Matthew J DiMagno
Affiliation: University of Michigan
DiMagno M, Spaete J, Ballard D, Wamsteker E, Saini S. Risk models for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP): smoking and chronic liver disease are predictors of protection against PEP. Pancreas. 2013;42:996-1003 pubmed publisher
..By using the newly identified protective variables with 3 predictive variables, we derived 2 risk models with a higher predictive value for PEP compared to prior studies. ..
DiMagno M, DiMagno E. Chronic pancreatitis. Curr Opin Gastroenterol. 2013;29:531-6 pubmed publisher
..Treatment of fat malabsorption requires 90,000 USP U of lipase with meals. Relief of pain from organ directed treatment of chronic pancreatitis may depend upon timing of interventions and whether pain is visceral or nonvisceral. ..
DiMagno M. Clinical update on fluid therapy and nutritional support in acute pancreatitis. Pancreatology. 2015;15:583-8 pubmed publisher
..All patients should be offered goal-directed FT during the first 6-12 h of presentation. Cautious FT is advised in those age >55 years or with preexisting organ failure or predictors of developing fluid sequestration. ..
DiMagno M, Lee S, Owyang C, Zhou S. Inhibition of acinar apoptosis occurs during acute pancreatitis in the human homologue DeltaF508 cystic fibrosis mouse. Am J Physiol Gastrointest Liver Physiol. 2010;299:G400-12 pubmed publisher
..Impaired transduction of increased apoptosis signaling in DeltaF508-CF acini may be biologically relevant to the pathogenesis of AP associated with CFTR mutations. ..
DiMagno M, Hao Y, Tsunoda Y, Williams J, Owyang C. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol Gastrointest Liver Physiol. 2004;286:G428-36 pubmed
..eNOS likely plays a dominant role, because eNOS deletion mimics NOS blockade by inhibiting CCK-8 and carbachol-stimulated secretion, whereas nNOS deletion augments CCK-8 but not carbachol-stimulated secretion. ..
DiMagno M, Williams J, Hao Y, Ernst S, Owyang C. Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2004;287:G80-7 pubmed
..Thus eNOS is the main isoform influencing the initiation of caerulein-induced AP. eNOS-derived NO exerts a protective effect through actions on nonacinar cell types, most likely endothelial cells, to produce greater PMBF. ..
DiMagno M, Lee S, Hao Y, Zhou S, McKenna B, Owyang C. A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) mice. Gastroenterology. 2005;129:665-81 pubmed
..These findings may explain the susceptibility to acute pancreatitis in persons with classic and nonclassic cystic fibrosis. ..