Binh An Diep
Affiliation: University of California
Diep B, Le V, Visram Z, Rouha H, Stulik L, Dip E, et al
. Improved Protection in a Rabbit Model of Community-Associated Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia upon Neutralization of Leukocidins in Addition to Alpha-Hemolysin. Antimicrob Agents Chemother. 2016;60:6333-40 pubmed publisher
..As the rabbit recapitulates the high susceptibility to leukocidins characteristic of humans, this species represents a valuable model for assessing novel, cytotoxin-targeting anti-S. aureus therapeutic approaches. ..
Diep B, Le V, Badiou C, Le H, Pinheiro M, Duong A, et al
. IVIG-mediated protection against necrotizing pneumonia caused by MRSA. Sci Transl Med. 2016;8:357ra124 pubmed publisher
..These results demonstrate the potential clinical utility of IVIG in the treatment of severe pneumonia induced by S. aureus. ..
Diep B, Hilliard J, Le V, Tkaczyk C, Le H, Tran V, et al
. Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia. Antimicrob Agents Chemother. 2017;61: pubmed publisher
..These results confirm that MEDI4893 is a promising candidate for immunotherapy against S. aureus pneumonia. ..
Le V, Le H, Pinheiro M, Hahn K, Dinh M, Larson K, et al
. Effects of Tedizolid Phosphate on Survival Outcomes and Suppression of Production of Staphylococcal Toxins in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia. Antimicrob Agents Chemother. 2017;61: pubmed publisher
..aureus necrotizing pneumonia because it inhibits the bacterial production of lung-damaging toxins at the site of infection. ..