HELEN DICHEK

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient "apoB-48-only" and "apoB-100-only" mice
    HELEN L DICHEK
    Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 45:551-60. 2004
  2. ncbi Divergent effects of the catalytic and bridging functions of hepatic lipase on atherosclerosis
    HELEN L DICHEK
    Department of Pediatrics, Box 356320, University of Washington, 1959 NE Pacific Street, Seattle WA 98195, USA
    Arterioscler Thromb Vasc Biol 24:1696-702. 2004
  3. ncbi Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology
    HELEN L DICHEK
    Dept of Pediatrics, Box 356320, Univ of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    Am J Physiol Endocrinol Metab 290:E908-15. 2006
  4. ncbi Reduced atherosclerosis in chow-fed mice expressing high levels of a catalytically inactive human hepatic lipase
    Kun Qian
    Department of Pediatrics, Box 356320, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Atherosclerosis 195:66-74. 2007
  5. ncbi Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis
    Harvey K Chiu
    Department of Pediatrics, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
    Endocrinology 151:993-1001. 2010
  6. ncbi TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice
    Andrew D Frutkin
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195 7710, USA
    Arterioscler Thromb Vasc Biol 29:1251-7. 2009
  7. ncbi Level of macrophage uPA expression is an important determinant of atherosclerotic lesion growth in Apoe-/- mice
    Ranjini Krishnan
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    Arterioscler Thromb Vasc Biol 29:1737-44. 2009
  8. ncbi Hormonal regulation of testicular steroid and cholesterol homeostasis
    Stephen M Eacker
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Mol Endocrinol 22:623-35. 2008

Research Grants

  1. The Role of Hepatic Lipase in Cholesterol Homeostatis
    HELEN DICHEK; Fiscal Year: 2005

Collaborators

Detail Information

Publications8

  1. ncbi The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient "apoB-48-only" and "apoB-100-only" mice
    HELEN L DICHEK
    Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 45:551-60. 2004
    ..Our results demonstrate that the bridging function removes apoB-48- and apoB-100-containing lipoproteins by whole particle uptake and other mechanisms...
  2. ncbi Divergent effects of the catalytic and bridging functions of hepatic lipase on atherosclerosis
    HELEN L DICHEK
    Department of Pediatrics, Box 356320, University of Washington, 1959 NE Pacific Street, Seattle WA 98195, USA
    Arterioscler Thromb Vasc Biol 24:1696-702. 2004
    ..We hypothesized that increased expression of both HL and ciHL reduces atherosclerosis in these mice...
  3. ncbi Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology
    HELEN L DICHEK
    Dept of Pediatrics, Box 356320, Univ of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    Am J Physiol Endocrinol Metab 290:E908-15. 2006
    ..These results demonstrate that HL deficiency, like LDLR deficiency, blunts the adrenal response to chronic ACTH stimulation and suggest a novel role for HL in adrenal physiology...
  4. ncbi Reduced atherosclerosis in chow-fed mice expressing high levels of a catalytically inactive human hepatic lipase
    Kun Qian
    Department of Pediatrics, Box 356320, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Atherosclerosis 195:66-74. 2007
    ..Also, these results demonstrate that ciHL increases LRP expression and suggest increased LRP-mediated lipoprotein clearance as a pathway for ciHL-mediated atherosclerosis reduction...
  5. ncbi Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis
    Harvey K Chiu
    Department of Pediatrics, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
    Endocrinology 151:993-1001. 2010
    ..Our results demonstrate that in mice, HL deficiency protects against diet-induced obesity and its hepatic sequelae. Inhibition of HL-activity may therefore have value in the prevention and/or treatment of obesity...
  6. ncbi TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice
    Andrew D Frutkin
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195 7710, USA
    Arterioscler Thromb Vasc Biol 29:1251-7. 2009
    ..The role of TGF-beta1 in aneurysm formation is also controversial. We tested whether overexpression of active TGF-beta1 in hyperlipidemic mice affects atherogenesis and aortic dilation...
  7. ncbi Level of macrophage uPA expression is an important determinant of atherosclerotic lesion growth in Apoe-/- mice
    Ranjini Krishnan
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    Arterioscler Thromb Vasc Biol 29:1737-44. 2009
    ..However, the mechanisms through which uPA acts remain unclear. In addition, although elevated uPA expression can accelerate murine atherosclerosis, there is not yet any evidence that decreased uPA expression would retard atherosclerosis...
  8. ncbi Hormonal regulation of testicular steroid and cholesterol homeostasis
    Stephen M Eacker
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Mol Endocrinol 22:623-35. 2008
    ..Surprisingly, accumulation of active sterol response element-binding protein 2 is not required for up-regulation of genes involved in cholesterol biosynthesis and uptake in Leydig cells...

Research Grants5

  1. The Role of Hepatic Lipase in Cholesterol Homeostatis
    HELEN DICHEK; Fiscal Year: 2005
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