Qiang Ding

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner
    Qiang Ding
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 283:26839-49. 2008
  2. pmc FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis
    Qiang Ding
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 39294, USA
    Am J Pathol 182:1572-84. 2013
  3. pmc Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle actin filaments during myofibroblast differentiation
    Guo Qiang Cai
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Physiol Lung Cell Mol Physiol 303:L692-702. 2012
  4. pmc Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins
    Sha Zhu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Lung Cell Mol Physiol 297:L97-108. 2009
  5. pmc Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts
    Guo Qiang Cai
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Exp Cell Res 316:1600-9. 2010
  6. pmc miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:1589-97. 2010
  7. ncbi request reprint The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged
    Qiang Ding
    Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, 35294, USA
    J Biol Chem 278:39882-91. 2003
  8. pmc Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction
    Xiangwei Huang
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Tinsley Harrison Tower 437B, 1900 University Blvd, Birmingham, AL 35294, USA
    Am J Respir Cell Mol Biol 47:340-8. 2012
  9. pmc Participation of miR-200 in pulmonary fibrosis
    Shanzhong Yang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Pathol 180:484-93. 2012
  10. ncbi request reprint p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain
    Qiang Ding
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 280:6802-15. 2005

Collaborators

Detail Information

Publications22

  1. pmc Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner
    Qiang Ding
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 283:26839-49. 2008
    ..These data further suggest that modulation FRNK expression may be a novel avenue for therapeutic intervention in tissue fibrosis...
  2. pmc FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis
    Qiang Ding
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 39294, USA
    Am J Pathol 182:1572-84. 2013
    ....
  3. pmc Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle actin filaments during myofibroblast differentiation
    Guo Qiang Cai
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Physiol Lung Cell Mol Physiol 303:L692-702. 2012
    ..Together, this study supports a critical role of N-WASP in integrating FAK and Arp2/3 signaling to mediate formation of α-SMA-containing cytoplasmic filaments during myofibroblast differentiation and maturation...
  4. pmc Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins
    Sha Zhu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Lung Cell Mol Physiol 297:L97-108. 2009
    ..Modulation of fibroblast invasion would be expected to lead to amelioration of fibroproliferative diseases of the lung...
  5. pmc Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts
    Guo Qiang Cai
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Exp Cell Res 316:1600-9. 2010
    ..These data for the first time provide evidence that downregulation of endogenous FRNK plays a role in promoting cell migration through FAK and Rho GTPase in fibrotic IPF lung fibroblasts...
  6. pmc miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:1589-97. 2010
    ..These experiments demonstrate an important role for miR-21 in fibrotic lung diseases and also suggest a novel approach using miRNA therapeutics in treating clinically refractory fibrotic diseases, such as IPF...
  7. ncbi request reprint The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged
    Qiang Ding
    Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, 35294, USA
    J Biol Chem 278:39882-91. 2003
    ..Notably, the data indicate that engagement of different integrins alters the identity of the Src family members that are activated on stimulation with PDGF...
  8. pmc Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction
    Xiangwei Huang
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Tinsley Harrison Tower 437B, 1900 University Blvd, Birmingham, AL 35294, USA
    Am J Respir Cell Mol Biol 47:340-8. 2012
    ....
  9. pmc Participation of miR-200 in pulmonary fibrosis
    Shanzhong Yang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Pathol 180:484-93. 2012
    ..Thus, the miR-200 family members participate importantly in fibrotic lung diseases and suggest that restoring miR-200 expression in the lungs may represent a novel therapeutic approach in treating pulmonary fibrotic diseases...
  10. ncbi request reprint p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain
    Qiang Ding
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 280:6802-15. 2005
    ..Taken together, our results indicate that FAK promotes proliferation of glioblastoma cells by enhancing exit from G(1) through a mechanism that involves cyclin D1 and p27(Kip1)...
  11. ncbi request reprint Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells
    Henry Haskell
    Department of Pathology, Division of Neuropathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Clin Cancer Res 9:2157-65. 2003
    ..To determine the role of FAK in angiogenesis in malignant astrocytic tumors, we investigated the expression and function of FAK in brain endothelial cells...
  12. ncbi request reprint A novel technique to quantify glioma tumor invasion using serial microscopy sections
    N Shastry Akella
    Department of Neurology, Division of Neuro Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Neurosci Methods 153:183-9. 2006
    ..This quantitative method will allow a future in vivo analysis of invasion characteristics in glioma cells expressing altered levels or function of invasion genes, and of new therapy targeting invading glioma cells...
  13. pmc Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury
    Jason S Zolak
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Am J Pathol 182:1239-47. 2013
    ..Our findings also support a potential role for pleural-based therapies to modulate pleural mesothelial activation and parenchymal fibrosis progression...
  14. pmc Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination
    Shuqin Zhan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochim Biophys Acta 1812:565-71. 2011
    ..These studies demonstrate that TNF-α can impair the function of the Hypocretin system by reducing the levels of both Prepro-Hypocretin and HcrtR2...
  15. ncbi request reprint Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells
    Timothy P Hecker
    Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncogene 23:3962-71. 2004
    ....
  16. ncbi request reprint Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: differences in integrin signaling during cell adhesion to osteopontin versus vitronectin
    Qiang Ding
    The Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, 701 South 19th Street, Birmingham, AL 35294, USA
    Cancer Res 62:5336-43. 2002
    ..These data indicate that the cell attachment protein, osteopontin, is expressed in the normal adult brain and that it has the potential to promote malignant astrocytoma cell invasion...
  17. doi request reprint New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis
    Qiang Ding
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, USA
    Drugs 71:981-1001. 2011
    ..Heterogeneity in biological and clinical phenotypes of IPF warrants a personalized medicine approach to diagnosis and treatment of this lung disorder...
  18. pmc Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors
    Kimberly E White
    Department of Medicine, University of Alabama at Birmingham 35294, USA
    J Immunol 180:637-46. 2008
    ..Such mechanisms may drive the fibroproliferative response to ALI...
  19. ncbi request reprint [Study of tracheal regeneration after injury induced by 5-fluorouracil in rats]
    Qiang Ding
    Department of Pathology, China Medical University, Shenyang 110001, China
    Zhonghua Bing Li Xue Za Zhi 33:143-5. 2004
    ..Localization of tracheal stem cells in rat trachea...
  20. ncbi request reprint [The mRNA expression of platelet-derived endothelial cell growth factor of bladder transitional cell carcinoma and its relation to invasiveness]
    Gang Li
    Department of Urology, First Affiliated Hospital, Soochow University, Suzhou 215006, China
    Zhonghua Zhong Liu Za Zhi 26:30-2. 2004
    ..To investigate the relationship between mRNA expression of platelet-derived endothelial cell growth factor (PD-ECGF) and invasion of bladder transitional cell carcinoma (BTCC)...
  21. ncbi request reprint Small molecules that induce cardiomyogenesis in embryonic stem cells
    Xu Wu
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 126:1590-1. 2004
    ..5, and spontaneously form beating regions. Such small molecules will serve as useful chemical probes to study cardiac muscle differentiation and may ultimately facilitate the therapeutic application of ESCs for cardiac repair...
  22. ncbi request reprint A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells
    Xu Wu
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 124:14520-1. 2002
    ..It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development...

Research Grants5

  1. The Role of FAK-related-non-kinase (FRNK) in Lung Fibrosis
    Qiang Ding; Fiscal Year: 2007
    ..These studies will support the long-term goal of my laboratory to utilize knowledge gained from these studies to develop novel therapeutic approaches targeted to idiopathic pulmonary fibrosis in humans. ..
  2. The Role of FAK-related-non-kinase (FRNK) in Lung Fibrosis
    Qiang Ding; Fiscal Year: 2010
    ..These studies will support the long-term goal of my laboratory to utilize knowledge gained from these studies to develop novel therapeutic approaches targeted to idiopathic pulmonary fibrosis in humans. ..
  3. The Role of FAK-related-non-kinase (FRNK) in Lung Fibrosis
    Qiang Ding; Fiscal Year: 2009
    ..These studies will support the long-term goal of my laboratory to utilize knowledge gained from these studies to develop novel therapeutic approaches targeted to idiopathic pulmonary fibrosis in humans. ..