Gerald A Dienel

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi request reprint Astrocytic contributions to bioenergetics of cerebral ischemia
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Glia 50:362-88. 2005
  2. ncbi request reprint Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises
    Gerald A Dienel
    Department of Neurology, Slot 500, University of Arkansas for Medical Sciences, 4301 W Markham Street, Shorey Building, Room 7S 15, Little Rock, AR 72205 U S A
    J Cereb Blood Flow Metab 22:1490-502. 2002
  3. ncbi request reprint Neighborly interactions of metabolically-activated astrocytes in vivo
    Gerald A Dienel
    Department of Neurology, Slot 500, University of Arkansas for Medical Sciences, 4301 W Markham St, Shorey Bldg, Room 7S15, Little Rock, AR 72205, USA
    Neurochem Int 43:339-54. 2003
  4. pmc A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurochem 102:466-78. 2007
  5. pmc Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes
    Kelly K Ball
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Cereb Blood Flow Metab 30:162-76. 2010
  6. pmc Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons
    Gautam K Gandhi
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurochem 111:522-36. 2009
  7. pmc Exchange-mediated dilution of brain lactate specific activity: implications for the origin of glutamate dilution and the contributions of glutamine dilution and other pathways
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurochem 109:30-7. 2009
  8. pmc Selective astrocytic gap junctional trafficking of molecules involved in the glycolytic pathway: impact on cellular brain imaging
    Gautam K Gandhi
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurochem 110:857-69. 2009
  9. pmc Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications
    Kelly K Ball
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurosci Res 89:2052-67. 2011
  10. ncbi request reprint Behavioral training increases local astrocytic metabolic activity but does not alter outcome of mild transient ischemia
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock 72205, USA
    Brain Res 961:201-12. 2003

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Astrocytic contributions to bioenergetics of cerebral ischemia
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Glia 50:362-88. 2005
    ..Novel pharmaceutical agents targeted to astrocytes and hyperoxic therapy that restores penumbral oxygen level during energy failure might improve postischemic outcome...
  2. ncbi request reprint Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises
    Gerald A Dienel
    Department of Neurology, Slot 500, University of Arkansas for Medical Sciences, 4301 W Markham Street, Shorey Building, Room 7S 15, Little Rock, AR 72205 U S A
    J Cereb Blood Flow Metab 22:1490-502. 2002
    ....
  3. ncbi request reprint Neighborly interactions of metabolically-activated astrocytes in vivo
    Gerald A Dienel
    Department of Neurology, Slot 500, University of Arkansas for Medical Sciences, 4301 W Markham St, Shorey Bldg, Room 7S15, Little Rock, AR 72205, USA
    Neurochem Int 43:339-54. 2003
    ..Local structure-function relationships need to be incorporated into experimental models of neuron-astrocyte and astrocyte-astrocyte interactions in working brain...
  4. pmc A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurochem 102:466-78. 2007
    ..The metabolic fate of glycogen is unknown, but adding glycogen to the fuel consumed during activation would contribute to a fall in CMR(O2)/CMR(glc) ratio...
  5. pmc Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes
    Kelly K Ball
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Cereb Blood Flow Metab 30:162-76. 2010
    ..Convergence of 'watershed' drainage to common pathways may facilitate perivascular amyloid plaque formation and pathway obstruction in Alzheimer's disease...
  6. pmc Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons
    Gautam K Gandhi
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurochem 111:522-36. 2009
    ....
  7. pmc Exchange-mediated dilution of brain lactate specific activity: implications for the origin of glutamate dilution and the contributions of glutamine dilution and other pathways
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurochem 109:30-7. 2009
    ....
  8. pmc Selective astrocytic gap junctional trafficking of molecules involved in the glycolytic pathway: impact on cellular brain imaging
    Gautam K Gandhi
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurochem 110:857-69. 2009
    ....
  9. pmc Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications
    Kelly K Ball
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurosci Res 89:2052-67. 2011
    ....
  10. ncbi request reprint Behavioral training increases local astrocytic metabolic activity but does not alter outcome of mild transient ischemia
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock 72205, USA
    Brain Res 961:201-12. 2003
    ..Behavioral therapy' (operant testing on the 4 days immediately following either sham manipulation or ischemia) did not alter ischemic outcome, but was associated with higher acetate utilization in regions involved in motor activities...
  11. ncbi request reprint Astrocyte activation in working brain: energy supplied by minor substrates
    Gerald A Dienel
    Department of Neurology, Shorey Bldg, Rm 715, Slot 830, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, 72205, USA
    Neurochem Int 48:586-95. 2006
    ..Because energy-generating reactions from minor substrates are not taken into account by routine assays of functional metabolism, they reflect a "hidden cost" of astrocyte work in vivo...
  12. ncbi request reprint Functional imaging of focal brain activation in conscious rats: impact of [(14)C]glucose metabolite spreading and release
    Nancy F Cruz
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neurosci Res 85:3254-66. 2007
    ..These findings help explain the fall in CMR(O2)/CMR(glc) during brain activation and suggest that lactate and other nonoxidized metabolites of glucose are quickly shuttled away from sites of functional activation...
  13. pmc Hyperglycaemia and diabetes impair gap junctional communication among astrocytes
    Gautam K Gandhi
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, U S A
    ASN Neuro 2:e00030. 2010
    ..Involvement of the microvasculature may contribute to diabetic complications in the brain, the cardiovascular system and other organs...
  14. pmc Astrocytic connexin distributions and rapid, extensive dye transfer via gap junctions in the inferior colliculus: implications for [(14)C]glucose metabolite trafficking
    Kelly K Ball
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neurosci Res 85:3267-83. 2007
    ....
  15. pmc Astrocytic gap junctional communication is reduced in amyloid-β-treated cultured astrocytes, but not in Alzheimer's disease transgenic mice
    Nancy F Cruz
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, U S A
    ASN Neuro 2:e00041. 2010
    ....
  16. ncbi request reprint Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain
    Nancy F Cruz
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neurochem 92:934-47. 2005
    ....
  17. ncbi request reprint Astrocyte activation in vivo during graded photic stimulation
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Neurochem 103:1506-22. 2007
    ..A model portraying regulation of acetate oxidation illustrates complex relationships among functional activation, cation levels, and astrocytic metabolism...
  18. ncbi request reprint High glycogen levels in brains of rats with minimal environmental stimuli: implications for metabolic contributions of working astrocytes
    Nancy F Cruz
    Department of Neurology, Slot 500, University of Arkansas for Medical Sciences, 4301 W Markham Street, Shorey Building, Room 7S 15, Little Rock, AR 72205, U S A
    J Cereb Blood Flow Metab 22:1476-89. 2002
    ..The very high glycogen levels in normal rat brain suggest an unrecognized role for astrocytic energy metabolism during brain activation...
  19. pmc Imaging brain activation: simple pictures of complex biology
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Ann N Y Acad Sci 1147:139-70. 2008
    ....
  20. ncbi request reprint Scaling up a microbore separation for semipreparative analysis: differential recoveries of radiolabeled amino acids
    Amelia Lasater
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Anal Biochem 342:28-33. 2005
    ....
  21. pmc Astrocytes are 'good scouts': being prepared also helps neighboring neurons
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Cereb Blood Flow Metab 30:1893-4. 2010
    ..Glucose buffering and glucose channeling (not lactate shuttling to neurons) are proposed to be the consequences of glycogenolysis...
  22. ncbi request reprint Nutrition during brain activation: does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought?
    Gerald A Dienel
    Department of Neurology, Slot 830, University of Arkansas for Medical Sciences, Room 715, Shorey Building, 4301 W Markham Street, Little Rock, AR 72205, USA
    Neurochem Int 45:321-51. 2004
    ..In vivo nutritional interactions between working neurons and astrocytes are not as simple as implied by "sweet (glucose-glycogen) and sour (lactate) food for thought."..
  23. ncbi request reprint Effect of reactive cell density on net [2-14C]acetate uptake into rat brain: labeling of clusters containing GFAP+- and lectin+-immunoreactive cells
    Neslihan Cetin
    Department of Neurology, University of Arkansas for Medical Sciences, Slot 500 4301 W Markham St, Little Rock 72205, USA
    Neurochem Int 42:359-74. 2003
    ....
  24. pmc The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes
    Katrine R Lind
    Department of Neurology, University of Arkansas for Medical Sciences Little Rock, AR 72205, USA
    Neurochem Int 62:784-95. 2013
    ..High-glucose cultured astrocytes and STZ-diabetic brain are relatively resistant to diabetes-induced ER stress, in sharp contrast with cultured retinal Müller cells and diabetic rodent retina...
  25. pmc Brain lactate metabolism: the discoveries and the controversies
    Gerald A Dienel
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Cereb Blood Flow Metab 32:1107-38. 2012
    ..Lactate can be an 'opportunistic', glucose-sparing substrate when present in high amounts, but most evidence supports glucose as the major fuel for normal, activated brain...
  26. ncbi request reprint Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats
    Dmitry Romanovsky
    Department of Anesthesiology, University of Arkansas for Medical Sciences, 4301 West Markham St, Little Rock, AR 72205, USA
    Neurobiol Dis 24:384-94. 2006
    ..Thus, at least one of early signs of diabetic neuropathy in STZ-treated rats, mechanical hyperalgesia, can be triggered by moderate insulinopenia, irrespective of glycemic status of the animals...
  27. ncbi request reprint beta-Adrenergics enhance brain extraction of levodopa
    Ergun Y Uc
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Mov Disord 17:54-9. 2002
    ..Thus, beta-adrenergic agonists might be useful in the treatment of patients with Parkinson's disease by enhancing delivery of L-dopa to the brain...
  28. ncbi request reprint Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, People s Republic of China
    J Cereb Blood Flow Metab 27:219-49. 2007
    ....
  29. ncbi request reprint Lactate transport and transporters: general principles and functional roles in brain cells
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, P R China
    J Neurosci Res 79:11-8. 2005
    ....
  30. ncbi request reprint Energy metabolism in the brain
    Leif Hertz
    Hong Kong DNA Chips, Ltd, Kowloon, Hong Kong, China
    Int Rev Neurobiol 51:1-102. 2002
  31. ncbi request reprint Lactate muscles its way into consciousness: fueling brain activation
    Gerald A Dienel
    Am J Physiol Regul Integr Comp Physiol 287:R519-21. 2004