D J Diekema

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Daptomycin exposure precedes infection and/or colonization with daptomycin non-susceptible enterococcus
    Jeremy C Storm
    University of Iowa Hospital and Clinics, Iowa City, IA, USA
    Antimicrob Resist Infect Control 1:19. 2012
  2. doi request reprint Rapid detection of antibiotic-resistant organism carriage for infection prevention
    Daniel J Diekema
    University of Iowa Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Clin Infect Dis 56:1614-20. 2013
  3. doi request reprint The changing epidemiology of healthcare-associated candidemia over three decades
    Daniel Diekema
    Division of Infectious Diseases, Department of Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 73:45-8. 2012
  4. pmc Evaluation of Etest and disk diffusion methods compared with broth microdilution antifungal susceptibility testing of clinical isolates of Candida spp. against posaconazole
    Daniel J Diekema
    Department of Pathology, Roy J and Lucille A Carver College of Medicine and College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    J Clin Microbiol 45:1974-7. 2007
  5. doi request reprint Current practice in Staphylococcus aureus screening and decolonization
    Daniel Diekema
    Division of Infectious Diseases, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Infect Control Hosp Epidemiol 32:1042-4. 2011
  6. pmc Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci
    Daniel J Diekema
    Department of Internal Medicine, University of Iowa Colleges of Medicine and Public Health, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:2659-61. 2003
  7. pmc Activities of available and investigational antifungal agents against rhodotorula species
    D J Diekema
    Department of Internal Medicine, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    J Clin Microbiol 43:476-8. 2005
  8. pmc Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi
    D J Diekema
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 41:3623-6. 2003
  9. ncbi request reprint Age-related trends in pathogen frequency and antimicrobial susceptibility of bloodstream isolates in North America: SENTRY Antimicrobial Surveillance Program, 1997-2000
    D J Diekema
    Department of Pathology, Medical Microbiology Division, C606 GH, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Int J Antimicrob Agents 20:412-8. 2002
  10. ncbi request reprint Look before you leap: active surveillance for multidrug-resistant organisms
    Daniel J Diekema
    University of Iowa Healthcare, Iowa City, IA, USA
    Clin Infect Dis 44:1101-7. 2007

Detail Information

Publications137 found, 100 shown here

  1. pmc Daptomycin exposure precedes infection and/or colonization with daptomycin non-susceptible enterococcus
    Jeremy C Storm
    University of Iowa Hospital and Clinics, Iowa City, IA, USA
    Antimicrob Resist Infect Control 1:19. 2012
    ..abstract:..
  2. doi request reprint Rapid detection of antibiotic-resistant organism carriage for infection prevention
    Daniel J Diekema
    University of Iowa Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Clin Infect Dis 56:1614-20. 2013
    ....
  3. doi request reprint The changing epidemiology of healthcare-associated candidemia over three decades
    Daniel Diekema
    Division of Infectious Diseases, Department of Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 73:45-8. 2012
    ..glabrata (15% had FLU MICs >32 µg/mL). The epidemiology of HAC is changing at our hospital, with continued emergence of C. glabrata, fewer cases among oncology patients, and lower in-hospital and 30-day mortality...
  4. pmc Evaluation of Etest and disk diffusion methods compared with broth microdilution antifungal susceptibility testing of clinical isolates of Candida spp. against posaconazole
    Daniel J Diekema
    Department of Pathology, Roy J and Lucille A Carver College of Medicine and College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    J Clin Microbiol 45:1974-7. 2007
    ..These agar-based methods hold promise as simple and reliable methods for determination of the posaconzole susceptibilities of Candida spp...
  5. doi request reprint Current practice in Staphylococcus aureus screening and decolonization
    Daniel Diekema
    Division of Infectious Diseases, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Infect Control Hosp Epidemiol 32:1042-4. 2011
    ..aureus. However, specific screening and decolonization practices are highly variable, are focused almost exclusively on methicillin-resistant S. aureus, and do not include testing for mupirocin or chlorhexidine resistance...
  6. pmc Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci
    Daniel J Diekema
    Department of Internal Medicine, University of Iowa Colleges of Medicine and Public Health, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:2659-61. 2003
    ..Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS...
  7. pmc Activities of available and investigational antifungal agents against rhodotorula species
    D J Diekema
    Department of Internal Medicine, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    J Clin Microbiol 43:476-8. 2005
    ..12 microg/ml) are both active in vitro, and the new and investigational triazoles all have some in vitro activity, with ravuconazole being the most active (MIC(50), 0.25 microg/ml)...
  8. pmc Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi
    D J Diekema
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 41:3623-6. 2003
    ..5 microg/ml. The new triazoles and caspofungin have excellent in vitro activity against a very large collection of recent clinical isolates of Aspergillus spp., and some in vitro activity against selected other filamentous fungi...
  9. ncbi request reprint Age-related trends in pathogen frequency and antimicrobial susceptibility of bloodstream isolates in North America: SENTRY Antimicrobial Surveillance Program, 1997-2000
    D J Diekema
    Department of Pathology, Medical Microbiology Division, C606 GH, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Int J Antimicrob Agents 20:412-8. 2002
    ..This information should be helpful for clinicians as they consider empirical antimicrobial therapy for patients with suspected BSI across the age continuum...
  10. ncbi request reprint Look before you leap: active surveillance for multidrug-resistant organisms
    Daniel J Diekema
    University of Iowa Healthcare, Iowa City, IA, USA
    Clin Infect Dis 44:1101-7. 2007
    ....
  11. ncbi request reprint Antimicrobial resistance trends and outbreak frequency in United States hospitals
    Daniel J Diekema
    Iowa City Veterans Affairs Medical Center, Dept of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Clin Infect Dis 38:78-85. 2004
    ..The most common resistant pathogen in US hospitals is ORSA, which accounts for many recognized outbreaks and is increasing in frequency in most facilities. Current practices to prevent and control antimicrobial resistance are inadequate...
  12. doi request reprint A global evaluation of voriconazole activity tested against recent clinical isolates of Candida spp
    Daniel J Diekema
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 63:233-6. 2009
    ..008/0.25 microg/mL; 98% susceptible). In comparison to 5866 Candida spp. isolates collected during global surveillance from 1997 to 2001, there were no changes in voriconazole mean MIC or MIC distribution...
  13. pmc Comparison of activities of broad-spectrum beta-lactam compounds against 1,128 gram-positive cocci recently isolated in cancer treatment centers
    D J Diekema
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Antimicrob Agents Chemother 43:940-3. 1999
    ....
  14. pmc Accuracy and appropriateness of antimicrobial susceptibility test reporting for bacteria isolated from blood cultures
    Daniel J Diekema
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52246, USA
    J Clin Microbiol 42:2258-60. 2004
    ..Further study is necessary to determine the impact of testing errors and suboptimal reporting of results on the management of bloodstream infection...
  15. pmc Epidemiology of candidemia: 3-year results from the emerging infections and the epidemiology of Iowa organisms study
    D J Diekema
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    J Clin Microbiol 40:1298-302. 2002
    ..However, C. glabrata has emerged as an important and potentially antifungal resistant cause of candidemia, particularly among the elderly...
  16. pmc In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America
    D J Diekema
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Antimicrob Agents Chemother 43:2236-9. 1999
    ..that were dose-dependently fluconazole susceptible and against those that were fluconazole resistant...
  17. ncbi request reprint Survey of bloodstream infections due to gram-negative bacilli: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997
    D J Diekema
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Clin Infect Dis 29:595-607. 1999
    ..coli and Klebsiella species from Latin America. Further investigation of the reasons for regional differences in resistance patterns is needed, as is ongoing surveillance to detect resistance trends and to guide antimicrobial use...
  18. ncbi request reprint Trends in antimicrobial susceptibility of bacterial pathogens isolated from patients with bloodstream infections in the USA, Canada and Latin America. SENTRY Participants Group
    D J Diekema
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Int J Antimicrob Agents 13:257-71. 2000
    ..Ongoing surveillance remains essential, and will enhance efforts to limit the scope of this worldwide problem...
  19. pmc Antimicrobial-drug use and changes in resistance in Streptococcus pneumoniae
    D J Diekema
    University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Emerg Infect Dis 6:552-6. 2000
    ..S. medical centers, we obtained data on outpatient antimicrobial-drug use for the regions surrounding 23 of these centers. We found an association between decreased penicillin susceptibility and use of beta-lactam antimicrobial drugs...
  20. pmc Rapid detection of antimicrobial-resistant organism carriage: an unmet clinical need
    Daniel J Diekema
    Department of Internal Medicine, Division of Medical Microbiology, C 606 GH, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Clin Microbiol 42:2879-83. 2004
  21. ncbi request reprint Genetic relatedness of multidrug-resistant, methicillin (oxacillin)-resistant Staphylococcus aureus bloodstream isolates from SENTRY Antimicrobial Resistance Surveillance Centers worldwide, 1998
    D J Diekema
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52246, USA
    Microb Drug Resist 6:213-21. 2000
    ..aureus bloodstream isolates worldwide. Although many MDR-MRSA strains group geographically, a few closely related epidemic strains have wide regional and even global range...
  22. ncbi request reprint Antimicrobial resistance in viridans group streptococci among patients with and without the diagnosis of cancer in the USA, Canada and Latin America
    D J Diekema
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Clin Microbiol Infect 7:152-7. 2001
    ..To investigate antimicrobial resistance in viridans group streptococci (VGS) among patients with and without the diagnosis of cancer in the USA, Canada and Latin America...
  23. ncbi request reprint Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillanc
    D J Diekema
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Clin Infect Dis 32:S114-32. 2001
    ..Given the increasing multidrug resistance among staphylococci and the possible emergence of vancomycin-resistant strains, global strategies are needed to control emergence and spread of multiply resistant staphylococci...
  24. ncbi request reprint Oxazolidinone antibiotics
    D J Diekema
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Lancet 358:1975-82. 2001
    ..New agents with greater potency and new spectra of activity could arise from further modification of the oxazolidinone nucleus...
  25. pmc Geographic and temporal trends in isolation and antifungal susceptibility of Candida parapsilosis: a global assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005
    M A Pfaller
    Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 46:842-9. 2008
    ..parapsilosis to fluconazole and voriconazole may vary by geographic region and clinical service...
  26. pmc International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surv
    M A Pfaller
    Department of Pathology, Iowa City, Iowa 52242, USA
    J Clin Microbiol 39:3254-9. 2001
    ....
  27. ncbi request reprint In vitro susceptibilities of rare Candida bloodstream isolates to ravuconazole and three comparative antifungal agents
    M A Pfaller
    Department of Pathology, University of Iowa College of Medicine and College of Public Health, Iowa City, IA, USA
    Diagn Microbiol Infect Dis 48:101-5. 2004
    ..Ravuconazole is clearly an "extended-spectrum" triazole with potent in vitro activity against these rare and potentially "emerging" opportunistic pathogens...
  28. pmc Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: 10.5-year analysis of susceptibilities of noncandidal yeast species to fluconazole and voriconazole determined by CLSI standardized disk diffusion testing
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 47:117-23. 2009
    ..These organisms may pose a future threat to optimal antifungal therapy and emphasize the importance of prompt and accurate species identification...
  29. pmc Evaluation of the Etest and disk diffusion methods for determining susceptibilities of 235 bloodstream isolates of Candida glabrata to fluconazole and voriconazole
    M A Pfaller
    Department of Pathology Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:1875-80. 2003
    ..The agar-based methods performed well in identifying isolates with resistance to fluconazole and decreased susceptibility to voriconazole...
  30. ncbi request reprint In vitro activities of voriconazole, posaconazole, and fluconazole against 4,169 clinical isolates of Candida spp. and Cryptococcus neoformans collected during 2001 and 2002 in the ARTEMIS global antifungal surveillance program
    M A Pfaller
    Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USA
    Diagn Microbiol Infect Dis 48:201-5. 2004
    ..and C. neoformans. These results provide further evidence for the increased spectrum and potency of the new triazoles against a large and geographically diverse collection of opportunistic fungal pathogens...
  31. pmc Use of fluconazole as a surrogate marker to predict susceptibility and resistance to voriconazole among 13,338 clinical isolates of Candida spp. Tested by clinical and laboratory standards institute-recommended broth microdilution methods
    M A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 45:70-5. 2007
    ..Clinical laboratories performing antifungal susceptibility testing of fluconazole against Candida spp. can reliably use these results as surrogate markers until commercial FDA-approved voriconazole susceptibility tests become available...
  32. pmc Comparison of the Vitek Gram-Positive Susceptibility 106 card and the MRSA-screen latex agglutination test for determining oxacillin resistance in clinical bloodstream isolates of Staphylococcus aureus
    T Yamazumi
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 39:53-6. 2001
    ..Both methods were sensitive and specific for detecting staphylococcal oxacillin resistance in the clinical microbiology laboratory...
  33. pmc Comparison of the broth microdilution (BMD) method of the European Committee on Antimicrobial Susceptibility Testing with the 24-hour CLSI BMD method for testing susceptibility of Candida species to fluconazole, posaconazole, and voriconazole by use of ep
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 49:845-50. 2011
    ..These results provide additional data in favor of the harmonization of these two methods...
  34. pmc Evaluation of the etest method using Mueller-Hinton agar with glucose and methylene blue for determining amphotericin B MICs for 4,936 clinical isolates of Candida species
    M A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA
    J Clin Microbiol 42:4977-9. 2004
    ..albicans, 95.1%; C. glabrata, 94.3%; C. krusei, 91.6%; C. parapsilosis, 86.6%; and C. tropicalis, 86.4%. The Etest method using MH-GMB appears to be a useful method for determining amphotericin B susceptibilities of Candida species...
  35. pmc In vitro activities of caspofungin compared with those of fluconazole and itraconazole against 3,959 clinical isolates of Candida spp., including 157 fluconazole-resistant isolates
    M A Pfaller
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Antimicrob Agents Chemother 47:1068-71. 2003
    ..These results provide further evidence for the spectrum and potency of caspofungin activity against a large and geographically diverse collection of clinically important isolates of Candida spp...
  36. pmc Comparison of results of voriconazole disk diffusion testing for Candida species with results from a central reference laboratory in the ARTEMIS global antifungal surveillance program
    M A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Clin Microbiol 43:5208-13. 2005
    ....
  37. pmc Wild-type MIC distribution and epidemiological cutoff values for Aspergillus fumigatus and three triazoles as determined by the Clinical and Laboratory Standards Institute broth microdilution methods
    M A Pfaller
    Medical Microbiology Division, Department of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 47:3142-6. 2009
    ..The establishment of the WT MIC distribution and ECVs for the azoles and A. fumigatus will be useful in resistance surveillance and is an important step toward the development of clinical breakpoints...
  38. pmc Candida rugosa, an emerging fungal pathogen with resistance to azoles: geographic and temporal trends from the ARTEMIS DISK antifungal surveillance program
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 44:3578-82. 2006
    ..C. rugosa should be considered, along with the established pathogens Candida krusei and Candida glabrata, as a species of Candida with reduced susceptibility to the azole antifungal agents...
  39. pmc Activities of fluconazole and voriconazole against 1,586 recent clinical isolates of Candida species determined by Broth microdilution, disk diffusion, and Etest methods: report from the ARTEMIS Global Antifungal Susceptibility Program, 2001
    M A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicine and College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:1440-6. 2003
    ..Continued surveillance and refinement of broth- and agar-based test methods will help to identify susceptibility trends and improve the laboratory capability for antifungal susceptibility testing...
  40. pmc In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp., including 315 isolates resistant to fluconazole
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 43:5425-7. 2005
    ..These results provide further evidence for the spectrum and potency of anidulafungin activity against a large and geographically diverse collection of clinically important isolates of Candida spp...
  41. pmc Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location in the United States in 2001 to 2007
    M A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 47:3185-90. 2009
    ..The oldest age group (> or = 80 years) had the highest proportion of BSI isolates that were C. glabrata (32%) and the lowest rate of fluconazole resistance (5%)...
  42. pmc Results from the ARTEMIS DISK Global Antifungal Surveillance study, 1997 to 2005: an 8.5-year analysis of susceptibilities of Candida species and other yeast species to fluconazole and voriconazole determined by CLSI standardized disk diffusion testing
    M A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 45:1735-45. 2007
    ..These organisms may pose a future threat to optimal antifungal therapy and emphasize the importance of prompt and accurate species identification...
  43. pmc Candida krusei, a multidrug-resistant opportunistic fungal pathogen: geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 46:515-21. 2008
    ..25 microg/ml). C. krusei is an uncommon but multidrug-resistant fungal pathogen. Among the systemically active antifungal agents, the echinocandins appear to be the most active against this important pathogen...
  44. pmc Selection of a surrogate agent (fluconazole or voriconazole) for initial susceptibility testing of posaconazole against Candida spp.: results from a global antifungal surveillance program
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 46:551-9. 2008
    ..0% M) when results for Candida krusei (not indicated for fluconazole testing) were omitted. Either fluconazole or voriconazole MIC results may serve as surrogate markers to predict the susceptibility of Candida spp. to posaconazole...
  45. pmc Cross-resistance between fluconazole and ravuconazole and the use of fluconazole as a surrogate marker to predict susceptibility and resistance to ravuconazole among 12,796 clinical isolates of Candida spp
    M A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Clin Microbiol 42:3137-41. 2004
    ..Fluconazole may serve as a surrogate marker to predict the susceptibility of Candida spp. to ravuconazole...
  46. doi request reprint Comparison of the Sensititre YeastOne colorimetric antifungal panel with CLSI microdilution for antifungal susceptibility testing of the echinocandins against Candida spp., using new clinical breakpoints and epidemiological cutoff values
    M A Pfaller
    University of Iowa College of Medicine, Iowa City, IA, USA
    Diagn Microbiol Infect Dis 73:365-8. 2012
    ..to the echinocandins when using the new (lower) CBPs and ECVs. Further study using defined fks mutant strains of Candida is warranted...
  47. pmc Wild-type MIC distributions and epidemiological cutoff values for the echinocandins and Candida spp
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 48:52-6. 2010
    ..9%) for C. guilliermondii. These WT MIC distributions and ECVs will be useful in surveillance for emerging reduced echinocandin susceptibility among Candida spp. and for determining the importance of various FKS1 or other mutations...
  48. pmc Activities of micafungin against 315 invasive clinical isolates of fluconazole-resistant Candida spp
    S A Messer
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 44:324-6. 2006
    ..Micafungin may prove useful in the treatment of infections due to azole-resistant Candida...
  49. pmc Wild-type MIC distributions and epidemiological cutoff values for posaconazole and voriconazole and Candida spp. as determined by 24-hour CLSI broth microdilution
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 49:630-7. 2011
    ..The CBP is inadequate in detecting the emergence of voriconazole resistance among most Candida species encountered clinically. The CBPs for voriconazole should be reassessed, with consideration for development of species-specific CBPs...
  50. pmc Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin: analysis and proposal for interpretive MIC breakpoints
    M A Pfaller
    Department of Pathology, 200 Hawkins Drive, University of Iowa, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 46:2620-9. 2008
    ..Subsequently, the isolates should be submitted to a reference laboratory that will confirm the results by using a CLSI reference dilution method...
  51. pmc In vitro susceptibilities of clinical isolates of Candida species, Cryptococcus neoformans, and Aspergillus species to itraconazole: global survey of 9,359 isolates tested by clinical and laboratory standards institute broth microdilution methods
    M A Pfaller
    Department of Pathology, Medical Microbiology Division, C606 GH, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 43:3807-10. 2005
    ..In light of the new intravenous formulation of itraconazole these data suggest that this agent remains a viable systemically active antifungal agent...
  52. pmc Multicenter comparison of the VITEK 2 antifungal susceptibility test with the CLSI broth microdilution reference method for testing amphotericin B, flucytosine, and voriconazole against Candida spp
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 45:3522-8. 2007
    ..9 to 97.4% at the 48-h BMD time point. The VITEK 2 system reliably detected flucytosine and voriconazole resistance among Candida spp. and demonstrated excellent quantitative and qualitative agreement with the reference BMD method...
  53. pmc In vitro susceptibilities of Candida spp. to caspofungin: four years of global surveillance
    M A Pfaller
    Departments of Pathology, Epidemiology, Roy J and Lucille A Carver College of Medicine and College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 44:760-3. 2006
    ..Our prospective sentinel surveillance reveals no evidence of emerging caspofungin resistance among invasive clinical isolates of Candida...
  54. pmc Comparison of results of fluconazole disk diffusion testing for Candida species with results from a central reference laboratory in the ARTEMIS global antifungal surveillance program
    M A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicin and College of Public Health, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 42:3607-12. 2004
    ....
  55. pmc Further standardization of broth microdilution methodology for in vitro susceptibility testing of caspofungin against Candida species by use of an international collection of more than 3,000 clinical isolates
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 42:3117-9. 2004
    ..The MICs for >99% of isolates were </=1 microg/ml, and thus these isolates were differentiated from strains with reduced in vitro and in vivo susceptibilities to caspofungin...
  56. pmc Evaluation of Etest method for determining fluconazole and voriconazole MICs for 279 clinical isolates of Candida species infrequently isolated from blood
    M J Maxwell
    Departments of Pathology Medicine Epidemiology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:1087-90. 2003
    ..The Etest method using RPMI agar appears to be a useful method for determining fluconazole and voriconazole susceptibilities of uncommon species of Candida...
  57. pmc Stability of Mueller-Hinton agar supplemented with glucose and methylene blue for disk diffusion testing of fluconazole and voriconazole
    M A Pfaller
    Departments of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 42:1288-9. 2004
    ..Prepared MH-GMB agar plates provide acceptable performance for disk diffusion testing for at least 30 days when stored at 5 degrees C...
  58. pmc In vitro activities of ravuconazole and voriconazole compared with those of four approved systemic antifungal agents against 6,970 clinical isolates of Candida spp
    M A Pfaller
    Department of Pathology, University of Iowa College of Medicine, and College of Public Health, Iowa City, Iowa 52242, USA
    Antimicrob Agents Chemother 46:1723-7. 2002
    ..krusei. These results provide further evidence for the spectrum and potency of ravuconazole and voriconazole against a large and geographically diverse collection of Candida spp...
  59. pmc Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location
    M A Pfaller
    Department of Pathology, Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:2176-9. 2003
    ..S. Bureau of the Census). Isolates from pediatric patients were virtually all susceptible to fluconazole, whereas the highest frequency of resistance was observed in isolates from patients 16 to 64 years of age...
  60. pmc Wild-type MIC distributions and epidemiological cutoff values for amphotericin B, flucytosine, and itraconazole and Candida spp. as determined by CLSI broth microdilution
    M A Pfaller
    JMI Laboratories, North Liberty, Iowa, USA
    J Clin Microbiol 50:2040-6. 2012
    ..0) for C. guilliermondii. In the absence of species-specific CBP values, these wild-type (WT) MIC distributions and ECVs will be useful for monitoring the emergence of reduced susceptibility to these well-established antifungal agents...
  61. ncbi request reprint In vitro susceptibility testing of filamentous fungi: comparison of Etest and reference M38-A microdilution methods for determining posaconazole MICs
    M A Pfaller
    Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 45:241-4. 2003
    ..The Etest method using RPMI agar appears to be a useful method for determining posaconazole susceptibilities of filamentous fungi...
  62. pmc Candida guilliermondii, an opportunistic fungal pathogen with decreased susceptibility to fluconazole: geographic and temporal trends from the ARTEMIS DISK antifungal surveillance program
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 44:3551-6. 2006
    ..5/1.0 microg/ml). C. guilliermondii, a species that exhibits reduced susceptibility to fluconazole, is the sixth most frequently isolated Candida species from this large survey and may be an emerging pathogen in Latin America...
  63. pmc In vitro susceptibility of invasive isolates of Candida spp. to anidulafungin, caspofungin, and micafungin: six years of global surveillance
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Clin Microbiol 46:150-6. 2008
    ..Our prospective sentinel surveillance reveals no evidence of emerging echinocandin resistance among invasive clinical isolates of Candida spp...
  64. pmc Comparison of the Vitek gram-positive susceptibility 106 card, the MRSA-Screen latex agglutination test, and mecA analysis for detecting oxacillin resistance in a geographically diverse collection of clinical isolates of coagulase-negative staphylococci
    T Yamazumi
    Medical Microbiology Division, Department of Pathology University of Iowa College of Medicine, Iowa City, Iowa, USA
    J Clin Microbiol 39:3633-6. 2001
    ..Although the MRSA-Screen test required a slight procedural modification, both commercial methods achieved a sensitivity and specificity at detecting oxacillin resistance in CoNS at a level that was acceptable for clinical laboratory use...
  65. pmc Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: a 10.5-year analysis of susceptibilities of Candida Species to fluconazole and voriconazole as determined by CLSI standardized disk diffusion
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 48:1366-77. 2010
    ..These organisms may pose a future threat to optimal antifungal therapy and underscore the importance of prompt and accurate species identification and antifungal susceptibility testing...
  66. pmc Validation of 24-hour posaconazole and voriconazole MIC readings versus the CLSI 48-hour broth microdilution reference method: application of epidemiological cutoff values to results from a global Candida antifungal surveillance program
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 49:1274-9. 2011
    ..to these important antifungal agents. The applications of ECVs to this large collection of Candida isolates suggests the potential to develop 24-h species-specific clinical breakpoints for both posaconazole and voriconazole...
  67. pmc In vitro activities of voriconazole, posaconazole, and four licensed systemic antifungal agents against Candida species infrequently isolated from blood
    M A Pfaller
    Department of Pathology, University of Iowa College of Medicine and College of Public Health, Iowa City, 52242, USA
    J Clin Microbiol 41:78-83. 2003
    ..Continued surveillance will be necessary to detect the emergence of these species as more prevalent, resistant pathogens. The new triazoles appear to offer acceptable coverage of uncommon Candida sp. bloodstream infections...
  68. pmc In vitro susceptibility testing of Aspergillus spp.: comparison of Etest and reference microdilution methods for determining voriconazole and itraconazole MICs
    J B Pfaller
    Departments of Pathology Medicine Epidemiology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:1126-9. 2003
    ..The Etest method using RPMI agar appears to be a useful method for determining the voriconazole and itraconazole susceptibilities of Aspergillus spp...
  69. pmc Evaluation of Etest method for determining voriconazole and amphotericin B MICs for 162 clinical isolates of Cryptococcus neoformans
    M J Maxwell
    Department of Pathology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:97-9. 2003
    ..The Etest method using RPG agar appears to be a useful method for determining the susceptibility of C. neoformans to voriconazole and amphotericin B...
  70. ncbi request reprint Epidemiology of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus in a rural state
    Philip M Polgreen
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, 52246, USA
    Infect Control Hosp Epidemiol 27:252-6. 2006
    ..Infection control personnel need to understand the epidemiology of MRSA and VRE across the continuum of care, including small rural hospitals, to develop effective control strategies...
  71. ncbi request reprint Descriptive epidemiology and case-control study of patients colonized with vancomycin-resistant enterococcus and methicillin-resistant Staphylococcus aureus
    Bryndis Sigurdardottir
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Infect Control Hosp Epidemiol 27:913-9. 2006
    ..aureus if the vanA gene is transferred from vancomycin-resistant enterococcus to methicillin-resistant S. aureus...
  72. pmc Identification of Candida nivariensis and Candida bracarensis in a large global collection of Candida glabrata isolates: comparison to the literature
    Shawn R Lockhart
    University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 47:1216-7. 2009
    ..Both species were very rare in this collection (0.2% prevalence), despite the number of isolates analyzed and the global distribution of the isolates. We saw no associated antifungal resistance in C. nivariensis...
  73. doi request reprint Emergence of the USA300 strain of methicillin-resistant Staphylococcus aureus in a burn-trauma unit
    Lucy A Wibbenmeyer
    Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Burn Care Res 29:790-7. 2008
    ..Burn patients may be at risk for numerous abscesses with USA300, because they have open wounds and their immune systems may be compromised...
  74. doi request reprint Initial treatment and outcome of Candida glabrata versus Candida albicans bloodstream infection
    Michael J Klevay
    Department of Medicine, University of Iowa, Iowa City, 52242, USA
    Diagn Microbiol Infect Dis 64:152-7. 2009
    ..The lack of difference in mortality between species may reflect the overriding importance of host variables and/or a difference in virulence by species: further study is needed to investigate these hypotheses...
  75. pmc Detection and treatment of bloodstream infection: laboratory reporting and antimicrobial management
    Erik L Munson
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 55242, USA
    J Clin Microbiol 41:495-7. 2003
    ..Most therapy interventions occurred at the time of phlebotomy and after notification of Gram stain results by telephone. Release of antimicrobial susceptibility data had the least impact on antimicrobial management...
  76. pmc Role of sentinel surveillance of candidemia: trends in species distribution and antifungal susceptibility
    M A Pfaller
    Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Clin Microbiol 40:3551-7. 2002
  77. doi request reprint Wild-type MIC distributions, epidemiological cutoff values and species-specific clinical breakpoints for fluconazole and Candida: time for harmonization of CLSI and EUCAST broth microdilution methods
    M A Pfaller
    University of Iowa, Iowa City, IA, USA
    Drug Resist Updat 13:180-95. 2010
    ..EUCAST CBPs are species-specific, and apply only to C. albicans, C. tropicalis and C. parapsilosis, while CLSI CBPs apply to all species. We reassessed the CLSI CBPs for FLU and Candida in light of recent data...
  78. pmc Effects of rapid detection of bloodstream infections on length of hospitalization and hospital charges
    S E Beekmann
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:3119-25. 2003
    ..The newest generation of automated continuous-monitoring blood culture systems, which shorten the time required to obtain a positive result, should impact length of hospitalization...
  79. pmc Clinical evaluation of a frozen commercially prepared microdilution panel for antifungal susceptibility testing of seven antifungal agents, including the new triazoles posaconazole, ravuconazole, and voriconazole
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 40:1694-7. 2002
    ..The overall agreement for each antifungal agent ranged from 96% for ravuconazole to 100% for amphotericin B. The Trek microdilution panel appears to be a viable alternative to frozen microdilution panels prepared in-house...
  80. pmc Minimizing the workup of blood culture contaminants: implementation and evaluation of a laboratory-based algorithm
    S S Richter
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 40:2437-44. 2002
    ..6% of 71 isolates. The laboratory-based algorithm provided an acceptably accurate means for assessing the clinical significance of potential contaminants recovered from blood cultures...
  81. doi request reprint Clinical breakpoints for the echinocandins and Candida revisited: integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria
    M A Pfaller
    University of Iowa, Iowa City, United States
    Drug Resist Updat 14:164-76. 2011
    ..12 mcg/ml (I), and ≥ 0.25 mcg/ml (R). New, species-specific CBPs for Candida and the echinocandins are more sensitive to detect emerging resistance associated with fks mutations, and better able to predict risk for clinical failure...
  82. pmc Clinical evaluation of the Sensititre YeastOne colorimetric antifungal panel for antifungal susceptibility testing of the echinocandins anidulafungin, caspofungin, and micafungin
    M A Pfaller
    Department of Pathology, Medical Microbiology Division, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 46:2155-9. 2008
    ..The YeastOne colorimetric method appears to be comparable to the CLSI reference method for testing the susceptibility of Candida spp. to the echinocandins anidulafungin, caspofungin, and micafungin...
  83. pmc Activity of MGCD290, a Hos2 histone deacetylase inhibitor, in combination with azole antifungals against opportunistic fungal pathogens
    M A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 47:3797-804. 2009
    ..g., Mucor and Fusarium). Further evaluation of fungal HDAC inhibitor-azole combinations is indicated...
  84. pmc Comparison of European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Etest methods with the CLSI broth microdilution method for echinocandin susceptibility testing of Candida species
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 48:1592-9. 2010
    ..All three test methods showed a high level of agreement and of ability to distinguish fks mutant strains of Candida species from WT strains using each of the echinocandins...
  85. pmc Validation of 24-hour fluconazole MIC readings versus the CLSI 48-hour broth microdilution reference method: results from a global Candida antifungal surveillance program
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 46:3585-90. 2008
    ..4%, with 0.1% VME. Both the MIC and the disk diffusion results obtained for fluconazole after only 24 h of incubation may be used to determine the susceptibilities of Candida spp. to this widely used antifungal agent...
  86. pmc Results from the ARTEMIS DISK Global Antifungal Surveillance Study: a 6.5-year analysis of susceptibilities of Candida and other yeast species to fluconazole and voriconazole by standardized disk diffusion testing
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 43:5848-59. 2005
    ....
  87. pmc Correlation of MIC with outcome for Candida species tested against voriconazole: analysis and proposal for interpretive breakpoints
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 44:819-26. 2006
    ..The corresponding disk test breakpoints are as follows: S, > or = 17 mm; SDD, 14 to 16 mm; and R, < or = 13 mm...
  88. pmc Epidemiology of invasive candidiasis: a persistent public health problem
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Microbiol Rev 20:133-63. 2007
    ..Further research to improve diagnostic, preventive, and therapeutic strategies is necessary to reduce the considerable morbidity and mortality associated with IC...
  89. ncbi request reprint Macrolide use identified as risk factor for macrolide-resistant Streptococcus pneumoniae in a 17-center case-control study
    S E Beekmann
    Division of Medical Microbiology, Department of Pathology 265 MRC, University of Iowa, Iowa, IA, 52242, USA
    Eur J Clin Microbiol Infect Dis 25:335-9. 2006
    ..pneumoniae. Macrolide resistance was associated with use of any antibiotic during the prior 6 weeks, and was most strongly associated with previous macrolide use...
  90. pmc Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus
    M A Pfaller
    Department of Pathology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 42:4419-31. 2004
  91. pmc Global trends in the antifungal susceptibility of Cryptococcus neoformans (1990 to 2004)
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 43:2163-7. 2005
    ..We conclude that in vitro resistance to antifungal agents used in the treatment of cryptococcosis remains uncommon among isolates of C. neoformans from five broad geographic regions and has not increased over a 15-year period...
  92. pmc Interpretive breakpoints for fluconazole and Candida revisited: a blueprint for the future of antifungal susceptibility testing
    M A Pfaller
    Department of Pathology, Medical Microbiology Division, C606 GH, University of Iowa College of Medicine, Iowa City, 52242, USA
    Clin Microbiol Rev 19:435-47. 2006
    ..S, MIC <or= 8 microg/ml; susceptible-dose dependent (SDD), MIC = 16 to 32 microg/ml; R, MIC >or= 64 microg/ml. The corresponding disk test breakpoints are as follows: S, >or=19 mm; SDD, 15 to 18 mm; R, <or=14 mm...
  93. pmc Multicenter comparison of the VITEK 2 yeast susceptibility test with the CLSI broth microdilution reference method for testing fluconazole against Candida spp
    M A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 45:796-802. 2007
    ..The VITEK 2 system reliably detected fluconazole resistance among Candida spp. and demonstrated excellent quantitative and qualitative agreement with the reference BMD method...
  94. pmc Geographic variation in the susceptibilities of invasive isolates of Candida glabrata to seven systemically active antifungal agents: a global assessment from the ARTEMIS Antifungal Surveillance Program conducted in 2001 and 2002
    M A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Clin Microbiol 42:3142-6. 2004
    ..06 microg/ml) and flucytosine (MIC(90), 0.12 microg/ml) and exhibited variable cross-resistance to posaconazole, ravuconazole, and voriconazole...
  95. pmc Evaluation of disk diffusion and Etest compared to broth microdilution for antifungal susceptibility testing of posaconazole against clinical isolates of filamentous fungi
    Shawn A Messer
    University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Clin Microbiol 45:1322-4. 2007
    ..These agar-based methods hold promise as simple and reliable methods for determining the posaconazole susceptibilities of filamentous fungi...
  96. doi request reprint Comparison of results of fluconazole and voriconazole disk diffusion testing for Candida spp. with results from a central reference laboratory in the ARTEMIS DISK Global Antifungal Surveillance Program
    Michael A Pfaller
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 65:27-34. 2009
    ....
  97. ncbi request reprint Incidence of invasive aspergillosis among allogeneic hematopoietic stem cell transplant patients receiving voriconazole prophylaxis
    Gregory T Siwek
    Program of Hospital Epidemiology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 55:209-12. 2006
    ..We report no cases of IA among 92 HSCT recipients who received voriconazole prophylaxis compared with a 10% (23/223) incidence among those receiving other systemic antifungals for prophylaxis (P < .0005)...
  98. ncbi request reprint Determining the clinical significance of coagulase-negative staphylococci isolated from blood cultures
    Susan E Beekmann
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Infect Control Hosp Epidemiol 26:559-66. 2005
    ..Our objective was to develop an algorithm to assist in determining the clinical significance of coagulase-negative staphylococci...
  99. doi request reprint Epidemiology of invasive mycoses in North America
    Michael A Pfaller
    Department of Pathology, University of Iowa, Iowa City, USA
    Crit Rev Microbiol 36:1-53. 2010
    ..This review discusses the epidemiologic profiles of these invasive mycoses in North America, as well as risk factors for infection, and the pathogens' antifungal susceptibility...
  100. ncbi request reprint Risk factors for groin wound infection after femoral artery catheterization: a case-control study
    Philip M Polgreen
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Infect Control Hosp Epidemiol 27:34-7. 2006
    ..Groin wound infection (GWI) after femoral artery catheterization is unusual. However, several reports of GWI associated with the use of a Perclose device appear in the surgical literature...
  101. ncbi request reprint Implementation of strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in U.S. hospitals
    Marcia M Ward
    Department of Health Management and Policy, University of Iowa, Iowa City, Iowa 52242 1008, USA
    Infect Control Hosp Epidemiol 26:21-30. 2005
    ....