George Dickinson


Affiliation: University of California, Irvine
Location: Irvine, USA


  1. Dickinson G, Patel S. Modulation of NAADP (nicotinic acid-adenine dinucleotide phosphate) receptors by K+ ions: evidence for multiple NAADP receptor conformations. Biochem J. 2003;375:805-12 pubmed
    ..Our results are consistent with the observation of multiple conformations of the NAADP receptor that are readily revealed in low K+-containing media. ..
  2. Churamani D, Dickinson G, Patel S. NAADP binding to its target protein in sea urchin eggs requires phospholipids. Biochem J. 2005;386:497-504 pubmed
    ..Our data highlight the importance of the lipid environment for interaction of NAADP with its target protein. ..
  3. Yamaguchi S, Jha A, Li Q, Soyombo A, Dickinson G, Churamani D, et al. Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J Biol Chem. 2011;286:22934-42 pubmed publisher
    ..We conclude that although TRPML1 and TPCs are present in the same complex, they function as two independent organellar ion channels and that TPCs, not TRPMLs, are the targets for NAADP. ..
  4. Navazio L, Bewell M, Siddiqua A, Dickinson G, Galione A, Sanders D. Calcium release from the endoplasmic reticulum of higher plants elicited by the NADP metabolite nicotinic acid adenine dinucleotide phosphate. Proc Natl Acad Sci U S A. 2000;97:8693-8 pubmed
    ..The existence of multiple Ca(2+) mobilization pathways and Ca(2+) release sites might contribute to the generation of stimulus-specific Ca(2+) signals in plant cells. ..
  5. Churamani D, Carrey E, Dickinson G, Patel S. Determination of cellular nicotinic acid-adenine dinucleotide phosphate (NAADP) levels. Biochem J. 2004;380:449-54 pubmed
    ..Our improved method for the quantification of NAADP should prove useful in the further assessment of its signalling role within cells. ..
  6. Dickinson G, Churchill G, Brailoiu E, Patel S. Deviant nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated Ca2+ signaling upon lysosome proliferation. J Biol Chem. 2010;285:13321-5 pubmed publisher
    ..Our data suggest that deregulated lysosomal Ca(2+) signaling through NAADP may contribute to neuronal dysfunction and highlight the usefulness of lysosomal hydrolase inhibition in probing NAADP action. ..
  7. request reprint
    Berridge G, Dickinson G, Parrington J, Galione A, Patel S. Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate. J Biol Chem. 2002;277:43717-23 pubmed
  8. Churamani D, Dickinson G, Ziegler M, Patel S. Time sensing by NAADP receptors. Biochem J. 2006;397:313-20 pubmed
    ..NAADP receptors, however, failed to stabilize at reduced temperature. We conclude that NAADP receptors possess a simple molecular memory endowing them with the remarkable ability to detect the duration of their activation. ..
  9. Dickinson G, Swaminathan D, Parker I. The probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster. Biophys J. 2012;102:1826-36 pubmed publisher


Detail Information


  1. Dickinson G, Ellefsen K, Dawson S, Pearson J, Parker I. Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action. Sci Signal. 2016;9:ra108 pubmed
    ..The predicted range of action of IP3 (<5 μm) is thus smaller than the size of typical mammalian cells, indicating that IP3 should better be considered as a local rather than a global cellular messenger. ..