Matthew J DiMagno

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. DiMagno M, Lee S, Owyang C, Zhou S. Inhibition of acinar apoptosis occurs during acute pancreatitis in the human homologue DeltaF508 cystic fibrosis mouse. Am J Physiol Gastrointest Liver Physiol. 2010;299:G400-12 pubmed publisher
    ..Impaired transduction of increased apoptosis signaling in DeltaF508-CF acini may be biologically relevant to the pathogenesis of AP associated with CFTR mutations. ..
  2. request reprint
    DiMagno M, Hao Y, Tsunoda Y, Williams J, Owyang C. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol Gastrointest Liver Physiol. 2004;286:G428-36 pubmed
    ..eNOS likely plays a dominant role, because eNOS deletion mimics NOS blockade by inhibiting CCK-8 and carbachol-stimulated secretion, whereas nNOS deletion augments CCK-8 but not carbachol-stimulated secretion. ..
  3. request reprint
    DiMagno M, Williams J, Hao Y, Ernst S, Owyang C. Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2004;287:G80-7 pubmed
    ..Thus eNOS is the main isoform influencing the initiation of caerulein-induced AP. eNOS-derived NO exerts a protective effect through actions on nonacinar cell types, most likely endothelial cells, to produce greater PMBF. ..
  4. request reprint
    DiMagno M, Lee S, Hao Y, Zhou S, McKenna B, Owyang C. A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) mice. Gastroenterology. 2005;129:665-81 pubmed
    ..These findings may explain the susceptibility to acute pancreatitis in persons with classic and nonclassic cystic fibrosis. ..

Locale

Detail Information

Publications4

  1. DiMagno M, Lee S, Owyang C, Zhou S. Inhibition of acinar apoptosis occurs during acute pancreatitis in the human homologue DeltaF508 cystic fibrosis mouse. Am J Physiol Gastrointest Liver Physiol. 2010;299:G400-12 pubmed publisher
    ..Impaired transduction of increased apoptosis signaling in DeltaF508-CF acini may be biologically relevant to the pathogenesis of AP associated with CFTR mutations. ..
  2. request reprint
    DiMagno M, Hao Y, Tsunoda Y, Williams J, Owyang C. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol Gastrointest Liver Physiol. 2004;286:G428-36 pubmed
    ..eNOS likely plays a dominant role, because eNOS deletion mimics NOS blockade by inhibiting CCK-8 and carbachol-stimulated secretion, whereas nNOS deletion augments CCK-8 but not carbachol-stimulated secretion. ..
  3. request reprint
    DiMagno M, Williams J, Hao Y, Ernst S, Owyang C. Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2004;287:G80-7 pubmed
    ..Thus eNOS is the main isoform influencing the initiation of caerulein-induced AP. eNOS-derived NO exerts a protective effect through actions on nonacinar cell types, most likely endothelial cells, to produce greater PMBF. ..
  4. request reprint
    DiMagno M, Lee S, Hao Y, Zhou S, McKenna B, Owyang C. A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) mice. Gastroenterology. 2005;129:665-81 pubmed
    ..These findings may explain the susceptibility to acute pancreatitis in persons with classic and nonclassic cystic fibrosis. ..