Research Topics
| P J DickinsonSummaryAffiliation: University of California Country: USA Publications
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Publications
Expression of the tumor suppressor genes NF2, 4.1B, and TSLC1 in canine meningiomasP J Dickinson
Department of Surgical and Radiological Sciences, Tupper Hall, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
Vet Pathol 46:884-92. 2009..In addition, it is likely that other, as yet unidentified, genes play an important role in canine meningioma formation and growth...
Congenital myasthenia gravis in Smooth-Haired Miniature Dachshund dogsPeter J Dickinson
Department of Surgical and Radiological Sciences, Tupper Hall, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Vet Intern Med 19:920-3. 2005..Unlike most previously reported cases of congenital myasthenia gravis that are relentlessly progressive, clinical signs resolved spontaneously by 6 months of age...- Feline neuromuscular disordersPeter J Dickinson
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California at Davis, Davis, CA 95616, USA
Vet Clin North Am Small Anim Pract 34:1307-59. 2004 - Vascular endothelial growth factor mRNA expression and peritumoral edema in canine primary central nervous system tumorsP J Dickinson
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Vet Pathol 45:131-9. 2008..Peritumoral edema was present in all tumor types; however, a significant association between the extent of peritumoral edema and the level of VEGF expression was not apparent... - Canine model of convection-enhanced delivery of liposomes containing CPT-11 monitored with real-time magnetic resonance imaging: laboratory investigationPeter J Dickinson
Department of Surgical and Radiological Sciences, Tupper Hall, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Neurosurg 108:989-98. 2008..Additionally any possible toxicity of liposomes containing Gd and the chemotherapeutic agent irinotecan (CPT-11) was assessed following direct intraparenchymal delivery... - Muscle and nerve biopsyPeter J Dickinson
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA
Vet Clin North Am Small Anim Pract 32:63-102, vi. 2002..The normal and pathological appearance of muscle and nerve using routine histochemical and histological techniques are described and illustrated emphasizing the basic myopathic and neuropathic responses of the neuromuscular system... 
Canine spontaneous glioma: a translational model system for convection-enhanced deliveryPeter J Dickinson
Department of Surgical and Radiological of Sciences, School of Veterinary Medicine, University of California Davis, Davis, California 95616 8745, USA
Neuro Oncol 12:928-40. 2010..Variability in Vd between tumors strongly suggests that real-time imaging should be an essential component of CED therapeutic trials to allow minimization of inappropriate infusions and accurate assessment of clinical outcomes...- Magnetic resonance imaging and histological classification of intracranial meningiomas in 112 dogsB K Sturges
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616 87471, USA
J Vet Intern Med 22:586-95. 2008..Classification of meningiomas by tumor grade and subtype has not been reported, and the value of magnetic resonance imaging (MRI) characteristics for predicting tumor subtype and grade has not been investigated... - Canine intraspinal meningiomas: imaging features, histopathologic classification, and long-term outcome in 34 dogsS A Petersen
Department of Surgical and Radiological Sciences, University of California, Davis, CA 95616 8747, USA
J Vet Intern Med 22:946-53. 2008.... - Choroid plexus tumors in 56 dogs (1985-2007)D R Westworth
William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, Davis, CA 95616 8747, USA
J Vet Intern Med 22:1157-65. 2008..The clinical utility of magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, or both in the presumptive diagnosis of CPTs has not been determined... - Clinical signs, imaging features, neuropathology, and outcome in cats and dogs with central nervous system cryptococcosis from CaliforniaJ E Sykes
Veterinary Medical Teaching Hospital, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Vet Intern Med 24:1427-38. 2010..Cryptococcus spp. is a fungal pathogen with a predilection for the central nervous system (CNS)... - Extradural spinal synovial cysts in nine dogsP J Dickinson
Veterinary Medical Teaching Hospital, University of California, Davis 95616, USA
J Small Anim Pract 42:502-9. 2001..The mean follow-up period was 17 months (range four to 36 months). At the time of follow-up, all dogs were fully ambulatory with improved neurological function compared with that at initial presentation... - Glioblastoma multiforme: clinical findings, magnetic resonance imaging, and pathology in five dogsD Lipsitz
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA
Vet Pathol 40:659-69. 2003..These canine GBMs shared many diagnostic neuroimaging, gross, microcopic, and immunoreactivity features similar to those of human GBMs... - Necrotizing meningoencephalitis in five Chihuahua dogsR J Higgins
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Vet Pathol 45:336-46. 2008..The clinical signs, distribution pattern, and histologic type of lesions bear close similarities to necrotizing meningoencephalitis as described in series of both Pug and Maltese breed dogs and less commonly in other breeds... - Canine intraneural perineuriomaR J Higgins
Department of Pathology, Immunology and Pathology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Vet Pathol 43:50-4. 2006..These morphologic and immunologic features distinguish this lesion from hypertrophic neuropathy and were consistent with intraneural perineurioma... - Radiation induced vertebral osteosarcoma following treatment of an intradural extramedullary spinal cord tumor in a dogP J Dickinson
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA
Vet Radiol Ultrasound 42:463-70. 2001..A lower dose per fraction, e.g., 3 Gy/fraction or less, is advisable when irradiating young dogs or any dog in which the life expectancy is 3-5 or more years after irradiation... - Growth inhibition of an orthotopic glioblastoma in immunocompetent mice by cationic lipid-DNA complexesRobert J Higgins
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA
Cancer Immunol Immunother 53:338-44. 2004..The results indicate that an i.v.-administered EV-CLDC can significantly inhibit the growth of a brain tumor in immunocompetent syngeneic mice... - Magnetic resonance imaging features of canine intracranial neoplasiaErik R Wisner
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Vet Radiol Ultrasound 52:S52-61. 2011..Characterization of neoplasms by histologic type and biological grade is based on the 2007 World Health Organization classification system for CNS tumors in humans... - Retrospective analysis of spinal arachnoid cysts in 14 dogsHelena Rylander
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, Davis, CA 95616 8747, USA
J Vet Intern Med 16:690-6. 2002..Furthermore, bilobed or multiple SACs can occur commonly, and myelography effectively localized SACs in dogs. Surgical resection of SACs resulted in improvement in neurological function in the majority of treated dogs... - Spontaneous canine gliomas: overexpression of EGFR, PDGFRalpha and IGFBP2 demonstrated by tissue microarray immunophenotypingRobert J Higgins
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
J Neurooncol 98:49-55. 2010..These findings support a role for the spontaneous canine glioma model in directed pathway-targeting therapeutic studies... - Clinical signs, magnetic resonance imaging features, and outcome after surgical and medical treatment of otogenic intracranial infection in 11 cats and 4 dogsBeverly K Sturges
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616 8747, USA
J Vet Intern Med 20:648-56. 2006.... - TP53 mutations in canine brain tumorsD York
Department of Surgical and Radiological Sciences, Tupper Hall, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Vet Pathol 49:796-801. 2012..This is markedly lower than that reported in comparable human tumors, suggesting that alternative mechanisms of p53 inactivation are likely to be present if p53 function contributes significantly to oncogenesis in canine brain tumors... - Quantitative assessment of blood volume and permeability in cerebral mass lesions using dynamic contrast-enhanced computed tomography in the dogAlexander G MacLeod
Veterinary Medical Teaching Hospital, University of California, Davis, School of Veterinary Medicine, Davis, CA 95616, USA
Acad Radiol 16:1187-95. 2009..To evaluate cerebral blood volume (CBV) and permeability (PS) in spontaneously occurring cerebral neoplastic and non-neoplastic lesions in dogs using dynamic contrast-enhanced computed tomography (DCE-CT)... - Assessment of the neurologic effects of dietary deficiencies of phenylalanine and tyrosine in catsPeter J Dickinson
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 65:671-80. 2004..Official present-day recommendations for dietary phenylalanine and tyrosine in cats may be insufficient to support normal long-term neurologic function... - Characteristics of cisternal cerebrospinal fluid associated with intracranial meningiomas in dogs: 56 cases (1985-2004)Peter J Dickinson
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Am Vet Med Assoc 228:564-7. 2006..Neutrophilic pleocytosis may not be detected in CSF samples from dogs with meningiomas located within the middle or rostral portion of the cranial fossae... - Enhanced gene transfer efficiency in the murine striatum and an orthotopic glioblastoma tumor model, using AAV-7- and AAV-8-pseudotyped vectorsThomas C Harding
Cell Genesys, South San Francisco, CA 94080, USA
Hum Gene Ther 17:807-20. 2006.... - AAV serotype 8-mediated gene delivery of a soluble VEGF receptor to the CNS for the treatment of glioblastomaThomas C Harding
Cell Genesys, Inc, 500 Forbes Boulevard, South San Francisco, CA 94080, USA
Mol Ther 13:956-66. 2006..We propose that rAAV-mediated gene transfer of a potent soluble VEGF inhibitor in the CNS represents an effective antiangiogenic treatment strategy for GBM...