Deborah L Diamond

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Quantitative analysis of human immunodeficiency virus type 1-infected CD4+ cell proteome: dysregulated cell cycle progression and nuclear transport coincide with robust virus production
    Eric Y Chan
    Department of Microbiology, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 81:7571-83. 2007
  2. ncbi request reprint Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction
    Deborah L Diamond
    Department of Microbiology, University of Washington, Seattle, WA 98195 8070, USA
    Hepatology 46:649-57. 2007
  3. pmc Topological analysis of protein co-abundance networks identifies novel host targets important for HCV infection and pathogenesis
    Jason E McDermott
    Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    BMC Syst Biol 6:28. 2012
  4. pmc Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus-mediated liver disease posttransplantation
    Deborah L Diamond
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    Hepatology 56:28-38. 2012
  5. pmc Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics
    Deborah L Diamond
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA
    PLoS Pathog 6:e1000719. 2010
  6. pmc Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients
    Angela L Rasmussen
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Hepatology 56:17-27. 2012
  7. pmc Proteome analysis of liver cells expressing a full-length hepatitis C virus (HCV) replicon and biopsy specimens of posttransplantation liver from HCV-infected patients
    Jon M Jacobs
    Department of Microbiology, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 79:7558-69. 2005
  8. pmc Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes
    Kathie Anne Walters
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 5:e1000269. 2009
  9. ncbi request reprint HepatoProteomics: applying proteomic technologies to the study of liver function and disease
    Deborah L Diamond
    Environmental Molecular Science Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA
    Hepatology 44:299-308. 2006
  10. pmc Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme A delta isomerase, required for hepatitis C virus replication and likely pathogenesis
    Angela L Rasmussen
    Department of Microbiology, University of Washington School of Medicine, Box 358070, Seattle, WA 98195, USA
    J Virol 85:11646-54. 2011

Collaborators

Detail Information

Publications18

  1. pmc Quantitative analysis of human immunodeficiency virus type 1-infected CD4+ cell proteome: dysregulated cell cycle progression and nuclear transport coincide with robust virus production
    Eric Y Chan
    Department of Microbiology, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 81:7571-83. 2007
    ..Continuing analyses are expected to focus on blocking virus replication by targeting these pathways and their effector proteins...
  2. ncbi request reprint Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction
    Deborah L Diamond
    Department of Microbiology, University of Washington, Seattle, WA 98195 8070, USA
    Hepatology 46:649-57. 2007
    ....
  3. pmc Topological analysis of protein co-abundance networks identifies novel host targets important for HCV infection and pathogenesis
    Jason E McDermott
    Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    BMC Syst Biol 6:28. 2012
    ..We present topological analysis of co-abundance networks as an alternative to differential regulation for confident identification of target proteins from two related global proteomics studies of hepatitis C virus (HCV) infection...
  4. pmc Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus-mediated liver disease posttransplantation
    Deborah L Diamond
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    Hepatology 56:28-38. 2012
    ..Computational modeling approaches further highlight a potentially important link between HCV-associated oxidative stress and epigenetic regulatory mechanisms impacting on liver fibrogenesis...
  5. pmc Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics
    Deborah L Diamond
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA
    PLoS Pathog 6:e1000719. 2010
    ....
  6. pmc Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients
    Angela L Rasmussen
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Hepatology 56:17-27. 2012
    ..Additionally, a common precursor state for different severe clinical outcomes was identified...
  7. pmc Proteome analysis of liver cells expressing a full-length hepatitis C virus (HCV) replicon and biopsy specimens of posttransplantation liver from HCV-infected patients
    Jon M Jacobs
    Department of Microbiology, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 79:7558-69. 2005
    ....
  8. pmc Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes
    Kathie Anne Walters
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 5:e1000269. 2009
    ..This in vitro system could be utilized to further define the cellular mechanism of this perturbation...
  9. ncbi request reprint HepatoProteomics: applying proteomic technologies to the study of liver function and disease
    Deborah L Diamond
    Environmental Molecular Science Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA
    Hepatology 44:299-308. 2006
    ....
  10. pmc Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme A delta isomerase, required for hepatitis C virus replication and likely pathogenesis
    Angela L Rasmussen
    Department of Microbiology, University of Washington School of Medicine, Box 358070, Seattle, WA 98195, USA
    J Virol 85:11646-54. 2011
    ..These findings demonstrate the utility of systems biology approaches to gain novel insight into the biology of HCV infection and identify novel, translationally relevant therapeutic targets...
  11. pmc Chronic immune activation is a distinguishing feature of liver and PBMC gene signatures from HCV/HIV coinfected patients and may contribute to hepatic fibrogenesis
    Angela L Rasmussen
    Department of Microbiology, University of Washington, Box 358070, Seattle, WA 98195, USA
    Virology 430:43-52. 2012
    ....
  12. pmc Virus-host interactions: from systems biology to translational research
    Xinxia Peng
    Department of Microbiology, University of Washington, Seattle, WA 98195 8070, USA
    Curr Opin Microbiol 12:432-8. 2009
    ..Can we save the world using these approaches? Read on...
  13. ncbi request reprint Analysis of prostate cancer by proteomics using tissue specimens
    Alvin Y Liu
    Department of Urology, University of Washington, Seattle, Washington 98195, USA
    J Urol 173:73-8. 2005
    ..We used quantitative proteomics based on glycopeptide capture followed by tandem mass spectrometry to identify differentially expressed proteins...
  14. ncbi request reprint Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria
    Yukiko Ikeda
    Children s Hospital and Regional Medical Center, University of Washington, Seattle, Wash 98105, USA
    Nephron Exp Nephrol 97:e123-35. 2004
    ..The present study was designed to investigate the effect of BMP-7 on interstitial fibrosis in the rat protein-overloaded model...
  15. pmc High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein
    Carlos Coito
    Department of Microbiology, Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    J Virol 78:3502-13. 2004
    ..Our results suggest that this novel approach may be generally applicable to the screening of other protein biochemical activities by mechanistic class...
  16. ncbi request reprint Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer
    Darrick Carter
    Department of Antigen Discovery, Corixa Corp, 1124 Columbia Street, Suite 200, Seattle, WA 98104, USA
    Biochemistry 41:6714-22. 2002
    ..This work describes the biochemistry of the mammaglobin/lipophilin B complex and lays the framework for use of this complex as a novel protein-based serological marker for breast cancer...
  17. ncbi request reprint Identification of serum amyloid A as a biomarker to distinguish prostate cancer patients with bone lesions
    Lyly Le
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Clin Chem 51:695-707. 2005
    ..Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) is an affinity-based approach that allows sensitive and high-throughput protein profiling and screening of biological samples...
  18. ncbi request reprint Use of ProteinChip array surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) to identify thymosin beta-4, a differentially secreted protein from lymphoblastoid cell lines
    Deborah L Diamond
    Ciphergen Biosystems Inc, Fremont, California, USA
    J Am Soc Mass Spectrom 14:760-5. 2003
    ..Thymosin beta-4 is a known marker in LCLs establishing the utility of this method to discover and identify proteins differentially expressed between cancers and their matched normal counterparts...