Marc A Dichter

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Posttraumatic epilepsy: the challenge of translating discoveries in the laboratory to pathways to a cure
    Marc A Dichter
    Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Epilepsia 50:41-5. 2009
  2. ncbi request reprint Innovative clinical trial designs for future antiepileptic drugs
    Marc A Dichter
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Epilepsia 48:26-30. 2007
  3. doi request reprint Emerging concepts in the pathogenesis of epilepsy and epileptogenesis
    Marc A Dichter
    Department of Neurology, University of Pennsylvania, 3 Gates Building, 3400 Spruce St, Philadelphia, PA 19104 4204, USA
    Arch Neurol 66:443-7. 2009
  4. ncbi request reprint Clinical trials in neuroprotection. 23-25 January 2003, Key Biscayne, Florida, USA
    Marc A Dichter
    PENN Epilepsy Center, Department of Neurology, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Expert Opin Emerg Drugs 8:267-71. 2003
  5. ncbi request reprint Neuroprotection and antiepileptogenesis: where are we now?
    Marc A Dichter
    Department of Neurology, University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurology 59:S36-8. 2002
  6. ncbi request reprint Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury
    Lauren A O'Donnell
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 102:1905-17. 2007
  7. ncbi request reprint Murine brain progenitor cells have the ability to differentiate into functional neurons and integrate into the CNS
    Shinghua Ding
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Transplant 15:699-710. 2006
  8. doi request reprint The use of specific AAV serotypes to stably transduce primary CNS neuron cultures
    Saafan Z Malik
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Methods Mol Biol 846:305-19. 2012
  9. pmc Specific AAV serotypes stably transduce primary hippocampal and cortical cultures with high efficiency and low toxicity
    Nicolas C Royo
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Brain Res 1190:15-22. 2008
  10. ncbi request reprint Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity
    Ying Wang
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 103:439-55. 2007

Collaborators

Detail Information

Publications23

  1. doi request reprint Posttraumatic epilepsy: the challenge of translating discoveries in the laboratory to pathways to a cure
    Marc A Dichter
    Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Epilepsia 50:41-5. 2009
    ....
  2. ncbi request reprint Innovative clinical trial designs for future antiepileptic drugs
    Marc A Dichter
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Epilepsia 48:26-30. 2007
    ..It will likely require significant changes from our current strategies to accomplish these goals...
  3. doi request reprint Emerging concepts in the pathogenesis of epilepsy and epileptogenesis
    Marc A Dichter
    Department of Neurology, University of Pennsylvania, 3 Gates Building, 3400 Spruce St, Philadelphia, PA 19104 4204, USA
    Arch Neurol 66:443-7. 2009
    ....
  4. ncbi request reprint Clinical trials in neuroprotection. 23-25 January 2003, Key Biscayne, Florida, USA
    Marc A Dichter
    PENN Epilepsy Center, Department of Neurology, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Expert Opin Emerg Drugs 8:267-71. 2003
    ....
  5. ncbi request reprint Neuroprotection and antiepileptogenesis: where are we now?
    Marc A Dichter
    Department of Neurology, University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurology 59:S36-8. 2002
  6. ncbi request reprint Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury
    Lauren A O'Donnell
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 102:1905-17. 2007
    ..Thus, apelin/APJ signaling likely represents an endogenous hippocampal neuronal survival response, and therefore apelin should be further investigated as a potential neuroprotectant against hippocampal injury...
  7. ncbi request reprint Murine brain progenitor cells have the ability to differentiate into functional neurons and integrate into the CNS
    Shinghua Ding
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Transplant 15:699-710. 2006
    ..These results suggest that both the environment and state of differentiation may dictate migration and the differentiation pathway of stem cells after transplantation...
  8. doi request reprint The use of specific AAV serotypes to stably transduce primary CNS neuron cultures
    Saafan Z Malik
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Methods Mol Biol 846:305-19. 2012
    ....
  9. pmc Specific AAV serotypes stably transduce primary hippocampal and cortical cultures with high efficiency and low toxicity
    Nicolas C Royo
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Brain Res 1190:15-22. 2008
    ..These vectors should prove highly useful for efficient overexpression or downregulation of genes in primary neuronal cultures at any developmental stage...
  10. ncbi request reprint Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity
    Ying Wang
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 103:439-55. 2007
    ..Taken together, our data suggest calpain activation of CDK5, a pathway activated in HIV-infected individuals, can mediate neuronal damage and death in a model of HIV-induced neurotoxicity...
  11. pmc Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector
    Russell C Addis
    Department of Cell and Developmental Biology, Institute for Regenerative Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e28719. 2011
    ..The present study is the first demonstration that a single vector can mediate reprogramming to dopaminergic neurons, and indicates that astrocytes are an ideal starting population for the direct generation of dopaminergic neurons...
  12. pmc Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome
    Fadia Ibrahim
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Rep 3:301-8. 2013
    ..Our study uncovers neuronal RNA networks impacted by TAF15 and sets the stage for investigating the role of TAF15 in ALS pathogenesis...
  13. ncbi request reprint Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes
    Lauren A O'Donnell
    Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:981-90. 2006
    ..Antagonists of NR2A and NR2B subunits as well as inhibitors of calpain activation offer attractive neuroprotective approaches against HIV in both developing and mature brain...
  14. ncbi request reprint Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture
    Henry C Tseng
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurobiol Dis 22:88-97. 2006
    ..The conversion of endogenous pluripotent precursor cells into neurons in response to local brain injury may be an important component of central nervous system homeostasis...
  15. ncbi request reprint Differential localization of ErbB receptor ensembles influences their signaling in hippocampal neurons
    Jinqiu Chen
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    DNA Cell Biol 24:553-62. 2005
    ..Collectively, these studies indicate that different ErbB ensembles localize to different locations on the neuron to mediate distinct signals and functions...
  16. ncbi request reprint Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons
    Henry C Tseng
    David Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurobiol Dis 19:77-83. 2005
    ....
  17. ncbi request reprint Differences in multiple forms of short-term plasticity between excitatory and inhibitory hippocampal neurons in culture
    Michael P Kaplan
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Synapse 50:41-52. 2003
    ....
  18. pmc Human clinical trails in antiepileptogenesis
    Ram Mani
    Department of Neurology, University of Pennsylvania, United States
    Neurosci Lett 497:251-6. 2011
    ..Elements of ideal trials designs for successful antiepileptogenic intervention are suggested...
  19. pmc Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
    Josep Dalmau
    Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 61:25-36. 2007
    ..To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis...
  20. ncbi request reprint Differential effects of the anticonvulsant topiramate on neurobehavioral and histological outcomes following traumatic brain injury in rats
    Rachel C Hoover
    Head Injury Center, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19103, USA
    J Neurotrauma 21:501-12. 2004
    ..Topiramate significantly improved composite neuroscores at 4 weeks postinjury and rotating pole performance at 1 and 4 weeks postinjury, suggesting a potentially beneficial effect on motor function following TBI...
  21. ncbi request reprint Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons
    Albert E Telfeian
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, U S A
    Epilepsia 44:143-9. 2003
    ..Our hypothesis was that differences in gene expression between inhibitory and excitatory neurons in the rat hippocampus might point to specific new targets for seizure pharmacotherapy...
  22. ncbi request reprint Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland
    James P Stables
    National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
    Epilepsia 43:1410-20. 2002
    ..To move toward new and more effective therapies, novel approaches to therapy discovery are needed...
  23. ncbi request reprint Models of epileptogenesis in adult animals available for antiepileptogenesis drug screening
    Marc A Dichter
    Epilepsy Res 68:31-5. 2006
    ..He describes several types of animal models and how they might be useful in developing effective strategies for preventing epilepsy...

Research Grants5

  1. The neurobiology of disease: a comprehensive graduate curriculum
    Marc Dichter; Fiscal Year: 2006
    ..Students will discuss how treatments have been developed in the past, and how their research in a laboratory can help to lead to new treatment in the future. ..
  2. An Implantable Device to predict and Prevent Seizures
    Marc Dichter; Fiscal Year: 2007
    ....
  3. Postdoc Training in Translational Research in Neural Injury and Neurodegeneration
    Marc Dichter; Fiscal Year: 2007
    ..Relevance: We propose to teach physicians to conduct laboratory research into causes of neurological diseases. A better understanding will lead to the development of new treatments and cures. ..