Research Topics
Genomes and Genes
| Chad A DickeySummaryAffiliation: University of South Florida Country: USA Publications
| Collaborators
|
Detail Information
Publications
Imbalance of Hsp70 family variants fosters tau accumulationUmesh K Jinwal
1University of South Florida, 4001 E Fletcher Ave, Room 325, Tampa, FL, 33613, USA
FASEB J 27:1450-9. 2013..Nordhues, B. A., Cockman, M., Zhang, J., Li, P., Zhang, B., Borysov, S., Uversky, V. N., Biernat, J., Mandelkow, E., Gestwicki, J. E., Zweckstetter, M., Dickey, C. A. Imbalance of Hsp70 family variants fosters tau accumulation...- Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burdenJohn C O'Leary
Department of Molecular Medicine, Byrd Alzheimer s Research Institute, University of South Florida, Tampa, FL 33613, USA
Mol Neurodegener 5:45. 2010..Thus, efforts to discover therapeutics for tauopathies emphasize soluble tau reductions as well as neuroprotection... - The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubulesUmesh K Jinwal
Johnnie B Byrd Sr Alzheimer s Research Institute and Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, USA
J Neurosci 30:591-9. 2010..Based on these new findings, we propose that FKBP51 can use the Hsp90 complex to isomerize tau, altering its phosphorylation pattern and stabilizing microtubules... - The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamicsUmesh K Jinwal
Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
J Biol Chem 286:16976-83. 2011..We propose that changes in the neuronal levels or activity of Cdc37 could dramatically alter the kinome, leading to profound changes in the tau phosphorylation signature, altering its proteotoxicity and stability... - Chemical manipulation of hsp70 ATPase activity regulates tau stabilityUmesh K Jinwal
Departments of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
J Neurosci 29:12079-88. 2009..These findings reveal an entirely novel path toward therapeutic intervention of tauopathies by inhibition of the previously untargeted ATPase activity of Hsp70... - Hsc70 rapidly engages tau after microtubule destabilizationUmesh K Jinwal
Department of Molecular Medicine, University of South Florida, Johnnie B Byrd Sr Alzheimer s Research Institute, Tampa, Florida 33613, USA
J Biol Chem 285:16798-805. 2010..Thus, under normal circumstances, MC1 formation may be a protective conformation facilitated by Hsc70. However, in a diseased environment, Hsc70 may preserve Tau in a more unstructured state, perhaps facilitating its pathogenicity... - DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tauJose F Abisambra
Department of Molecular Medicine, Byrd Alzheimer s Research Institute, University of South Florida, Tampa, FL 33613, USA
J Mol Biol 421:653-61. 2012..Further investigations could provide new insights about triage decisions that facilitate or prevent amyloidogenesis of tau and other proteins associated with neurodegenerative disease... - The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tauJeffrey R Jones
Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, United States
J Nat Prod 74:38-44. 2011..Myricanol may represent a novel scaffold for drug development efforts targeting tau turnover in AD... - Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 proteinUmesh K Jinwal
Department of Pharmaceutical Sciences, University of South Florida Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
J Biol Chem 287:24814-20. 2012..But when tau accumulation is occurring, cleaved TDP-43 can no longer be cleared, perhaps explaining the emergence of these co-pathologies... - Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanismAmirthaa Suntharalingam
Department of Molecular Medicine and Byrd Alzheimer s Research Institute, University of South Florida, Tampa, FL 33613, USA
J Biol Chem 287:40661-9. 2012..Mutant myocilin accumulates in the endoplasmic reticulum for unknown reasons... - Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistanceJohn Koren
Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, College of Medicine, University of South Florida, Tampa, Florida, United States of America
PLoS ONE 7:e35566. 2012..Thus, modifications to the rhodocyanine scaffold could potentially be made to improve efficacy and pharmacokinetic properties. Moreover, the impact on tamoxifen sensitivity could be a new utility for this compound family... - Akt and CHIP coregulate tau degradation through coordinated interactionsChad A Dickey
Department of Molecular Pharmacology and Physiology and H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
Proc Natl Acad Sci U S A 105:3622-7. 2008..Hence, Akt serves as a major regulator of tau biology by manipulating both tau kinases and protein quality control, providing a link to several common pathways that have demonstrated dysfunction in Alzheimer's disease... - Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathiesJohn Koren
Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, Tampa, FL 33613, USA
Mol Neurobiol 44:65-70. 2011..This, combined with compelling evidence that the prolyl isomerase Pin1 regulates tau stability and phosphorylation dynamics, suggests an emerging role for isomerization in tau pathogenesis... - Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic miceJose F Abisambra
Department of Molecular Medicine, University of South Florida Health Byrd Alzheimer s Institute, Tampa, Florida 33613, USA
J Neurosci 30:15374-82. 2010.... - LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 miceDaniel C Lee
Byrd Alzheimer s Institute, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA
J Neuroinflammation 7:56. 2010.... - Chaperone signalling complexes in Alzheimer's diseaseJohn Koren
Johnnie B Byrd Sr Alzheimer s Center and Research Institute, Department of Molecular Medicine, University of South Florida, Tampa, USA
J Cell Mol Med 13:619-30. 2009..Here, we present the current understandings of chaperone biology and examine the literature investigating these proteins in the context of AD... - Facilitating Akt clearance via manipulation of Hsp70 activity and levelsJohn Koren
Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, USA
J Biol Chem 285:2498-505. 2010..Thus, increasing Hsp70 levels combined with inhibiting its ATPase function may serve to dramatically reduce Akt levels and facilitate cell death in certain types of cancer... - Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeuticsJose F Abisambra
Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, Tampa, FL 33613, USA
Curr Neuropharmacol 9:623-31. 2011..It will particularly focus on the pharmacological targeting of the Hsp70/90 system and the value of manipulating Hsp27 for treating Alzheimer's disease... 
Neuronal life span versus health span: principles of natural selection at work in the degenerating brainJohn C O'Leary
USF Health Byrd Alzheimer s Institute, Tampa, FL 33613, USA
J Mol Neurosci 45:467-72. 2011..These data imply that multiple drugs may be necessary to ameliorate the different disease components. In fact, strategies to preserve neurons without affecting the soluble protein burden within neurons may accelerate the disease course...- Aging enhances classical activation but mitigates alternative activation in the central nervous systemDaniel C Lee
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA University of South Florida Byrd Alzheimer s Institute, Tampa, FL, USA
Neurobiol Aging 34:1610-20. 2013..Importantly, selective transcripts were induced at all ages by CKT-1, whereas selective gene transcripts induced by CKT-2 decreased with age suggesting an age-related reduction in the IL-4/ IL-13 signaling pathway... - Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathyMaj Linda B Selenica
Department of Molecular Pharmacology and Physiology, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Fla, USA
Neurodegener Dis 11:165-81. 2013..These data suggest that even brief elevations in Aβ production, may have enduring impact on the risk for tauopathy... - Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic miceLori Lebson
Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612, USA
J Neurosci 30:9651-8. 2010..Moreover, these data support the results from bone marrow grafts that circulating CD11b+ cells can enter the CNS without requiring the use of lethal irradiation... - Natural products as a rich source of tau-targeting drugs for Alzheimer's diseaseLaurent Calcul
Department of Chemistry and Center for Drug Discovery and Innovation, University of South Florida, FL, USA
Future Med Chem 4:1751-61. 2012..The overlooked approach of clearing tau aggregation will most likely be the next objective for AD drug discovery... - A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51John C O'Leary
Department of Molecular Medicine, Byrd Alzheimer s Research Institute, University of South Florida, Tampa, Florida, United States of America
PLoS ONE 6:e24840. 2011..Age-dependent anxiety was also modulated by FKBP5 deletion. Therefore, drug discovery efforts focused on depleting FKBP51 levels may yield novel antidepressant therapies... - ApoER2 function in the establishment and maintenance of retinal synaptic connectivityJustin H Trotter
Molecular Pharmacology and Physiology, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
J Neurosci 31:14413-23. 2011..Interestingly, age-related reductions in rod and cone function were observed in both ApoER2 and VLDLR KOs. These results support a pivotal role for ApoER2 in the establishment and maintenance of normal retinal synaptic connectivity... - Cell-based assays for regulators of tau biologyUmesh K Jinwal
Department of Molecular Medicine, Byrd Alzheimer s Institute, University of South Florida, Tampa, FL, USA
Methods Mol Biol 670:93-108. 2011..We provide some tips on where mistakes are most likely to occur, and we interpret our standard Western data, providing some estimation as to the composition of the banding pattern that is typical for this enigmatic protein...