10934-46 pubmed publisher
    ..Therefore, chronic deletion (KO) and acute knockdown of Parkin have differential responses to APAP-induced mitophagy and liver injury in mice. ..
  6. Manley S, Ni H, Williams J, Kong B, DiTacchio L, Guo G, et al. Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biol. 2014;2:991-1002 pubmed publisher
    ..These results suggest that lack of FXR impaired FoxO3a-mediated autophagy and in turn exacerbated alcohol-induced liver injury. ..
  7. Yang H, Ni H, Guo F, Ding Y, Shi Y, Lahiri P, et al. Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice. J Biol Chem. 2016;291:18663-74 pubmed publisher
    ..Taken together, our results indicate that autophagy is important for the removal of excess ER and hepatic CYP enzymes in mouse livers, a process associated with the autophagy receptor protein p62. ..
  8. Li Y, McGreal S, Zhao J, Huang R, Zhou Y, Zhong H, et al. A cell-based quantitative high-throughput image screening identified novel autophagy modulators. Pharmacol Res. 2016;110:35-49 pubmed publisher
    ..Our data suggest that image-based autophagic flux qHTS can efficiently identify autophagy inducers and inhibitors. ..
  9. Ni H, McGill M, Chao X, Du K, Williams J, Xie Y, et al. Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice. J Hepatol. 2016;65:354-62 pubmed publisher
    ..Activation of autophagy-lysosomal degradation pathway can help to remove acetaminophen protein adducts. Pharmacological induction of autophagy may be a novel promising approach for treating APAP-induced liver injury. ..

More Information


  1. Williams J, Ding W. Targeting Pink1-Parkin-mediated mitophagy for treating liver injury. Pharmacol Res. 2015;102:264-9 pubmed publisher
    ..In this review, we discuss regulation of Parkin-mediated mitophagy and possible therapeutic targets of intervention in this pathway. ..
  2. Ni H, McGill M, Chao X, Woolbright B, Jaeschke H, Ding W. Caspase Inhibition Prevents Tumor Necrosis Factor-?-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro. Am J Pathol. 2016;186:2623-36 pubmed publisher
    ..Moreover, results from our study also raised concerns about the safety of currently ongoing clinical trials that use caspase inhibitors. ..
  3. Williams J, Ding W. A Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease. Biomolecules. 2015;5:2619-42 pubmed publisher
    ..Targeting removal of damaged mitochondria by mitophagy or inducing formation of mitochondrial spheroids may be promising therapeutic options for treatment of ALD. ..
  4. Williams J, Ni H, Ding Y, Ding W. Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice. Am J Physiol Gastrointest Liver Physiol. 2015;309:G324-40 pubmed publisher
    ..Overall, our findings indicate that Parkin is an important mediator of protection against alcohol-induced mitochondrial damage, steatosis, and liver injury. ..
  5. Ding W, Yin X. Mitophagy: mechanisms, pathophysiological roles, and analysis. Biol Chem. 2012;393:547-64 pubmed publisher
    ..In this review, we summarize our current knowledge on the mechanisms of mitophagy. We also discuss the pathophysiological roles of mitophagy and current assays used to monitor mitophagy. ..
  6. Williams J, Ding W. Mitophagy, mitochondrial spheroids, and mitochondrial-derived vesicles in alcohol-induced liver injury. Am J Physiol Gastrointest Liver Physiol. 2015;309:G515 pubmed publisher
  7. Yang X, Wang H, Ni H, Xiong A, Wang Z, Sesaki H, et al. Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice. Redox Biol. 2017;12:264-273 pubmed publisher
    ..Targeting Drp1-mediated mitochondrial fragmentation and apoptosis may be a potential avenue to prevent and treat hepatotoxicity induced by PAs. ..
  8. Du K, Ramachandran A, McGill M, Mansouri A, Asselah T, Farhood A, et al. Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food Chem Toxicol. 2017;108:339-350 pubmed publisher
    ..Thus, induction of MB is an important feature during APAP hepatotoxicity and liver regeneration. ..
  9. Ni H, Woolbright B, Williams J, COPPLE B, Cui W, Luyendyk J, et al. Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy. J Hepatol. 2014;61:617-25 pubmed publisher
    ..We also demonstrate that persistent activation of Nrf2 is critical for liver inflammation, fibrosis and eventual tumorigenesis that occur in mice with defects in hepatocyte autophagy. ..
  10. Ni H, Du K, You M, Ding W. Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am J Pathol. 2013;183:1815-1825 pubmed publisher
    ..FoxO3a thus plays a critical role in ethanol-induced autophagy in mouse liver. Modulating the FoxO3a autophagy pathway may offer novel therapeutic approaches for treating alcoholic liver pathogenesis. ..
  11. Ding W, Guo F, Ni H, Bockus A, Manley S, Stolz D, et al. Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation. J Biol Chem. 2012;287:42379-88 pubmed publisher
    ..Mitochondrial spheroid formation and mitophagy could represent different strategies of mitochondrial homeostatic response to oxidative stress and are reciprocally regulated by mitofusins and Parkin. ..