Sean P Dineen

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi request reprint CT reconstructions of right-sided blunt diaphragm rupture
    Sean Dineen
    UT Southwestern, Division of Burns, Trauma, Critical Care, Department of Surgery, Dallas, Texas, USA
    J Trauma 64:1412. 2008
  2. pmc The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer
    Sean P Dineen
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX 75390 8593, USA
    BMC Cancer 8:352. 2008
  3. doi request reprint Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts
    Christina L Roland
    Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Mol Cancer Ther 8:1761-71. 2009
  4. doi request reprint Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts
    Christina L Roland
    Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical School, Dallas, TX, USA
    Exp Biol Med (Maywood) 235:263-70. 2010
  5. pmc Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer
    Christina L Roland
    Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e7669. 2009
  6. pmc Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer
    Sean P Dineen
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX, USA
    Cancer Res 70:2852-61. 2010
  7. doi request reprint The acellular fraction of stored platelets promotes tumor cell invasion
    Sean P Dineen
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Surg Res 153:132-7. 2009
  8. pmc Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma
    Shanna A Arnold
    Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dis Model Mech 3:57-72. 2010
  9. doi request reprint Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice
    Sean P Dineen
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Cancer Res 68:4340-6. 2008
  10. pmc Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice
    Ken L Chambliss
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Invest 120:2319-30. 2010

Collaborators

Detail Information

Publications12

  1. doi request reprint CT reconstructions of right-sided blunt diaphragm rupture
    Sean Dineen
    UT Southwestern, Division of Burns, Trauma, Critical Care, Department of Surgery, Dallas, Texas, USA
    J Trauma 64:1412. 2008
  2. pmc The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer
    Sean P Dineen
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX 75390 8593, USA
    BMC Cancer 8:352. 2008
    ..This small protein is based on a human fibronectin domain and has beneficial properties in that it is fully human, stable, and is produced in bacteria. CT-322 binds to and inhibits activation of VEGFR2...
  3. doi request reprint Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts
    Christina L Roland
    Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Mol Cancer Ther 8:1761-71. 2009
    ..These findings further define the complex molecular interactions in the tumor microenvironment and provide a translational tool that may be relevant to the treatment of breast cancer...
  4. doi request reprint Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts
    Christina L Roland
    Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical School, Dallas, TX, USA
    Exp Biol Med (Maywood) 235:263-70. 2010
    ..These results suggest that tumor-derived ICAM-1 is a sufficient ligand for tumor-associated PMNs and may play a role in subsequent tumor growth and metastasis...
  5. pmc Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer
    Christina L Roland
    Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e7669. 2009
    ..In addition, we found that changes in serum IL-1beta and IL-6 levels correlated with response to therapy, identifying two possible biomarkers for assessing the effectiveness of anti-VEGF therapy in breast cancer patients...
  6. pmc Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer
    Sean P Dineen
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX, USA
    Cancer Res 70:2852-61. 2010
    ..The continued development of JP1201 and other strategies designed to enhance therapy-induced apoptosis in pancreatic cancer is warranted...
  7. doi request reprint The acellular fraction of stored platelets promotes tumor cell invasion
    Sean P Dineen
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Surg Res 153:132-7. 2009
    ..Platelets are ubiquitously present in blood transfusions and contain numerous growth factors that may contribute to tumor growth. We hypothesized that such growth factors released during routine platelet storage promote cancer invasion...
  8. pmc Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma
    Shanna A Arnold
    Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dis Model Mech 3:57-72. 2010
    ....
  9. doi request reprint Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice
    Sean P Dineen
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Cancer Res 68:4340-6. 2008
    ..Our results show an underappreciated mechanism of action that may directly contribute to the antitumor activity of angiogenesis inhibitors that block the VEGFR2 pathway...
  10. pmc Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice
    Ken L Chambliss
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Invest 120:2319-30. 2010
    ..These processes potentially could be harnessed to provide vascular benefit without increasing the risk of uterine or breast cancer...
  11. doi request reprint A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity
    D Gomika Udugamasooriya
    Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9185, USA
    J Am Chem Soc 130:5744-52. 2008
    ....
  12. pmc Clonal analysis reveals a common progenitor for endothelial, myeloid, and lymphoid precursors in umbilical cord blood
    Aline Lisie Ramos
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, USA
    Circ Res 107:1460-9. 2010
    ..However, it is not clear which cell type in these hematopoietic tissues gives rise to endothelial progenitor cells...