Genomes and Genes
Affiliation: University of Rochester
- Conditional control of gene expression in the mouse retinaQian Ding
University of Rochester Eye Institute, University of Rochester, Rochester, NY, USA
Methods Mol Biol 884:3-15. 2012..It also discusses the current issues in the use of Cre/loxP-based gene-targeting approach...
- MATH5 controls the acquisition of multiple retinal cell fatesLiang Feng
Flaum Eye Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Mol Brain 3:36. 2010..Collectively, these data suggest that Math5 regulates the generation of multiple retinal cell types via different mechanisms during retinogenesis...
- BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cordQian Ding
Flaum Eye Institute and Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 109:1566-71. 2012..Taken together, these results elucidate BARHL2 as a critical postmitotic regulator of dI1 subtype diversification, as well as its intermediate position in the dI1 genetic hierarchy...
- Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cellsYing Jiang
Flaum Eye Institute and Department of Ophthalmology, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 288:18429-38. 2013..Taken together, these findings elucidate SoxC genes as essential contributors to maintain the survival of RGCs, and imply their intermediate position between Math5 and Brn3b in the genetic hierarchy of RGC development. ..
- BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cellsJeffrey M Harder
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Mol Cell Neurosci 51:53-9. 2012..However, the loss of BCL-X in adult RGCs did significantly increase the rate of death of RGCs after axonal injury. Thus, in developing and injured RGCs there appears to be an active cell survival program preventing neuronal death...
- BARHL2 differentially regulates the development of retinal amacrine and ganglion neuronsQian Ding
University of Rochester Eye Institute, University of Rochester, Rochester, New York 14642, USA
J Neurosci 29:3992-4003. 2009..Thus, BARHL2 appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival...