Robert Dickson

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Mutant analysis reveals complex regulation of sphingolipid long chain base phosphates and long chain bases during heat stress in yeast
    Stacey R Ferguson-Yankey
    Department of Molecular and Cellular Biochemistry, Lucille P Markey Cancer Center, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA
    Yeast 19:573-86. 2002
  2. ncbi request reprint Sphingolipid requirement for generation of a functional v1 component of the vacuolar ATPase
    Ji Hyun Chung
    Department of Molecular and Cellular Biochemistry and the Lucille P Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 278:28872-81. 2003
  3. pmc Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles
    Martin Valachovic
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, 40536
    Genetics 173:1893-908. 2006
  4. ncbi request reprint Roles for sphingolipids in Saccharomyces cerevisiae
    Robert C Dickson
    Department of Molecular and Cellular Biochemistry, Lucille P Markey Cancer Center, University of Kentucky College of Medicine, 741 S Limestone St, BBSRB, 8173, Lexington, Kentucky 40536 0509, USA
    Adv Exp Med Biol 688:217-31. 2010
  5. ncbi request reprint Sphingolipid functions in Saccharomyces cerevisiae
    Robert C Dickson
    Department of Cellular and Molecular Biochemistry and the Lucille P Markey Cancer Center, University of Kentucky College of Medicine, Lexington 40536 0298, USA
    Biochim Biophys Acta 1583:13-25. 2002
  6. pmc Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast
    Robert C Dickson
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    J Lipid Res 49:909-21. 2008
  7. doi request reprint More chores for TOR: de novo ceramide synthesis
    Robert C Dickson
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Cell Metab 7:99-100. 2008
  8. ncbi request reprint Functions and metabolism of sphingolipids in Saccharomyces cerevisiae
    Robert C Dickson
    Department of Molecular and Cellular Biochemistry and the Lucille Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    Prog Lipid Res 45:447-65. 2006
  9. pmc The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover
    Guangzuo Luo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 283:10433-44. 2008
  10. ncbi request reprint The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9
    Ke Liu
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, 40536, USA
    J Biol Chem 280:22679-87. 2005

Research Grants

Collaborators

  • STEPHEN STURLEY
  • Katsuhide Fujita
  • Ying Liu
  • Robert L Lester
  • Xiping Zhang
  • Guangzuo Luo
  • Jennifer L Brace
  • Martin Valachovic
  • Sabrina Zink
  • Ke Liu
  • Ji Hyun Chung
  • John D Hearn
  • Nitai C Hait
  • Stacey R Ferguson-Yankey
  • Ole N Jensen
  • Albrecht Gruhler
  • Charles M Rudin
  • Dina Balderes
  • M Shah Alam Bhuiyan
  • James Eckstein
  • Bart M Bareither
  • Lisa Wilcox
  • Martin Bard
  • Robert Barbuch
  • Constance Mehlgarten
  • Raffael Schaffrath
  • Michael J R Stark
  • Hiroko K Kitamoto
  • Junko Nagase
  • Daniel Jablonowski
  • Marek S Skrzypek

Detail Information

Publications15

  1. ncbi request reprint Mutant analysis reveals complex regulation of sphingolipid long chain base phosphates and long chain bases during heat stress in yeast
    Stacey R Ferguson-Yankey
    Department of Molecular and Cellular Biochemistry, Lucille P Markey Cancer Center, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA
    Yeast 19:573-86. 2002
    ..Our data provide a basis for determining how the basal and heat-induced levels of individual species of LCBs and LCBPs are governed by the Lcb4p and Lcb5p kinases, the Dpl1p lyase and the Lcb3p phosphatase...
  2. ncbi request reprint Sphingolipid requirement for generation of a functional v1 component of the vacuolar ATPase
    Ji Hyun Chung
    Department of Molecular and Cellular Biochemistry and the Lucille P Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 278:28872-81. 2003
    ..Reciprocal experiments with V0 from sur4Delta cells show that it is normal. We conclude that sphingolipids with a C26 acyl group are required for generating fully functional V1 domains...
  3. pmc Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles
    Martin Valachovic
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, 40536
    Genetics 173:1893-908. 2006
    ..We show that deletion of YND1, like deletion of GDA1, alters the sphingolipid profiles, suggesting that changes in sphingolipids compensate for lethality produced by changes in sterol composition and abundance...
  4. ncbi request reprint Roles for sphingolipids in Saccharomyces cerevisiae
    Robert C Dickson
    Department of Molecular and Cellular Biochemistry, Lucille P Markey Cancer Center, University of Kentucky College of Medicine, 741 S Limestone St, BBSRB, 8173, Lexington, Kentucky 40536 0509, USA
    Adv Exp Med Biol 688:217-31. 2010
    ..Advances in our knowledge of sphingolipids and their roles in yeast are impressive but molecular mechanisms remain elusive and are a primary challenge for further progress in understanding the specific functions of sphingolipids...
  5. ncbi request reprint Sphingolipid functions in Saccharomyces cerevisiae
    Robert C Dickson
    Department of Cellular and Molecular Biochemistry and the Lucille P Markey Cancer Center, University of Kentucky College of Medicine, Lexington 40536 0298, USA
    Biochim Biophys Acta 1583:13-25. 2002
    ..Other studies suggest roles for sphingolipids in exocytosis, growth regulation and longevity. Finally, some progress has been made in understanding how sphingolipid synthesis is regulated and how sphingolipid levels are maintained...
  6. pmc Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast
    Robert C Dickson
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    J Lipid Res 49:909-21. 2008
    ..This new knowledge provides a foundation for greatly advancing our understanding of sphingolipid biology in yeast...
  7. doi request reprint More chores for TOR: de novo ceramide synthesis
    Robert C Dickson
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Cell Metab 7:99-100. 2008
    ..This work may provide insight into how chemotherapeutic drugs increase de novo ceramide synthesis and promote cell death in humans...
  8. ncbi request reprint Functions and metabolism of sphingolipids in Saccharomyces cerevisiae
    Robert C Dickson
    Department of Molecular and Cellular Biochemistry and the Lucille Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    Prog Lipid Res 45:447-65. 2006
    ....
  9. pmc The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover
    Guangzuo Luo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 283:10433-44. 2008
    ..Eisosomes then control endocytosis to align the composition and function of the plasma membrane to match demand...
  10. ncbi request reprint The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9
    Ke Liu
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, 40536, USA
    J Biol Chem 280:22679-87. 2005
    ..Thus, our data support a model in which PHS, rather than simply being an upstream activator of Pkh1, also activates kinases that are downstream targets of Pkh1 including Ypk1/2 and Sch9...
  11. ncbi request reprint Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p
    Xiping Zhang
    Department of Molecular and Cellular Biochemistry and the Lucille P Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 279:22030-8. 2004
    ..Homologs of Pil1p and Lsp1p are widespread in nature, and our results suggest that they may be negative regulators of PDK-like protein kinases and their downstream cellular pathways that control cell growth and survival...
  12. ncbi request reprint Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes
    Nitai C Hait
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    FEBS Lett 532:97-102. 2002
    ..These results indicate that LCBs made in the endoplasmic reticulum must transit to the Golgi to be converted into LCBPs, which must then return to the endoplasmic reticulum to be degraded...
  13. ncbi request reprint The uracil transporter Fur4p associates with lipid rafts
    John D Hearn
    Department of Molecular and Cellular Biochemistry and Lucille P Markey Cancer Center, University of Kentucky College of Medicine, Lexington 40536, USA
    J Biol Chem 278:3679-86. 2003
    ..Further studies using lcb1-100 cells should reveal new roles of sphingolipids in nutrient uptake and other membrane-dependent processes...
  14. pmc SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae
    Jennifer L Brace
    Johns Hopkins University, Baltimore, Maryland 21231, USA
    Genetics 175:65-76. 2007
    ..Together, these data suggest that compartmentalized generation of distinct intracellular subsets of sphingoid bases may be critical for activation of signaling pathways that control cell growth and survival...
  15. pmc Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin
    Sabrina Zink
    Biologicum, Institut fur Genetik, Martin Luther Universitat Halle Wittenberg, Weinbergweg 10, D 06120 Halle Saale, Germany
    Eukaryot Cell 4:879-89. 2005
    ..In sum, M(IP)(2)C operates in a plasma membrane step that follows recognition of cell wall chitin by zymocin but precedes the involvement of elongator, the potential toxin target...

Research Grants30

  1. MOLECULAR GENETIC ANALYSIS OF YEAST SPHINGOLIPIDS
    Robert Dickson; Fiscal Year: 2001
    ..This new knowledge may identify novel targets for pharmacological intervention. ..
  2. FUNCTION OF LONG CHAIN BASE KINASES AND THEIR PRODUCTS
    Robert Dickson; Fiscal Year: 2003
    ....
  3. MOLECULAR GENETIC ANALYSIS OF YEAST SPHINGOLIPIDS
    Robert Dickson; Fiscal Year: 2005
    ....
  4. Characterization of the Sch9 Longevity Pathway in Yeast
    Robert Dickson; Fiscal Year: 2006
    ..Since Sch9 is a homolog of human Akt/PKB protein kinases, our results may identify specific roles for Akts/PKBs in human aging and longevity. ..
  5. MOLECULAR GENETIC ANALYSIS OF YEAST SPHINGOLIPIDS
    Robert Dickson; Fiscal Year: 1993
    ..Yeast sphingolipids provide a local focus for the rational design of antifungal agents for use in alleviating human fungal infections...
  6. Characterization of the Sch9 -Longevity Pathway in Yeast
    Robert C Dickson; Fiscal Year: 2010
    ..Thus, information gained from these studies should provide a more mechanistic basis for understanding how aging and life span are regulated in humans. ..